R Rubenstein

Summary

Affiliation: State University of New York
Country: USA

Publications

  1. ncbi request reprint Dynamics of the nucleated polymerization model of prion replication
    R Rubenstein
    SUNY Down State Medical Center, Brooklyn, NY 11203, USA
    Biophys Chem 125:360-7. 2007
  2. doi request reprint A novel method for preclinical detection of PrPSc in blood
    Richard Rubenstein
    Departments of Neurology and Physiology Pharmacology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    J Gen Virol 91:1883-92. 2010
  3. doi request reprint PrPC expression and calpain activity independently mediate the effects of closed head injury in mice
    Richard Rubenstein
    Laboratory of Neurodegenerative Diseases and CNS Biomarker Discovery, Departments of Neurology and Physiology Pharmacology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Box 1213, Brooklyn, NY 11203 2098, USA Electronic address
    Behav Brain Res . 2016
  4. pmc Release of Full-Length PrP(C) from Cultured Neurons Following Neurotoxic Challenges
    Kevin K W Wang
    Departments of Psychiatry and Neuroscience, Center of Neuroproteomics and Biomarker Research, McKnight Brain Institute, University of Florida Gainesville, FL, USA Laboratory of Neurodegenerative Diseases and Central Nervous System Biomarkers, Departments of Neurology and Physiology Pharmacology, State University of NewYork Downstate Medical Center Brooklyn, NY, USA
    Front Neurol 3:147. 2012
  5. pmc Influence of Mabs on PrP(Sc) formation using in vitro and cell-free systems
    Binggong Chang
    Department of Neurology, State University New York Downstate Medical Center, Brooklyn, New York, United States of America
    PLoS ONE 7:e41626. 2012
  6. pmc Re-assessment of PrP(Sc) distribution in sporadic and variant CJD
    Richard Rubenstein
    Department of Neurology and Physiology Pharmacology, State University of New York Downstate Medical Center, Brooklyn, New York, United States of America
    PLoS ONE 8:e66352. 2013
  7. pmc Role of CD40 in prion disease and the immune response to recombinant PrP
    Richard Rubenstein
    Department of Neurology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    J Neuroimmunol 257:21-7. 2013
  8. doi request reprint Prion protein as a mediator of neurocardiosympathetic interactions
    Richard Rubenstein
    Department of Neurology, SUNY Downstate Medical Center, Brooklyn, NY, USA
    Electrophoresis 33:3720-7. 2012
  9. doi request reprint Proteomic analysis of prion diseases: creating clarity or causing confusion?
    Richard Rubenstein
    Department of Neurology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Electrophoresis 33:3631-43. 2012
  10. doi request reprint PrP(Sc) detection and infectivity in semen from scrapie-infected sheep
    Richard Rubenstein
    Department of Neurology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    J Gen Virol 93:1375-83. 2012

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Dynamics of the nucleated polymerization model of prion replication
    R Rubenstein
    SUNY Down State Medical Center, Brooklyn, NY 11203, USA
    Biophys Chem 125:360-7. 2007
    ..The implications of these dynamics on protein misfolding cyclic amplification (PMCA) is discussed...
  2. doi request reprint A novel method for preclinical detection of PrPSc in blood
    Richard Rubenstein
    Departments of Neurology and Physiology Pharmacology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    J Gen Virol 91:1883-92. 2010
    ..We did not find any enhancement of sPMCA with the addition of polyadenylic acid nor was it necessary to match the genotypes of the PrP(C) and PrP(Sc) sources for efficient amplification...
  3. doi request reprint PrPC expression and calpain activity independently mediate the effects of closed head injury in mice
    Richard Rubenstein
    Laboratory of Neurodegenerative Diseases and CNS Biomarker Discovery, Departments of Neurology and Physiology Pharmacology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Box 1213, Brooklyn, NY 11203 2098, USA Electronic address
    Behav Brain Res . 2016
    ....
  4. pmc Release of Full-Length PrP(C) from Cultured Neurons Following Neurotoxic Challenges
    Kevin K W Wang
    Departments of Psychiatry and Neuroscience, Center of Neuroproteomics and Biomarker Research, McKnight Brain Institute, University of Florida Gainesville, FL, USA Laboratory of Neurodegenerative Diseases and Central Nervous System Biomarkers, Departments of Neurology and Physiology Pharmacology, State University of NewYork Downstate Medical Center Brooklyn, NY, USA
    Front Neurol 3:147. 2012
    ..However, the robust neurotoxin-mediated release of full-length PrP(C) into the cell culture media suggests an unidentified neuroprotective mechanism for PrP(C)...
  5. pmc Influence of Mabs on PrP(Sc) formation using in vitro and cell-free systems
    Binggong Chang
    Department of Neurology, State University New York Downstate Medical Center, Brooklyn, New York, United States of America
    PLoS ONE 7:e41626. 2012
    ....
  6. pmc Re-assessment of PrP(Sc) distribution in sporadic and variant CJD
    Richard Rubenstein
    Department of Neurology and Physiology Pharmacology, State University of New York Downstate Medical Center, Brooklyn, New York, United States of America
    PLoS ONE 8:e66352. 2013
    ..Further, these studies also provide circumstantial evidence that in human prion diseases, as in the animal prion diseases, a direct comparison and intraspecies correlation cannot be made between the levels of PrP(Sc) and infectivity. ..
  7. pmc Role of CD40 in prion disease and the immune response to recombinant PrP
    Richard Rubenstein
    Department of Neurology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    J Neuroimmunol 257:21-7. 2013
    ....
  8. doi request reprint Prion protein as a mediator of neurocardiosympathetic interactions
    Richard Rubenstein
    Department of Neurology, SUNY Downstate Medical Center, Brooklyn, NY, USA
    Electrophoresis 33:3720-7. 2012
    ..Overexpression of PrP(C) in the tga20 group may be associated with higher LV mass after a 2 wk regimen of isoproterenol...
  9. doi request reprint Proteomic analysis of prion diseases: creating clarity or causing confusion?
    Richard Rubenstein
    Department of Neurology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Electrophoresis 33:3631-43. 2012
    ..While the amount of data obtained is impressive, the ability to relate it to the disease and validating its usefulness in diagnostic biomarker development remains a formidable challenge...
  10. doi request reprint PrP(Sc) detection and infectivity in semen from scrapie-infected sheep
    Richard Rubenstein
    Department of Neurology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    J Gen Virol 93:1375-83. 2012
    ..These results suggest that the transmissible agent, or at least the seeding activity, for sheep scrapie is present in semen. This may be a strain-specific phenomenon...
  11. pmc Prion disease detection, PMCA kinetics, and IgG in urine from sheep naturally/experimentally infected with scrapie and deer with preclinical/clinical chronic wasting disease
    Richard Rubenstein
    SUNY Downstate Medical Center, Department of Neurology, Box 1213, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    J Virol 85:9031-8. 2011
    ....
  12. ncbi request reprint Mucosal vaccination delays or prevents prion infection via an oral route
    F Goni
    Department of Neurology, New York University School of Medicine, New York, NY 10016, USA
    Neuroscience 133:413-21. 2005
    ..This promising finding suggests that mucosal vaccination may be a useful method for overcoming tolerance to PrP and preventing prion infection among animal and potentially human populations at risk...
  13. ncbi request reprint Immune surveillance and antigen conformation determines humoral immune response to the prion protein immunogen
    R Rubenstein
    Department of Virology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Neurovirol 5:401-13. 1999
    ..Information on the forces directing immune responses to PrP will lead to a better understanding of host-PrP interactions. It will also assist in the development of new strategies for generating additional tools for immunodiagnosis...
  14. pmc Infectious amyloid precursor gene sequences in primates used for experimental transmission of human spongiform encephalopathy
    L Cervenakova
    Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 91:12159-62. 1994
    ....
  15. ncbi request reprint Mutations in familial Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker's syndrome
    D Goldgaber
    Department of Psychiatry, State University of New York, Stony Brook 11794 8101
    Exp Neurol 106:204-6. 1989
    ..We did not find it in six unaffected relatives of the GSS patients or in other individuals including sporadic and familial CJD patients. A rare insertion described earlier in one CJD family was also absent in all tested individuals...