Ellen Hsu

Summary

Affiliation: State University of New York
Country: USA

Publications

  1. pmc Evidence for Ig Light Chain Isotype Exclusion in Shark B Lymphocytes Suggests Ordered Mechanisms.
    Anna Iacoangeli
    J Immunol 199:1875-1885. 2017
  2. pmc Assembly and Expression of Shark Ig Genes
    Ellen Hsu
    Department of Physiology and Pharmacology, The State University of New York Health Science Center at Brooklyn, Brooklyn, NY 11203
    J Immunol 196:3517-23. 2016
  3. ncbi request reprint V(D)J recombination: of mice and sharks
    Ellen Hsu
    Department of Physiology and Pharmacology, State University of New York, Health Science Center at Brooklyn, Brooklyn, New York, USA
    Adv Exp Med Biol 650:166-79. 2009
  4. pmc The invention of lymphocytes
    Ellen Hsu
    Department of Physiology and Pharmacology, State University of New York and Health Science Center at Brooklyn, Brooklyn, NY 11203, USA
    Curr Opin Immunol 23:156-62. 2011
  5. pmc Diverse immunoglobulin light chain organizations in fish retain potential to revise B cell receptor specificities
    Ellen Hsu
    Department of Physiology and Pharmacology, State University of New York Health Science Center at Brooklyn, Brooklyn, NY 11203, USA
    J Immunol 177:2452-62. 2006
  6. pmc The plasticity of immunoglobulin gene systems in evolution
    Ellen Hsu
    Department of Physiology and Pharmacology, State University of New York Health Science Center at Brooklyn, Brooklyn, NY 11203, USA
    Immunol Rev 210:8-26. 2006
  7. pmc Immunoglobulin heavy chain exclusion in the shark
    Karolina Malecek
    Department of Physiology and Pharmacology, State University of New York Health Science Center at Brooklyn, Brooklyn, New York, United States of America
    PLoS Biol 6:e157. 2008
  8. ncbi request reprint Somatic hypermutation and junctional diversification at Ig heavy chain loci in the nurse shark
    Karolina Malecek
    Department of Physiology and Pharmacology, State University of New York Health Science Center, Brooklyn, NY 11203, USA
    J Immunol 175:8105-15. 2005
  9. pmc Origin of immunoglobulin isotype switching
    Catherine Zhu
    Department of Physiology and Pharmacology, State University of New York Health Science Center at Brooklyn, Brooklyn, NY 11203, USA
    Curr Biol 22:872-80. 2012
  10. pmc The evolution of multiple isotypic IgM heavy chain genes in the shark
    Victor Lee
    Department of Physiology and Pharmacology, State University of New York Health Science Center, Brooklyn, NY 11203, USA
    J Immunol 180:7461-70. 2008

Collaborators

  • Yuko Ohta
  • Martin Flajnik
  • Michael F Criscitiello
  • Lynn L Rumfelt
  • Louis Du Pasquier
  • Catherine Zhu
  • Anna Iacoangeli
  • Karolina Malecek
  • Victor Lee
  • Anita Lui
  • Cecilia Zhang
  • Wendy Feng
  • Jing Li Huang
  • Marshall Fleurant
  • Ashley Haines
  • Ushma Naik
  • Susan S Lee
  • Kate Senger
  • Ali A Zarrin
  • Alyssa Finn
  • Jeremy Weedon
  • Pauline Hua
  • Dimitre Stefanov
  • Arne Mooers
  • Ming Fai Lui
  • Jennie E Brodsky
  • Julie Brandman
  • Lily Changchien
  • Chin Tung Chen
  • Daniel Tranchina

Detail Information

Publications17

  1. pmc Evidence for Ig Light Chain Isotype Exclusion in Shark B Lymphocytes Suggests Ordered Mechanisms.
    Anna Iacoangeli
    J Immunol 199:1875-1885. 2017
    ..Based on the mRNA content found in the B cell subpopulations, an order of L chain gene activation is suggested as: σ-2 followed by κ, then σ and λ...
  2. pmc Assembly and Expression of Shark Ig Genes
    Ellen Hsu
    Department of Physiology and Pharmacology, The State University of New York Health Science Center at Brooklyn, Brooklyn, NY 11203
    J Immunol 196:3517-23. 2016
    ..This review describes how the shark primary Ab repertoire is generated in the absence of structural features considered essential in mammalian Ig gene assembly and expression. ..
  3. ncbi request reprint V(D)J recombination: of mice and sharks
    Ellen Hsu
    Department of Physiology and Pharmacology, State University of New York, Health Science Center at Brooklyn, Brooklyn, New York, USA
    Adv Exp Med Biol 650:166-79. 2009
    ....
  4. pmc The invention of lymphocytes
    Ellen Hsu
    Department of Physiology and Pharmacology, State University of New York and Health Science Center at Brooklyn, Brooklyn, NY 11203, USA
    Curr Opin Immunol 23:156-62. 2011
    ..VLR and Ig/TCR arose independently, but the convergent evolution they display actually reflects their selection in cells with specialized functions...
  5. pmc Diverse immunoglobulin light chain organizations in fish retain potential to revise B cell receptor specificities
    Ellen Hsu
    Department of Physiology and Pharmacology, State University of New York Health Science Center at Brooklyn, Brooklyn, NY 11203, USA
    J Immunol 177:2452-62. 2006
    ....
  6. pmc The plasticity of immunoglobulin gene systems in evolution
    Ellen Hsu
    Department of Physiology and Pharmacology, State University of New York Health Science Center at Brooklyn, Brooklyn, NY 11203, USA
    Immunol Rev 210:8-26. 2006
    ....
  7. pmc Immunoglobulin heavy chain exclusion in the shark
    Karolina Malecek
    Department of Physiology and Pharmacology, State University of New York Health Science Center at Brooklyn, Brooklyn, New York, United States of America
    PLoS Biol 6:e157. 2008
    ..This regulation may be shared by higher vertebrates in which additional mechanistic and regulatory elements have evolved with their structurally complex IgH locus...
  8. ncbi request reprint Somatic hypermutation and junctional diversification at Ig heavy chain loci in the nurse shark
    Karolina Malecek
    Department of Physiology and Pharmacology, State University of New York Health Science Center, Brooklyn, NY 11203, USA
    J Immunol 175:8105-15. 2005
    ..The cis-regulatory elements targeting somatic hypermutation must have already existed in the ancestral Ig gene, before H and L chain divergence...
  9. pmc Origin of immunoglobulin isotype switching
    Catherine Zhu
    Department of Physiology and Pharmacology, State University of New York Health Science Center at Brooklyn, Brooklyn, NY 11203, USA
    Curr Biol 22:872-80. 2012
    ....
  10. pmc The evolution of multiple isotypic IgM heavy chain genes in the shark
    Victor Lee
    Department of Physiology and Pharmacology, State University of New York Health Science Center, Brooklyn, NY 11203, USA
    J Immunol 180:7461-70. 2008
    ..We found that all domains changed at comparable rates, but V(H) appears to be under strong positive selection for increased amino acid sequence diversity, and surprisingly, so does Cmicro2...
  11. pmc Shark IgW C region diversification through RNA processing and isotype switching
    Cecilia Zhang
    Department of Physiology and Pharmacology, State University of New York Health Science Center at Brooklyn, Brooklyn, NY 11203, USA
    J Immunol 191:3410-8. 2013
    ..The wide array of pathogens recognized by Abs requires different disposal pathways, and our findings demonstrate complex and unique pathways for C effector function diversity that evolved independently in cartilaginous fishes. ..
  12. pmc The multiple shark Ig H chain genes rearrange and hypermutate autonomously
    Catherine Zhu
    Department of Physiology and Pharmacology, State University of New York Health Science Center at Brooklyn, Brooklyn, NY 11203, USA
    J Immunol 187:2492-501. 2011
    ....
  13. pmc Biased Immunoglobulin Light Chain Gene Usage in the Shark
    Anna Iacoangeli
    Department of Physiology and Pharmacology, State University of New York Health Science Center at Brooklyn, Brooklyn, NY 11203 and
    J Immunol 195:3992-4000. 2015
    ..We speculate that, in the shark, the differential activation of the multiple isotypes can be advantageously used in receptor editing...
  14. pmc Error-prone DNA repair activity during somatic hypermutation in shark B lymphocytes
    Catherine Zhu
    Department of Physiology and Pharmacology, State University of New York, Health Science Center at Brooklyn, Brooklyn, NY 11203 2098, USA
    J Immunol 185:5336-47. 2010
    ..8-kb J-C intron, perhaps a self-regulating aspect of activation-induced cytidine deaminase action that is conserved in evolution...
  15. ncbi request reprint Hypermutation in shark immunoglobulin light chain genes results in contiguous substitutions
    Susan S Lee
    Department of Physiology and Pharmacology, The State University of New York Health Science Center at Brooklyn, Brooklyn, NY 11203, USA
    Immunity 16:571-82. 2002
    ..We suggest this is one of several pathways of hypermutation diversifying shark antigen-receptor genes--point mutations, tandem mutations, and mutations with a G-C preference--that coevolved with or preceded gene rearrangement...
  16. ncbi request reprint Shark Ig light chain junctions are as diverse as in heavy chains
    Marshall Fleurant
    Department of Physiology and Pharmacology, State University of New York Health Science Center, Brooklyn, NY 11203, USA
    J Immunol 173:5574-82. 2004
    ....