Thomas D Wang
Affiliation: Stanford University
- Dual-axis confocal microscope for high-resolution in vivo imagingThomas D Wang
Stanford University School of Medicine, 269 Campus Drive, Stanford, California 94305 5187, USA
Opt Lett 28:414-6. 2003..3 and 2.1 microm, respectively, in free space, and confirm subcellular resolution in excised esophageal mucosa. The optics may be scaled to millimeter dimensions and fiber coupled for collection of high-resolution images in vivo...
- Dual-axes confocal microscopy with post-objective scanning and low-coherence heterodyne detectionThomas D Wang
Stanford University School of Medicine, Stanford, California 94305, USA
Opt Lett 28:1915-7. 2003..This architecture can be scaled down to millimeter dimensions with microelectromechanical systems technology for performance of in vivo optical biopsy...
- Confocal fluorescence microscope with dual-axis architecture and biaxial postobjective scanningThomas D Wang
Stanford University School of Medicine, Stanford, California 94305, USA
J Biomed Opt 9:735-42. 2004..Furthermore, the scanning mechanism produces only small differences in aberrations over the image FOV. These results demonstrate proof of concept of the dual-axis confocal architecture for in vivo molecular and cellular imaging...
- Functional imaging of colonic mucosa with a fibered confocal microscope for real-time in vivo pathologyThomas D Wang
Division of Gastroenterology, Stanford University School of Medicine, Stanford, California, USA
Clin Gastroenterol Hepatol 5:1300-5. 2007..The aim of this study was to show the use of functional optical imaging of viable mucosa for quantitative evaluation of colonic neoplasia in real time...
- Three-dimensional in vivo imaging by a handheld dual-axes confocal microscopeHyejun Ra
Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA
Opt Express 16:7224-32. 2008..The transverse and axial resolutions of the handheld probe are 1.7 microm and 5.8 microm, respectively. Capability to perform real time small animal imaging is demonstrated in vivo in transgenic mice...
- Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopyPei Lin Hsiung
Department of Pediatrics, Radiology and Microbiology and Immunology, Stanford University School of Medicine, 318 Campus Dr, Rm E 150, Stanford, California 94305, USA
Nat Med 14:454-8. 2008..This methodology represents a promising diagnostic imaging approach for the early detection of colorectal cancer and potentially of other epithelial malignancies...
- In vivo near-infrared dual-axis confocal microendoscopy in the human lower gastrointestinal tractWibool Piyawattanametha
Stanford University, James H Clark Center for Biomedical Engineering and Sciences, Department of Pediatrics, Stanford, California 94305, USA
J Biomed Opt 17:021102. 2012..These results suggest that DAC microendoscopy may have utility for visualizing the anatomical and, perhaps, functional changes associated with colorectal pathology for the early detection of colorectal cancer...
- Dual-axes confocal reflectance microscope for distinguishing colonic neoplasiaJonathan T C Liu
Ginzton Laboratory, Stanford University, Stanford, California 94305, USA
J Biomed Opt 11:054019. 2006..This design is scalable to millimeter dimensions, and the results demonstrate the potential for a miniature instrument to detect precancerous tissues, and hence to perform in vivo histopathology...
- In vivo targeting of colonic dysplasia on fluorescence endoscopy with near-infrared octapeptideZhongyao Liu
Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA
Gut 62:395-403. 2013..To demonstrate a near-infrared (NIR) peptide that is highly specific for colonic adenomas on fluorescence endoscopy in vivo...
- Efficient rejection of scattered light enables deep optical sectioning in turbid media with low-numerical-aperture optics in a dual-axis confocal architectureJonathan T C Liu
Stanford University, Department of Electrical Engineering, Ginzton Laboratory, and School of Medicine, James H Clark Center for Biomedical Engineering and Science, Stanford, California 94305, USA
J Biomed Opt 13:034020. 2008..Our results demonstrate efficient rejection of scattered light in a DACM, which enables deep optical sectioning in tissue with subcellular resolution that can distinguish between normal and premalignant pathologies...
- Use of an endoscope-compatible probe to detect colonic dysplasia with Fourier transform infrared spectroscopyMark A Mackanos
Stanford Medical Center, Department of Pediatrics, E 150 Clark Center, 318 Campus Drive, Stanford, California 94305, USA
J Biomed Opt 14:044006. 2009....
- Miniature near-infrared dual-axes confocal microscope utilizing a two-dimensional microelectromechanical systems scannerJonathan T C Liu
Edward L Ginzton Laboratory, Stanford University, Stanford, California 94305, USA
Opt Lett 32:256-8. 2007..Reflectance and fluorescence images are obtained with a laser source at 785 nm, demonstrating the ability to perform real-time optical biopsy...
- Multimodal endoscope can quantify wide-field fluorescence detection of Barrett's neoplasiaBishnu P Joshi
Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA
Endoscopy 48:A1-A13. 2016..To demonstrate the clinical use of a multimodal endoscope with a targeted fluorescently labeled peptide for quantitative detection of Barrett's neoplasia...
- Detection of endogenous biomolecules in Barrett's esophagus by Fourier transform infrared spectroscopyThomas D Wang
Division of Gastroenterology, Stanford University School of Medicine, Palo Alto Veterans Affairs Health Care System, Palo Alto, CA 94304, USA
Proc Natl Acad Sci U S A 104:15864-9. 2007....
- Near-infrared-labeled peptide multimer functions as phage mimic for high affinity, specific targeting of colonic adenomas in vivo (with videos)Bishnu P Joshi
Department of Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
Gastrointest Endosc 76:1197-206.e1-5. 2012..Fluorescent-labeled peptides are being developed to improve the endoscopic detection of colonic dysplasia...
- Targeted detection of murine colonic dysplasia in vivo with flexible multispectral scanning fiber endoscopySharon J Miller
University of Michigan, Department of Internal Medicine, Division of Gastroenterology, 109 Zina Pitcher Pl BSRB 1522, Ann Arbor, Michigan 48109 2200, USA
J Biomed Opt 17:021103. 2012..Specific binding of two or more peptides can be distinguished in vivo using a novel multispectral endoscope to localize colonic dysplasia on real-time wide-field imaging...
- Improved rejection of multiply scattered photons in confocal microscopy using dual-axes architectureLarry K Wong
Stanford University, CA 94305, USA
Opt Lett 32:1674-6. 2007....
- Targeted imaging of esophageal neoplasia with a fluorescently labeled peptide: first-in-human resultsMatthew B Sturm
Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Sci Transl Med 5:184ra61. 2013....
- Fibered confocal microscopy of bladder tumors: an ex vivo studyGeoffrey A Sonn
Department of Urology, Stanford University School of Medicine, Stanford, California 94305 5118, USA
J Endourol 23:197-201. 2009..We report the initial use of this technology to visualize tumors in the human bladder...
- EGFR Overexpressed in Colonic Neoplasia Can be Detected on Wide-Field Endoscopic ImagingJuan Zhou
Division of Gastroenterology, Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA
Clin Transl Gastroenterol 6:e101. 2015..Dysplasia can be flat in morphology, focal in size, and patchy in distribution, and thus it appears "invisible" on conventional wide-field endoscopy...
- Gastrointestinal imaging in 2015: Emerging trends in endoscopic imagingBishnu P Joshi
Department of Internal Medicine, Division of Gastroenterology, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109 2200, USA
Nat Rev Gastroenterol Hepatol 13:72-3. 2016..These studies reflect the future role for ‘smart’ contrast agents and fluorescence endoscopes to provide a molecular basis for disease detection, identify precancerous lesions and determine optimal choice of therapy...
- Imaging: Dynamic imaging of gut function--allowing the blind to seeBishnu P Joshi
Department of Medicine, Division of Gastroenterology, University of Michigan, 109 Zina Pitcher Place BSRB 1522, Ann Arbor, MI 48109 220, USA
Nat Rev Gastroenterol Hepatol 11:584-6. 2014..Moreover, radiotracer labelling of these nanoparticles facilitates multimodal detection using PET...
- Optical biopsy: a new frontier in endoscopic detection and diagnosisThomas D Wang
Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, CA 94305, USA
Clin Gastroenterol Hepatol 2:744-53. 2004..This review describes the basic biophysics of light-tissue interactions, assesses the strengths and weaknesses of each method, and examines clinical and preclinical evidence for each approach...
- Confocal microscopy from the bench to the bedsideThomas D Wang
Gastrointest Endosc 62:696-7. 2005
- Autofluorescence imaging: have we finally seen the light?Thomas D Wang
Gastrointest Endosc 61:686-8. 2005
- Detection of high-grade dysplasia in Barrett's esophagus by spectroscopy measurement of 5-aminolevulinic acid-induced protoporphyrin IX fluorescenceStephan Brand
Gastrointestinal Unit, Wellman Laboratories of Photomedicine, Boston, Massachusetts, USA
Gastrointest Endosc 56:479-87. 2002..This study used quantitative methods to determine whether aminolevulinic acid-induced protoporphyrin IX fluorescence can differentiate between Barrett's mucosa with and without dysplasia...