Gerald D Silverberg

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Elevated cerebrospinal fluid pressure in patients with Alzheimer's disease
    Gerald Silverberg
    Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cerebrospinal Fluid Res 3:7. 2006
  2. pmc Temporal course of cerebrospinal fluid dynamics and amyloid accumulation in the aging rat brain from three to thirty months
    Catherine Chiu
    Department of Neurosurgery, Warren Alpert Medical School, Brown University and Aldrich Neurosurgery Research Laboratories, Rhode Island Hospital, Providence, RI, 02903, USA
    Fluids Barriers CNS 9:3. 2012
  3. doi request reprint Amyloid efflux transporter expression at the blood-brain barrier declines in normal aging
    Gerald D Silverberg
    Department of Neurosurgery, Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA
    J Neuropathol Exp Neurol 69:1034-43. 2010
  4. doi request reprint Amyloid and Tau accumulate in the brains of aged hydrocephalic rats
    Gerald D Silverberg
    Department of Clinical Neuroscience, Rhode Island Hospital and the Warren Alpert Medical School, Brown University, Providence, RI, USA
    Brain Res 1317:286-96. 2010
  5. ncbi request reprint The cerebrospinal fluid production rate is reduced in dementia of the Alzheimer's type
    G D Silverberg
    Department of Neurosurgery, Stanford University School of Medicine, CA 94305 5327, USA
    Neurology 57:1763-6. 2001
  6. doi request reprint Amyloid deposition and influx transporter expression at the blood-brain barrier increase in normal aging
    Gerald D Silverberg
    Department of Clinical Neuroscience, Warren Alpert Medical School, Brown University and Aldrich Neurosurgery Research Laboratories, Rhode Island Hospital, Providence, Rhode Island, USA
    J Neuropathol Exp Neurol 69:98-108. 2010
  7. pmc Amyloid-beta transporter expression at the blood-CSF barrier is age-dependent
    Crissey L Pascale
    Warren Alpert Medical School Brown University, RI Hospital Department of Neurosurgery 593 Eddy St, Providence, RI 02903 USA
    Fluids Barriers CNS 8:21. 2011
  8. doi request reprint Continuous CSF drainage in AD: results of a double-blind, randomized, placebo-controlled study
    G D Silverberg
    Warren Alpert School of Medicine, Brown University, Providence, RI, USA
    Neurology 71:202-9. 2008
  9. pmc Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's disease
    Miles C Miller
    Division of Neuropathology, Department of Pathology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, 593 Eddy Street APC 12 219, Providence, RI 02903, USA
    Brain Res 1230:273-80. 2008
  10. ncbi request reprint Alzheimer's disease, normal-pressure hydrocephalus, and senescent changes in CSF circulatory physiology: a hypothesis
    Gerald D Silverberg
    Stanford University School of Medicine, Stanford, CA 94305, USA
    Lancet Neurol 2:506-11. 2003

Collaborators

Detail Information

Publications21

  1. pmc Elevated cerebrospinal fluid pressure in patients with Alzheimer's disease
    Gerald Silverberg
    Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cerebrospinal Fluid Res 3:7. 2006
    ....
  2. pmc Temporal course of cerebrospinal fluid dynamics and amyloid accumulation in the aging rat brain from three to thirty months
    Catherine Chiu
    Department of Neurosurgery, Warren Alpert Medical School, Brown University and Aldrich Neurosurgery Research Laboratories, Rhode Island Hospital, Providence, RI, 02903, USA
    Fluids Barriers CNS 9:3. 2012
    ..Alterations in cerebrospinal fluid (CSF) dynamics are also associated with normal aging and AD. This study analyzed CSF volume, production and turnover rate in relation to amyloid-beta peptide (Aβ) accumulation in the aging rat brain...
  3. doi request reprint Amyloid efflux transporter expression at the blood-brain barrier declines in normal aging
    Gerald D Silverberg
    Department of Neurosurgery, Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA
    J Neuropathol Exp Neurol 69:1034-43. 2010
    ..0004). These data indicate that alterations in LRP-1 and P-gp expression seem to contribute progressively to Aβ accumulation in aging...
  4. doi request reprint Amyloid and Tau accumulate in the brains of aged hydrocephalic rats
    Gerald D Silverberg
    Department of Clinical Neuroscience, Rhode Island Hospital and the Warren Alpert Medical School, Brown University, Providence, RI, USA
    Brain Res 1317:286-96. 2010
    ..As distinct from brain injury models, no increase in AbetaPP expression was demonstrated. Rather, altered CSF dynamics appears to impair Abeta clearance in this NPH model...
  5. ncbi request reprint The cerebrospinal fluid production rate is reduced in dementia of the Alzheimer's type
    G D Silverberg
    Department of Neurosurgery, Stanford University School of Medicine, CA 94305 5327, USA
    Neurology 57:1763-6. 2001
    ..To evaluate the production rate of CSF in patients with differing disease states...
  6. doi request reprint Amyloid deposition and influx transporter expression at the blood-brain barrier increase in normal aging
    Gerald D Silverberg
    Department of Clinical Neuroscience, Warren Alpert Medical School, Brown University and Aldrich Neurosurgery Research Laboratories, Rhode Island Hospital, Providence, Rhode Island, USA
    J Neuropathol Exp Neurol 69:98-108. 2010
    ..These data indicate an association between amyloid and microvessel RAGE during aging. An increase in capillary RAGE expression seems to play a role in the later Abeta accumulation but not in the initial increase...
  7. pmc Amyloid-beta transporter expression at the blood-CSF barrier is age-dependent
    Crissey L Pascale
    Warren Alpert Medical School Brown University, RI Hospital Department of Neurosurgery 593 Eddy St, Providence, RI 02903 USA
    Fluids Barriers CNS 8:21. 2011
    ..Expression of the Aβ transporters at the choroid plexus (CP) epithelium as a function of aging was the subject of this study...
  8. doi request reprint Continuous CSF drainage in AD: results of a double-blind, randomized, placebo-controlled study
    G D Silverberg
    Warren Alpert School of Medicine, Brown University, Providence, RI, USA
    Neurology 71:202-9. 2008
    ..We hypothesized that improving clearance of macromolecules from the CNS might slow the progression of dementia...
  9. pmc Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's disease
    Miles C Miller
    Division of Neuropathology, Department of Pathology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, 593 Eddy Street APC 12 219, Providence, RI 02903, USA
    Brain Res 1230:273-80. 2008
    ..038). Our data suggest that microvascular RAGE levels increase in conjunction with the onset of AD, and continue to increase linearly as a function of AD pathologic severity (p < 0.0001)...
  10. ncbi request reprint Alzheimer's disease, normal-pressure hydrocephalus, and senescent changes in CSF circulatory physiology: a hypothesis
    Gerald D Silverberg
    Stanford University School of Medicine, Stanford, CA 94305, USA
    Lancet Neurol 2:506-11. 2003
    ..We postulate a new nosological entity of CSF circulatory failure, with features of AD and NPH. NPH-AD may cover an important subset of patients who carry the diagnosis of either AD or NPH...
  11. pmc Brain ventricular volume and cerebrospinal fluid biomarkers of Alzheimer's disease
    Brian R Ott
    Department of Neurology, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    J Alzheimers Dis 20:647-57. 2010
    ..The basis for the apparent effect of APOE epsilon4 genotype on the relationship of ventricular volume to Abeta and tau levels is unknown, but could involve altered CSF-blood-brain barrier function during the course of disease...
  12. ncbi request reprint RAGE, LRP-1, and amyloid-beta protein in Alzheimer's disease
    John E Donahue
    Department of Clinical Neurosciences, Rhode Island Hospital and Brown Medical School, Providence, RI 02903, USA
    Acta Neuropathol 112:405-15. 2006
    ..They also suggest that the proportion of amyloid within the brains of AD patients that is derived from the systemic circulation may be significant...
  13. ncbi request reprint Novel ventriculo-peritoneal shunt in Alzheimer's disease cerebrospinal fluid biomarkers
    Gerald D Silverberg
    Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Expert Rev Neurother 4:97-107. 2004
    ....
  14. pmc Multiplicity of cerebrospinal fluid functions: New challenges in health and disease
    Conrad E Johanson
    Department of Clinical Neurosciences, Warren Alpert Medical School at Brown University, Providence, RI 02903, USA
    Cerebrospinal Fluid Res 5:10. 2008
    ..A model is presented that links CSF and ISF homeostasis to coordinated fluxes of water and solutes at both the blood-CSF and blood-brain transport interfaces...
  15. pmc Kaolin-induced chronic hydrocephalus accelerates amyloid deposition and vascular disease in transgenic rats expressing high levels of human APP
    Gerald D Silverberg
    Department of Neurosurgery, The Warren Alpert Medical School of Brown University and the Aldrich Laboratories at Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903 USA Stanford University, 710 Frenchmans Rd, Stanford, CA 94305 USA
    Fluids Barriers CNS 12:2. 2015
    ..al. Brain Res. 2010, 1317:286-296). We postulated that hydrocephalus would similarly affect an AD rat model...
  16. ncbi request reprint Biologic effects of and clinical disorders caused by nonprotein amino acids
    E Rubenstein
    Department of Medicine, Stanford University School of Medicine, California, USA
    Medicine (Baltimore) 79:80-9. 2000
    ..To what extent this mechanism is responsible for highly prevalent diseases of autoimmunity remains to be determined...
  17. doi request reprint P-glycoprotein expression and amyloid accumulation in human aging and Alzheimer's disease: preliminary observations
    Catherine Chiu
    Department of Neurosurgery, Warren Alpert Medical School, Brown University and Aldrich Neurosurgery Research Laboratories, Rhode Island Hospital, Providence, RI, USA
    Neurobiol Aging 36:2475-82. 2015
    ..Decreased P-gp expression may be related to Aβ plaques in aging and AD. Downregulating P-gp to allow pharmaceuticals into the central nervous system may increase Aβ accumulation. ..
  18. pmc Low levels of amyloid-beta and its transporters in neonatal rats with and without hydrocephalus
    Kelley E Deren
    Department of Neurosurgery, Division of Pediatric Neurosurgery, Primary Children s Medical Center and the University of Utah, Salt Lake City, Utah 84132, USA
    Cerebrospinal Fluid Res 6:4. 2009
    ..Because hydrocephalus occurs frequently in children, we evaluated the expression of Abeta and its transporters and reactive astrocytosis in animals with neonatal hydrocephalus...
  19. doi request reprint Predictors of clinical and angiographic outcome after surgical or endovascular therapy of very large and giant intracranial aneurysms
    Tim E Darsaut
    Department of Neurosurgery, Stanford Stroke Center and Stanford Institute for Neuro Innovation and Translational Neurosciences, Stanford University School of Medicine, Stanford, California 94305 5325, USA
    Neurosurgery 68:903-15; discussion 915. 2011
    ..Risk factors for poor outcome in the treatment of very large (≥20-24 mm) and giant (≥25 mm) intracranial aneurysms remain incompletely defined...
  20. ncbi request reprint Downregulation of cerebrospinal fluid production in patients with chronic hydrocephalus
    Gerald D Silverberg
    Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA
    J Neurosurg 97:1271-5. 2002
    ..The goal of this study was to determine the effect of hydrocephalus on cerebrospinal fluid (CSF) production rates in patients with acute and chronic hydrocephalus...
  21. ncbi request reprint Relationship of senescence of cerebrospinal fluid circulatory system to dementias of the aged
    E Rubenstein
    Stanford University School of Medicine, California, USA
    Lancet 351:283-5. 1998
    ..The hypothesis is that senescence of the cerebrospinal fluid circulatory system plays a part in some dementias of the aged...