J R Pomerening
Affiliation: Stanford University
- Emi2 at the crossroads: where CSF meets MPFDavid V Hansen
Department of Tumor Biology and Angiogenesis, Genentech, Inc, South San Francisco, California 94080, USA
Cell Cycle 6:732-8. 2007..Finally, we propose that inactivation of Emi2 by Cdc2 permits mitotic progression during early embryonic cleavage cycles...
- Mutation of a conserved CDK site converts a metazoan Elongation Factor 1Bbeta subunit into a replacement for yeast eEF1BalphaJ R Pomerening
Department of Molecular Pharmacology, Stanford University School of Medicine, 269 West Campus Drive, CCSR 3160, Stanford, CA 94305 5174, USA
Mol Genet Genomics 269:776-88. 2003....
- Systems-level dissection of the cell-cycle oscillator: bypassing positive feedback produces damped oscillationsJoseph R Pomerening
Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305, USA
Cell 122:565-78. 2005..This work also underscores the fundamental similarity of cell-cycle oscillations in embryos to repetitive action potentials in pacemaker neurons, with both systems relying on a combination of negative and positive-feedback loops...
- Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2Joseph R Pomerening
Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
Nat Cell Biol 5:346-51. 2003..We also show that Cdc2 activation exhibits hysteresis, a property of bistable systems with particular relevance to biochemical oscillators. These findings help establish the basic systems-level logic of the mitotic oscillator...
- Cyclin A2 regulates nuclear-envelope breakdown and the nuclear accumulation of cyclin B1Delquin Gong
Department of Chemical and Systems Biology, CCSR, MC 5174, Stanford University School of Medicine, Stanford, California 94305, USA
Curr Biol 17:85-91. 2007..Nevertheless cyclin B1 translocates to the nucleus just prior to NEB in a cyclin A2-dependent fashion and is capable of supporting NEB if rendered constitutively nuclear...
- Robust, tunable biological oscillations from interlinked positive and negative feedback loopsTony Yu Chen Tsai
Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
Science 321:126-9. 2008..Positive-plus-negative oscillators also appear to be more robust and easier to evolve, rationalizing why they are found in contexts where an adjustable frequency is unimportant...
- Uncovering mechanisms of bistability in biological systemsJoseph R Pomerening
Department of Biology and The Biocomplexity Institute, Indiana University, 212 South Hawthorne Drive, Simon Hall SI MSB, Room 043F, Bloomington, IN 47405 7003, United States
Curr Opin Biotechnol 19:381-8. 2008..These will include the role of positive feedback loops, the potential function of dual phosphorylation cycles, and substrate competition as a means of generating ultrasensitivity...