Affiliation: Stanford University
- Transient gastric irritation in the neonatal rats leads to changes in hypothalamic CRF expression, depression- and anxiety-like behavior as adultsLiansheng Liu
Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, California, United States of America
PLoS ONE 6:e19498. 2011..We hypothesized that psychological morbidity in these conditions may result from gastrointestinal problems, rather than causing them...
- Divergent fate and origin of neurosphere-like bodies from different layers of the gutLaren Becker
Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University, Stanford, California 94305, USA
Am J Physiol Gastrointest Liver Physiol 302:G958-65. 2012..NLBs from the myenteric plexus layer contain more neural crest-derived ENSCs while those from submucosal plexus appear more heterogeneous, likely containing a population of mesenchymal stem cells...
- Unraveling the mystery of pain in chronic pancreatitisPankaj Jay Pasricha
Stanford University School of Medicine, 300 Pasteur Drive, M211 Alway Building, Stanford, CA 94305, USA
Nat Rev Gastroenterol Hepatol 9:140-51. 2012..Studies have also indicated novel therapeutic targets for this condition...
- Stem cell transplantation in neurodegenerative disorders of the gastrointestinal tract: future or fiction?Subhash Kulkarni
Division of Gastroenterology and Hepatology, Stanford University, School of Medicine, Stanford, CA 94305, USA
Gut 61:613-21. 2012..This review summarises the current status of research in this field, identifies the major gaps in our knowledge and discusses the potential opportunities and hurdles for clinical application...
- The endogenous hydrogen sulfide producing enzyme cystathionine-beta synthase contributes to visceral hypersensitivity in a rat model of irritable bowel syndromeGuang Yin Xu
Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 0655, USA
Mol Pain 5:44. 2009..Dorsal root ganglion (DRG) neurons innervating the colon were labeled by injection of DiI (1,1'-dioleyl-3,3,3',3-tetramethylindocarbocyanine methanesulfonate) into the colon wall...
- Computational prediction and experimental validation associating FABP-1 and pancreatic adenocarcinoma with diabetesRavi N Sharaf
Department of Gastroenterology and Hepatology, Stanford University School of Medicine, Alway Building, Room M211, 300 Pasteur Drive, MC 5187, Stanford, CA 94305 5187, USA
BMC Gastroenterol 11:5. 2011..We identified fatty acid binding protein-1 (FABP-1) as one of several candidates. The primary aim of this pilot study was to experimentally validate the predicted association between FABP-1 with PaC and PaC with diabetes...
- NOTES and other emerging trends in gastrointestinal endoscopy and surgery: the change that we need and the change that is realPankaj Jay Pasricha
Division of Gastroenterology and Hepatology, Stanford University Medical Center, Alway Building, Room M211, 300 Pasteur Drive, MC 5187, Stanford, California 94305, USA
Am J Gastroenterol 104:2384-6. 2009..In this piece, we discuss the circumstances that led to the development of NOTES and other innovative procedures, the peril that lies in ignoring them, and the true promise that they hold for our specialties...
- Characteristics of patients with chronic unexplained nausea and vomiting and normal gastric emptyingPankaj J Pasricha
Division of Gastroenterology and Hepatology, Stanford University School of Medicine, 300 Pasteur Drive, Palo Alto, California 94305 5187, USA
Clin Gastroenterol Hepatol 9:567-76.e1-4. 2011..Chronic nausea and vomiting with normal gastric emptying is a poorly understood syndrome; we analyzed its characteristics...
- Systemic administration of anti-NGF increases A-type potassium currents and decreases pancreatic nociceptor excitability in a rat model of chronic pancreatitisYaohui Zhu
Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California 94305, USA
Am J Physiol Gastrointest Liver Physiol 302:G176-81. 2012..No significant differences were seen among those. These findings emphasize a key role for NGF in maintaining neuronal excitability in CP specifically via downregulation of I(A) by as yet unknown mechanisms...
- Changes in the gastric enteric nervous system and muscle: a case report on two patients with diabetic gastroparesisPankaj J Pasricha
Division of Gastroenterology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
BMC Gastroenterol 8:21. 2008..The aim of this study was to use modern analytical methods to determine morphological and molecular changes in the gastric wall in patients with diabetic gastroparesis...
- In vivo gastric and intestinal slow waves in W/WV miceXiaohua Hou
Division of Gastroenterology, University of Texas Medical Branch, Galveston, Texas 77555 0764, USA
Dig Dis Sci 50:1335-41. 2005..There may be some abnormality of smooth muscle cells in W/WV mice that causes a reduction in the frequency, rhythmicity, and antegrade propagation of slow waves...
- Rhythmic and spatial abnormalities of gastric slow waves in patients with functional dyspepsiaWeihong Sha
Division of Gastroenterology, University of Texas Medical Branch, Galveston, TX, USA
J Clin Gastroenterol 43:123-9. 2009..The objectives of this study were to assess differences in gastric slow waves measured by a newly approved multichannel electrogastrogram (EGG) device between patients with functional dyspepsia (FD) and healthy controls...
- Gut-derived factors promote neurogenesis of CNS-neural stem cells and nudge their differentiation to an enteric-like neuronal phenotypeSubhash Kulkarni
Div of Gastroenterology and Hepatology, Stanford Univ School of Medicine, CA 94305, USA
Am J Physiol Gastrointest Liver Physiol 301:G644-55. 2011..Our results show that the gut microenvironment induces CNS-NSC to produce neurons that share some of the characteristics of classical enteric neurons, further supporting the therapeutic use of these cells for gastrointestinal disorders...
- Substance P and calcitonin gene related peptide mediate pain in chronic pancreatitis and their expression is driven by nerve growth factorLiansheng Liu
Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, CA, USA
JOP 12:389-94. 2011..Calcitonin gene-related peptide (CGRP), substance P and nerve growth factor play an important role in inflammatory pain in various somatic pain models but their role in chronic pancreatitis has not been well studied...
- Improvement of gastric motility with gastric electrical stimulation in STZ-induced diabetic ratsJinsong Liu
Division of Gastroenterology, University of Texas Medical Branch, Galveston, Tex, USA
Digestion 70:159-66. 2004..The aims of this study were to observe whether gastric motility was impaired in streptozotocin (STZ)-induced diabetic rats and whether gastric electrical stimulation was able to restore the impaired motility...
- Electroacupuncture accelerates gastric emptying in association with changes in vagal activityHui Ouyang
Division of Gastroenterology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0632, USA
Am J Physiol Gastrointest Liver Physiol 282:G390-6. 2002..The effect may be attributed to improvement in gastric slow-wave rhythmicity and antral contractile (spike) activity and may possibly involve the vagal pathway...
- A novel safe approach to the peritoneal cavity for per-oral transgastric endoscopic proceduresSergey V Kantsevoy
Division of Gastroenterology, Johns Hopkins Hospital, 1550 Orleans Street, Baltimore, MD 21231, USA
Gastrointest Endosc 65:497-500. 2007..We have previously reported the feasibility and safety of per-oral transgastric endoscopic procedures in a porcine model...
- A novel role of VIP in colonic motility function: induction of excitation-transcription coupling in smooth muscle cellsXuan Zheng Shi
Department of Internal Medicine, Enteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology, The University of Texas Medical Branch at Galveston, Galveston, Texas 77555, USA
Gastroenterology 132:1388-400. 2007..The aim of this study was to investigate whether the phosphorylation of CREB induces gene expression of the pore-forming alpha(1C) subunit of Ca(v)1.2 channels (L-type calcium channels), whose promoter has 2 binding sites for CREB...
- Feasibility of gastric electrical stimulation by use of endoscopically placed electrodesXiaohong Xu
Division of Gastroenterology, University of Texas Medical Branch, Galveston, Texas, USA
Gastrointest Endosc 66:981-6. 2007..New methods are needed for implanting GES electrodes in a safer and more feasible way...
- The treatment of diabetic gastroparesis with botulinum toxin injection of the pylorusBrian E Lacy
Marvin M Schuster Center for Digestive and Motility Disorders, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
Diabetes Care 27:2341-7. 2004....
- Development of a new access device for transgastric surgeryLee L Swanstrom
Department of Minimally Invasive Surgery, Legacy Health System, Portland, Oregon 97210, USA
J Gastrointest Surg 9:1129-36; discussion 1136-7. 2005..This technology may serve as the needed platform for transgastric cholecystectomy, gastric reduction, fundoplication, hiatus hernia repair, or other advanced endosurgical procedures...
- An unusual electrocardiogram artifact: what is its source?Nischita K Reddy
Department of Neurology, The University of Texas Medical Branch, Galveston, TX 77555 0553, USA
J Electrocardiol 38:337-9. 2005..The patient had an implanted gastric electrical stimulation system for treating her diabetic gastroparesis. Recent DC shock for ventricular fibrillation during coronary angiography caused malfunction of the gastric pacemaker...
- Mechanisms of disease: the pathological basis of gastroparesis--a review of experimental and clinical studiesHarsha Vittal
Maine Medical Center, University of Texas Medical Branch, Galveston, TX 77555 0764, USA
Nat Clin Pract Gastroenterol Hepatol 4:336-46. 2007..Future studies should focus on understanding the molecular pathways that lead to gastric dysfunction, in animal models and in humans, and pave the way for the development of rational therapies...
- Beyond gastric emptying: a "toxic" lesson about gastroparesisPankaj J Pasricha
Am J Gastroenterol 103:424-6. 2008....
- TRYPSIN, PAR-2 AND THE PAIN OF PANCREATITISPANKAJ PASRICHA; Fiscal Year: 2004..These studies will provide insight into the underlying mechanism of pancreatic pain that may eventually lead to new and more effective forms of therapy. ..