Genomes and Genes
Khoa D Nguyen
Affiliation: Stanford University
- Serum amyloid A induces mitogenic signals in regulatory T cells via monocyte activationKhoa D Nguyen
Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA Electronic address
Mol Immunol 59:172-9. 2014..Collectively, these results point to a novel mechanism, by which SAA initiates a monocyte-dependent process that drives mitogenic signals in Treg. ..
- TSLP directly impairs pulmonary Treg function: association with aberrant tolerogenic immunity in asthmatic airwayKhoa D Nguyen
Department of Pediatrics, Stanford University, Stanford, CA, USA
Allergy Asthma Clin Immunol 6:4. 2010..TSLP mediated inhibition of Treg function might present a novel pathologic mechanism to dampen tolerogenic immune responses in inflamed asthmatic airway...
- Serum amyloid A overrides Treg anergy via monocyte-dependent and Treg-intrinsic, SOCS3-associated pathwaysKhoa D Nguyen
Department of Pediatrics, Immunology Program, Stanford University School of Medicine, 259 Campus Drive, Stanford, CA 94305, USA
Blood 117:3793-8. 2011..Collectively, these evidences suggest a novel anti-inflammatory role of SAA in the induction of a micro-environment that supports T(reg) expansion at sites of infection or tissue injury, likely to curb (auto)-inflammatory responses...
- Altered signaling in systemic juvenile idiopathic arthritis monocytesClaudia Macaubas
Department of Pediatrics, Program in Immunology, Stanford University, Stanford, CA, USA
Clin Immunol 163:66-74. 2016..Recent changes in medication in sJIA may alter the IFN hyporesponsiveness. Impaired IFN/pSTAT1 signaling is consistent with skewing of sJIA monocytes away from an M1 phenotype and may contribute to disease pathology. ..
- Impaired IL-10-dependent induction of tolerogenic dendritic cells by CD4+CD25hiCD127lo/- natural regulatory T cells in human allergic asthmaKhoa D Nguyen
Department of Pediatrics, Stanford University, Stanford, California 94305, USA
Am J Respir Crit Care Med 180:823-33. 2009..However, the significance of the influence of natural regulatory T cells on tolerogenic dendritic cells in the disease has not been investigated...
- Alternative activation in systemic juvenile idiopathic arthritis monocytesClaudia Macaubas
Department of Pediatrics, Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Clin Immunol 142:362-72. 2012..The persistence of some of these phenotypes during clinically inactive disease argues that this state reflects compensated inflammation...
- Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic developmentDiana Milojevic
Department of Pediatrics, UCSF, San Francisco, CA 94143, USA
Pediatr Rheumatol Online J 6:20. 2008..We also review the literature on the role of these T cells in rheumatic diseases and discuss the potential for their use in immunotherapy...
- Plasma profiles in active systemic juvenile idiopathic arthritis: Biomarkers and biological implicationsXuefeng B Ling
Department of Pediatrics, Stanford University, Stanford, CA 94305 5164, USA
Proteomics 10:4415-30. 2010..Pathway analyses of the 15 proteins in the SJIA flare versus quiescence signature corroborate growing evidence for a key role for IL-1 at disease flare...
- Eosinophils secrete IL-4 to facilitate liver regenerationY P Sharon Goh
Department of Genetics and Pathology, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 110:9914-9. 2013..Instead, IL-4 exerts its proliferative actions via IL-4Rα in hepatocytes. Our findings thus provide a unique mechanism by which eosinophil-derived IL-4 stimulates hepatocyte proliferation in regenerating liver...