Jonathan T C Liu
Affiliation: Stanford University
- Large-modulation-depth 2f spectroscopy with diode lasers for rapid temperature and species measurements in gases with blended and broadened spectraJonathan T C Liu
Department of Mechanical Engineering, High Temperature Gasdynamics Laboratory, Stanford University, Stanford, California 94305, USA
Appl Opt 43:6500-9. 2004..Comparisons of experimental results with 2f simulations, based on the HITRAN spectral database, provide confirmation of the capability of this method for rapid measurements of gas temperature and species concentration...
- Near-infrared diode laser absorption diagnostic for temperature and water vapor in a scramjet combustorJonathan T C Liu
High Temperature Gasdynamics Laboratory, Department of Mechanical Engineering, Stanford University, Stanford, California 94305, USA
Appl Opt 44:6701-11. 2005..The improved signal quality afforded by 2f measurements, in the case of weak absorption, demonstrates the utility of a scanned wavelength modulation strategy in such situations...
- Miniature near-infrared dual-axes confocal microscope utilizing a two-dimensional microelectromechanical systems scannerJonathan T C Liu
Edward L Ginzton Laboratory, Stanford University, Stanford, California 94305, USA
Opt Lett 32:256-8. 2007..Reflectance and fluorescence images are obtained with a laser source at 785 nm, demonstrating the ability to perform real-time optical biopsy...
- Efficient rejection of scattered light enables deep optical sectioning in turbid media with low-numerical-aperture optics in a dual-axis confocal architectureJonathan T C Liu
Stanford University, Department of Electrical Engineering, Ginzton Laboratory, and School of Medicine, James H Clark Center for Biomedical Engineering and Science, Stanford, California 94305, USA
J Biomed Opt 13:034020. 2008..Our results demonstrate efficient rejection of scattered light in a DACM, which enables deep optical sectioning in tissue with subcellular resolution that can distinguish between normal and premalignant pathologies...
- Micromirror-scanned dual-axis confocal microscope utilizing a gradient-index relay lens for image guidance during brain surgeryJonathan T C Liu
Stanford University School of Medicine, Clark Center for Biomedical Engineering and Science, Stanford, California 94305, USA
J Biomed Opt 15:026029. 2010..Optically sectioned fluorescence images of brain tissues are obtained in living mice to demonstrate the utility of this microscope for image-guided resections...
- In vivo near-infrared dual-axis confocal microendoscopy in the human lower gastrointestinal tractWibool Piyawattanametha
Stanford University, James H Clark Center for Biomedical Engineering and Sciences, Department of Pediatrics, Stanford, California 94305, USA
J Biomed Opt 17:021102. 2012..These results suggest that DAC microendoscopy may have utility for visualizing the anatomical and, perhaps, functional changes associated with colorectal pathology for the early detection of colorectal cancer...
- Functional imaging of colonic mucosa with a fibered confocal microscope for real-time in vivo pathologyThomas D Wang
Division of Gastroenterology, Stanford University School of Medicine, Stanford, California, USA
Clin Gastroenterol Hepatol 5:1300-5. 2007..The aim of this study was to show the use of functional optical imaging of viable mucosa for quantitative evaluation of colonic neoplasia in real time...
- Dual-axes confocal reflectance microscope for distinguishing colonic neoplasiaJonathan T C Liu
Ginzton Laboratory, Stanford University, Stanford, California 94305, USA
J Biomed Opt 11:054019. 2006..This design is scalable to millimeter dimensions, and the results demonstrate the potential for a miniature instrument to detect precancerous tissues, and hence to perform in vivo histopathology...
- A real-time clinical endoscopic system for intraluminal, multiplexed imaging of surface-enhanced Raman scattering nanoparticlesEllis Garai
Department of Mechanical Engineering, Stanford University, Stanford, California, United States of America Molecular Imaging Program at Stanford MIPS, Stanford University, Stanford, California, United States of America
PLoS ONE 10:e0123185. 2015....
- A Raman-based endoscopic strategy for multiplexed molecular imagingCristina L Zavaleta
Department of Radiology, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 110:E2288-97. 2013..Using this endoscope as a key part of a multiplexed detection approach could allow endoscopists to distinguish between normal and precancerous tissues rapidly and to identify flat lesions that are otherwise missed...
- Quantifying cell-surface biomarker expression in thick tissues with ratiometric three-dimensional microscopyJonathan T C Liu
Ginzton Labs, Department of Electrical Engineering, Stanford University, Stanford, California, USA
Biophys J 96:2405-14. 2009..This strategy enables rapid, quantitative, and unambiguous volumetric microscopy of biomarker expression in thick tissues, including whole biopsies, and will enable real-time optical assessment of disease markers in the living body...
- Identification of cell surface targets through meta-analysis of microarray dataHenry Haeberle
Department of Pediatrics, Stanford University, Stanford, CA 94305, USA
Neoplasia 14:666-9. 2012..This bioinformatics method has broad utility for the identification of accessible molecular targets in a variety of cancers and will enable probe development for guided resection...
- Quantitative molecular phenotyping with topically applied SERS nanoparticles for intraoperative guidance of breast cancer lumpectomyYu Wang
Department of Mechanical Engineering, University of Washington, Seattle, WA 98195, USA
Sci Rep 6:21242. 2016....
- Multiplexed Molecular Imaging of Fresh Tissue Surfaces Enabled by Convection-Enhanced Topical Staining with SERS-Coded NanoparticlesYu W Wang
Department of Mechanical Engineering, University of Washington, Seattle, WA, 98195, USA
Small 12:5612-5621. 2016..5 mm and a raster-scanned imaging rate of >5 cm2 min-1 ...