Kevin V Lemley
Affiliation: Stanford University
- Podocytopenia and disease severity in IgA nephropathyKevin V Lemley
Division of Pediatric Nephrology, Stanford University School of Medicine, Stanford, California 94305 5208, USA
Kidney Int 61:1475-85. 2002..The present study was designed to investigate functional and morphological covariates of disease severity in patients with IgA nephropathy...
- A basis for accelerated progression of diabetic nephropathy in Pima IndiansKevin V Lemley
Division of Pediatric Nephrology, Stanford University School of Medicine, Stanford, California 94305, USA
Kidney Int Suppl . 2003..Similar factors may play a role in the rapid loss of GFR associated with progressive glomerular diseases in other indigenous populations in whom glomerulomegaly and glomerulopenia coexist...
- Neonatal nephrotic presentation of a child with heterozygous NPHS1 mutationKevin V Lemley
Division of Nephrology, S161, Stanford University Medical Center, Stanford, CA 94305 5114, USA
Pediatr Nephrol 21:864-6. 2006....
- Modeling GFR trajectories in diabetic nephropathyKevin V Lemley
Division of Pediatric Nephrology, Stanford Univ School of Medicine, Stanford, CA 94305 5208, USA
Am J Physiol Renal Physiol 289:F863-70. 2005....
- Prediction of early progression in recently diagnosed IgA nephropathyKevin V Lemley
Division of Nephrology, Stanford University School of Medicine, Stanford, CA 94305, USA
Nephrol Dial Transplant 23:213-22. 2008..Most studies of prognosis in IgA nephropathy (IgAN) have tried to predict dichotomous outcomes based on a small number of clinical or semi-quantitative histological variables in large numbers of patients...
- Determinants of glomerular hypofiltration in aging humansKhoi Hoang
Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
Kidney Int 64:1417-24. 2003..The purpose of the present study was to confirm the extent to which glomerular filtration rate (GFR) is depressed in healthy, aging subjects and to elucidate the mechanism of such hypofiltration...
- Estimation of glomerular podocyte number: a selection of valid methodsKevin V Lemley
Division of Nephrology, Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
J Am Soc Nephrol 24:1193-202. 2013..We propose the use of the disector/fractionator method for studies in which controlled sectioning of tissue is feasible, reserving the Weibel and Gomez method for studies based on archival or routine pathology material. ..
- Gene expression in the normal adult human kidney assessed by complementary DNA microarrayJohn P T Higgins
Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
Mol Biol Cell 15:649-56. 2004..The distinctive patterns of gene expression in discrete portions of the kidney may serve as a resource for further understanding of renal physiology and the molecular and cellular organization of the nephron...
- Diabetes and chronic kidney disease: lessons from the Pima IndiansKevin V Lemley
Division of Nephrology, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
Pediatr Nephrol 23:1933-40. 2008..At this point, most evidence in humans suggests detachment of intact podocytes from the glomerular basement membrane, rather than apoptosis, as the predominant mechanism of podocyte loss...
- When to initiate ACEI/ARB therapy in patients with type 1 and 2 diabetesKevin V Lemley
Division of Nephrology, MS 40, Childrens Hospital Los Angeles, 4650 Sunset Boulevard, Los Angeles, CA 90027, USA
Pediatr Nephrol 25:2021-34. 2010..Recent studies suggest that very early initiation of ACEI/ARB therapy may not have demonstrable beneficial effects even over a period of years...
- Kidney disease in nail-patella syndromeKevin V Lemley
Division of Nephrology, MS 40, Childrens Hospital Los Angeles, 4650 Sunset Blvd, Los Angeles, CA 90027, USA
Pediatr Nephrol 24:2345-54. 2009..g. NPHS2, CD2AP), the transription of which is regulated by LMX1B...
- Protecting podocytes: how good do we need to be?Kevin V Lemley
Division of Nephrology, Children s Hospital Los Angeles, Los Angeles, California 90027, USA
Kidney Int 81:9-11. 2012..Quantitative monitoring of podocyte loss (e.g., to assess therapy) remains a challenge...
- Urinary excretion of viable podocytes in health and renal diseaseStefanie U Vogelmann
Division of Nephrology, Department of Medicine, Stanford University School of Medicine, CA 94305, USA
Am J Physiol Renal Physiol 285:F40-8. 2003....
- National Kidney Foundation's Kidney Disease Outcomes Quality Initiative clinical practice guidelines for chronic kidney disease in children and adolescents: evaluation, classification, and stratificationRonald J Hogg
North Texas Hospital for Children and the Department of Clinical Research at Medical City Dallas Hospital, Dallas, Texas 75230, USA
Pediatrics 111:1416-21. 2003....
- The effect of dopamine on glomerular filtration rate in normotensive, oliguric premature neonatesSusan K Lynch
Department of Pediatrics, West Virginia University School of Medicine, West Virginia, USA
Pediatr Nephrol 18:649-52. 2003..5 micro g/kg per min of dopamine. This probably reflects the effects of afferent vasodilatation and may be important clinically when enhancement of GFR is the major treatment objective...
- Podocytes, parietal cells, and glomerular pathology: the role of cell cycle proteinsMichio Nagata
Department of Pathology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, 305 8575, Tsukuba, Japan
Pediatr Nephrol 18:3-8. 2003..This review discusses the role of cell cycle molecules in the differentiation, function, and pathology of podocytes...
- Yet more ways to skin a cat: nephrin mutations outside the neonatal periodKevin V Lemley
J Am Soc Nephrol 19:1837-8. 2008