Ava Kwong

Summary

Affiliation: Stanford University School of Medicine
Country: USA

Publications

  1. ncbi Sentinel lymph node technique for breast cancer: radiation safety issues
    Martin Law
    Department of Clinical Oncology, The University of Hong Kong, Queen Mary Hospital
    Semin Oncol 31:298-303. 2004
  2. ncbi Chrysomya bezziana: a rare infestation of the breast
    Ava Kwong
    Department of Surgery, Stanford University School of Medicine, Stanford, California, USA
    Breast J 13:297-301. 2007
  3. ncbi Characterization of the pathogenic mechanism of a novel BRCA2 variant in a Chinese family
    Ava Kwong
    Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
    Fam Cancer 7:125-33. 2008
  4. ncbi The acceptance and feasibility of breast cancer screening in the East
    Ava Kwong
    Breast Care Centre, Hong Kong Sanatorium and Hospital, Hong Kong, China
    Breast 17:42-50. 2008
  5. ncbi Factors affecting false-negative breast sentinel node biopsy in Chinese patients
    Kenneth S H Chok
    Division of Breast Surgery, Department of Surgery, The University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR, China
    ANZ J Surg 77:866-9. 2007
  6. doi Mammographic screening in women at increased risk of breast cancer after treatment of Hodgkin's disease
    Ava Kwong
    Department of Radiology, Standford Unviersity School of Medicine, Stanford, California, USA
    Breast J 14:39-48. 2008
  7. pmc Circulating microRNAs as specific biomarkers for breast cancer detection
    Enders K O Ng
    Department of Surgery, The University of Hong Kong, Hong Kong, China
    PLoS ONE 8:e53141. 2013
  8. doi Breast cancer risk factors differ between Asian and white women with BRCA1/2 mutations
    Monique A de Bruin
    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Fam Cancer 11:429-39. 2012
  9. doi MicroRNA-143 is downregulated in breast cancer and regulates DNA methyltransferases 3A in breast cancer cells
    Enders K O Ng
    Department of Surgery, The University of Hong Kong, Hong Kong SAR, Hong Kong
    Tumour Biol 35:2591-8. 2014
  10. ncbi Triple negative status is a poor prognostic indicator in Chinese women with breast cancer: a ten year review
    K K Ma
    Division of Breast Surgery, Department of Surgery, Queen Mary and Tung Wah Hospital, Happy Valley, Hong Kong, China
    Asian Pac J Cancer Prev 13:2109-14. 2012

Detail Information

Publications36

  1. ncbi Sentinel lymph node technique for breast cancer: radiation safety issues
    Martin Law
    Department of Clinical Oncology, The University of Hong Kong, Queen Mary Hospital
    Semin Oncol 31:298-303. 2004
    ....
  2. ncbi Chrysomya bezziana: a rare infestation of the breast
    Ava Kwong
    Department of Surgery, Stanford University School of Medicine, Stanford, California, USA
    Breast J 13:297-301. 2007
  3. ncbi Characterization of the pathogenic mechanism of a novel BRCA2 variant in a Chinese family
    Ava Kwong
    Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
    Fam Cancer 7:125-33. 2008
    ..We report the identification of a novel BRCA2 variant (c.7806-9T > G) in a Chinese family with multiple breast cancers and document it as a pathogenic mutation...
  4. ncbi The acceptance and feasibility of breast cancer screening in the East
    Ava Kwong
    Breast Care Centre, Hong Kong Sanatorium and Hospital, Hong Kong, China
    Breast 17:42-50. 2008
    ..3 per 1000 screens and a recall rate of 9.2% were found. Despite culture differences and differences in breast characteristics (denser and smaller breasts), breast screening is feasible and acceptable in the East...
  5. ncbi Factors affecting false-negative breast sentinel node biopsy in Chinese patients
    Kenneth S H Chok
    Division of Breast Surgery, Department of Surgery, The University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR, China
    ANZ J Surg 77:866-9. 2007
    ..The objective of the research was to validate our results on sentinel lymph node biopsy (SLNB) and to determine factors affecting false-negative (FN) rates of SLNB in Chinese patients with invasive breast cancers...
  6. doi Mammographic screening in women at increased risk of breast cancer after treatment of Hodgkin's disease
    Ava Kwong
    Department of Radiology, Standford Unviersity School of Medicine, Stanford, California, USA
    Breast J 14:39-48. 2008
    ..However, early mammographic screening facilitated diagnosis of in situ and early invasive cancer in 3.5% of our subjects...
  7. pmc Circulating microRNAs as specific biomarkers for breast cancer detection
    Enders K O Ng
    Department of Surgery, The University of Hong Kong, Hong Kong, China
    PLoS ONE 8:e53141. 2013
    ..We previously showed microRNAs (miRNAs) in plasma are potential biomarkers for colorectal cancer detection. Here, we aimed to develop specific blood-based miRNA assay for breast cancer detection...
  8. doi Breast cancer risk factors differ between Asian and white women with BRCA1/2 mutations
    Monique A de Bruin
    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Fam Cancer 11:429-39. 2012
    ..Further investigation of racial differences in BRCA1/2 mutation epidemiology could inform targeted cancer risk-reduction strategies...
  9. doi MicroRNA-143 is downregulated in breast cancer and regulates DNA methyltransferases 3A in breast cancer cells
    Enders K O Ng
    Department of Surgery, The University of Hong Kong, Hong Kong SAR, Hong Kong
    Tumour Biol 35:2591-8. 2014
    ..These findings elucidated a tumor-suppressive role of miR-143 in epigenetic aberration of breast cancer, providing a potential development of miRNA-based treatment for breast cancer...
  10. ncbi Triple negative status is a poor prognostic indicator in Chinese women with breast cancer: a ten year review
    K K Ma
    Division of Breast Surgery, Department of Surgery, Queen Mary and Tung Wah Hospital, Happy Valley, Hong Kong, China
    Asian Pac J Cancer Prev 13:2109-14. 2012
    ..We studied the tumor characteristics and factors which may influence the presentation and prognosis of triple negative breast cancers (TNC) in a cohort of Chinese women...
  11. doi Male breast cancer: a population-based comparison with female breast cancer in Hong Kong, Southern China: 1997-2006
    Ava Kwong
    Division of Breast Surgery, Department of Surgery, The University of Hong Kong, Hong Kong, Hong Kong
    Ann Surg Oncol 21:1246-53. 2014
    ..This is the largest population-based study to compare Chinese MBC patients with female patients during a 10-year period in Hong Kong, Southern China...
  12. doi Interpreting differences in patterns of supportive care needs between patients with breast cancer and patients with colorectal cancer
    Wylie W Y Li
    Centre for Psycho Oncology Research and Training, School of Public Health, The University of Hong Kong, Hong Kong, China
    Psychooncology 22:792-8. 2013
    ..We therefore examined the prevalence of supportive care needs in Chinese breast (BC) and colorectal cancer (CRC) patients to identify prevalence and correlates of unmet needs...
  13. pmc Accuracy of BRCA1/2 mutation prediction models for different ethnicities and genders: experience in a southern Chinese cohort
    Ava Kwong
    Division of Breast Surgery, Department of Surgery, The University of Hong Kong, Hong Kong, China
    World J Surg 36:702-13. 2012
    ..Results are conflicting in Asian populations. Most studies did not account for gender-specific prediction. We evaluated the performance of these models in a Chinese cohort, including males, before BRCA1/2 mutation testing...
  14. pmc Breast cancer in Hong Kong, Southern China: the first population-based analysis of epidemiological characteristics, stage-specific, cancer-specific, and disease-free survival in breast cancer patients: 1997-2001
    Ava Kwong
    Division of Breast Surgery, Department of Surgery, Queen Mary and Tung Wah Hospital, The University of Hong Kong, Hong Kong, China
    Ann Surg Oncol 18:3072-8. 2011
    ..This is the first comprehensive population-based breast cancer study performed using population database of the Hong Kong Cancer Registry...
  15. doi Breast cancer in Chinese women younger than age 40: are they different from their older counterparts?
    Ava Kwong
    Breast Care Center, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong, China
    World J Surg 32:2554-61. 2008
    ..This study is the first to report the tumor characteristics and management of breast cancer in Chinese women younger than age 40 and a comparison with their older counterparts...
  16. doi Is sentinel lymph node biopsy after neoadjuvant chemotherapy feasible in Chinese patients with invasive breast cancers?
    Tanfo T Cheung
    Department of Surgery, The University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR, China
    ANZ J Surg 79:719-23. 2009
    ..This study aimed to be the first to evaluate the feasibility and accuracy of SLNB after neoadjuvant chemotherapy in Chinese patients with breast cancer...
  17. doi Choice of management of southern Chinese BRCA mutation carriers
    Ava Kwong
    Division of Breast Surgery, The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, Hong Kong, China
    World J Surg 34:1416-26. 2010
    ..Families carrying the mutation can have intensive surveillance and take preventative measures. This is the first report on the uptake of such interventions in Chinese mutation carriers residing in Asia...
  18. doi Breast-conserving surgery in Hong Kong Chinese women
    Dacita Suen
    Department of Surgery, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, Hong Kong
    World J Surg 32:2549-53. 2008
    ..This study aimed to review the rate of BCS in Hong Kong Chinese breast cancer patients and the possible clinicopathologic and psychosocial factors that may have affected the choice of surgery...
  19. pmc miR-199a-5p confers tumor-suppressive role in triple-negative breast cancer
    Jiawei Chen
    Breast Surgery Division, Department of Surgery, The University of Hong Kong, Hong Kong, SAR, China
    BMC Cancer 16:887. 2016
    ..Thus, we investigated the functional implication of miR-199a-5p in TNBC and its potential underlying mechanisms...
  20. pmc Comprehensive spectrum of BRCA1 and BRCA2 deleterious mutations in breast cancer in Asian countries
    Ava Kwong
    Department of Surgery, The University of Hong Kong, Hong Kong, Hong Kong Hong Kong Hereditary Breast Cancer Family Registry, Hong Kong, Hong Kong Departments of Medicine Oncology and Genetics, Stanford University School of Medicine, Stanford, California, USA Department of Surgery, Hong Kong Sanatorium and Hospital, Hong Kong, Hong Kong
    J Med Genet 53:15-23. 2016
    ..Understanding BRCA1/BRCA2 mutations in Asians will help provide better risk assessment and clinical management of breast cancer. ..
  21. doi The importance of analysis of long-range rearrangement of BRCA1 and BRCA2 in genetic diagnosis of familial breast cancer
    Ava Kwong
    Department of Surgery, The University of Hong Kong, Hong Kong SAR, China Hong Kong Hereditary Breast Cancer Family Registry, Hong Kong Sanatorium and Hospital, Hong Kong SAR, China Department of Oncology, Stanford University School of Medicine, Stanford, California, USA Department of Surgery, Hong Kong Sanatorium and Hospital, Hong Kong SAR, China Electronic address
    Cancer Genet 208:448-54. 2015
    ..We suggest that MLPA should be incorporated into the standard practice for genetic testing to avoid false-negative results, which would greatly affect the management of these high-risk families. ..
  22. pmc Psychometric assessment of the Chinese version of the decisional conflict scale in Chinese women making decision for breast cancer surgery
    Wendy W T Lam
    Department of Community Medicine and Unit for Behavioural Sciences, Centre for Psycho oncological Research and Training, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Health Expect 18:210-20. 2015
    ..This study examined the validity and reliability of the Chinese version of the DCS in Hong Kong Chinese women deciding breast cancer (BC) surgery...
  23. pmc Development and pilot-testing of a Decision Aid for use among Chinese women facing breast cancer surgery
    Angel H Y Au
    Centre for Psycho oncological Research and Training, School of Public Health, The University of Hong Kong, Hong Kong, China
    Health Expect 14:405-16. 2011
    ..Decision Aids (DAs) may facilitate TDM, but there are no DAs designed for Chinese populations. We developed a DA for Chinese women newly diagnosed with breast cancer, for use during the initial surgical consultation...
  24. pmc Localization of hRad9 in breast cancer
    Vivian Chan
    University Department of Medicine, Queen Mary Hospital, Hong Kong, China
    BMC Cancer 8:196. 2008
    ..We have previously shown that the mRNA up-regulation correlated with tumor size and local recurrence. Immunohistochemical studies were made to better define the role of hRad9 in breast carcinogenesis...
  25. doi Detection of Germline Mutation in Hereditary Breast and/or Ovarian Cancers by Next-Generation Sequencing on a Four-Gene Panel
    Ava Kwong
    Department of Surgery, The University of Hong Kong, Hong Kong, People s Republic of China Department of Surgery, Hong Kong Sanatorium and Hospital, Hong Kong, People s Republic of China Hong Kong Hereditary Breast Cancer Family Registry, Hong Kong, People s Republic of China Electronic address
    J Mol Diagn 18:580-94. 2016
    ..Our data suggest that hotspot mutations screening such as SNaPshot could be an effective preliminary screening alternative adopted in a standard clinical laboratory without NGS setup. ..
  26. pmc A three-miRNA signature as promising non-invasive diagnostic marker for gastric cancer
    Vivian Yvonne Shin
    Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong, SAR, China
    Mol Cancer 14:202. 2015
    ..Despite the declining incidence of gastric cancer, mortality rate remains high due to late presentation. We aimed to evaluate the sensitivity of miRNA as a diagnostic marker for gastric cancer in the circulation...
  27. doi Identifying risk factors for brain metastasis in breast cancer patients: Implication for a vigorous surveillance program
    Lorraine Chow
    Division of Breast Surgery, Department of Surgery, The University of Hong Kong, Pok Fu Lam, Hong Kong
    Asian J Surg 38:220-3. 2015
    ..This study aims to identify tumor characteristics of primary breast cancer, which are related to brain metastases in Hong Kong Chinese patients...
  28. pmc Ovarian cancer susceptibility alleles and risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers
    Susan J Ramus
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, California, USA
    Hum Mutat 33:690-702. 2012
    ..The identification of multiple loci modifying ovarian cancer risk may be useful for counseling women with BRCA1 and BRCA2 mutations regarding their risk of ovarian cancer...
  29. pmc Integrating molecular mechanisms and clinical evidence in the management of trastuzumab resistant or refractory HER-2⁺ metastatic breast cancer
    Hilda Wong
    Division of Hematology and Medical Oncology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Oncologist 16:1535-46. 2011
    ..The identification of predictive biomarkers is of paramount importance to optimize health economic costs and enhance stratification of anti-HER-2 targeted therapies...
  30. ncbi Mastectomy technique using a self-designed self-retaining retractor system
    Michael Co
    Division of Breast Surgery, Department of Surgery, The University of Hong Kong, Pok Fu Lam, Hong Kong
    Surg Today . 2016
    ..The retractor ring costs less than $200 USD, and the disposable elastic hooks cost around $50 USD. In conclusion, this new technique is simple, versatile, and effective...
  31. doi Preoperative Sentinel Node Mapping in Sentinel Node Biopsy in Early Breast Cancers - Is It Cost-Effective?
    Michael Co
    Division of Breast Surgery, Department of Surgery, Queen Mary Hospital, Hong Kong Department of Surgery, The University of Hong Kong, Hong Kong
    Clin Breast Cancer . 2016
    ..Here, we analyze the cost-effectiveness of the utilization of scintigraphy in detection of SLNs...
  32. doi Plasma miR-940 may serve as a novel biomarker for gastric cancer
    Xin Liu
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    Tumour Biol 37:3589-97. 2016
    ..It is the first report that miR-940 may mainly express in the stomach. Downregulation of plasma miR-940 may serve as a novel biomarker for detection of gastric cancer. ..
  33. doi Macrometastasis, micrometastasis, and isolated tumor cells in sentinel lymph nodes of early breast cancers: a 10-year histopathological and survival analysis of 537 Asian patients
    Michael Co
    Department of Surgery, Queen Mary Hospital, Pok Fu Lam, Hong Kong
    World J Surg 39:1438-42. 2015
    ..However, there is only limited data on the rate of positive non-SLN (NSLN) in those who have micrometastasis and isolated tumor cells (ITC) in the literature...
  34. doi Work-life balance of female versus male surgeons in Hong Kong based on findings of a questionnaire designed by a Japanese surgeon
    Ava Kwong
    Division of Breast Surgery, Department of Surgery, The University of Hong Kong, Hong Kong, Hong Kong
    Surg Today 44:62-72. 2014
    ..We evaluated the attitudes of female and male surgeons in Hong Kong to work, personal life, and work-life balance, through a questionnaire survey...
  35. ncbi Telephone pre-anaesthesia assessment for ambulatory breast surgery
    T T Law
    Division of Breast Surgery, Department of Surgery, The University of Hong Kong Li Ka Shing Faculty of Medicine, Tung Wah Hospital, Sheung Wan, Hong Kong
    Hong Kong Med J 15:179-82. 2009
    ..To review the efficacy of telephone preoperative anaesthesia assessment in patients undergoing ambulatory breast surgery...
  36. pmc Quantitative analysis and diagnostic significance of methylated SLC19A3 DNA in the plasma of breast and gastric cancer patients
    Enders K O Ng
    Department of Surgery, The University of Hong Kong, Hong Kong, Special Administrative Region, People s Republic of China
    PLoS ONE 6:e22233. 2011
    ..Here, we aim to develop a new biomarker for cancer diagnosis using methylated SLC19A3 DNA in plasma...