Michael J Griffiths
Affiliation: Stanford University
- Genomewide analysis of the host response to malaria in Kenyan childrenMichael J Griffiths
Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, UK
J Infect Dis 191:1599-611. 2005..The delineation of subjects on the basis of patterns of gene expression provides a molecular perspective of the host response to malaria and further functional insight into the underlying processes of pathogenesis...
- Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populationsTaane G Clark
Wellcome Trust Centre for Human Genetics, University of Oxford, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom
J Infect Dis 199:569-75. 2009..Therefore, more-detailed mapping of variants across TNF/LTA genes and their flanking regions in the Gambian and allied populations may need to be undertaken to find any causal polymorphisms...
- Association of the GNAS locus with severe malariaSarah Auburn
Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, UK
Hum Genet 124:499-506. 2008..88 (0.81-0.96), P = 0.005 and OR = 1.12 (1.03-1.20), P = 0.005]. The evidence presented here indicates that the influence of G-alpha-s on erythrocyte invasion efficacy may, indeed, alter individual susceptibility to disease...
- Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypesAndrew E Fry
Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
Hum Mol Genet 18:2683-92. 2009..98). These results suggest a range of possible explanations including the existence of alternative selection pressures on CD36, co-evolution between host and parasite or confounding caused by allelic heterogeneity of CD36 deficiency...
- Common variation in the ABO glycosyltransferase is associated with susceptibility to severe Plasmodium falciparum malariaAndrew E Fry
The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
Hum Mol Genet 17:567-76. 2008..5-99.9th centile). This low F(ST) region may be a signal of long-standing balancing selection at the ABO locus, caused by multiple infectious pathogens including P. falciparum...