Michael J Griffiths

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Genomewide analysis of the host response to malaria in Kenyan children
    Michael J Griffiths
    Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, UK
    J Infect Dis 191:1599-611. 2005
  2. pmc Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations
    Taane G Clark
    Wellcome Trust Centre for Human Genetics, University of Oxford, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Infect Dis 199:569-75. 2009
  3. pmc Association of the GNAS locus with severe malaria
    Sarah Auburn
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, UK
    Hum Genet 124:499-506. 2008
  4. pmc Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes
    Andrew E Fry
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Hum Mol Genet 18:2683-92. 2009
  5. pmc Common variation in the ABO glycosyltransferase is associated with susceptibility to severe Plasmodium falciparum malaria
    Andrew E Fry
    The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Hum Mol Genet 17:567-76. 2008

Detail Information

Publications5

  1. ncbi request reprint Genomewide analysis of the host response to malaria in Kenyan children
    Michael J Griffiths
    Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, UK
    J Infect Dis 191:1599-611. 2005
    ..The delineation of subjects on the basis of patterns of gene expression provides a molecular perspective of the host response to malaria and further functional insight into the underlying processes of pathogenesis...
  2. pmc Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations
    Taane G Clark
    Wellcome Trust Centre for Human Genetics, University of Oxford, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Infect Dis 199:569-75. 2009
    ..Therefore, more-detailed mapping of variants across TNF/LTA genes and their flanking regions in the Gambian and allied populations may need to be undertaken to find any causal polymorphisms...
  3. pmc Association of the GNAS locus with severe malaria
    Sarah Auburn
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, UK
    Hum Genet 124:499-506. 2008
    ..88 (0.81-0.96), P = 0.005 and OR = 1.12 (1.03-1.20), P = 0.005]. The evidence presented here indicates that the influence of G-alpha-s on erythrocyte invasion efficacy may, indeed, alter individual susceptibility to disease...
  4. pmc Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes
    Andrew E Fry
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Hum Mol Genet 18:2683-92. 2009
    ..98). These results suggest a range of possible explanations including the existence of alternative selection pressures on CD36, co-evolution between host and parasite or confounding caused by allelic heterogeneity of CD36 deficiency...
  5. pmc Common variation in the ABO glycosyltransferase is associated with susceptibility to severe Plasmodium falciparum malaria
    Andrew E Fry
    The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Hum Mol Genet 17:567-76. 2008
    ..5-99.9th centile). This low F(ST) region may be a signal of long-standing balancing selection at the ABO locus, caused by multiple infectious pathogens including P. falciparum...