Utkan Demirci

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Photonic crystals: emerging biosensors and their promise for point-of-care applications
    Hakan Inan
    Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Stanford University School of Medicine, Department of Radiology, Canary Center at Stanford for Cancer Early Detection, 3155 Porter Drive, Palo Alto, CA 94304, USA
    Chem Soc Rev . 2016
  2. ncbi request reprint Forward-viewing CMUT arrays for medical imaging
    Utkan Demirci
    E L Ginzton Laboratory, Stanford University, Stanford, CA 94305 4088, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 51:887-95. 2004
  3. ncbi request reprint Coherent array imaging using phased subarrays. Part II: simulations and experimental results
    Jeremy A Johnson
    Stanford University, Edward L Ginzton Laboratory, Stanford, CA, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 52:51-64. 2005
  4. pmc Nanoplasmonic quantitative detection of intact viruses from unprocessed whole blood
    Fatih Inci
    Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02139, USA
    ACS Nano 7:4733-45. 2013
  5. pmc Advances in biosensing strategies for HIV-1 detection, diagnosis, and therapeutic monitoring
    Mark A Lifson
    Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Radiology Department, Canary Center at Stanford for Cancer Early Detection, Stanford University School of Medicine, Palo Alto, CA, USA
    Adv Drug Deliv Rev 103:90-104. 2016
  6. ncbi request reprint Capacitive micromachined ultrasonic transducers: next-generation arrays for acoustic imaging?
    Omer Oralkan
    Edward L Ginzton Laboratory, and Center for Integrated Systems, Stanford University, Stanford, CA 94305 4070, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 49:1596-610. 2002
  7. pmc Toxicology Study of Single-walled Carbon Nanotubes and Reduced Graphene Oxide in Human Sperm
    Waseem Asghar
    Demirci BAMM Labs, Department of Radiology, Canary Center at Stanford for Cancer Early Detection, School of Medicine, Stanford University, Palo Alto 94304, CA
    Sci Rep 6:30270. 2016
  8. pmc Integrating Cell Phone Imaging with Magnetic Levitation (i-LEV) for Label-Free Blood Analysis at the Point-of-Living
    Murat Baday
    Canary Center at Stanford for Cancer Early Detection, Radiology Department, School of Medicine, Stanford University, CA, 94304, USA
    Small 12:1222-9. 2016
  9. pmc Magnetic levitation of single cells
    Naside Gozde Durmus
    Department of Biochemistry, School of Medicine, Stanford University, Stanford, CA 94304 Stanford Genome Technology Center, Stanford University, Stanford, CA 94304
    Proc Natl Acad Sci U S A 112:E3661-8. 2015
  10. pmc Engineering long shelf life multi-layer biologically active surfaces on microfluidic devices for point of care applications
    Waseem Asghar
    Bio Acoustic MEMS in Medicine BAMM Laboratory, Department of Radiology, Canary Center at Stanford for Cancer Early Detection, Stanford University School of Medicine, Electrical Engineering Department by courtesy, Stanford University, Palo Alto, CA 94304
    Sci Rep 6:21163. 2016

Collaborators

  • Mustafa Karaman
  • Omer Oralkan
  • Timothy J Henrich
  • Feng Xu
  • Michael Zhang
  • Martin L Yarmush
  • Shiladitya Sengupta
  • Brian T Cunningham
  • Baoqiang Li
  • A Sanli Ergun
  • Margherita Cioffi
  • Mehmet Toner
  • Frederic Padilla
  • Fatih Inci
  • Shuqi Wang
  • Sinan Güven
  • Pu Chen
  • Savas Tasoglu
  • Hadi Shafiee
  • Naside Gozde Durmus
  • Waseem Asghar
  • Murat Baday
  • Rami El Assal
  • Mark A Lifson
  • Daniel R Kuritzkes
  • Umut Atakan Gurkan
  • Hakan Inan
  • Lars M Steinmetz
  • Ronald W Davis
  • Onur Tokel
  • Umut A Gurkan
  • Charlène Bouyer
  • Gizem Calibasi Kocal
  • Thiruppathiraja Chinnasamy
  • Mehmet Yuksekkaya
  • Raymond M Anchan
  • Muntasir Jahangir
  • Kenneth M Kaye
  • Semih Calamak
  • Franceline Juillard
  • Mehmet Ozgun Ozen
  • U Hakan Yildiz
  • Kaushik Sridhar
  • H Cumhur Tekin
  • Daryl T Y Lau
  • Umit Hakan Yildiz
  • Ionita Ghiran
  • Amit Singhal
  • Amir Manbachi
  • Xuanhong Cheng
  • Jeremy A Johnson
  • Sanli Ergun
  • Thomas J F Nieland
  • Vanessa Velasco
  • Yasemin Baskin
  • Shirui Guo
  • Chantal Beauchemin
  • Alessandro Tocchio
  • Sebnem Unluisler
  • Serli Canikyan
  • Mihrimah Ozkan
  • George L Mutter
  • Aaron Goldman
  • Kira Foygel
  • Mustafa Kocakulak
  • Adhithi Rajagopalan
  • Alyssa Holman
  • Mehmet O Ozen
  • Srikar Srivatsa
  • Muhammet Poyraz
  • Tugrul Tolga Demirtas
  • Ramasamy Paulmurugan
  • Cengiz S Ozkan
  • Vasu R Sah
  • Max L Nibert
  • Michael L Vetter
  • Ahu Arslan Yildiz
  • Burcu Erkmen
  • Ishwari Poudel
  • Clémence Thomas
  • Osman Berk Usta
  • Burak Turker
  • Margot Carocci
  • Emily Hanhauser
  • Behzad Gerami-Naini
  • Ionita C Ghiran
  • Gizem Calibasi
  • Okan Oner Ekiz
  • Steven C Schachter
  • Sireesha Chinthala

Detail Information

Publications33

  1. ncbi request reprint Photonic crystals: emerging biosensors and their promise for point-of-care applications
    Hakan Inan
    Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Stanford University School of Medicine, Department of Radiology, Canary Center at Stanford for Cancer Early Detection, 3155 Porter Drive, Palo Alto, CA 94304, USA
    Chem Soc Rev . 2016
    ..Finally, we discuss current challenges associated with existing biosensors, and provide an outlook for PC-based biosensors and their promise at the POC...
  2. ncbi request reprint Forward-viewing CMUT arrays for medical imaging
    Utkan Demirci
    E L Ginzton Laboratory, Stanford University, Stanford, CA 94305 4088, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 51:887-95. 2004
    ....
  3. ncbi request reprint Coherent array imaging using phased subarrays. Part II: simulations and experimental results
    Jeremy A Johnson
    Stanford University, Edward L Ginzton Laboratory, Stanford, CA, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 52:51-64. 2005
    ..The simulated and experimental test results presented in this paper validate theoretical expectations and illustrate the flexibility of PSA imaging as a way to exchange SNR and frame rate for simplified front-end hardware...
  4. pmc Nanoplasmonic quantitative detection of intact viruses from unprocessed whole blood
    Fatih Inci
    Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02139, USA
    ACS Nano 7:4733-45. 2013
    ..Thus, this broadly applicable detection platform holds great promise to be implemented at POC settings, hospitals, and primary care settings. ..
  5. pmc Advances in biosensing strategies for HIV-1 detection, diagnosis, and therapeutic monitoring
    Mark A Lifson
    Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Radiology Department, Canary Center at Stanford for Cancer Early Detection, Stanford University School of Medicine, Palo Alto, CA, USA
    Adv Drug Deliv Rev 103:90-104. 2016
    ..In this review, we discuss current challenges in HIV-1 diagnosis and therapy in resource-limited settings and present emerging technologies that aim to address these challenges using innovative solutions. ..
  6. ncbi request reprint Capacitive micromachined ultrasonic transducers: next-generation arrays for acoustic imaging?
    Omer Oralkan
    Edward L Ginzton Laboratory, and Center for Integrated Systems, Stanford University, Stanford, CA 94305 4070, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 49:1596-610. 2002
    ..A tail also was observed in the point spread function (PSF) in the axial direction, indicating the existence of crosstalk. The relative amplitude of this tail with respect to the mainlobe was less than -20 dB...
  7. pmc Toxicology Study of Single-walled Carbon Nanotubes and Reduced Graphene Oxide in Human Sperm
    Waseem Asghar
    Demirci BAMM Labs, Department of Radiology, Canary Center at Stanford for Cancer Early Detection, School of Medicine, Stanford University, Palo Alto 94304, CA
    Sci Rep 6:30270. 2016
    ..Further, we demonstrate that exposure to these nanomaterials does not hinder the sperm sorting process, and microfluidic sorting systems can select the sperm that show low oxidative stress post-exposure. ..
  8. pmc Integrating Cell Phone Imaging with Magnetic Levitation (i-LEV) for Label-Free Blood Analysis at the Point-of-Living
    Murat Baday
    Canary Center at Stanford for Cancer Early Detection, Radiology Department, School of Medicine, Stanford University, CA, 94304, USA
    Small 12:1222-9. 2016
    ..In addition, cells levitated in i-LEV can be distinguished at single-cell resolution, potentially enabling diagnosis and monitoring, as well as clinical and research applications. ..
  9. pmc Magnetic levitation of single cells
    Naside Gozde Durmus
    Department of Biochemistry, School of Medicine, Stanford University, Stanford, CA 94304 Stanford Genome Technology Center, Stanford University, Stanford, CA 94304
    Proc Natl Acad Sci U S A 112:E3661-8. 2015
    ....
  10. pmc Engineering long shelf life multi-layer biologically active surfaces on microfluidic devices for point of care applications
    Waseem Asghar
    Bio Acoustic MEMS in Medicine BAMM Laboratory, Department of Radiology, Canary Center at Stanford for Cancer Early Detection, Stanford University School of Medicine, Electrical Engineering Department by courtesy, Stanford University, Palo Alto, CA 94304
    Sci Rep 6:21163. 2016
    ..The developed immunochemistry stabilization method can potentially be applied broadly to other diagnostic immuno-assays such as viral load measurements, chemotherapy monitoring, and biomarker detection for cancer patients at the POC. ..
  11. pmc Paper and flexible substrates as materials for biosensing platforms to detect multiple biotargets
    Hadi Shafiee
    Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Division of Biomedical Engineering, Division of Renal Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Sci Rep 5:8719. 2015
    ....
  12. pmc Flexible Substrate-Based Devices for Point-of-Care Diagnostics
    Shuqi Wang
    State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, 310003, China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, Zhejiang Province, 310003, China Institute for Translational Medicine, Zhejiang University, Hangzhou, Zhejiang Province, 310029, China Bio Acoustic MEMS in Medicine BAMM Laboratory, Canary Center at Stanford for Cancer Early Detection, Department of Radiology, Stanford University, School of Medicine, Palo Alto, CA 94304, USA Electronic address
    Trends Biotechnol 34:909-921. 2016
    ..Here, we focus on the latest advances in developing flexible substrate-based diagnostic devices, including paper and polymers, and their clinical applications...
  13. pmc Multiscale assembly for tissue engineering and regenerative medicine
    Sinan Güven
    Bio Acoustic MEMS in Medicine BAMM Laboratory, Canary Center at Stanford for Cancer Early Detection, Department of Radiology, Stanford School of Medicine, Palo Alto, CA 94304, USA
    Trends Biotechnol 33:269-79. 2015
    ..Additionally, we discuss driving mechanisms for self- and guided assembly to create micro-to-macro scale tissue structures. ..
  14. ncbi request reprint Medical imaging using capacitive micromachined ultrasonic transducer arrays
    Jeremy Johnson
    Edward L Ginzton Laboratory, Stanford University, CA 94305, USA
    Ultrasonics 40:471-6. 2002
    ..Beamforming and image formation algorithms that aim to reduce the complexity of data acquisition hardware are tested via numerical simulations and using real data acquired from our system...
  15. pmc 3-D Microwell Array System for Culturing Virus Infected Tumor Cells
    Rami El Assal
    Demirci Bio Acoustic MEMS in Medicine BAMM Laboratories, Canary Center at Stanford for Cancer Early Detection, Department of Radiology, Stanford University School of Medicine, Palo Alto, CA, 94304, USA
    Sci Rep 6:39144. 2016
    ..Cells in 3-D also demonstrated a higher rate of lytic reactivation. The 3-D microwell array system has the potential to improve 3-D cell oncology models and allow for better-controlled studies for drug discovery...
  16. pmc Microscale assembly directed by liquid-based template
    Pu Chen
    Bio Acoustic MEMS in Medicine BAMM Lab, Department of Radiology, Canary Center for Early Cancer Detection, Stanford University, School of Medicine, Stanford University, Palo Alto, CA, 94304, USA
    Adv Mater 26:5936-41. 2014
    ..The broad applicability of this technology is illustrated by assembling diverse materials from soft matter, rigid bodies, individual cells, cell spheroids and cell-seeded microcarrier beads. ..
  17. pmc Multitarget, quantitative nanoplasmonic electrical field-enhanced resonating device (NE2RD) for diagnostics
    Fatih Inci
    Demirci Bio Acoustic Microelectromechanical Systems in Medicine BAMM Laboratory, Canary Center at Stanford for Cancer Early Detection, Radiology Department, Stanford University School of Medicine, Palo Alto, CA 94304
    Proc Natl Acad Sci U S A 112:E4354-63. 2015
    ....
  18. pmc Functional maintenance of differentiated embryoid bodies in microfluidic systems: a platform for personalized medicine
    Sinan Güven
    BAMM Labs, Canary Center at Stanford for Early Cancer Detection, Stanford University School of Medicine, Palo Alto, California, USA BAMM Labs, Department of Medicine and Center for Infertility and Reproductive Surgery, Obstetrics Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Stem Cells Transl Med 4:261-8. 2015
    ..These results present a platform for the development of a new therapeutic system for personalized medicine. ..
  19. pmc Dynamic Microenvironment Induces Phenotypic Plasticity of Esophageal Cancer Cells Under Flow
    Gizem Calibasi Kocal
    Bio Acoustic MEMS in Medicine Laboratory, Canary Center at Stanford for Early Cancer Detection, Department of Radiology, Department of Electrical Engineering by courtesy, Stanford School of Medicine, Palo Alto, California, 94304, USA
    Sci Rep 6:38221. 2016
    ..Such in vitro microfluidic system could potentially be used to monitor how the interstitial fluid dynamics affect cancer microenvironment and plasticity on a simple, highly controllable and inexpensive bioengineered platform...
  20. doi request reprint A Bio-Acoustic Levitational (BAL) Assembly Method for Engineering of Multilayered, 3D Brain-Like Constructs, Using Human Embryonic Stem Cell Derived Neuro-Progenitors
    Charlène Bouyer
    Bio Acoustic MEMS in Medicine BAMM Lab, Canary Center for Early Cancer Detection, Department of Radiology, School of Medicine, Stanford University, Palo Alto, CA, 94304, USA
    Adv Mater 28:161-7. 2016
    ..The neuro-progenitor cells are subsequently differentiated in neural cells, resulting in a 3D neuronal construct with inter and intralayer neurite elongations. ..
  21. pmc Paramagnetic levitational assembly of hydrogels
    Savas Tasoglu
    Bio Acoustic MEMS in Medicine BAMM Laboratory, Division of Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA, Harvard MIT Health Sciences and Technology, Cambridge, MA, 02139, USA
    Adv Mater 25:1137-43. 2013
    ..We have performed experimental and theoretical analyses to describe hydrogel motion in a fluidic environment under a magnetic field...
  22. pmc Biotunable acoustic node assembly of organoids
    Pu Chen
    Bio Acoustic MEMS in Medicine BAMM Lab, Canary Center at Stanford for Early Cancer Detection, Department of Radiology, School of Medicine, Stanford University, Palo Alto, CA, 94304, USA
    Adv Healthc Mater 4:1937-43. 2015
    ..A large number of cell spheroids (>10(4) ) are assembled in seconds into a closely packed structure in a scaffold-free fashion under nodal pattern of the standing waves in a fluidic environment. ..
  23. pmc Point-of-care assays for tuberculosis: role of nanotechnology/microfluidics
    Shuqi Wang
    Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Division of Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Biotechnol Adv 31:438-49. 2013
    ..Here, we review the current assays used for TB diagnosis, and highlight the recent advances in nanotechnology and microfluidics that potentially enable new approaches for TB diagnosis in resource-constrained settings...
  24. pmc Recent advances in micro/nanotechnologies for global control of hepatitis B infection
    U Hakan Yildiz
    Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Stanford University School of Medicine, Canary Center at Stanford for Cancer Early Detection, Palo Alto, CA 94304, United States
    Biotechnol Adv 33:178-90. 2015
    ..This review aims to highlight recent advances in nanotechnology and microfabrication processes that are employed for developing point-of-care (POC) HBV assays. ..
  25. pmc Portable microfluidic integrated plasmonic platform for pathogen detection
    Onur Tokel
    Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Sci Rep 5:9152. 2015
    ..aureus samples. The presented platform technology could potentially be applicable to capture and detect other pathogens at the POC and primary care settings...
  26. pmc Efficient on-chip isolation of HIV subtypes
    Shuqi Wang
    Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Harvard MIT Health Sciences and Technology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 65 Landsdowne St, 267, Cambridge, MA 02139, USA
    Lab Chip 12:1508-15. 2012
    ..The presented immuno-sensing device enables the development of POC on-chip technologies to monitor viral load and guide antiretroviral treatment (ART) in resource-constrained settings...
  27. pmc Release of magnetic nanoparticles from cell-encapsulating biodegradable nanobiomaterials
    Feng Xu
    Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02139, USA
    ACS Nano 6:6640-9. 2012
    ....
  28. pmc Bio-inspired cryo-ink preserves red blood cell phenotype and function during nanoliter vitrification
    Rami El Assal
    Bio Acoustic MEMS in Medicine BAMM Laboratory, Canary Center at Stanford for Cancer Early Detection, Department of Radiology, Stanford University School of Medicine, Palo Alto, CA, 94304, USA Bio Acoustic MEMS in Medicine BAMM Laboratory, Division for Biomedical Engineering, Division of Infectious Diseases, Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Cambridge, MA, 02139, USA
    Adv Mater 26:5815-22. 2014
    ..An innovative approach to preserve human red-blood-cell morphology, mechanics, and function following vitrification in nanoliter volumes is developed using a novel cryo-ink integrated with a bioprinting approach. ..
  29. pmc Levitational Image Cytometry with Temporal Resolution
    Savas Tasoglu
    Department of Radiology, Stanford School of Medicine, Demirci Bio acoustic MEMS in Medicine BAMM Labs, Canary Center at Stanford for Cancer Early Detection, Palo Alto, CA, 94304, USA
    Adv Mater 27:3901-8. 2015
    ..This method allows a wide variety of cellular processes to be studied, accompanied by transient or permanent changes in cells' fundamental characteristics as a biological material. ..
  30. doi request reprint Microchip ELISA coupled with cell phone to detect ovarian cancer HE4 biomarker in urine
    Shuqi Wang
    Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Canary Center at Stanford for Early Cancer Detection, School of Medicine, Stanford University, 3155 Porter Drive, Palo Alto, CA, 94304, USA
    Methods Mol Biol 1256:111-21. 2015
    ..The presented microchip ELISA coupled with a cell phone is portable as opposed to traditional ELISA, and this method can facilitate the detection of ovarian cancer at the point-of-care (POC). ..
  31. pmc Microcirculation within grooved substrates regulates cell positioning and cell docking inside microfluidic channels
    Amir Manbachi
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 65 Landsdowne Street, Room 252, Cambridge, MA 02139, USA
    Lab Chip 8:747-54. 2008
    ..Therefore, our studies suggest that microscale shear stresses greatly influence cellular docking, immobilization, and retention in fluidic systems and should be considered for the design of cell-based microdevices...
  32. ncbi request reprint Single cell epitaxy by acoustic picolitre droplets
    Utkan Demirci
    Bio Acoustic MEMS in Medicine Laboratory, Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Lab Chip 7:1139-45. 2007
    ..Overall, the techniques described have the potential for widespread impact on many high-throughput testing applications in the biological and health sciences...
  33. pmc Cell detection and counting through cell lysate impedance spectroscopy in microfluidic devices
    Xuanhong Cheng
    BioMEMS Resource Center and Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Lab Chip 7:746-55. 2007
    ....