J David Clark

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Epigenetic regulation of spinal cord gene expression controls opioid-induced hyperalgesia
    De Yong Liang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Pain 10:59. 2014
  2. pmc The Netrin-1 receptor DCC is a regulator of maladaptive responses to chronic morphine administration
    De Yong Liang
    Anesthesiology Service, Veterans Affairs Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, USA
    BMC Genomics 15:345. 2014
  3. pmc Effects of methyl donor diets on incisional pain in mice
    Yuan Sun
    Department of Anesthesiology, Stanford University School of Medicine, Stanford, California, United States of America Department of Anesthesiology, Veterans Affairs Palo Alto Health Care System, Palo Alto, California, United States of America
    PLoS ONE 8:e77881. 2013
  4. pmc Keratinocyte expression of inflammatory mediators plays a crucial role in substance P-induced acute and chronic pain
    Tzuping Wei
    Physical Medicine and Rehabilitation Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
    J Neuroinflammation 9:181. 2012
  5. pmc Chronic morphine administration enhances nociceptive sensitivity and local cytokine production after incision
    DeYong Liang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA
    Mol Pain 4:7. 2008
  6. pmc Expression genetics identifies spinal mechanisms supporting formalin late phase behaviors
    Xiangqi Li
    Veterans Affairs Palo Alto Healthcare System, Palo Alto, CA, USA
    Mol Pain 6:11. 2010
  7. pmc Formalin injection causes a coordinated spinal cord CO/NO-cGMP signaling system response
    Xiaoyou Shi
    Department of Anesthesiology, Stanford University, Stanford, CA, USA
    Mol Pain 1:33. 2005
  8. pmc Increased local concentration of complement C5a contributes to incisional pain in mice
    Jun H Jang
    Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    J Neuroinflammation 8:80. 2011
  9. pmc Designing an automated clinical decision support system to match clinical practice guidelines for opioid therapy for chronic pain
    Jodie A Trafton
    Center for Health Care Evaluation CHCE, VA Palo Alto Health Care System and Stanford University Medical School, 795 Willow Road 152 MPD, Menlo Park, CA 94025, USA
    Implement Sci 5:26. 2010
  10. pmc Activity of opioid ligands in cells expressing cloned mu opioid receptors
    Parham Gharagozlou
    Department of Pharmacology, Molecular Research Institute, Mountain View, CA 94043, USA
    BMC Pharmacol 3:1. 2003

Research Grants

  1. MECHANISMS FOR TOLERANCE TO ACTIONS OF A2 AGONISTS
    David Clark; Fiscal Year: 2002
  2. Genetics of Opioid Induced Hyperalgesia
    David Clark; Fiscal Year: 2004
  3. The Roles of Heme Oxygenase in Pain
    David Clark; Fiscal Year: 2005
  4. Opioid Efficacy In Humans: A Twin Study
    DAVID J contact CLARK; Fiscal Year: 2010

Collaborators

Detail Information

Publications19

  1. pmc Epigenetic regulation of spinal cord gene expression controls opioid-induced hyperalgesia
    De Yong Liang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Pain 10:59. 2014
    ..The present work seeks to identify gene targets supporting the epigenetic effects responsible for OIH prolongation...
  2. pmc The Netrin-1 receptor DCC is a regulator of maladaptive responses to chronic morphine administration
    De Yong Liang
    Anesthesiology Service, Veterans Affairs Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, USA
    BMC Genomics 15:345. 2014
    ....
  3. pmc Effects of methyl donor diets on incisional pain in mice
    Yuan Sun
    Department of Anesthesiology, Stanford University School of Medicine, Stanford, California, United States of America Department of Anesthesiology, Veterans Affairs Palo Alto Health Care System, Palo Alto, California, United States of America
    PLoS ONE 8:e77881. 2013
    ..However, the dietary effects of methyl donors on pain have not been explored. In this study, we evaluated the effects of dietary methyl donor content on pain responses in mice...
  4. pmc Keratinocyte expression of inflammatory mediators plays a crucial role in substance P-induced acute and chronic pain
    Tzuping Wei
    Physical Medicine and Rehabilitation Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
    J Neuroinflammation 9:181. 2012
    ..Collectively our data indicate that SP acting through NK1 receptors supports the nociceptive and vascular components of CRPS, but not the bone-related changes...
  5. pmc Chronic morphine administration enhances nociceptive sensitivity and local cytokine production after incision
    DeYong Liang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA
    Mol Pain 4:7. 2008
    ..Most of these proposed mechanisms involve plastic events in the central or peripheral nervous systems. Alterations in the abundance of peripheral mediators of nociception have not previously been explored...
  6. pmc Expression genetics identifies spinal mechanisms supporting formalin late phase behaviors
    Xiangqi Li
    Veterans Affairs Palo Alto Healthcare System, Palo Alto, CA, USA
    Mol Pain 6:11. 2010
    ..By using correlative analysis between spinal gene expression and mouse strain-dependent intensity of late phase behavior, we hypothesized genes participating in variability of the response could be identified...
  7. pmc Formalin injection causes a coordinated spinal cord CO/NO-cGMP signaling system response
    Xiaoyou Shi
    Department of Anesthesiology, Stanford University, Stanford, CA, USA
    Mol Pain 1:33. 2005
    ..While individual components have been examined in isolation, little study has been dedicated to understanding the regulation and functioning of the system as a whole...
  8. pmc Increased local concentration of complement C5a contributes to incisional pain in mice
    Jun H Jang
    Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    J Neuroinflammation 8:80. 2011
    ..In this study, we further examined the possible contribution of wound area C5a to incisional pain...
  9. pmc Designing an automated clinical decision support system to match clinical practice guidelines for opioid therapy for chronic pain
    Jodie A Trafton
    Center for Health Care Evaluation CHCE, VA Palo Alto Health Care System and Stanford University Medical School, 795 Willow Road 152 MPD, Menlo Park, CA 94025, USA
    Implement Sci 5:26. 2010
    ..The process and experiences described provide a model for development of other DSSs that translate written guidelines into actionable, real-time clinical recommendations...
  10. pmc Activity of opioid ligands in cells expressing cloned mu opioid receptors
    Parham Gharagozlou
    Department of Pharmacology, Molecular Research Institute, Mountain View, CA 94043, USA
    BMC Pharmacol 3:1. 2003
    ..Efficacies and potencies of these ligands were determined relative to the endogenous ligand beta-endorphin and the common mu agonist, morphine...
  11. pmc Activation profiles of opioid ligands in HEK cells expressing delta opioid receptors
    Parham Gharagozlou
    Molecular Research Institute, Mountain View, CA 94043, USA
    BMC Neurosci 3:19. 2002
    ..Activation profiles of most of these ligands at delta opioid receptors had not been previously characterized in vitro. Receptor activation was assessed by measuring the inhibition of forskolin-stimulated cAMP production...
  12. doi The pitfalls of profoundly effective analgesic therapies
    John David Clark
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA
    Clin J Pain 24:825-31. 2008
    ..Depending on their mechanisms of action, there may be significant downsides to the use of these new medications. The objective of this report was to explore the consequences of developing profoundly effective analgesic agents...
  13. pmc Morphine reduces local cytokine expression and neutrophil infiltration after incision
    J David Clark
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA
    Mol Pain 3:28. 2007
    ..Our studies were directed towards determining if opioids alter cytokine production near incisions and to identify cell populations responsible for producing these cytokines...
  14. ncbi Blockade of the complement C5a receptor reduces incisional allodynia, edema, and cytokine expression
    J David Clark
    Department of Anesthesia, Stanford University School of Medicine, California 94304, USA
    Anesthesiology 104:1274-82. 2006
    ..Complement-mediated enhancement of the inflammation surrounding surgical incisions may increase pain...
  15. ncbi Modulation of the NO/CO-cGMP signaling cascade during chronic morphine exposure in mice
    De Yong Liang
    Department of Anesthesiology, Stanford University and Veterans Affairs Palo Alto Health Care System, 112A, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
    Neurosci Lett 365:73-7. 2004
    ....
  16. ncbi A case of a methadone-induced movement disorder
    J D Clark
    Veterans Affairs Palo Alto Health Care System, California 94304, USA
    Clin J Pain 17:375-7. 2001
    ..To increase awareness of the possibility of opioid induced movement disorders...
  17. pmc Preprotachykinin-A gene disruption attenuates nociceptive sensitivity after opioid administration and incision by peripheral and spinal mechanisms in mice
    Peyman Sahbaie
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA
    J Pain 13:997-1007. 2012
    ..A similar pattern was seen for 5-HT3 receptor expression in tissue from dorsal root ganglia. Therefore, SP may work at both central and peripheral sites to enhance nociceptive sensitization after morphine treatment and incision...
  18. pmc From mouse to man: the 5-HT3 receptor modulates physical dependence on opioid narcotics
    Larry F Chu
    Department of Anesthesiology, Stanford University, Palo Alto, California, USA
    Pharmacogenet Genomics 19:193-205. 2009
    ..The analysis of opioid dependence using contemporary in-silico techniques offers an approach to discover novel treatments for dependence and addiction...
  19. pmc Sex differences in a Murine Model of Complex Regional Pain Syndrome
    Maral Tajerian
    Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, United States Department of Anesthesiology, Stanford University School of Medicine, Stanford, CA, United States Palo Alto Institute of Research and Education, Palo Alto, CA, United States Electronic address
    Neurobiol Learn Mem 123:100-9. 2015
    ....

Research Grants4

  1. MECHANISMS FOR TOLERANCE TO ACTIONS OF A2 AGONISTS
    David Clark; Fiscal Year: 2002
    ..Data from these studies can be used to develop therapeutic strategies to prevent or reverse tolerance. ..
  2. Genetics of Opioid Induced Hyperalgesia
    David Clark; Fiscal Year: 2004
    ..Thus our overall goal is to bring a unique and complimentary approach to the ongoing studies of OIH by using genomics to objectively identify genes involved in this phenomenon. ..
  3. The Roles of Heme Oxygenase in Pain
    David Clark; Fiscal Year: 2005
    ....
  4. Opioid Efficacy In Humans: A Twin Study
    DAVID J contact CLARK; Fiscal Year: 2010
    ....