Affiliation: Stanford University
- Cancer stem cells: models and conceptsPiero Dalerba
Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California 94304, USA
Annu Rev Med 58:267-84. 2007..This model, first developed in human myeloid leukemias, is today being extended to solid tumors, such as breast and brain cancer. We review the biological basis and the therapeutic implications of the stem cell model of cancer...
- Cancer stem cells and tumor metastasis: first steps into uncharted territoryPiero Dalerba
Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Palo Alto, CA 94304, USA
Cell Stem Cell 1:241-2. 2007..In this issue of Cell Stem Cell, Hermann et al. (2007) analyze the relationship between CSC and tumor metastasis...
- Oncogenic miRNAs and the perils of losing control of a stem cell's epigenetic identityPiero Dalerba
Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA
Cell Stem Cell 13:5-6. 2013..In back-to-back articles in Cell and Cell Stem Cell, Song et al. identify miR-22 as both a repressor of TET proteins and a powerful oncogene in the mammary epithelium and hematopoietic system. ..
- Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in miceMichael E Rothenberg
Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford, California 94305, USA
Gastroenterology 142:1195-1205.e6. 2012..Although the colon also contains Lgr5(+) stem cells, it does not contain Paneth cells. We investigated the existence of colonic Paneth-like cells that have a distinct transcriptional signature and support Lgr5(+) stem cells...
- Quantitative assessment of single-cell RNA-sequencing methodsAngela R Wu
Department of Bioengineering, Stanford University, Stanford, California, USA
Nat Methods 11:41-6. 2014....
- Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse modelsHuiping Liu
Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Palo Alto, CA 94304, USA
Proc Natl Acad Sci U S A 107:18115-20. 2010....
- A Quiescent Bcl11b High Stem Cell Population Is Required for Maintenance of the Mammary GlandShang Cai
Institute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA
Cell Stem Cell . 2016..Taken together, these results suggest that Bcl11b acts as a central intrinsic regulator of mammary epithelial stem cell quiescence and exhaustion and is necessary for long-term maintenance of the mammary gland...
- Downregulation of miRNA-200c links breast cancer stem cells with normal stem cellsYohei Shimono
Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, 1050 Arastradero Road, Palo Alto, CA 94304, USA
Cell 138:592-603. 2009..The coordinated downregulation of three microRNA clusters and the similar functional regulation of clonal expansion by miR-200c provide a molecular link that connects BCSCs with normal stem cells...
- The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumorsStephen B Willingham
Institute for Stem Cell Biology and Regenerative Medicine, Stanford University Medical Center, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 109:6662-7. 2012..CD47 is therefore a validated target for cancer therapies...
- CDX2 as a Prognostic Biomarker in Stage II and Stage III Colon CancerPiero Dalerba
From the Herbert Irving Comprehensive Cancer Center and the Departments of Pathology and Cell Biology and Medicine, Columbia University, New York P D Institute for Stem Cell Biology and Regenerative Medicine P D, D S, P S R, S P M, S H, J H, D Q, M F C and the Departments of Pathology X G, E F, M R, and Medicine, Division of Oncology N W F, G A F, M F C, Stanford University, Stanford, and the Departments of Pediatrics and Computer Science and Engineering, University of California San Diego, San Diego D S both in California Faculty of Engineering, Bar Ilan University, Ramat Gan, Israel T K the National Surgical Adjuvant Breast and Bowel Project, NRG Oncology S P, G Y, N S, N W and the Allegheny Cancer Center at Allegheny General Hospital N W both in Pittsburgh Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, South Korea S P and the Department of Biochemistry and Molecular Biology, Medical School of Henan University, Kaifeng, China X G
N Engl J Med 374:211-22. 2016..Funded by the National Comprehensive Cancer Network, the National Institutes of Health, and others.). ..
- miR-142 regulates the tumorigenicity of human breast cancer stem cells through the canonical WNT signaling pathwayTaichi Isobe
Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, United States
elife 3:. 2014..These results suggest that in some tumors, miR-142 regulates the properties of BCSCs at least in part by activating the WNT signaling pathway and miR-150 expression. ..
- Single-cell dissection of transcriptional heterogeneity in human colon tumorsPiero Dalerba
Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California, USA
Nat Biotechnol 29:1120-7. 2011....
- The 5th International Society for Stem Cell Research (ISSCR) Annual Meeting, June 2007Vinagolu K Rajasekhar
Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Rockefeller Research Laboratories, New York, New York 10021, USA
Stem Cells 26:292-8. 2008..This hypothesis was widely explored at the conference to shed new light on the mechanisms of tumor origin and progression and to unveil novel antitumor therapeutic approaches...
- Identification of pancreatic cancer stem cellsChenwei Li
Department of Surgery, University of Michigan Medical Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
Cancer Res 67:1030-7. 2007....
- Immunity to cancer: attack and escape in T lymphocyte-tumor cell interactionLicia Rivoltini
Units of Human Tumor Immunotherapy and Immunobiology, Istituto Nazionale Tumori, Milan, Italy
Immunol Rev 188:97-113. 2002..Finally, we discuss the role of inducible nitric oxide synthases in determining the inhibition of apoptosis in melanoma cells, which can make such tumor cells resistant to the T-cell attack...
- Cancer immunotherapy with peptide-based vaccines: what have we achieved? Where are we going?Giorgio Parmiani
Unit of Immunotherapy of Human Tumors, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
J Natl Cancer Inst 94:805-18. 2002....