Genomes and Genes
Antony A Boucard
Affiliation: Stanford University
- High affinity neurexin binding to cell adhesion G-protein-coupled receptor CIRL1/latrophilin-1 produces an intercellular adhesion complexAntony A Boucard
Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
J Biol Chem 287:9399-413. 2012....
- Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validationJaewon Ko
Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University School of Medicine, Palo Alto, CA 94304 5543, USA
EMBO J 28:3244-55. 2009..Thus, neuroligin-1 performs diverse synaptic functions by mechanisms that include as essential components of alpha-neurexin binding and neuroligin dimerization, but extend beyond these activities...
- Latrophilins function as heterophilic cell-adhesion molecules by binding to teneurins: regulation by alternative splicingAntony A Boucard
From the Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University School of Medicine, Palo Alto, California 94305
J Biol Chem 289:387-402. 2014..Thus, mammalian teneurins act as heterophilic cell-adhesion molecules that may be involved in trans-neuronal interaction processes such as synapse formation or maintenance. ..
- A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysisDemet Arac
Howard Hughes Medical Institute, Stanford, CA, USA
EMBO J 31:1364-78. 2012..Thus, the GAIN domain embodies a unique, evolutionarily ancient and widespread autoproteolytic fold whose function is likely relevant for GPCR signalling and for multiple human diseases...
- Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactionsDemet Arac
Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
Neuron 56:992-1003. 2007..Our results provide molecular insights for understanding the role of cell-adhesion proteins in synapse function...