Frank Z Stanczyk

Summary

Country: USA

Publications

  1. doi Relationships of sex steroid hormone levels in benign and cancerous breast tissue and blood: A critical appraisal of current science
    Frank Z Stanczyk
    Departments of Obstetrics and Gynecology, and Preventive Medicine, University of Southern California Keck School of Medicine, 1321 N Mission Rd, Los Angeles, CA 90033, USA Electronic address
    Steroids 99:91-102. 2015
  2. pmc Study design and methods for the Breast Cancer and Exercise Trial in Alberta (BETA)
    Christine M Friedenreich
    Department of Cancer Epidemiology and Prevention Research, Cancer Control Alberta, Alberta Health Services, 1820 Richmond Road SW, Calgary T2T 5C7, AB, Canada
    BMC Cancer 14:919. 2014
  3. doi Use of medroxyprogesterone acetate for hormone therapy in postmenopausal women: is it safe?
    Frank Z Stanczyk
    Department of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA Electronic address
    J Steroid Biochem Mol Biol 142:30-8. 2014
  4. ncbi Ovarian androgen production in postmenopausal women
    Robin H Fogle
    Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA 90033, USA
    J Clin Endocrinol Metab 92:3040-3. 2007
  5. ncbi The effect of transdermal and vaginal estrogen therapy on markers of postmenopausal estrogen status
    Pratima Gupta
    Departments of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Menopause 15:94-7. 2008
  6. doi Anthropometric, dietary, and hormonal correlates of serum adiponectin in Asian American women
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90089, USA
    Nutr Cancer 63:549-57. 2011
  7. doi Follicular development in a 7-day versus 4-day hormone-free interval with an oral contraceptive containing 20 mcg ethinyl estradiol and 1 mg norethindrone acetate
    Radhika D Rible
    Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Contraception 79:182-8. 2009
  8. doi Dietary patterns and breast cancer risk in Asian American women
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA
    Am J Clin Nutr 89:1145-54. 2009
  9. doi Effect of subcutaneous depot-medroxyprogesterone acetate (DMPA-SC) on serum androgen markers in normal-weight, obese, and extremely obese women
    Penina Segall-Gutierrez
    Department of Obstetrics and Gynecology, Los Angeles, CA 90033, USA
    Contraception 86:739-45. 2012
  10. doi Ethinyl estradiol and 17β-estradiol in combined oral contraceptives: pharmacokinetics, pharmacodynamics and risk assessment
    Frank Z Stanczyk
    Departments of Obstetrics and Gynecology and Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Contraception 87:706-27. 2013

Collaborators

Detail Information

Publications50

  1. doi Relationships of sex steroid hormone levels in benign and cancerous breast tissue and blood: A critical appraisal of current science
    Frank Z Stanczyk
    Departments of Obstetrics and Gynecology, and Preventive Medicine, University of Southern California Keck School of Medicine, 1321 N Mission Rd, Los Angeles, CA 90033, USA Electronic address
    Steroids 99:91-102. 2015
    ..The controversies regarding the source of intratumoral estrogens in the breast are summarized. ..
  2. pmc Study design and methods for the Breast Cancer and Exercise Trial in Alberta (BETA)
    Christine M Friedenreich
    Department of Cancer Epidemiology and Prevention Research, Cancer Control Alberta, Alberta Health Services, 1820 Richmond Road SW, Calgary T2T 5C7, AB, Canada
    BMC Cancer 14:919. 2014
    ..Secondary aims are to compare intervention effects on psychosocial and quality of life outcomes as well as understand exercise adherence at 12 and 24 months, and maintenance of all study outcomes at 24 months...
  3. doi Use of medroxyprogesterone acetate for hormone therapy in postmenopausal women: is it safe?
    Frank Z Stanczyk
    Department of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA Electronic address
    J Steroid Biochem Mol Biol 142:30-8. 2014
    ....
  4. ncbi Ovarian androgen production in postmenopausal women
    Robin H Fogle
    Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA 90033, USA
    J Clin Endocrinol Metab 92:3040-3. 2007
    ..Several studies previously reported that the postmenopausal ovary produces androgens. However, these findings have recently been questioned in a group of women with adrenal insufficiency...
  5. ncbi The effect of transdermal and vaginal estrogen therapy on markers of postmenopausal estrogen status
    Pratima Gupta
    Departments of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Menopause 15:94-7. 2008
    ..5 microg of E2 per day...
  6. doi Anthropometric, dietary, and hormonal correlates of serum adiponectin in Asian American women
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90089, USA
    Nutr Cancer 63:549-57. 2011
    ..0001) and the ratios of total testosterone (T)/total estradiol (E2) (P trend <0.004) after adjustment for BMI and WHR. Confirmation of our findings on green tea and adiponectin is needed...
  7. doi Follicular development in a 7-day versus 4-day hormone-free interval with an oral contraceptive containing 20 mcg ethinyl estradiol and 1 mg norethindrone acetate
    Radhika D Rible
    Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Contraception 79:182-8. 2009
    ..This study evaluates differences in follicular development during a 7-day versus 4-day hormone-free interval in a COC regimen with 20 mcg EE and 1 mg norethindrone acetate...
  8. doi Dietary patterns and breast cancer risk in Asian American women
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA
    Am J Clin Nutr 89:1145-54. 2009
    ..The role of diet as a cause of breast cancer in Asian Americans has not been adequately studied...
  9. doi Effect of subcutaneous depot-medroxyprogesterone acetate (DMPA-SC) on serum androgen markers in normal-weight, obese, and extremely obese women
    Penina Segall-Gutierrez
    Department of Obstetrics and Gynecology, Los Angeles, CA 90033, USA
    Contraception 86:739-45. 2012
    ..The effects of subcutaneous depo-medroxyprogesterone acetate (DMPA-SC) injection on androgenic markers in obese women have not previously been studied...
  10. doi Ethinyl estradiol and 17β-estradiol in combined oral contraceptives: pharmacokinetics, pharmacodynamics and risk assessment
    Frank Z Stanczyk
    Departments of Obstetrics and Gynecology and Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Contraception 87:706-27. 2013
    ..This review provides a brief summary of the pharmacology of EE and E₂, including metabolism, pharmacokinetics and pharmacodynamics, as well as adverse effects of these estrogens...
  11. doi Comparison of serum and cervical mucus hormone levels during hormone-free interval of 24/4 vs. 21/7 combined oral contraceptives
    Heather Fels
    Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Contraception 87:732-7. 2013
    ..21/7 (NETA/EE-21) regimens...
  12. pmc Associations between markers of inflammation and physiological and pharmacological levels of circulating sex hormones in postmenopausal women
    Roksana Karim
    Department of Pediatrics and Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Menopause 17:785-90. 2010
    ..It is not known how sex hormone concentrations relate to the markers of inflammation in postmenopausal women taking or not taking hormone therapy...
  13. doi Dexamethasone suppressibility and adrenal and ovarian venous effluents of 5α-reduced C19 conjugates in hyperandrogenic women
    Frank Z Stanczyk
    Department of Obstetrics and Gynecology, University of Southern California, Keck School of Medicine, Los Angeles, CA, United States Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, United States Electronic address
    J Steroid Biochem Mol Biol 139:73-7. 2014
    ..However, since no adrenal or ovarian vein gradient exists, these markers of the manifestations of androgen excess largely reflect peripheral androgen metabolism. ..
  14. ncbi Effects of transdermal and oral contraceptives on estrogen-sensitive hepatic proteins
    Terry White
    Department of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Contraception 74:293-6. 2006
    ..The purpose of this study was to evaluate the effects of the contraceptive patch and an oral contraceptive (OC) on serum concentrations of estrogen-sensitive hepatic proteins, ethinyl estradiol (EE) and levonorgestrel (LNG)...
  15. ncbi Racial/ethnic differences in postmenopausal endogenous hormones: the multiethnic cohort study
    Veronica Wendy Setiawan
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 15:1849-55. 2006
    ..Many of the differences in endogenous postmenopausal hormonal milieu across these five racial/ethnic groups are consistent with the known differences in breast cancer incidence across these populations...
  16. pmc Sleep duration, spot urinary 6-sulfatoxymelatonin levels and risk of breast cancer among Chinese women in Singapore
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089 9175, USA
    Int J Cancer 132:891-6. 2013
    ..Melatonin levels derived from randomly timed spot urine are unrelated to breast cancer. Randomly timed, spot urine-derived melatonin levels are noninformative as surrogates of nocturnal melatonin production...
  17. ncbi Diagnosis of hyperandrogenism: biochemical criteria
    Frank Z Stanczyk
    Department of Obstetrics and Gynecology, University of Southern California, Keck School of Medicine, Women s and Children s Hospital, Room 1M2, 1240 North Mission Road, Los Angeles, CA 90033, USA
    Best Pract Res Clin Endocrinol Metab 20:177-91. 2006
    ..However, distal metabolites of DHT have been shown to be good markers of clinical manifestations of hirsutism, acne and alopecia. Assays for these peripheral markers need improvement for routine clinical testing...
  18. doi Effects of progestin-only long-acting contraception on metabolic markers in obese women
    Nicole M Bender
    Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA 90033, USA
    Contraception 88:418-25. 2013
    ....
  19. pmc Effect of 2-month controlled green tea intervention on lipoprotein cholesterol, glucose, and hormone levels in healthy postmenopausal women
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Cancer Prev Res (Phila) 5:393-402. 2012
    ..008) and insulin (P = 0.01) were found. In summary, green tea (400- and 800-mg EGCG as PPE; ∼5-10 cups) supplementation for 2 months had suggestive beneficial effects on LDL-cholesterol concentrations and glucose-related markers...
  20. doi Temporal changes in cervical mucus after insertion of the levonorgestrel-releasing intrauterine system
    Melissa F Natavio
    Los Angeles County University of Southern California Medical Center, Los Angeles, CA 90033, USA
    Contraception 87:426-31. 2013
    ..No study to date has examined the temporal relationship between the insertion of the LNG-IUS and changes in CM quality and sperm penetration...
  21. doi Effect of finasteride on serum levels of androstenedione, testosterone and their 5α-reduced metabolites in men at risk for prostate cancer
    Frank Z Stanczyk
    Department of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, United States Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, United States Electronic address
    J Steroid Biochem Mol Biol 138:10-6. 2013
    ..3%). The present data suggest that either 3α-diol G or DHT S may serve as a potential diagnostic marker of intraprostatic 5α-reductase activity during treatment of patients with 5α-reductase inhibitors. ..
  22. pmc Breast epithelial cell proliferation is markedly increased with short-term high levels of endogenous estrogen secondary to controlled ovarian hyperstimulation
    Karine Chung
    Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Breast Cancer Res Treat 132:653-60. 2012
    ..Whether their short durations of greatly increased E2 levels are associated with any long-term beneficial effects on the breast, as occurring in rodent models, is not known...
  23. ncbi Diabetes and risk of breast cancer in Asian-American women
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA
    Carcinogenesis 28:1561-6. 2007
    ..08) than women without such a history after adjusting for BMI and WHR. Our results support the hypothesis that diabetes may have a role in the development of breast cancer, influencing risk via both sex hormone and insulin pathways...
  24. ncbi Does St. John's wort interfere with the antiandrogenic effect of oral contraceptive pills?
    Robin H Fogle
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Women s and Children s Hospital, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Contraception 74:245-8. 2006
    ..We investigated whether the simultaneous use of SJW with OCPs resulted in elevated serum androgen levels with implications of impaired OCP treatment of hirsutism and acne...
  25. ncbi Increased insulin-like growth factor-1 after oophorectomy in postmenopausal women
    Robin H Fogle
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Fertil Steril 90:1236-9. 2008
    ..This finding raises concerns, given the association between increased IGF-1 and elevated colon cancer risk, and adds to the literature suggesting a potential benefit from ovarian preservation...
  26. pmc Sleep duration, melatonin and breast cancer among Chinese women in Singapore
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Carcinogenesis 29:1244-8. 2008
    ..However, data are inconclusive from the three studies conducted in Western populations on sleep duration and breast cancer risk...
  27. ncbi Measurement of androgens in women
    Frank Z Stanczyk
    Department of Obstetrics and Gynecology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Semin Reprod Med 24:78-85. 2006
    ..Androgens also can be measured in saliva, but major methodologic problems are associated with the measurements. In addition, there is a misconception that salivary testosterone levels reflect free testosterone levels in serum...
  28. pmc Effect of protease inhibitors on steady-state pharmacokinetics of oral norethindrone contraception in HIV-infected women
    Jessica Atrio
    Department of Obstetrics and Gynecology and Laboratory of Applied Pharmacokinetics, Keck School of Medicine, University of Southern California, Los Angeles, CA Department of Pharmacy Practice, College of Pharmacy, Oregon State University Oregon Health and Science University, Portland, OR and Maternal Child and Adolescent Center for Infectious Diseases, Keck School of Medicine, University of Southern California, Los Angeles, CA
    J Acquir Immune Defic Syndr 65:72-7. 2014
    ..However, such information is lacking for progestin-only oral contraception. We sought to define the steady-state pharmacokinetic interaction between norethindrone (NET) and PI in HIV-infected women...
  29. doi Deterioration in cardiometabolic risk markers in obese women during depot medroxyprogesterone acetate use
    Penina Segall-Gutierrez
    Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Contraception 85:36-41. 2012
    ..The purpose of this 18-week prospective experimental study was to compare the impact of subcutaneous depot medroxyprogesterone acetate (DMPA-SC) on cardiometabolic markers in obese and normal-weight women...
  30. doi The role of progestogens in regulating matrix metalloproteinase activity in macrophages and microglial cells
    Juliana Hwang-Levine
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Ave, PSC 612, Los Angeles, CA 90033, USA
    Neurochem Res 36:1870-5. 2011
    ....
  31. ncbi Standardization of steroid hormone assays: why, how, and when?
    Frank Z Stanczyk
    Department of Obstetrics and Gynecology, University of Southern California, Keck School of Medicine, Women s and Children s Hospital, Room 1M2, 1240 North Mission Road, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 16:1713-9. 2007
    ..These criteria would allow validation of sensitivity, specificity, precision, and accuracy of current steroid hormone assay methodology and provide surrogates until a true gold standard can be developed...
  32. doi AKR1C1 and SRD5A1 messenger RNA expression at term in the human myometrium and chorioamniotic membranes
    Richard H Lee
    Department of Obstetrics and Gynecology, Women s and Children s Hospital, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Am J Perinatol 25:577-82. 2008
    ....
  33. doi Suppression of lysyl oxidase gene expression by methylation in pelvic organ prolapse
    John Klutke
    Department of Obstetrics and Gynecology, USC Keck School of Medicine, Los Angeles, CA, USA
    Int Urogynecol J 21:869-72. 2010
    ..We measured promoter methylation in the LOX gene in women with pelvic organ prolapse and in women without prolapse...
  34. pmc Methods and baseline cardiovascular data from the Early versus Late Intervention Trial with Estradiol testing the menopausal hormone timing hypothesis
    Howard N Hodis
    From the 1Atherosclerosis Research Unit, Keck School of Medicine, University of Southern California, Los Angeles, CA 2Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 3Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 4Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, CA 5Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA 6Los Angeles Biomedical Research Institute at Harbor University of California at Los Angeles Medical Center, Torrance, CA and 7Departments of Health Research and Policy Epidemiology and Neurology and Neurological Sciences, Stanford University, Stanford, CA
    Menopause 22:391-401. 2015
    ..The timing hypothesis posits that HT effects depend on the temporal initiation of HT relative to time since menopause...
  35. ncbi Acute effects of metformin therapy include improvement of insulin resistance and ovarian morphology
    Aykut Bayrak
    Department of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Fertil Steril 87:870-5. 2007
    ..To evaluate the acute effects of metformin therapy on biochemical markers and polycystic ovarian morphology among insulin-resistant (IR) and noninsulin-resistant (NIR) patients with polycystic ovary syndrome (PCOS)...
  36. doi Percutaneous progesterone delivery via cream or gel application in postmenopausal women: a randomized cross-over study of progesterone levels in serum, whole blood, saliva, and capillary blood
    Joanna Y Du
    From the 1Department of Obstetrics and Gynecology and 2Southern California Clinical and Translational Science Institute, University of Southern California Keck School of Medicine, Los Angeles, CA and 3ZRT Laboratory, Beaverton, OR and 4Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA
    Menopause 20:1169-75. 2013
    ..This study aims to investigate the distribution of progesterone in venous whole blood, venous serum, fingertip capillary blood, and saliva after its topical application in both cream and gel formulations...
  37. doi Pharmacokinetics of dehydroepiandrosterone and its metabolites after long-term oral dehydroepiandrosterone treatment in postmenopausal women
    Frank Z Stanczyk
    Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Menopause 16:272-8. 2009
    ..We investigated the pharmacokinetics of dehydroepiandrosterone and its relevant metabolites after prolonged treatment of postmenopausal women with 25 mg/d of dehydroepiandrosterone...
  38. pmc Progestogens used in postmenopausal hormone therapy: differences in their pharmacological properties, intracellular actions, and clinical effects
    Frank Z Stanczyk
    Department of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Livingston Research Building, 1321 North Mission Road, Room 201, Los Angeles, California 90033, USA
    Endocr Rev 34:171-208. 2013
    ....
  39. doi Bile acid concentration reference ranges in a pregnant Latina population
    Richard H Lee
    Department of Obstetrics and Gynecology, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA
    Am J Perinatol 30:389-93. 2013
    ..The purpose of this study was to establish pregnancy-specific reference ranges for the TBA concentration among Latina women...
  40. doi Limitations of direct immunoassays for measuring circulating estradiol levels in postmenopausal women and men in epidemiologic studies
    Frank Z Stanczyk
    Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Cancer Epidemiol Biomarkers Prev 19:903-6. 2010
    ..Instead, we recommend the use of a well-validated RIA with purification steps to improve sensitivity and specificity and to help achieve the necessary accuracy and reliability needed for epidemiologic studies...
  41. ncbi Comparison of vaginal and oral administration of emergency contraception
    Eliran Mor
    Department of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Fertil Steril 84:40-5. 2005
    ..To compare the physiologic effects of vaginally and orally administered emergency contraception...
  42. doi Advantages and challenges of mass spectrometry assays for steroid hormones
    Frank Z Stanczyk
    Departments of Obstetrics and Gynecology, and Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    J Steroid Biochem Mol Biol 121:491-5. 2010
    ..The present review discusses the advantages of MS assays over conventional RIAs and direct immunoassays in steroid hormone measurements, and points out some of the important challenges facing the rapid increase in usage of MS assays...
  43. doi Pituitary and ovarian hormone activity during the 7-day hormone-free interval of various combined oral contraceptive regimens
    Michael Cho
    Departments of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033
    Contraception 90:94-6. 2014
    ..The objective was to investigate changes in luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2) and progesterone (P) during the hormone-free interval (HFI) of 6 combined oral contraceptives (COCs)...
  44. doi Can highly sensitive antimüllerian hormone testing predict failed response to ovarian stimulation?
    Heather R Burks
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, California
    Fertil Steril 104:643-8. 2015
    ....
  45. pmc Correcting oral contraceptive pharmacokinetic alterations due to obesity: a randomized controlled trial
    Alison B Edelman
    Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR 97239, USA Electronic address
    Contraception 90:550-6. 2014
    ..To determine if increasing the hormone dose or eliminating the hormone-free interval improves key pharmacokinetic (PK) alterations caused by obesity during oral contraceptive (OC) use...
  46. ncbi Impaired dihydrotestosterone catabolism in human prostate cancer: critical role of AKR1C2 as a pre-receptor regulator of androgen receptor signaling
    Qing Ji
    Department of Medicine, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    Cancer Res 67:1361-9. 2007
    ..We speculate that selective loss of AKR1C2 in prostate cancer promotes clonal expansion of tumor cells by enhancement of androgen-dependent cellular proliferation by reducing DHT metabolism...
  47. ncbi Percutaneous administration of progesterone: blood levels and endometrial protection
    Frank Z Stanczyk
    Department of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Menopause 12:232-7. 2005
    ..In contrast to progesterone creams, progesterone gels are water-soluble and appear to enter the microcirculation rapidly, thus giving rise to elevated serum progesterone levels with progesterone doses comparable to those used in creams...
  48. ncbi Decreased endopelvic fascia elastin content in uterine prolapse
    John Klutke
    Department of Obstetrics and Gynecology, USC Keck School of Medicine, Women s and Children s Hospital, Los Angeles, CA 90033, USA
    Acta Obstet Gynecol Scand 87:111-5. 2008
    ..The purpose of this study was to determine elastin content and RNA expression of related enzymes of elastin synthesis in uterosacral ligament biopsies from women with severe prolapse, and controls with normal pelvic support...
  49. ncbi Effect of oral versus transdermal steroidal contraceptives on androgenic markers
    Terry White
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of South California Keck School of Medicine, Los Angeles, USA
    Am J Obstet Gynecol 192:2055-9. 2005
    ..The purpose of this study was to compare biochemical androgen profiles in women treated with the contraceptive patch versus an oral contraceptive (OC)...
  50. doi Gestodene: a review of its pharmacology, potency and tolerability in combined contraceptive preparations
    Frank Z Stanczyk
    University of Southern California Keck School of Medicine, Los Angeles, CA, USA Electronic address
    Contraception 89:242-52. 2014
    ..In this review we present an overview of the pharmacology, potency and tolerability of gestodene...