Rachel Zufferey

Summary

Affiliation: St. John's University
Country: USA

Publications

  1. pmc In Vitro Assay to Measure Phosphatidylethanolamine Methyltransferase Activity
    Rachel Zufferey
    Department of Biological Sciences, St John s University
    J Vis Exp . 2016
  2. pmc The N-terminal domain and glycosomal localization of Leishmania initial acyltransferase LmDAT are important for lipophosphoglycan synthesis
    Gada K Al-Ani
    Department of Biochemistry, Kansas State University, Manhattan, Kansas, United States of America
    PLoS ONE 6:e27802. 2011
  3. doi request reprint Characterization of a compensatory mutant of Leishmania major that lacks ether lipids but exhibits normal growth, and G418 and hygromycin resistance
    Rachel Zufferey
    Department of Biological Sciences, St John s University, 8000 Utopia Parkway, Jamaica, NY 11439, USA
    Exp Parasitol 130:200-4. 2012
  4. pmc Leishmania dihydroxyacetonephosphate acyltransferase LmDAT is important for ether lipid biosynthesis but not for the integrity of detergent resistant membranes
    Rachel Zufferey
    Department of Biological Sciences, St John s University, 8000 Utopia Parkway, Jamaica, NY 11439, USA
    Mol Biochem Parasitol 168:177-85. 2009
  5. pmc The Glycerol-3-Phosphate Acyltransferase TbGAT is Dispensable for Viability and the Synthesis of Glycerolipids in Trypanosoma brucei
    Nipul Patel
    Department of Biological Sciences, St John s University, 8000 Utopia Parkway, Jamaica, New York, 11439
    J Eukaryot Microbiol 63:598-609. 2016
  6. pmc Characterization of Leishmania major phosphatidylethanolamine methyltransferases LmjPEM1 and LmjPEM2 and their inhibition by choline analogs
    Stergios S Bibis
    Department of Biological Sciences, St John s University, 8000 Utopia Parkway, Jamaica, NY 11439, USA
    Mol Biochem Parasitol 196:90-9. 2014

Collaborators

  • Nipul Patel
  • Tongtong Zhu
  • Stergios S Bibis
  • Karim A Pirani
  • Gada K Al-Ani
  • Daniel G Chen
  • Sungsu Lee
  • Melanie Cheung-See-Kit
  • Kelly Dahlstrom
  • Subbhalakshmi Dhalladoo

Detail Information

Publications6

  1. pmc In Vitro Assay to Measure Phosphatidylethanolamine Methyltransferase Activity
    Rachel Zufferey
    Department of Biological Sciences, St John s University
    J Vis Exp . 2016
    ..This assay can potentially be applied to any other cell types and used to test inhibitors/drugs specific to a phosphatidylethanolamine methyltransferase of interest without the need to purify the enzyme. ..
  2. pmc The N-terminal domain and glycosomal localization of Leishmania initial acyltransferase LmDAT are important for lipophosphoglycan synthesis
    Gada K Al-Ani
    Department of Biochemistry, Kansas State University, Manhattan, Kansas, United States of America
    PLoS ONE 6:e27802. 2011
    ..These results emphasize the importance of this enzyme's compartmentalization in the glycosome for the generation of lipophosphoglycan and parasite's biology...
  3. doi request reprint Characterization of a compensatory mutant of Leishmania major that lacks ether lipids but exhibits normal growth, and G418 and hygromycin resistance
    Rachel Zufferey
    Department of Biological Sciences, St John s University, 8000 Utopia Parkway, Jamaica, NY 11439, USA
    Exp Parasitol 130:200-4. 2012
    ..Surprisingly, its sensitivity to aminoglycoside based antibiotics G418 and hygromycin was lower than that of the null mutant, wild type and complemented line...
  4. pmc Leishmania dihydroxyacetonephosphate acyltransferase LmDAT is important for ether lipid biosynthesis but not for the integrity of detergent resistant membranes
    Rachel Zufferey
    Department of Biological Sciences, St John s University, 8000 Utopia Parkway, Jamaica, NY 11439, USA
    Mol Biochem Parasitol 168:177-85. 2009
    ..Last, despite the fact that LmDAT is important for virulence the null mutant still exhibited the typical characteristics of metacyclics...
  5. pmc The Glycerol-3-Phosphate Acyltransferase TbGAT is Dispensable for Viability and the Synthesis of Glycerolipids in Trypanosoma brucei
    Nipul Patel
    Department of Biological Sciences, St John s University, 8000 Utopia Parkway, Jamaica, New York, 11439
    J Eukaryot Microbiol 63:598-609. 2016
    ..Our data suggest that an alternative initial acyltransferase takes over TbGAT's function in its absence. ..
  6. pmc Characterization of Leishmania major phosphatidylethanolamine methyltransferases LmjPEM1 and LmjPEM2 and their inhibition by choline analogs
    Stergios S Bibis
    Department of Biological Sciences, St John s University, 8000 Utopia Parkway, Jamaica, NY 11439, USA
    Mol Biochem Parasitol 196:90-9. 2014
    ..Finally, we have demonstrated using inhibition studies with choline analogs that miltefosine and octadecyltrimethylammonium bromide are potent inhibitors of this metabolic pathway. ..