Gabriele Stocco

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. pmc Multilocus genotypes of relevance for drug metabolizing enzymes and therapy with thiopurines in patients with acute lymphoblastic leukemia
    Gabriele Stocco
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital Memphis, TN, USA Department of Life Sciences, University of Trieste Trieste, Italy
    Front Genet 3:309. 2012
  2. ncbi Personalized therapies in pediatric inflammatory and autoimmune diseases
    Gabriele Stocco
    Department of Life Sciences, University of Trieste, Trieste, 34127 TS, Italy
    Curr Pharm Des 18:5766-75. 2012
  3. doi Genetic predictors of glucocorticoid response in pediatric patients with inflammatory bowel diseases
    Sara De Iudicibus
    Department of Life Sciences, University of Trieste, Trieste, Italy
    J Clin Gastroenterol 45:e1-7. 2011
  4. doi Response to glucocorticoids and toxicity in childhood acute lymphoblastic leukemia: role of polymorphisms of genes involved in glucocorticoid response
    Sara Marino
    I R C C S Burlo Garofolo, UO Pediatric Hemato Oncology, Trieste, Italy
    Pediatr Blood Cancer 53:984-91. 2009
  5. doi Usefulness of the measurement of azathioprine metabolites in the assessment of non-adherence
    Gabriele Stocco
    Department of Life Sciences, University of Trieste, Italy
    J Crohns Colitis 4:599-602. 2010
  6. pmc Thiopurine metabolites variations during co-treatment with aminosalicylates for inflammatory bowel disease: effect of N-acetyl transferase polymorphisms
    Gabriele Stocco
    Gabriele Stocco, Giuliana Decorti, Department of Life Sciences, University of Trieste, I 34127 Trieste, Italy
    World J Gastroenterol 21:3571-8. 2015
  7. pmc Pharmacogenetics of azathioprine in inflammatory bowel disease: a role for glutathione-S-transferase?
    Gabriele Stocco
    Gabriele Stocco, Marco Pelin, Giuliana Decorti, Department of Life Sciences, University of Trieste, I 34127 Trieste, Italy
    World J Gastroenterol 20:3534-41. 2014
  8. ncbi Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease
    Gabriele Stocco
    Department of Biomedical Sciences, University of Trieste, Trieste, Italy
    Inflamm Bowel Dis 13:57-64. 2007
  9. doi Glucocorticoid pharmacogenetics in pediatric idiopathic nephrotic syndrome
    Eva Cuzzoni
    Graduate School in Reproduction and Developmental Sciences, University of Trieste, I 34127 Trieste, Italy
    Pharmacogenomics 16:1631-48. 2015
  10. doi Deletion of glutathione-s-transferase m1 reduces azathioprine metabolite concentrations in young patients with inflammatory bowel disease
    Gabriele Stocco
    Departments of Life Sciences Medical, Surgical, and Health Sciences Scuola di Dottorato di Ricerca in Scienze della Riproduzione, University of Trieste Institute for Maternal and Child Health IRCCS Burlo Garofolo Department of Prevention, Sanitary Services Agency Number 1, Trieste, Italy
    J Clin Gastroenterol 48:43-51. 2014

Collaborators

  • Giuseppe Toffoli
  • Alessandra Pontillo
  • Giovanni Montini
  • Sara De Iudicibus
  • Giuliana Decorti
  • Fiora Bartoli
  • Alessandro Ventura
  • Marco Pelin
  • Sara Marino
  • Serena Pastore
  • Diego Favretto
  • Eva Cuzzoni
  • Stefano Martelossi
  • Lorenzo Calligaris
  • Eleonora Taboga
  • Andrea Pasini
  • Loredana Lepore
  • Laura Fusco
  • Raffaella Franca
  • Valentina Moressa
  • Giulia Pellizzari
  • Cristina Lagatolla
  • Luigi ZandonĂ 
  • Noelia Malusa
  • Marianna Lucafò
  • Roberto Di Lenarda
  • Camillo Pico
  • Massimo Borelli
  • Lorenzo Bevilacqua
  • Gaetano Castronovo
  • Roberto Racano
  • Arrigo Barabino
  • Paolo Lionetti
  • Margherita Londero
  • Egle Ebner
  • Marco Rabusin
  • Federico Marchetti
  • Egidio Barbi
  • Federico Verzegnassi
  • Paolo Tamaro
  • Marco Carrozzi
  • Rossana Bussani
  • Alessandro De Pellegrin

Detail Information

Publications17

  1. pmc Multilocus genotypes of relevance for drug metabolizing enzymes and therapy with thiopurines in patients with acute lymphoblastic leukemia
    Gabriele Stocco
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital Memphis, TN, USA Department of Life Sciences, University of Trieste Trieste, Italy
    Front Genet 3:309. 2012
    ..The knowledge basis and clinical applications for multilocus genotypes of importance for therapy with mercaptopurine in pediatric ALL is discussed in the present review...
  2. ncbi Personalized therapies in pediatric inflammatory and autoimmune diseases
    Gabriele Stocco
    Department of Life Sciences, University of Trieste, Trieste, 34127 TS, Italy
    Curr Pharm Des 18:5766-75. 2012
    ..The present review will be focused on the personalized therapy approaches already available or in development for pediatric patients with IBD or JRA, comprising pharmacokinetic, pharmacodynamic and pharmacogenetic assays...
  3. doi Genetic predictors of glucocorticoid response in pediatric patients with inflammatory bowel diseases
    Sara De Iudicibus
    Department of Life Sciences, University of Trieste, Trieste, Italy
    J Clin Gastroenterol 45:e1-7. 2011
    ..Glucocorticoids (GCs) are used in moderate-to-severe inflammatory bowel diseases (IBD) but their effect is often unpredictable...
  4. doi Response to glucocorticoids and toxicity in childhood acute lymphoblastic leukemia: role of polymorphisms of genes involved in glucocorticoid response
    Sara Marino
    I R C C S Burlo Garofolo, UO Pediatric Hemato Oncology, Trieste, Italy
    Pediatr Blood Cancer 53:984-91. 2009
    ....
  5. doi Usefulness of the measurement of azathioprine metabolites in the assessment of non-adherence
    Gabriele Stocco
    Department of Life Sciences, University of Trieste, Italy
    J Crohns Colitis 4:599-602. 2010
    ....
  6. pmc Thiopurine metabolites variations during co-treatment with aminosalicylates for inflammatory bowel disease: effect of N-acetyl transferase polymorphisms
    Gabriele Stocco
    Gabriele Stocco, Giuliana Decorti, Department of Life Sciences, University of Trieste, I 34127 Trieste, Italy
    World J Gastroenterol 21:3571-8. 2015
    ..To evaluate variation of the concentration of thiopurine metabolites after 5-aminosalicylate (5-ASA) interruption and the role of genetic polymorphisms of N-acetyl transferase (NAT) 1 and 2...
  7. pmc Pharmacogenetics of azathioprine in inflammatory bowel disease: a role for glutathione-S-transferase?
    Gabriele Stocco
    Gabriele Stocco, Marco Pelin, Giuliana Decorti, Department of Life Sciences, University of Trieste, I 34127 Trieste, Italy
    World J Gastroenterol 20:3534-41. 2014
    ..Therefore, genetic polymorphisms in genes for GSTs may be useful to predict response to azathioprine even if more in vitro and clinical validation studies are needed. ..
  8. ncbi Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease
    Gabriele Stocco
    Department of Biomedical Sciences, University of Trieste, Trieste, Italy
    Inflamm Bowel Dis 13:57-64. 2007
    ..The association between polymorphisms of GST-M1, GST-P1, GST-T1, and TPMT genes and the adverse effects of azathioprine was therefore investigated...
  9. doi Glucocorticoid pharmacogenetics in pediatric idiopathic nephrotic syndrome
    Eva Cuzzoni
    Graduate School in Reproduction and Developmental Sciences, University of Trieste, I 34127 Trieste, Italy
    Pharmacogenomics 16:1631-48. 2015
    ..Aim of this review is to highlight the current knowledge on genetic variants that could affect GC response, particularly focusing on children with idiopathic nephrotic syndrome...
  10. doi Deletion of glutathione-s-transferase m1 reduces azathioprine metabolite concentrations in young patients with inflammatory bowel disease
    Gabriele Stocco
    Departments of Life Sciences Medical, Surgical, and Health Sciences Scuola di Dottorato di Ricerca in Scienze della Riproduzione, University of Trieste Institute for Maternal and Child Health IRCCS Burlo Garofolo Department of Prevention, Sanitary Services Agency Number 1, Trieste, Italy
    J Clin Gastroenterol 48:43-51. 2014
    ....
  11. doi Carbamazepine hypersensitivity syndrome triggered by a human herpes virus reactivation in a genetically predisposed patient
    Lorenzo Calligaris
    IRCCS Burlo Garofolo, Pediatric Clinic, University of Trieste, Trieste IT 34127, Italy
    Int Arch Allergy Immunol 149:173-7. 2009
    ..In conclusion, we document a case of severe carbamazepine hypersensitivity triggered by viral reactivation in a patient presenting the interaction of 2 unfavorable genetic factors...
  12. doi Role of oxidative stress mediated by glutathione-s-transferase in thiopurines' toxic effects
    Marco Pelin
    Department of Life Sciences, University of Trieste, 34127 Trieste, Italy
    Chem Res Toxicol 28:1186-95. 2015
    ..These results provide the molecular basis to shed light on the clinical evidence suggesting a role of GST-M1 genotype in influencing the toxic effects of AZA treatment...
  13. ncbi ABCB1 gene polymorphisms and expression of P-glycoprotein and long-term prognosis in colorectal cancer
    Sara De Iudicibus
    Department of Life Sciences, University of Trieste, Italy
    Anticancer Res 28:3921-8. 2008
    ..The association of two ABCB1 polymorphisms with the occurrence of colon cancer and long-term prognosis was evaluated in a selected patient population. The expression of Pgp in neoplastic and normal intestinal mucosa was also studied...
  14. ncbi Patients' Induced Pluripotent Stem Cells to Model Drug Induced Adverse Events: A Role in Predicting Thiopurine Induced Pancreatitis?
    Gabriele Stocco
    University of Trieste, Department of Life Sciences, Via A Fleming 22, Trieste, I 34127, Italy
    Curr Drug Metab 17:91-8. 2015
    ..Such pancreatic cells can provide excellent insights into the molecular mechanism of TIP. In particular three hypotheses on the mechanism of TIP could be explored: drug biotransformation, innate immunity and adaptative immunity. ..
  15. doi 5-Aminoimidazole-4-carboxamide ribonucleotide-transformylase and inosine-triphosphate-pyrophosphatase genes variants predict remission rate during methotrexate therapy in patients with juvenile idiopathic arthritis
    Serena Pastore
    University of Trieste, Trieste, Italy
    Rheumatol Int 35:619-27. 2015
    ....
  16. doi Effect of periodontal therapy on the course of cyclosporin-induced gingival overgrowth: role of ABCB1 and PAI-1 gene polymorphisms
    Sara De Iudicibus
    Dipartimento Universitario Clinico di Scienze Mediche, Chirurgiche e della Salute, University of Trieste, Trieste, Italy
    Quintessence Int 44:249-60. 2013
    ..This study aimed to evaluate the role of polymorphisms in PAI-1 and A BCB1 genes on the course of this side effect following periodontal therapy...
  17. ncbi Prevalence of methylenetetrahydrofolate reductase polymorphisms in young patients with inflammatory bowel disease
    Gabriele Stocco
    Department of Biomedical Sciences, University of Trieste, Trieste, Italy
    Dig Dis Sci 51:474-9. 2006
    ..The incidence of mutations in the MTHFR gene was not different between patients with IBD and control subjects; the mutated genotype was not associated with an increased risk of toxicity during thiopurine treatment...