Amber M Smith

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. doi request reprint Secondary bacterial infections in influenza virus infection pathogenesis
    Amber M Smith
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN, 38105, USA
    Curr Top Microbiol Immunol 385:327-56. 2014
  2. pmc Kinetics of coinfection with influenza A virus and Streptococcus pneumoniae
    Amber M Smith
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS Pathog 9:e1003238. 2013
  3. pmc Arginine usage in mycobacteria-infected macrophages depends on autocrine-paracrine cytokine signaling
    Joseph E Qualls
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Sci Signal 3:ra62. 2010
  4. pmc Modulation of adaptive immunity by different adjuvant-antigen combinations in mice lacking Nod2
    Lilian O Moreira
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Vaccine 26:5808-13. 2008
  5. pmc Sustained generation of nitric oxide and control of mycobacterial infection requires argininosuccinate synthase 1
    Joseph E Qualls
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell Host Microbe 12:313-23. 2012
  6. pmc Molecular signatures of virulence in the PB1-F2 proteins of H5N1 influenza viruses
    Amber M Smith
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Virus Res 178:146-50. 2013
  7. pmc TNF Counterbalances the Emergence of M2 Tumor Macrophages
    Franz Kratochvill
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell Rep 12:1902-14. 2015
  8. pmc Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia
    Julie L McAuley
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell Host Microbe 2:240-9. 2007
  9. pmc Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens
    Karim C El Kasmi
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38015, USA
    Nat Immunol 9:1399-406. 2008
  10. pmc The TLR2-MyD88-NOD2-RIPK2 signalling axis regulates a balanced pro-inflammatory and IL-10-mediated anti-inflammatory cytokine response to Gram-positive cell walls
    Lilian O Moreira
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Cell Microbiol 10:2067-77. 2008

Collaborators

Detail Information

Publications13

  1. doi request reprint Secondary bacterial infections in influenza virus infection pathogenesis
    Amber M Smith
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN, 38105, USA
    Curr Top Microbiol Immunol 385:327-56. 2014
    ..Here, we review recent advances regarding transmission and disease potential of influenza-associated bacterial infections and discuss the current gaps in knowledge...
  2. pmc Kinetics of coinfection with influenza A virus and Streptococcus pneumoniae
    Amber M Smith
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS Pathog 9:e1003238. 2013
    ..Our model provides a framework to investigate pathogen interaction during coinfections and to uncover dynamical differences based on inoculum size and strain...
  3. pmc Arginine usage in mycobacteria-infected macrophages depends on autocrine-paracrine cytokine signaling
    Joseph E Qualls
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Sci Signal 3:ra62. 2010
    ....
  4. pmc Modulation of adaptive immunity by different adjuvant-antigen combinations in mice lacking Nod2
    Lilian O Moreira
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Vaccine 26:5808-13. 2008
    ..Collectively, our results argue that oil emulsions deserve greater attention for their immunostimulatory properties...
  5. pmc Sustained generation of nitric oxide and control of mycobacterial infection requires argininosuccinate synthase 1
    Joseph E Qualls
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell Host Microbe 12:313-23. 2012
    ..Thus, extracellular arginine fuels rapid NO production in activated macrophages, and citrulline recycling via Ass1 and Asl is a fail-safe system that sustains optimum NO production...
  6. pmc Molecular signatures of virulence in the PB1-F2 proteins of H5N1 influenza viruses
    Amber M Smith
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Virus Res 178:146-50. 2013
    ..Surveillance efforts should include sequencing of the PB1 gene segment and analysis for these molecular signatures to allow for the potential prioritization of resources during pandemic planning. ..
  7. pmc TNF Counterbalances the Emergence of M2 Tumor Macrophages
    Franz Kratochvill
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell Rep 12:1902-14. 2015
    ..Our results show macrophage polarization in cancer is dynamic and dependent on the balance between TNF and IL-13, thus providing a strategy for manipulating TAMs...
  8. pmc Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia
    Julie L McAuley
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell Host Microbe 2:240-9. 2007
    ..These findings help explain both the unparalleled virulence of the 1918 strain and the high incidence of fatal pneumonia during the pandemic...
  9. pmc Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens
    Karim C El Kasmi
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38015, USA
    Nat Immunol 9:1399-406. 2008
    ..Specific elimination of Arg1 in macrophages favored host survival during T. gondii infection and decreased lung bacterial load during tuberculosis infection...
  10. pmc The TLR2-MyD88-NOD2-RIPK2 signalling axis regulates a balanced pro-inflammatory and IL-10-mediated anti-inflammatory cytokine response to Gram-positive cell walls
    Lilian O Moreira
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Cell Microbiol 10:2067-77. 2008
    ....
  11. pmc Myeloid-derived suppressor activity is mediated by monocytic lineages maintained by continuous inhibition of extrinsic and intrinsic death pathways
    Jessica M Haverkamp
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA Department of Immunology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Immunity 41:947-59. 2014
    ..Thus, death pathway modulation defines the development, survival, and function of myeloid suppressor cells...
  12. pmc Agammaglobulinemia and absent B lineage cells in a patient lacking the p85α subunit of PI3K
    Mary Ellen Conley
    Department of Pediatrics, University of Tennessee College of Medicine, Memphis, TN 38163, USA
    J Exp Med 209:463-70. 2012
    ..In contrast, the absence of p85α in the patient results in an early and severe defect in B cell development but minimal findings in other organ systems...
  13. pmc A distal enhancer in Il12b is the target of transcriptional repression by the STAT3 pathway and requires the basic leucine zipper (B-ZIP) protein NFIL3
    Amber M Smith
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 286:23582-90. 2011
    ..Myeloid cells lacking NFIL3 produce excessive IL-12p40 and increased IL-12p70. Thus, the STAT3-dependent expression of NFIL3 is a key component of a negative feedback pathway in myeloid cells that suppresses proinflammatory responses...