Charles G Mullighan

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. doi request reprint T-lineage lymphoblastic lymphoma and leukemia-a MASSive problem
    Charles G Mullighan
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer Cell 18:297-9. 2010
  2. pmc Genomic characterization of childhood acute lymphoblastic leukemia
    Charles G Mullighan
    Department of Pathology and the Hematological Malignancies Program, St Jude Children s Research Hospital, Memphis, TN Electronic address
    Semin Hematol 50:314-24. 2013
  3. doi request reprint The molecular genetic makeup of acute lymphoblastic leukemia
    Charles G Mullighan
    Hematological Malignancies Program, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Hematology Am Soc Hematol Educ Program 2012:389-96. 2012
  4. pmc Molecular genetics of B-precursor acute lymphoblastic leukemia
    Charles G Mullighan
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Clin Invest 122:3407-15. 2012
  5. doi request reprint Single nucleotide polymorphism microarray analysis of genetic alterations in cancer
    Charles G Mullighan
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN, USA
    Methods Mol Biol 730:235-58. 2011
  6. doi request reprint Genome-wide profiling of genetic alterations in acute lymphoblastic leukemia: recent insights and future directions
    C G Mullighan
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Leukemia 23:1209-18. 2009
  7. doi request reprint Genomic analysis of acute leukemia
    C G Mullighan
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Int J Lab Hematol 31:384-97. 2009
  8. doi request reprint JAK2--a new player in acute lymphoblastic leukaemia
    Charles G Mullighan
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet 372:1448-50. 2008
  9. doi request reprint Mannose-binding lectin status is associated with risk of major infection following myeloablative sibling allogeneic hematopoietic stem cell transplantation
    Charles G Mullighan
    Institute of Medical and Veterinary Science, Adelaide, Australia
    Blood 112:2120-8. 2008
  10. doi request reprint TET2 mutations in myelodysplasia and myeloid malignancies
    Charles G Mullighan
    Department of Pathology, St Jude s Research Hospital, Memphis, TN, USA
    Nat Genet 41:766-7. 2009

Collaborators

Detail Information

Publications73

  1. doi request reprint T-lineage lymphoblastic lymphoma and leukemia-a MASSive problem
    Charles G Mullighan
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer Cell 18:297-9. 2010
    ..In this issue of Cancer Cell, Feng et al. show that dysregulation of BCL2, AKT signaling, and cell adhesion pathways are hallmarks of T-LBL...
  2. pmc Genomic characterization of childhood acute lymphoblastic leukemia
    Charles G Mullighan
    Department of Pathology and the Hematological Malignancies Program, St Jude Children s Research Hospital, Memphis, TN Electronic address
    Semin Hematol 50:314-24. 2013
    ..This review describes the recent advances in our understanding of the genetics of ALL, with an emphasis on those alterations of key pathogenic or therapeutic importance. ..
  3. doi request reprint The molecular genetic makeup of acute lymphoblastic leukemia
    Charles G Mullighan
    Hematological Malignancies Program, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Hematology Am Soc Hematol Educ Program 2012:389-96. 2012
    ....
  4. pmc Molecular genetics of B-precursor acute lymphoblastic leukemia
    Charles G Mullighan
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Clin Invest 122:3407-15. 2012
    ..This article reviews these advances, discusses results from ongoing second-generation sequencing studies of ALL, and highlights challenges and opportunities for future genetic profiling approaches...
  5. doi request reprint Single nucleotide polymorphism microarray analysis of genetic alterations in cancer
    Charles G Mullighan
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN, USA
    Methods Mol Biol 730:235-58. 2011
    ..This chapter provides methods and guidelines for preparing samples, processing and analyzing data, and validation of novel lesions. Specific examples are provided for Affymetrix SNP arrays in acute lymphoblastic leukemia...
  6. doi request reprint Genome-wide profiling of genetic alterations in acute lymphoblastic leukemia: recent insights and future directions
    C G Mullighan
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Leukemia 23:1209-18. 2009
    ..Here, we review recent data obtained from genome-wide profiling studies in ALL, and discuss potential avenues for future investigation...
  7. doi request reprint Genomic analysis of acute leukemia
    C G Mullighan
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Int J Lab Hematol 31:384-97. 2009
    ....
  8. doi request reprint JAK2--a new player in acute lymphoblastic leukaemia
    Charles G Mullighan
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet 372:1448-50. 2008
  9. doi request reprint Mannose-binding lectin status is associated with risk of major infection following myeloablative sibling allogeneic hematopoietic stem cell transplantation
    Charles G Mullighan
    Institute of Medical and Veterinary Science, Adelaide, Australia
    Blood 112:2120-8. 2008
    ..Studies examining the role of MBL replacement therapy to prevent infection in this setting should be considered...
  10. doi request reprint TET2 mutations in myelodysplasia and myeloid malignancies
    Charles G Mullighan
    Department of Pathology, St Jude s Research Hospital, Memphis, TN, USA
    Nat Genet 41:766-7. 2009
    ..A new study reports common mutations in the TET2 gene in myelodysplasia and related myeloid malignancies, suggesting that TET2 has an important role in hematopoiesis and in the pathogenesis of this disease...
  11. doi request reprint New strategies in acute lymphoblastic leukemia: translating advances in genomics into clinical practice
    Charles G Mullighan
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Clin Cancer Res 17:396-400. 2011
    ..JAK inhibitor therapy is under investigation in children with relapsed and refractory malignancies, including leukemia...
  12. ncbi request reprint New directions in the genomics of allogeneic hematopoietic stem cell transplantation
    Charles G Mullighan
    Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Biol Blood Marrow Transplant 13:127-44. 2007
    ..This review examines the current data regarding the non-HLA genomics of allo-HCT and appraises the promises and pitfalls for integration of this new genetic information into clinical transplantation practice...
  13. ncbi request reprint Genomic polymorphism and allogeneic hematopoietic transplantation outcome
    Charles G Mullighan
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Biol Blood Marrow Transplant 12:19-27. 2006
    ....
  14. pmc Genomic profiling of B-progenitor acute lymphoblastic leukemia
    Charles G Mullighan
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Best Pract Res Clin Haematol 24:489-503. 2011
    ..Importantly, several of these alterations are important determinants of risk of relapse and are potential targets for therapeutic intervention. Here, these advances and future directions in the genomic analysis of ALL are discussed...
  15. pmc Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia
    Charles G Mullighan
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Science 322:1377-80. 2008
    ..These data suggest that genomic abnormalities contributing to ALL relapse are selected for during treatment, and they point to new targets for therapeutic intervention...
  16. pmc Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia
    Charles G Mullighan
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    N Engl J Med 360:470-80. 2009
    ..Recent genomewide analyses have identified a high frequency of DNA copy-number abnormalities in ALL, but the prognostic implications of these abnormalities have not been defined...
  17. pmc The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
    Jinghui Zhang
    Department of Computational Biology and Bioinformatics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 481:157-63. 2012
    ..These findings suggest that addition of myeloid-directed therapies might improve the poor outcome of ETP ALL...
  18. pmc Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse
    Virginia Pérez-Andreu
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Genet 45:1494-8. 2013
    ..Our results provide insights into interactions between inherited and somatic variants and their role in ALL pathogenesis and prognosis. ..
  19. pmc Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia
    Deborah French
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Blood 113:4512-20. 2009
    ..We conclude that acquired genetic variation in leukemia cells has a stronger influence on MTXPG accumulation than inherited genetic variation...
  20. pmc Genomic analysis reveals few genetic alterations in pediatric acute myeloid leukemia
    Ina Radtke
    Department of Pathology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 106:12944-9. 2009
    ..These data reflect a remarkably low burden of genomic alterations within pediatric de novo AML, which is in stark contrast to most other human malignancies...
  21. pmc Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia
    Kathryn G Roberts
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer Cell 22:153-66. 2012
    ..Importantly, several of these alterations induce transformation that is attenuated with tyrosine kinase inhibitors, suggesting the treatment outcome of these patients may be improved with targeted therapy...
  22. ncbi request reprint High Frequency and Poor Outcome of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia in Adults
    Kathryn G Roberts
    Kathryn G Roberts, Zhaohui Gu, Debbie Payne Turner, Kelly McCastlain, Deqing Pei, Ilaria Iacobucci, Marcus Valentine, Stanley B Pounds, Lei Shi, Yongjin Li, Jinghui Zhang, Cheng Cheng, and Charles G Mullighan, St Jude Children s Research Hospital, Memphis, TN Richard C Harvey, I Ming Chen, and Cheryl L Willman, University of New Mexico Cancer Center, Albuquerque, NM Alessandro Rambaldi, Manuela Tosi, and Orietta Spinelli, Ospedale Papa Giovanni XXIII, Bergamo, Italy Jerald P Radich, Fred Hutchinson Cancer Research Center, Seattle, WA Mark D Minden, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada Jacob M Rowe, Shaare Zedek Medical Center, Jerusalem, Afula
    J Clin Oncol . 2016
    ..Trials comparing the addition of tyrosine kinase inhibitors to conventional therapy are required to evaluate the clinical utility of these agents in the treatment of Ph-like ALL...
  23. pmc Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations
    Heng Xu
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    J Natl Cancer Inst 105:733-42. 2013
    ..Although accumulating evidence indicates inherited predisposition to ALL, the genetic basis of ALL susceptibility in diverse ancestry has not been comprehensively examined...
  24. pmc Acute lymphoblastic leukaemia
    Hiroto Inaba
    Department of Oncology, St Jude Children s Research Hospital and University of Tennessee Health Science Center, Memphis, TN 38105, USA
    Lancet 381:1943-55. 2013
    ....
  25. pmc Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia
    Elaine Coustan-Smith
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet Oncol 10:147-56. 2009
    ..We studied leukaemic cells, collected at diagnosis, to identify cases with ETP features and determine their clinical outcome...
  26. pmc Deregulation of DUX4 and ERG in acute lymphoblastic leukemia
    Jinghui Zhang
    Department of Computational Biology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Genet 48:1481-1489. 2016
    ....
  27. pmc Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia
    Zhaohui Gu
    Department of Pathology and Hematological Malignancies Program, St Jude Children s Research Hospital, 262 Danny Thomas Place, MS 342, Memphis, Tennessee 38105, USA
    Nat Commun 7:13331. 2016
    ..Thus, MEF2D-rearranged ALL represents a distinct form of high-risk leukaemia, for which new therapeutic approaches should be considered...
  28. pmc PAX5 is a tumor suppressor in mouse mutagenesis models of acute lymphoblastic leukemia
    Jinjun Dang
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN
    Blood 125:3609-17. 2015
    ..This cross-species analysis also validates the importance of concomitant alterations of multiple cellular growth, signaling, and tumor suppression pathways in the pathogenesis of B-ALL. ..
  29. pmc Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential
    Louise M Treanor
    Department of Hematology and 2 Department of Pathology, Division of Experimental Hematology, St Jude Children s Research Hospital, Memphis, TN 38105
    J Exp Med 211:701-13. 2014
    ..This new murine model recapitulates several important cellular and molecular features of ETP-ALL and should be useful to further define novel therapeutic approaches for this aggressive leukemia. ..
  30. ncbi request reprint Mannose-binding lectin and infection following allogeneic hemopoietic stem cell transplantation
    Charles G Mullighan
    Division of Haematology, Institute of Medical and Veterinary Science, PO Box 14, Rundle Mall, Adelaide, SA, 5000 Australia
    Leuk Lymphoma 45:247-56. 2004
    ..Further studies examining other host defence genes are warranted, and are in progress...
  31. pmc Efficacy of Retinoids in IKZF1-Mutated BCR-ABL1 Acute Lymphoblastic Leukemia
    Michelle L Churchman
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer Cell 28:343-56. 2015
    ..Retinoids potentiated the activity of dasatinib in mouse and human BCR-ABL1 ALL, providing an additional therapeutic option in IKZF1-mutated ALL. ..
  32. pmc The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias
    Anna K Andersson
    1 Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee, USA 2 Department of Clinical Genetics, Lund University, Lund, Sweden
    Nat Genet 47:330-7. 2015
    ..5 mutations/case versus 1.3 mutations/case, P = 7.15 × 10(-5)) and had frequent mutations (45%) in epigenetic regulators, a category of genes that, with the exception of MLL, was rarely mutated in infant MLL-R ALL. ..
  33. pmc The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes
    Robert Huether
    1 Department of Computational Biology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA 2
    Nat Commun 5:3630. 2014
    ..Collectively, our results help to define the landscape of mutations in epigenetic regulatory genes in paediatric cancer and yield a valuable new database for investigating the role of epigenetic dysregulations in cancer. ..
  34. pmc JAK mutations in high-risk childhood acute lymphoblastic leukemia
    Charles G Mullighan
    Departments of Pathology and Biostatistics, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 106:9414-8. 2009
    ..These results suggest that inhibition of JAK signaling is a logical target for therapeutic intervention in JAK mutated ALL...
  35. doi request reprint The genomic landscape of core-binding factor acute myeloid leukemias
    Zachary J Faber
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Genet 48:1551-1556. 2016
    ..This detailed analysis provides insights into the pathogenesis and development of CBF-AML, while highlighting dramatic differences in the landscapes of cooperating mutations for these related AML subtypes...
  36. pmc Inherited coding variants at the CDKN2A locus influence susceptibility to acute lymphoblastic leukaemia in children
    Heng Xu
    1 Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA 2 Department of Laboratory Medicine, National Key Laboratory of Biotherapy Collaborative Innovation Center of Biotherapy, and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
    Nat Commun 6:7553. 2015
    ..These results provide direct functional evidence for the influence of inherited genetic variation on ALL risk, highlighting the important and complex roles of CDKN2A-CDKN2B tumour suppressors in leukaemogenesis. ..
  37. pmc CONSERTING: integrating copy-number analysis with structural-variation detection
    Xiang Chen
    1 Department of Computational Biology, St Jude Children s Research Hospital, Memphis, Tennessee, USA 2 Pediatric Cancer Genome Project, St Jude Children s Research Hospital and Washington University School of Medicine, Memphis, Tennessee, USA
    Nat Methods 12:527-30. 2015
    ..Analysis of 43 cancer genomes from both pediatric and adult patients revealed novel oncogenic CNAs, complex rearrangements and subclonal CNAs missed by alternative approaches. ..
  38. doi request reprint BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros
    Charles G Mullighan
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 453:110-4. 2008
    ..These findings suggest that genetic lesions resulting in the loss of Ikaros function are an important event in the development of BCR-ABL1 ALL...
  39. pmc The genomic landscape of hypodiploid acute lymphoblastic leukemia
    Linda Holmfeldt
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Genet 45:242-52. 2013
    ....
  40. pmc CREBBP mutations in relapsed acute lymphoblastic leukaemia
    Charles G Mullighan
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 471:235-9. 2011
    ..These results extend the landscape of genetic alterations in leukaemia, and identify mutations targeting transcriptional and epigenetic regulation as a mechanism of resistance in ALL...
  41. ncbi request reprint Genomic assessment of pediatric acute leukemia
    Charles G Mullighan
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer J 11:268-82. 2005
    ..This review provides an overview of these techniques in clinical practice and as research tools to develop new therapeutic approaches in pediatric leukemia...
  42. pmc Truncating Erythropoietin Receptor Rearrangements in Acute Lymphoblastic Leukemia
    Ilaria Iacobucci
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer Cell 29:186-200. 2016
    ..Expression of truncated EPOR in mouse B cell progenitors induced ALL in vivo. Human leukemic cells with EPOR rearrangements were sensitive to JAK-STAT inhibition, suggesting a therapeutic option in high-risk ALL. ..
  43. doi request reprint Advances in the Genetics and Therapy of Acute Lymphoblastic Leukemia
    Sabina Chiaretti
    From the Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Rome, Italy Chao Family Comprehensive Cancer Center, School of Medicine, University of California, Irvine, CA Department of Pathology, St Jude Children s Research Hospital, Memphis, TN
    Am Soc Clin Oncol Educ Book 35:e314-22. 2016
    ..Ph-like ALL is also associated with poor outcome, for which precision medicine trials identifying kinase alterations and testing TKI therapy are being developed. ..
  44. pmc Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia
    Maria E Figueroa
    Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA
    J Clin Invest 123:3099-111. 2013
    ..Together, these results demonstrate subtype- and disease-specific alterations in cytosine methylation in ALL that influence transcriptional activity, and are likely to exert a key role in leukemogenesis. ..
  45. pmc Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas
    Jinghui Zhang
    Department of Computational Biology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Genet 45:602-12. 2013
    ..Focusing on the therapeutically challenging diffuse LGGs, our study of 151 tumors has discovered genetic alterations and potential therapeutic targets across the entire range of pediatric LGGs and LGGNTs...
  46. pmc Replicative potential of human natural killer cells
    Hiroyuki Fujisaki
    Department of Oncology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis TN 38105, USA
    Br J Haematol 145:606-13. 2009
    ..We suggest that the methods described here should have many applications in studies of NK cell biology and NK cell-based therapies...
  47. pmc Failure of CDKN2A/B (INK4A/B-ARF)-mediated tumor suppression and resistance to targeted therapy in acute lymphoblastic leukemia induced by BCR-ABL
    Charles G Mullighan
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 22:1411-5. 2008
    ..Why is this the case, and how do these genetic lesions contribute to an aggressive disease that fails to durably respond to targeted kinase inhibitors?..
  48. pmc Pediatric acute lymphoblastic leukemia: where are we going and how do we get there?
    Ching Hon Pui
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    Blood 120:1165-74. 2012
    ..We discuss specific areas of research that promise to further refine current treatment and to improve the cure rate and quality of life of the patients...
  49. pmc CREST maps somatic structural variation in cancer genomes with base-pair resolution
    Jianmin Wang
    Department of Information Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Methods 8:652-4. 2011
    ..Experimental validation exceeded 80%, demonstrating that CREST had a high predictive accuracy...
  50. ncbi request reprint Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia
    Charles G Mullighan
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 446:758-64. 2007
    ..Moreover, these data demonstrate the power of high-resolution, genome-wide approaches to identify new molecular lesions in cancer...
  51. pmc Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group
    Jinghui Zhang
    St Jude Children s Research Hospital, Memphis, TN, USA
    Blood 118:3080-7. 2011
    ..These data extend the range of genes that are recurrently mutated in high-risk childhood B-precursor acute lymphoblastic leukemia and highlight important new therapeutic targets for selected patient subsets...
  52. pmc Clinical significance of low levels of minimal residual disease at the end of remission induction therapy in childhood acute lymphoblastic leukemia
    Patricia Stow
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Blood 115:4657-63. 2010
    ..047). Thus, low levels of MRD (0.001%-< 0.01%) at the end of remission induction therapy have prognostic significance in childhood ALL, suggesting that patients with this finding should be monitored closely for adverse events...
  53. pmc Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia
    Xiaotu Ma
    Computational Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Commun 6:6604. 2015
    ..These results provide important insights into the genetic basis of treatment failure in ALL and have implications for the early detection of mutations driving relapse. ..
  54. pmc Emergence of polyclonal FLT3 tyrosine kinase domain mutations during sequential therapy with sorafenib and sunitinib in FLT3-ITD-positive acute myeloid leukemia
    Sharyn D Baker
    Authors Affiliations Departments of Pharmaceutical Sciences, Structural Biology, Pathology, and Oncology, Hartwell Center for Bioinformatics and Biotechnology, St Jude Children s Research Hospital and Department of Pediatrics, University of Tennessee, Memphis, Tennessee
    Clin Cancer Res 19:5758-68. 2013
    ....
  55. doi request reprint How new advances in genetic analysis are influencing the understanding and treatment of childhood acute leukemia
    Kathryn G Roberts
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Curr Opin Pediatr 23:34-40. 2011
    ..This review describes the recent advances in genomic profiling that have provided critical new insights into the biology of acute leukemia in children...
  56. pmc Global genomic characterization of acute lymphoblastic leukemia
    Charles G Mullighan
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Semin Hematol 46:3-15. 2009
    ..In this article, we review the key findings from the published data on genome-wide analyses of ALL and highlight some of the technical aspects of data generation and analysis that must be carefully controlled to obtain optimal results...
  57. pmc Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells
    Barthélémy Diouf
    Hematological Malignancies Program, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Med 17:1298-303. 2011
    ..These findings reveal a previously unrecognized mechanism whereby somatic deletions of genes regulating MSH2 degradation result in undetectable levels of MSH2 protein in leukemia cells, DNA mismatch repair deficiency and drug resistance...
  58. doi request reprint Genome sequencing of lymphoid malignancies
    Charles G Mullighan
    Department of Pathology and the Hematological Malignancies Program, St Jude Children s Research Hospital, Memphis, TN
    Blood 122:3899-907. 2013
    ....
  59. pmc Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
    Gang Wu
    Department of Computational Biology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Genet 44:251-3. 2012
    ..3, or in the related HIST1H3B, encoding histone H3.1, that caused a p.Lys27Met amino acid substitution in each protein. An additional 14% of non-BS-PGs had somatic mutations in H3F3A causing a p.Gly34Arg alteration...
  60. doi request reprint Genome-wide study links PNPLA3 variant with elevated hepatic transaminase after acute lymphoblastic leukemia therapy
    Yiwei Liu
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN
    Clin Pharmacol Ther . 2017
    ..024). This is an example of a pharmacogenetic variant overlapping with a disease risk variant. This article is protected by copyright. All rights reserved...
  61. pmc Ikaros: Exploiting and targeting the hematopoietic stem cell niche in B-progenitor acute lymphoblastic leukemia
    Michelle L Churchman
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN, USA
    Exp Hematol 46:1-8. 2017
    ....
  62. ncbi request reprint Tumor-specific genetic lesions and their influence on therapy in pediatric acute lymphoblastic leukemia
    James R Downing
    St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    Hematology Am Soc Hematol Educ Program . 2006
    ..The identification of these lesions should provide the bases for defining the molecular "Achilles heels" against which new targeted therapies can be developed...
  63. doi request reprint Genomics in acute lymphoblastic leukaemia: insights and treatment implications
    Kathryn G Roberts
    Department of Pathology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Mail Stop 342, Memphis, TN 38105, USA
    Nat Rev Clin Oncol 12:344-57. 2015
    ..Many of these findings are of direct clinical relevance and ongoing studies implementing clinical sequencing in leukaemia diagnosis and management have great potential to improve the outcome of patients with high-risk ALL. ..
  64. pmc Generation of human acute lymphoblastic leukemia xenografts for use in oncology drug discovery
    Linda Holmfeldt
    Pathology, St Jude Children s Research Hospital, Memphis, Tennessee The Beijer Laboratory for Gene and Neurosciences, Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Curr Protoc Pharmacol 68:14.32.1-19. 2015
    ..Detailed in this unit are procedures for the establishment and maintenance of primary ALL xenograft panels for use in basic research and translational studies...
  65. doi request reprint Advances in the genetics of high-risk childhood B-progenitor acute lymphoblastic leukemia and juvenile myelomonocytic leukemia: implications for therapy
    Mignon L Loh
    Department of Pediatrics and the Helen Diller Comprehensive Cancer Center, Benioff Children s Hospital, University of California, San Francisco, San Francisco, California, USA
    Clin Cancer Res 18:2754-67. 2012
    ..Recent insights into the clonal heterogeneity of leukemic samples and the implications for diagnostic and therapeutic approaches are also discussed...
  66. ncbi request reprint The role of TET2 in hematologic neoplasms
    Linda Holmfeldt
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer Cell 20:1-2. 2011
    ..In this issue of Cancer Cell, two studies show that inactivation of Tet2 enhances hematopoietic stem cell self renewal and promotes the development of myeloproliferative disorders...
  67. doi request reprint Genetic alterations targeting lymphoid development in acute lymphoblastic leukemia
    J RACQUEL COLLINS-UNDERWOOD
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Curr Top Dev Biol 94:171-96. 2011
    ..We also discuss the genetic lesions identified from these studies and how novel therapeutics directed at these targets may improve survival of pediatric ALL patients at high risk for relapse...
  68. ncbi request reprint Mannose-binding lectin gene polymorphisms are associated with major infection following allogeneic hemopoietic stem cell transplantation
    Charles G Mullighan
    Research and Development, Australian Red Cross Blood Service, South Australia
    Blood 99:3524-9. 2002
    ..These findings raise the possibility that MBL replacement therapy may be useful following transplantation...
  69. ncbi request reprint Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-beta, FAS, and mannose-binding protein C gene polymorphisms in Australian women: Risk of preterm birth
    Margaret F Annells
    Department of Microbiology and Infectious Diseases, Women s and Children s Hospital, North Adelaide, South Australia
    Am J Obstet Gynecol 191:2056-67. 2004
    ..The purpose of this study was to examine the relationship between preterm birth and 22 single nucleotide polymorphisms in genes that encode cytokines and mediators of apoptosis and host defense...
  70. ncbi request reprint Mannose-binding lectin and gastric cancer
    Daniel L Worthley
    Int J Cancer 120:2751-2; author reply 2750. 2007
  71. ncbi request reprint Mannose-binding lectin deficiency does not increase the prevalence of Helicobacter pylori seropositivity
    Daniel L Worthley
    Department of Gastroenterology and Hepatology, Flinders Medical Centre, Australia
    Eur J Gastroenterol Hepatol 19:147-52. 2007
    ..Helicobacter pylori is one of the most common human infections and can bind mannose-binding lectin. Therefore, we examined whether mannose-binding lectin status influences the prevalence of H. pylori infection...
  72. ncbi request reprint Mannose-binding lectin and liver transplantation
    Daniel L Worthley
    Gastroenterology 129:1805-6; author reply 1806-7. 2005
  73. ncbi request reprint Tissue plasminogen activator -7351C/T enhancer polymorphism is a risk factor for lacunar stroke
    Jim Jannes
    Department of Medicine, University of Adelaide, The Queen Elizabeth Hospital, Woodville South, South Australia
    Stroke 35:1090-4. 2004
    ..In this study, we investigated the risk of lacunar and nonlacunar ischemic stroke associated with the TPA -7351C/T polymorphism...