Larry Kun

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. doi request reprint Endocrine outcomes for children with embryonal brain tumors after risk-adapted craniospinal and conformal primary-site irradiation and high-dose chemotherapy with stem-cell rescue on the SJMB-96 trial
    Stephen J Laughton
    Division of Neuro Oncology, Department of Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Clin Oncol 26:1112-8. 2008
  2. ncbi request reprint Introduction to the special issue: a tribute to the life of Raymond K. Mulhern
    Larry Kun
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Pediatr Psychol 32:1025-8. 2007
  3. doi request reprint Radiation therapy for children: evolving technologies in the era of ALARA
    Larry E Kun
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Pediatr Radiol 39:S65-70. 2009
  4. doi request reprint High-dose chemotherapy with autologous stem cell rescue for children with recurrent malignant brain tumors
    Chie Schin Shih
    Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Cancer 112:1345-53. 2008
  5. ncbi request reprint Abnormal hippocampal development in children with medulloblastoma treated with risk-adapted irradiation
    Bonnie J Nagel
    Division of Behavioral Medicine, St Jude Children s Research Hospital, Memphis, TN, USA
    AJNR Am J Neuroradiol 25:1575-82. 2004
  6. doi request reprint Hearing loss after radiotherapy for pediatric brain tumors: effect of cochlear dose
    Chiaho Hua
    Division of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    Int J Radiat Oncol Biol Phys 72:892-9. 2008
  7. ncbi request reprint Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma
    Amar Gajjar
    St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    J Clin Oncol 22:984-93. 2004
  8. ncbi request reprint Clear cell ependymoma: a clinicopathologic and radiographic analysis of 10 patients
    Maryam Fouladi
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 98:2232-44. 2003
  9. ncbi request reprint Medullomyoblastoma: a radiographic and clinicopathologic analysis of six cases and review of the literature
    Kathleen J Helton
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Cancer 101:1445-54. 2004
  10. ncbi request reprint Risk-adapted, combined-modality therapy with VAMP/COP and response-based, involved-field radiation for unfavorable pediatric Hodgkin's disease
    Melissa M Hudson
    Department of Hematology Oncology, Radiological Sciences and Biostatistics, St Jude Children s Research Hospital and the University of Tennessee College of Medicine, Memphis, TN 38105, USA
    J Clin Oncol 22:4541-50. 2004

Research Grants

Detail Information

Publications83

  1. doi request reprint Endocrine outcomes for children with embryonal brain tumors after risk-adapted craniospinal and conformal primary-site irradiation and high-dose chemotherapy with stem-cell rescue on the SJMB-96 trial
    Stephen J Laughton
    Division of Neuro Oncology, Department of Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Clin Oncol 26:1112-8. 2008
    ....
  2. ncbi request reprint Introduction to the special issue: a tribute to the life of Raymond K. Mulhern
    Larry Kun
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Pediatr Psychol 32:1025-8. 2007
  3. doi request reprint Radiation therapy for children: evolving technologies in the era of ALARA
    Larry E Kun
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Pediatr Radiol 39:S65-70. 2009
    ....
  4. doi request reprint High-dose chemotherapy with autologous stem cell rescue for children with recurrent malignant brain tumors
    Chie Schin Shih
    Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Cancer 112:1345-53. 2008
    ..High-dose chemotherapy (HDCT) with autologous stem cell rescue (ASCR) has been reported to be effective in treating children with recurrent central nervous system (CNS) malignancies...
  5. ncbi request reprint Abnormal hippocampal development in children with medulloblastoma treated with risk-adapted irradiation
    Bonnie J Nagel
    Division of Behavioral Medicine, St Jude Children s Research Hospital, Memphis, TN, USA
    AJNR Am J Neuroradiol 25:1575-82. 2004
    ..Therefore, we hypothesized that longitudinal hippocampal volume measurements are abnormal in patients with medulloblastoma and thereby provide a possible substrate for explaining memory dysfunction...
  6. doi request reprint Hearing loss after radiotherapy for pediatric brain tumors: effect of cochlear dose
    Chiaho Hua
    Division of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    Int J Radiat Oncol Biol Phys 72:892-9. 2008
    ..To determine the effect of cochlear dose on sensorineural hearing loss in pediatric patients with brain tumor treated by using conformal radiation therapy (CRT)...
  7. ncbi request reprint Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma
    Amar Gajjar
    St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    J Clin Oncol 22:984-93. 2004
    ..To assess the feasibility of performing central molecular analyses of fresh medulloblastomas obtained from multiple institutions and using these data to identify prognostic markers for contemporaneously treated patients...
  8. ncbi request reprint Clear cell ependymoma: a clinicopathologic and radiographic analysis of 10 patients
    Maryam Fouladi
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 98:2232-44. 2003
    ..Histologically, it may mimic oligodendroglioma, central neurocytoma, hemangioblastoma, and renal cell carcinoma...
  9. ncbi request reprint Medullomyoblastoma: a radiographic and clinicopathologic analysis of six cases and review of the literature
    Kathleen J Helton
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Cancer 101:1445-54. 2004
    ..Medullomyoblastoma (MMB) is a rare cerebellar embryonal neoplasm that occurs almost exclusively in children. It is biphasic by microscopy, containing myoblastic and primitive neuroectodermal components...
  10. ncbi request reprint Risk-adapted, combined-modality therapy with VAMP/COP and response-based, involved-field radiation for unfavorable pediatric Hodgkin's disease
    Melissa M Hudson
    Department of Hematology Oncology, Radiological Sciences and Biostatistics, St Jude Children s Research Hospital and the University of Tennessee College of Medicine, Memphis, TN 38105, USA
    J Clin Oncol 22:4541-50. 2004
    ....
  11. ncbi request reprint Polar spongioblastoma of the spinal cord: a case report
    Christine Fuller
    Department of Pathology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    Pediatr Dev Pathol 9:75-80. 2006
    ..Discrimination of these rare aggressive lesions from other CNS tumors with focal palisaded architecture is crucial as the treatment and prognosis of the latter may differ significantly...
  12. ncbi request reprint Survival and late mortality in long-term survivors of pediatric CNS tumors
    E Brannon Morris
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 25:1532-8. 2007
    ..To describe the pattern of survival and late mortality among contemporary long-term survivors of pediatric CNS tumor...
  13. pmc Safe anesthesia for radiotherapy in pediatric oncology: St. Jude Children's Research Hospital Experience, 2004-2006
    Doralina L Anghelescu
    Division of Anesthesiology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Int J Radiat Oncol Biol Phys 71:491-7. 2008
    ..To determine the incidence of anesthesia-related complications in children undergoing radiotherapy and the associated risk factors...
  14. ncbi request reprint Phase I trial of single-dose temozolomide and continuous administration of o6-benzylguanine in children with brain tumors: a pediatric brain tumor consortium report
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Clin Cancer Res 13:6712-8. 2007
    ..To estimate the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of escalating doses of temozolomide combined with O(6)-benzylguanine in patients < or =21 years with recurrent brain tumors...
  15. pmc Childhood central nervous system leukemia: historical perspectives, current therapy, and acute neurological sequelae
    Fred H Laningham
    Division of Diagnostic Imaging MS 210, Department of Radiological Sciences, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN, 38105 2794, USA
    Neuroradiology 49:873-88. 2007
    ....
  16. ncbi request reprint Intratumoral hemorrhage among children with newly diagnosed, diffuse brainstem glioma
    Alberto Broniscer
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Cancer 106:1364-71. 2006
    ..In the current study, the authors assessed the characteristics and estimated the cumulative incidence of IH among children with BSG...
  17. ncbi request reprint Phase II trial of conformal radiation therapy for pediatric patients with craniopharyngioma and correlation of surgical factors and radiation dosimetry with change in cognitive function
    Thomas E Merchant
    Division of Radiation Oncology, Department of Biostatistics, St Jude Children s Research Hospital, and Semmes Murphey Neurologic and Spine Institute, Memphis, Tennessee 38105 2794, USA
    J Neurosurg 104:94-102. 2006
    ..A Phase II trial of conformal radiation therapy (CRT) for craniopharyngioma was conducted to determine whether the irradiated volume could be safely reduced to decrease effects on cognitive function...
  18. ncbi request reprint Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial
    Amar Gajjar
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet Oncol 7:813-20. 2006
    ..We aimed to investigate the effectiveness of risk-adapted radiotherapy followed by a shortened period of dose-intense chemotherapy in children with medulloblastoma...
  19. pmc Multi-institution prospective trial of reduced-dose craniospinal irradiation (23.4 Gy) followed by conformal posterior fossa (36 Gy) and primary site irradiation (55.8 Gy) and dose-intensive chemotherapy for average-risk medulloblastoma
    Thomas E Merchant
    Department of Radiological Sciences, Division of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 70:782-7. 2008
    ..Conformal RT to less than the entire posterior fossa (PF) after craniospinal irradiation might reduce neurocognitive sequelae and requires evaluation...
  20. ncbi request reprint A model for quantitative changes in the magnetic resonance parameters of muscle in children after therapeutic irradiation
    Matthew J Krasin
    Division of Radiation Oncology, Department of Radiological Sciences, St Jude Children s Research Hospital, and Department of Pediatrics, University of Tennessee School of Medicine, Memphis, TN 38105 2794, USA
    Magn Reson Imaging 24:1319-24. 2006
    ....
  21. ncbi request reprint Clinical and molecular characteristics of malignant transformation of low-grade glioma in children
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 25:682-9. 2007
    ..To analyze the clinical and molecular characteristics of malignant transformation (MT) of low-grade glioma (LGG) in children...
  22. pmc Initial response to salvage therapy determines prognosis in relapsed pediatric Hodgkin lymphoma patients
    Monika L Metzger
    Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Cancer 116:4376-84. 2010
    ..Pediatric Hodgkin lymphoma (HL) is a highly curable disease; however, prognostic factors for the survival of patients who develop recurrent disease have not been clearly defined...
  23. doi request reprint Treatment planning and delivery of external beam radiotherapy for pediatric sarcoma: the St. Jude Children's Research Hospital experience
    Chiaho Hua
    Division of Radiation Oncology, Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Int J Radiat Oncol Biol Phys 70:1598-606. 2008
    ..Jude Children's Research Hospital. The treatment characteristics serve as a baseline for future comparison with developing treatment modalities...
  24. pmc Incidence and correlates of radiation pneumonitis in pediatric patients with partial lung irradiation
    Chiaho Hua
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    Int J Radiat Oncol Biol Phys 78:143-9. 2010
    ..To provide a radiation pneumonitis risk estimate and investigate the correlation of clinical and dosimetric factors in pediatric patients receiving chest irradiation...
  25. pmc Preliminary results from a prospective study using limited margin radiotherapy in pediatric and young adult patients with high-grade nonrhabdomyosarcoma soft-tissue sarcoma
    Matthew J Krasin
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 76:874-8. 2010
    ..To demonstrate the safety and efficacy of limited margin radiotherapy in the local control of pediatric and young adult patients with high-grade nonrhabdomyosarcoma soft tissue sarcoma (NRSTS)...
  26. pmc Phase II trial of conformal radiation therapy for pediatric low-grade glioma
    Thomas E Merchant
    Dept of Radiological Sciences, Mail Stop 220, St Jude Children s Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105 3678, USA
    J Clin Oncol 27:3598-604. 2009
    ..We conducted a phase II trial of conformal radiation therapy (CRT) to estimate disease control by using a 10-mm clinical target volume (CTV) margin...
  27. pmc Treating childhood acute lymphoblastic leukemia without cranial irradiation
    Ching Hon Pui
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    N Engl J Med 360:2730-41. 2009
    ..Prophylactic cranial irradiation has been a standard treatment in children with acute lymphoblastic leukemia (ALL) who are at high risk for central nervous system (CNS) relapse...
  28. doi request reprint Advances in surgical techniques for resection of childhood cerebellopontine angle ependymomas are key to survival
    Robert A Sanford
    Semmes Murphey Clinic, 6325 Humphreys Boulevard, Memphis, TN 38120, USA
    Childs Nerv Syst 25:1229-40. 2009
    ..As CPA ependymomas grow, they distort the anatomy and encase cranial nerves and vessels, thereby making resection a formidable surgical challenge...
  29. pmc Abnormal timing of menarche in survivors of central nervous system tumors: A report from the Childhood Cancer Survivor Study
    Gregory T Armstrong
    Department of Epidemiology and Cancer Control, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 115:2562-70. 2009
    ..To the authors' knowledge, data regarding the risk of altered timing of menarche after higher dose radiotherapy (RT), as used in the treatment of central nervous system (CNS) tumors, are limited...
  30. pmc Conformal radiotherapy after surgery for paediatric ependymoma: a prospective study
    Thomas E Merchant
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN, USA
    Lancet Oncol 10:258-66. 2009
    ..We extended this treatment approach to include children under the age of 3 years with the aim of improving tumour control...
  31. pmc Renal function after ifosfamide, carboplatin and etoposide (ICE) chemotherapy, nephrectomy and radiotherapy in children with Wilms tumour
    Najat C Daw
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    Eur J Cancer 45:99-106. 2009
    ..Treatment with ICE, nephrectomy and radiotherapy significantly reduces GFR, largely as the result of nephrectomy. Adjustment of carboplatin dosage on the basis of GFR and careful monitoring of renal function may alleviate nephrotoxicity...
  32. pmc M1 Medulloblastoma: high risk at any age
    Robert P Sanders
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    J Neurooncol 90:351-5. 2008
    ..The prognosis for children with M1 medulloblastoma (positive CSF cytology) has not been well-defined...
  33. pmc Amifostine protects against cisplatin-induced ototoxicity in children with average-risk medulloblastoma
    Maryam Fouladi
    Department of Oncology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105 2794, USA
    J Clin Oncol 26:3749-55. 2008
    ....
  34. doi request reprint Young age may predict a better outcome for children with diffuse pontine glioma
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 113:566-72. 2008
    ..Because diffuse pontine glioma (DPG) is rare among young children, the outcome of affected patients is unknown...
  35. doi request reprint A retrospective study of surgery and reirradiation for recurrent ependymoma
    Thomas E Merchant
    Department of Radiological Sciences, Division of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 71:87-97. 2008
    ..To report disease control for patients with recurrent ependymoma (EP) treated with surgery and a second course of radiation therapy (RT(2))...
  36. doi request reprint Diffusion tensor imaging of brainstem tumors: axonal degeneration of motor and sensory tracts
    Kathleen J Helton
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Neurosurg Pediatr 1:270-6. 2008
    ..The authors sought to determine whether DT imaging and white matter tractography could detect axonal degeneration in patients with brainstem tumors...
  37. doi request reprint Effect of race on the outcome of pediatric patients with Hodgkin's lymphoma
    Monika L Metzger
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Clin Oncol 26:1282-8. 2008
    ..We examine the effects of race on clinical outcomes among children with Hodgkin's lymphoma (HL) treated with contemporary therapy at a tertiary care children's hospital...
  38. ncbi request reprint Patterns of treatment failure in pediatric and young adult patients with Hodgkin's disease: local disease control with combined-modality therapy
    Matthew J Krasin
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 23:8406-13. 2005
    ..This study defines the cumulative incidence (CI) of local failure (LF) and prognostic factors for pediatric patients treated for HD with combined-modality therapy (CMT)...
  39. ncbi request reprint Temozolomide after radiotherapy for newly diagnosed high-grade glioma and unfavorable low-grade glioma in children
    Alberto Broniscer
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    J Neurooncol 76:313-9. 2006
    ..Although the heterogeneity of prognostic factors in our patients made assessment of treatment outcome more difficult, the addition of 6 cycles of temozolomide after radiotherapy did not seem to alter the poor outcome of these patients...
  40. ncbi request reprint A chemosensitive pediatric extraosseous osteosarcoma: case report and review of the literature
    Karen Wodowski
    Departments of Hematology Oncology, St Jude s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
    J Pediatr Hematol Oncol 25:73-7. 2003
    ..Children with extraosseous osteosarcoma may have a more favorable response to treatment than adults; thus, a curative approach using combined modality therapy appears warranted...
  41. ncbi request reprint Efficacy of combined surgery and irradiation for localized Ewings sarcoma family of tumors
    Matthew J Krasin
    Division of Radiation Oncology, Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Pediatr Blood Cancer 43:229-36. 2004
    ..Local failure rates for patients who received combined surgery and RT were reviewed to determine outcome and prognostic factors...
  42. ncbi request reprint Improved outcome for children with acute lymphoblastic leukemia: results of Total Therapy Study XIIIB at St Jude Children's Research Hospital
    Ching Hon Pui
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Blood 104:2690-6. 2004
    ..01% or more at the end of the 6-week remission induction phase. Our results suggest the efficacy of early intensification of intrathecal chemotherapy and provide the basis for studies omitting cranial irradiation altogether...
  43. ncbi request reprint Late neurocognitive sequelae in survivors of brain tumours in childhood
    Raymond K Mulhern
    Division of Behavioral Medicine, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Lancet Oncol 5:399-408. 2004
    ..Further efforts to limit neurocognitive sequelae have included design of clinical trials to test the effectiveness of cognitive, behavioural, and pharmacological interventions...
  44. ncbi request reprint Second neoplasms in pediatric patients with primary central nervous system tumors: the St. Jude Children's Research Hospital experience
    Alberto Broniscer
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 100:2246-52. 2004
    ..Details on second neoplasms (SNs) following pediatric central nervous system (CNS) tumors are scant, because of the rarity of such SNs. The goal of the current study was to investigate and characterize these rare SNs...
  45. ncbi request reprint Craniopharyngioma: the St. Jude Children's Research Hospital experience 1984-2001
    Thomas E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
    Int J Radiat Oncol Biol Phys 53:533-42. 2002
    ..To review our institution's experience in the treatment of craniopharyngioma and assess the merits of initial therapy with limited surgery and irradiation...
  46. ncbi request reprint Preirradiation endocrinopathies in pediatric brain tumor patients determined by dynamic tests of endocrine function
    Thomas E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 54:45-50. 2002
    ..To prospectively evaluate pediatric patients with localized primary brain tumors for evidence of endocrinopathy before radiotherapy (RT)...
  47. ncbi request reprint Attentional functioning and white matter integrity among survivors of malignant brain tumors of childhood
    Raymond K Mulhern
    Division of Behavioral Medicine, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Int Neuropsychol Soc 10:180-9. 2004
    ..No gender effects were observed. The results of the present study further support the contention that NAWM is an important substrate for treatment-induced neurocognitive problems among survivors of malignant brain tumors of childhood...
  48. ncbi request reprint Early neuro-otologic effects of three-dimensional irradiation in children with primary brain tumors
    Thomas E Merchant
    Department ofRadiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 58:1194-207. 2004
    ..We modeled hearing threshold levels (HTL) after CRT in children with localized primary brain tumors (ependymoma, low- or high-grade astrocytoma, craniopharyngioma, or CNS germinoma) by using cochlear dose and clinical variables...
  49. ncbi request reprint Predicting intellectual outcome among children treated with 35-40 Gy craniospinal irradiation for medulloblastoma
    Shawna L Palmer
    Division of Behavioral Medicine, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Neuropsychology 17:548-55. 2003
    ..A steeper decline was found for those with higher baseline performance. Clinicians may use the proposed predictive model to identify those patients who are at risk of significant intellectual decline...
  50. ncbi request reprint Extended follow-up of long-term survivors of childhood acute lymphoblastic leukemia
    Ching Hon Pui
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    N Engl J Med 349:640-9. 2003
    ..We determined the long-term survival and the rates of health insurance coverage, marriage, and employment among patients who had attained at least 10 years of event-free survival...
  51. ncbi request reprint Medulloblastoma metastatic to the suprasellar region at diagnosis: a report of six cases with clinicopathologic correlation
    Kathleen J Helton
    St Jude Children s Research Hospital, Semmes Murphy Clinic, Memphis, TN 38105, USA
    Pediatr Neurosurg 37:111-7. 2002
    ..8%. Patients with tumors that show large cell/anaplastic features may be at higher risk for early metastatic involvement of this unusual site...
  52. ncbi request reprint Treatment of intraocular retinoblastoma with vincristine and carboplatin
    Carlos Rodriguez-Galindo
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    J Clin Oncol 21:2019-25. 2003
    ..To evaluate the efficacy of chemoreduction using vincristine and carboplatin in preventing or delaying external-beam radiotherapy (EBRT) or enucleation in patients with intraocular retinoblastoma...
  53. ncbi request reprint Survival and functional outcome of children with hypothalamic/chiasmatic tumors
    Maryam Fouladi
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 97:1084-92. 2003
    ..We evaluated the impact of clinical and neuroimaging parameters and primary therapy on overall (OS) and progression-free (PFS) survival and on neuroendocrine and neurocognitive outcome in children with H and/or C tumors...
  54. ncbi request reprint Granulocyte colony-stimulating factor and the risk of secondary myeloid malignancy after etoposide treatment
    Mary V Relling
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Blood 101:3862-7. 2003
    ..Even when children receiving irradiation were excluded, the incidence was still higher in those receiving G-CSF (P =.019). In the setting of intensive antileukemic therapy, short-term use of G-CSF may increase the risk of t-ML...
  55. ncbi request reprint Preliminary results from a phase II trial of conformal radiation therapy and evaluation of radiation-related CNS effects for pediatric patients with localized ependymoma
    Thomas E Merchant
    Department of Biostatistics, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    J Clin Oncol 22:3156-62. 2004
    ....
  56. ncbi request reprint Definitive irradiation in multidisciplinary management of localized Ewing sarcoma family of tumors in pediatric patients: outcome and prognostic factors
    Matthew J Krasin
    Department of Radiological Sciences, Division of Radiation Oncology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105 2794, USA
    Int J Radiat Oncol Biol Phys 60:830-8. 2004
    ..To assess the effect of radiation dose on local tumor control of the Ewing sarcoma family of tumors in 79 patients with localized disease treated at a single institution...
  57. ncbi request reprint White matter lesions detected by magnetic resonance imaging after radiotherapy and high-dose chemotherapy in children with medulloblastoma or primitive neuroectodermal tumor
    Maryam Fouladi
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Clin Oncol 22:4551-60. 2004
    ....
  58. ncbi request reprint Intellectual and functional outcome of children 3 years old or younger who have CNS malignancies
    Maryam Fouladi
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    J Clin Oncol 23:7152-60. 2005
    ....
  59. ncbi request reprint Ocular preservation after 36 Gy external beam radiation therapy for retinoblastoma
    Thomas E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Pediatr Hematol Oncol 24:246-9. 2002
    ..The purpose of this study was to document the ocular preservation rate after 36 Gy external beam radiation therapy (EBRT) for retinoblastoma...
  60. ncbi request reprint Survival after recurrence of Ewing tumors: the St Jude Children's Research Hospital experience, 1979-1999
    Carlos Rodriguez-Galindo
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 94:561-9. 2002
    ..Despite improved therapies, 30-40% of patients with Ewing tumors (ET) experience recurrence and have a poor prognosis. The authors analyzed factors prognostic of survival in patients with recurrent ET...
  61. ncbi request reprint Seizures in children with primary brain tumors: incidence and long-term outcome
    Raja B Khan
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Epilepsy Res 64:85-91. 2005
    ..To estimate the incidence and long-term outcome of brain tumor related seizures in children and to identify risk factors for adverse seizure outcome...
  62. ncbi request reprint Preliminary results from a Phase II trail of conformal radiation therapy for pediatric patients with localised low-grade astrocytoma and ependymoma
    Thomas E Merchant
    Department of Radiation Oncology St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 52:325-32. 2002
    ....
  63. pmc Atypical white matter volume development in children following craniospinal irradiation
    Wilburn E Reddick
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Neuro Oncol 7:12-9. 2005
    ..Therefore, volumetric monitoring of brain development can be used to guide the care of survivors, assess the toxicity of previous and current clinical trials, and aid in the design of therapies that minimize toxicity...
  64. ncbi request reprint Influence of tumor grade on time to progression after irradiation for localized ependymoma in children
    Thomas E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 53:52-7. 2002
    ..To investigate the influence of histologic grade on progression-free survival (PFS) after irradiation (RT) for pediatric patients with localized ependymoma...
  65. ncbi request reprint Types, causes, and outcome of intracranial hemorrhage in children with cancer
    Evgeny E Kyrnetskiy
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Neurosurg 102:31-5. 2005
    ..The aim of this study was to investigate the cause and outcome of intracranial hemorrhage (ICH) in children with cancer...
  66. ncbi request reprint Neurocognitive consequences of risk-adapted therapy for childhood medulloblastoma
    Raymond K Mulhern
    Division of Behavioral Medicine, Department of Biostatistics, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Clin Oncol 23:5511-9. 2005
    ....
  67. ncbi request reprint Atypical teratoid/rhabdoid tumors (ATRT): improved survival in children 3 years of age and older with radiation therapy and high-dose alkylator-based chemotherapy
    Tanya M Tekautz
    Department of Hematology Oncology, Mail Stop 260, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    J Clin Oncol 23:1491-9. 2005
    ..To describe clinical features, therapeutic approaches, and prognostic factors in pediatric patients with atypical teratoid/rhabdoid tumors (ATRT) treated at St Jude Children's Research Hospital (SJCRH)...
  68. doi request reprint Comparison of gallium and PET scans at diagnosis and follow-up of pediatric patients with Hodgkin lymphoma
    Melissa Hines-Thomas
    University of Tennessee School of Medicine, Memphis, Tennessee, USA
    Pediatr Blood Cancer 51:198-203. 2008
    ..Positron emission tomography (PET) and gallium scans facilitate diagnosis and staging, evaluation of response to therapy, and monitoring for relapse in Hodgkin lymphoma (HL), but have not been compared in pediatric HL...
  69. ncbi request reprint Primary perineal alveolar rhabdomyosarcoma metastatic to an extraocular muscle
    Melanie L McCarty
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Ophthal Plast Reconstr Surg 19:333-5. 2003
    ..Alveolar rhabdomyosarcoma from distant sites rarely metastasizes to the extraocular muscles. However, our case shows that alveolar rhabdomyosarcoma may metastasize to the orbit and involve a single muscle...
  70. ncbi request reprint Hearing loss as a late complication of radiotherapy in children with brain tumors
    Glenn B Williams
    Department of Otolaryngology, University of Tennessee, 956 Court Ave, Suite B226, Memphis, TN 38163, USA
    Ann Otol Rhinol Laryngol 114:328-31. 2005
    ....
  71. pmc Evaluation of memory impairment in aging adult survivors of childhood acute lymphoblastic leukemia treated with cranial radiotherapy
    Gregory T Armstrong
    Department of Epidemiology and Cancer Control, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Natl Cancer Inst 105:899-907. 2013
    ..Cranial radiotherapy (CRT) is a known risk factor for neurocognitive impairment in survivors of childhood cancer and may increase risk for mild cognitive impairment and dementia in adulthood...
  72. ncbi request reprint Histopathologic grading of medulloblastomas: a Pediatric Oncology Group study
    Charles G Eberhart
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer 94:552-60. 2002
    ....
  73. ncbi request reprint Phase I trial of intrathecal spartaject busulfan in children with neoplastic meningitis: a Pediatric Brain Tumor Consortium Study (PBTC-004)
    Sridharan Gururangan
    The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Cancer Res 12:1540-6. 2006
    ..San Ramon, CA) was conducted in children with neoplastic meningitis following recurrent primary brain tumors to describe toxicities, estimate the maximum tolerated dose (MTD), and document evidence of responses to this agent...
  74. pmc Unilateral and bilateral breast cancer in women surviving pediatric Hodgkin's disease
    Swati K Basu
    Department of Community and Preventive Medicine, James P Wilmot Cancer Center at the University of Rochester, Rochester, NY 14642, USA
    Int J Radiat Oncol Biol Phys 72:34-40. 2008
    ..To define demographic and therapeutic associations with the risk of breast cancer in children treated for Hodgkin's disease (HD), particularly the frequency and interval to the development of contralateral breast cancer...
  75. ncbi request reprint Final results of a prospective clinical trial with VAMP and low-dose involved-field radiation for children with low-risk Hodgkin's disease
    Sarah S Donaldson
    Stanford University Medical Center, Stanford, CA, USA
    J Clin Oncol 25:332-7. 2007
    ....
  76. pmc Phase I trial of imatinib in children with newly diagnosed brainstem and recurrent malignant gliomas: a Pediatric Brain Tumor Consortium report
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Neuro Oncol 9:145-60. 2007
    ..Imatinib may increase the risk of ITH, although the incidence of spontaneous hemorrhages in brainstem glioma is sufficiently high that this should be considered in studies of agents in which hemorrhage is a concern...
  77. ncbi request reprint Intracranial germinoma: on whole-ventricular irradiation
    David Roberge
    Department of Radiation Oncology, McGill University Health Center, Montreal, Quebec, Canada
    Pediatr Blood Cancer 44:358-62. 2005
    ..A current focus in the treatment of intracranial germinoma is on decreasing the volume of radiotherapy. We studied the theoretical impact of selecting different target volumes and treatment techniques...
  78. ncbi request reprint Phase I and pharmacokinetic study of the oral farnesyltransferase inhibitor lonafarnib administered twice daily to pediatric patients with advanced central nervous system tumors using a modified continuous reassessment method: a Pediatric Brain Tumor Cons
    Mark W Kieran
    Dana Farber Cancer Institute and Children s Hospital Boston, Boston, MA 02115, USA
    J Clin Oncol 25:3137-43. 2007
    ..Primary objectives were to estimate the maximum-tolerated dose (MTD) and to describe the dose-limiting toxicities (DLTs) and pharmacokinetics of lonafarnib. Farnesylation inhibition of HDJ-2 in peripheral blood was also measured...
  79. doi request reprint Phase I trial of VNP40101M (Cloretazine) in children with recurrent brain tumors: a pediatric brain tumor consortium study
    Sridharan Gururangan
    The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Cancer Res 14:1124-30. 2008
    ..VNP40101M (Cloretazine), a novel DNA alkylating agent, was evaluated in a phase I study in children with recurrent brain tumors...
  80. pmc Phase I trial of tipifarnib in children with newly diagnosed intrinsic diffuse brainstem glioma
    Daphne A Haas-Kogan
    University of California, San Francisco, San Francisco, CA, USA
    Neuro Oncol 10:341-7. 2008
    ..The MTD of tipifarnib with concurrent radiation is 125 mg/m(2)/dose b.i.d. One-year survival and progression-free survival estimates are 36.4% (SE 16.7%) and 9.4% (SE 6.3%), respectively...
  81. pmc Subsequent malignancies in children treated for Hodgkin's disease: associations with gender and radiation dose
    Louis S Constine
    Department of Radiation Oncology, University of Rochester, Rochester, NY 14642, USA
    Int J Radiat Oncol Biol Phys 72:24-33. 2008
    ..We evaluated select demographic and therapeutic factors associated with SMNs, specifically gender and radiation dose...
  82. ncbi request reprint A phase II window trial of procarbazine and topotecan in children with high-grade glioma: a report from the children's oncology group
    Murali M Chintagumpala
    Baylor College of Medicine, 6621 Fannin, CC 1510 00, Houston, TX, USA
    J Neurooncol 77:193-8. 2006
    ..Future trials should consider strategies to overcome the resistance mechanisms in children with high-grade glioma...
  83. ncbi request reprint Lymphoid gene expression as a predictor of risk of secondary brain tumors
    Mathew J Edick
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, University of Tennessee, Memphis, Tennessee, USA
    Genes Chromosomes Cancer 42:107-16. 2005
    ..These data suggest that gene expression profiling from accessible tissues may identify targets involved in therapy-related malignancies in unrelated tissues...

Research Grants1

  1. STJUDE PARTICIPATION IN PEDIATRIC BRAIN TUMOR CONSORTIUM
    Larry Kun; Fiscal Year: 2003
    ..The institutional contributions to the PBTCTC combine laboratory and clinical science with a sizable patient base that will be dedicated to consortium trials. ..