Hans Hacker

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. ncbi request reprint Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
    Hans Hacker
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nature 439:204-7. 2006
  2. doi request reprint Expanding TRAF function: TRAF3 as a tri-faced immune regulator
    Hans Hacker
    Department of Infectious Diseases, St Jude Childrens Research Hospital, Memphis, Tennessee 38105, USA
    Nat Rev Immunol 11:457-68. 2011
  3. ncbi request reprint Regulation and function of IKK and IKK-related kinases
    Hans Hacker
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Sci STKE 2006:re13. 2006
  4. ncbi request reprint Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8
    Gang G Wang
    Department of Pathology and Molecular Pathology Graduate Program, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Nat Methods 3:287-93. 2006
  5. pmc Hematopoietic progenitor cell lines with myeloid and lymphoid potential
    Vanessa Redecke
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Methods 10:795-803. 2013
  6. ncbi request reprint Cutting edge: activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma
    Vanessa Redecke
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Immunol 172:2739-43. 2004
  7. pmc NIK prevents the development of hypereosinophilic syndrome-like disease in mice independent of IKKα activation
    Hans Hacker
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 188:4602-10. 2012
  8. pmc Type I interferon protects against pneumococcal invasive disease by inhibiting bacterial transmigration across the lung
    Kim S LeMessurier
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS Pathog 9:e1003727. 2013
  9. pmc A20-binding inhibitor of NF-κB (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein β activation and protects from inflammatory disease
    Jingran Zhou
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 108:E998-1006. 2011
  10. pmc The E3 ubiquitin ligase mind bomb-2 (MIB2) protein controls B-cell CLL/lymphoma 10 (BCL10)-dependent NF-κB activation
    Cinthia C Stempin
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 286:37147-57. 2011

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
    Hans Hacker
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nature 439:204-7. 2006
    ....
  2. doi request reprint Expanding TRAF function: TRAF3 as a tri-faced immune regulator
    Hans Hacker
    Department of Infectious Diseases, St Jude Childrens Research Hospital, Memphis, Tennessee 38105, USA
    Nat Rev Immunol 11:457-68. 2011
    ..In this Review, we discuss our current understanding of the role of TRAF3 in TNFR and TLR signalling pathways, and its role in disease...
  3. ncbi request reprint Regulation and function of IKK and IKK-related kinases
    Hans Hacker
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Sci STKE 2006:re13. 2006
    ..Together, the IKKs and IKK-related kinases are instrumental for activation of the host defense system. This Review focuses on the functions of IKK and IKK-related kinases and the molecular mechanisms that regulate their activities...
  4. ncbi request reprint Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8
    Gang G Wang
    Department of Pathology and Molecular Pathology Graduate Program, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Nat Methods 3:287-93. 2006
    ..Using knockout or small interfering RNA (siRNA) technologies, this ER-Hoxb8 phagocyte maturation system represents a rapid analytical tool for studying macrophage and neutrophil biology...
  5. pmc Hematopoietic progenitor cell lines with myeloid and lymphoid potential
    Vanessa Redecke
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Methods 10:795-803. 2013
    ..The simplicity of this system and the unlimited proliferative capacity of Hoxb8-FL cells will enable studies of immune-cell differentiation and function. ..
  6. ncbi request reprint Cutting edge: activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma
    Vanessa Redecke
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Immunol 172:2739-43. 2004
    ....
  7. pmc NIK prevents the development of hypereosinophilic syndrome-like disease in mice independent of IKKα activation
    Hans Hacker
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 188:4602-10. 2012
    ....
  8. pmc Type I interferon protects against pneumococcal invasive disease by inhibiting bacterial transmigration across the lung
    Kim S LeMessurier
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS Pathog 9:e1003727. 2013
    ..e. PAF receptor-mediated transcytosis and tight junction-dependent pericellular migration, ultimately limiting progression from a site-restricted lung infection to invasive, lethal disease. ..
  9. pmc A20-binding inhibitor of NF-κB (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein β activation and protects from inflammatory disease
    Jingran Zhou
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 108:E998-1006. 2011
    ..Together, our data reveal ABIN1 as an essential anti-inflammatory component of TLR-signaling pathways that controls C/EBPβ activity...
  10. pmc The E3 ubiquitin ligase mind bomb-2 (MIB2) protein controls B-cell CLL/lymphoma 10 (BCL10)-dependent NF-κB activation
    Cinthia C Stempin
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 286:37147-57. 2011
    ..Knockdown of MIB2 inhibited BCL10-dependent NF-κB activation. Together, our results identify MIB2 as a novel component of the activated BCL10 signaling complex and a missing link in the BCL10-dependent NF-κB signaling pathway...
  11. pmc SHARPIN controls the development of regulatory T cells
    Vanessa Redecke
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN, USA
    Immunology 148:216-26. 2016
    ..Taken together, these findings show that SHARPIN controls TCR signalling and is required for efficient generation of Treg cells in vivo, whereas the inhibitory function of mature Treg cells appears to be independent of SHARPIN. ..
  12. pmc Keratinocytes contribute intrinsically to psoriasis upon loss of Tnip1 function
    Sirish K Ippagunta
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105
    Proc Natl Acad Sci U S A 113:E6162-E6171. 2016
    ..Together, the data establish Tnip1 as a critical regulator of IL-17 biology and reveal a causal role of keratinocytes in the pathogenesis of psoriasis...
  13. pmc Quantitative proteomic analysis of the influenza A virus nonstructural proteins NS1 and NS2 during natural cell infection identifies PACT as an NS1 target protein and antiviral host factor
    Kazuki Tawaratsumida
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    J Virol 88:9038-48. 2014
    ..Together, our data describe a novel approach to identify virus-host protein interactions and demonstrate that NS1 interferes with PACT, whose function is critical for robust IFN-I production...
  14. pmc Inhibition of T cells provides protection against early invasive pneumococcal disease
    Kim LeMessurier
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Infect Immun 78:5287-94. 2010
    ..Our results reveal an important and adverse role of CD4(+) T cells in the pathogenesis of IPD and suggest that modulation of T-cell activation during early phases of S. pneumoniae invasive infection may provide a therapeutic option...
  15. pmc Analysis of nondegradative protein ubiquitylation with a monoclonal antibody specific for lysine-63-linked polyubiquitin
    Haopeng Wang
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Proc Natl Acad Sci U S A 105:20197-202. 2008
    ..This unique mAb will facilitate the analysis of K63-linked polyubiquitylation ex vivo and presents a strategy for the generation of similar reagents against other forms of polyUb...
  16. ncbi request reprint Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway
    Karim C El Kasmi
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 179:7215-9. 2007
    ..Collectively our data suggest that ETV3 and SBNO2 are components of the pathways that contribute to the downstream anti-inflammatory effects of IL-10...
  17. ncbi request reprint Is NF-kappaB2/p100 a direct activator of programmed cell death?
    Hans Hacker
    Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cancer Cell 2:431-3. 2002
    ..Further, it is suggested that loss of the proapoptotic function of NF-kappaB2/p100 is directly linked to its oncogenic activity in lymphomas...