Richard J Gilbertson

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. ncbi request reprint Wnt/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular sub-group of medulloblastomas associated with a favorable prognosis
    Steven C Clifford
    Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Cell Cycle 5:2666-70. 2006
  2. ncbi request reprint Regression of experimental medulloblastoma following transfer of HER2-specific T cells
    Nabil Ahmed
    Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children s Hospital, The Methodist Hospital, Houston, Texas 77030, USA
    Cancer Res 67:5957-64. 2007
  3. ncbi request reprint Tumorigenesis in the brain: location, location, location
    Richard J Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 67:5579-82. 2007
  4. pmc Medulloblastoma Genotype Dictates Blood Brain Barrier Phenotype
    Timothy N Phoenix
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Cancer Cell 29:508-22. 2016
  5. pmc Novel mutations target distinct subgroups of medulloblastoma
    Giles Robinson
    St Jude Children s Research Hospital, Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA
    Nature 488:43-8. 2012
  6. pmc A mouse model of the most aggressive subgroup of human medulloblastoma
    Daisuke Kawauchi
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Cancer Cell 21:168-80. 2012
  7. pmc Phase I study of vismodegib in children with recurrent or refractory medulloblastoma: a pediatric brain tumor consortium study
    Amar Gajjar
    Authors Affiliations Departments of Oncology, Pharmaceutical Sciences, Pathology, Radiological Sciences, Biostatistics, and Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee Center for Neuroscience Research, Children s National Medical Center, Washington, DC Division of Hematology Oncology, Ann and Robert H Lurie Children s Hospital of Chicago, Chicago, Illinois Department of Pediatrics, Texas Children s Hospital, Houston, Texas Investigational Drug Branch, Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland and Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania
    Clin Cancer Res 19:6305-12. 2013
  8. pmc C11orf95-RELA fusions drive oncogenic NF-κB signalling in ependymoma
    Matthew Parker
    1 St Jude Children s Research Hospital Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA 2 Department of Computational Biology and Bioinformatics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA 3
    Nature 506:451-5. 2014
  9. pmc Phase I trial of lapatinib in children with refractory CNS malignancies: a Pediatric Brain Tumor Consortium study
    Maryam Fouladi
    St Jude Children s Research Hospital, Memphis, TN, USA
    J Clin Oncol 28:4221-7. 2010
  10. pmc Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation
    Liqin Zhu
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
    Nature 457:603-7. 2009

Detail Information

Publications72

  1. ncbi request reprint Wnt/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular sub-group of medulloblastomas associated with a favorable prognosis
    Steven C Clifford
    Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Cell Cycle 5:2666-70. 2006
    ....
  2. ncbi request reprint Regression of experimental medulloblastoma following transfer of HER2-specific T cells
    Nabil Ahmed
    Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children s Hospital, The Methodist Hospital, Houston, Texas 77030, USA
    Cancer Res 67:5957-64. 2007
    ..In contrast, delivery of nontransduced T cells did not change the tumor growth pattern. Adoptive transfer of HER2-specific T cells may represent a promising immunotherapeutic approach for medulloblastoma...
  3. ncbi request reprint Tumorigenesis in the brain: location, location, location
    Richard J Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 67:5579-82. 2007
    ..These new findings imply an interaction between the cell of origin, the tumor microenvironment, and specific cancer-causing genetic changes in the evolution of central nervous system tumors...
  4. pmc Medulloblastoma Genotype Dictates Blood Brain Barrier Phenotype
    Timothy N Phoenix
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Cancer Cell 29:508-22. 2016
    ..Thus, medulloblastoma genotype dictates tumor vessel phenotype, explaining in part the disparate prognoses among medulloblastoma subtypes and suggesting an approach to enhance the chemoresponsiveness of other brain tumors...
  5. pmc Novel mutations target distinct subgroups of medulloblastoma
    Giles Robinson
    St Jude Children s Research Hospital, Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA
    Nature 488:43-8. 2012
    ..These data provide important new insights into the pathogenesis of medulloblastoma subgroups and highlight targets for therapeutic development...
  6. pmc A mouse model of the most aggressive subgroup of human medulloblastoma
    Daisuke Kawauchi
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Cancer Cell 21:168-80. 2012
    ..This mouse model should significantly accelerate understanding and treatment of the most aggressive form of medulloblastoma and infers distinct roles for MYC and MYCN in tumorigenesis...
  7. pmc Phase I study of vismodegib in children with recurrent or refractory medulloblastoma: a pediatric brain tumor consortium study
    Amar Gajjar
    Authors Affiliations Departments of Oncology, Pharmaceutical Sciences, Pathology, Radiological Sciences, Biostatistics, and Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee Center for Neuroscience Research, Children s National Medical Center, Washington, DC Division of Hematology Oncology, Ann and Robert H Lurie Children s Hospital of Chicago, Chicago, Illinois Department of Pediatrics, Texas Children s Hospital, Houston, Texas Investigational Drug Branch, Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland and Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania
    Clin Cancer Res 19:6305-12. 2013
    ..To investigate the safety, dose-limiting toxicities, and pharmacokinetics of the smoothened inhibitor vismodegib in children with refractory or relapsed medulloblastoma...
  8. pmc C11orf95-RELA fusions drive oncogenic NF-κB signalling in ependymoma
    Matthew Parker
    1 St Jude Children s Research Hospital Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA 2 Department of Computational Biology and Bioinformatics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA 3
    Nature 506:451-5. 2014
    ..Our data identify a highly recurrent genetic alteration of RELA in human cancer, and the C11orf95-RELA fusion protein as a potential therapeutic target in supratentorial ependymoma...
  9. pmc Phase I trial of lapatinib in children with refractory CNS malignancies: a Pediatric Brain Tumor Consortium study
    Maryam Fouladi
    St Jude Children s Research Hospital, Memphis, TN, USA
    J Clin Oncol 28:4221-7. 2010
    ....
  10. pmc Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation
    Liqin Zhu
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
    Nature 457:603-7. 2009
    ..Our data indicate that Prom1 marks stem cells in the adult small intestine that are susceptible to transformation into tumours retaining a fraction of mutant Prom1(+) tumour cells...
  11. pmc Simvastatin Hydroxy Acid Fails to Attain Sufficient Central Nervous System Tumor Exposure to Achieve a Cytotoxic Effect: Results of a Preclinical Cerebral Microdialysis Study
    Yogesh T Patel
    Departments of Pharmaceutical Sciences Y T P, M O J, A D D, D C T C F S, Hematology N B, and Developmental Neurobiology R J G, Preclinical Pharmacokinetic Shared Resource P K V, B B F, St Jude Children s Research Hospital, Memphis, Tennessee Merck, Rahway, New Jersey D C T and Cambridge Cancer Centre, Cambridge, United Kingdom R J G
    Drug Metab Dispos 44:591-4. 2016
    ..084 ± 0.008. Compared with in vitro washout IC50 values, we did not achieve sufficient exposure of SVA in tECF to suggest tumor growth inhibition; therefore, SV was not carried forward in subsequent preclinical efficacy studies. ..
  12. pmc Cross-species genomics matches driver mutations and cell compartments to model ependymoma
    Robert A Johnson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
    Nature 466:632-6. 2010
    ..Our data demonstrate the power of cross-species genomics to meticulously match subgroup-specific driver mutations with cellular compartments to model and interrogate cancer subgroups...
  13. pmc Phase I study of temsirolimus in pediatric patients with recurrent/refractory solid tumors
    Sheri L Spunt
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    J Clin Oncol 29:2933-40. 2011
    ....
  14. pmc A procedure to statistically evaluate agreement of differential expression for cross-species genomics
    Stan Pounds
    Department of Biostatistics, St Jude Children s Research Hospital, Memphis, TN, USA
    Bioinformatics 27:2098-103. 2011
    ..In principle, microarrays collect the necessary data to evaluate the transcriptomic fidelity of an animal model in terms of the similarity of expression with the human disease. However, statistical methods for this purpose are lacking...
  15. pmc Preclinical studies of 5-fluoro-2'-deoxycytidine and tetrahydrouridine in pediatric brain tumors
    Marie Morfouace
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA
    J Neurooncol 126:225-34. 2016
    ..Our comprehensive and integrated preclinical drug development pipeline should reduce the attrition of drugs in clinical trials...
  16. pmc Cross-Species Genomics Identifies TAF12, NFYC, and RAD54L as Choroid Plexus Carcinoma Oncogenes
    Yiai Tong
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Cancer Cell 27:712-27. 2015
    ..Our data identify a group of concurrently gained oncogenes that cooperate in the formation of CPC and reveal potential avenues for therapy. ..
  17. pmc A molecular biology and phase II trial of lapatinib in children with refractory CNS malignancies: a pediatric brain tumor consortium study
    Maryam Fouladi
    St Jude Children s Research Hospital, Memphis, TN, USA
    J Neurooncol 114:173-9. 2013
    ..Lapatinib was well-tolerated in children with recurrent or CNS malignancies, but did not inhibit target in tumor and had little single agent activity...
  18. pmc Pediatric phase I trial and pharmacokinetic study of vorinostat: a Children's Oncology Group phase I consortium report
    Maryam Fouladi
    St Jude Children s Research Hospital, Memphis, TN, USA
    J Clin Oncol 28:3623-9. 2010
    ....
  19. pmc An in vivo screen identifies ependymoma oncogenes and tumor-suppressor genes
    Kumarasamypet M Mohankumar
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Genet 47:878-87. 2015
    ....
  20. pmc Phase I study of 5-fluorouracil in children and young adults with recurrent ependymoma
    Karen D Wright
    Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee K D W, R J G, A G Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee V M D, D C T, C F S Department of Biostatistics, St Jude Children s Research Hospital, Memphis, Tennessee A O T Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee N B, R J G Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee B A O
    Neuro Oncol 17:1620-7. 2015
    ..We report a phase I study to examine the pharmacokinetics, safety, and recommended dosage of weekly intravenous bolus 5-fluorouracil (5-FU) in children and young adults with recurrent ependymoma...
  21. pmc Subtypes of medulloblastoma have distinct developmental origins
    Paul Gibson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
    Nature 468:1095-9. 2010
    ..Our data provide an explanation for the marked molecular and clinical differences between SHH- and WNT-subtype medulloblastomas and have profound implications for future research and treatment of this important childhood cancer...
  22. ncbi request reprint ERBB2 up-regulates S100A4 and several other prometastatic genes in medulloblastoma
    Roberto Hernan
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 63:140-8. 2003
    ..These data identify an ERBB2 driven prometastatic pathway that may provide a novel target for therapeutic intervention in metastatic medulloblastoma...
  23. ncbi request reprint Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma
    Amar Gajjar
    St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    J Clin Oncol 22:984-93. 2004
    ..To assess the feasibility of performing central molecular analyses of fresh medulloblastomas obtained from multiple institutions and using these data to identify prognostic markers for contemporaneously treated patients...
  24. pmc Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation
    Yasmine A Valentin-Vega
    Department of Cell and Molecular Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Sci Rep 6:25996. 2016
    ....
  25. pmc The miR-17~92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma
    Tamar Uziel
    Department of Genetics and Tumor Cell Biology, Saint Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 106:2812-7. 2009
    ..Our findings suggest a functional collaboration between the miR-17 approximately 92 cluster and the SHH signaling pathway in the development of MBs in mouse and man...
  26. pmc Phase I study of vandetanib during and after radiotherapy in children with diffuse intrinsic pontine glioma
    Alberto Broniscer
    St Jude Children s Research Hospital, Memphis, TN, USA
    J Clin Oncol 28:4762-8. 2010
    ....
  27. ncbi request reprint Molecular profiling of pediatric brain tumors: insight into biology and treatment
    Robert Johnson
    Departments of Developmental Neurobiology and Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Curr Oncol Rep 11:68-72. 2009
    ....
  28. pmc An integrated in vitro and in vivo high-throughput screen identifies treatment leads for ependymoma
    Jennifer M Atkinson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer Cell 20:384-99. 2011
    ..g., 5-fluorouracil. Our comprehensive approach advances understanding of the biology and treatment of ependymoma including the discovery of several treatment leads for immediate clinical translation...
  29. ncbi request reprint A molecular fingerprint for medulloblastoma
    Youngsoo Lee
    Department of Genetics and Tumor Cell Biology, Saint Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 63:5428-37. 2003
    ..Coordinated deregulation of these same genes also occurred in a large subset of human medulloblastomas. These data identify a group of genes that is central to medulloblastoma tumorigenesis...
  30. pmc The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes
    Robert Huether
    1 Department of Computational Biology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA 2
    Nat Commun 5:3630. 2014
    ..Collectively, our results help to define the landscape of mutations in epigenetic regulatory genes in paediatric cancer and yield a valuable new database for investigating the role of epigenetic dysregulations in cancer. ..
  31. ncbi request reprint Genetic alterations in mouse medulloblastomas and generation of tumors de novo from primary cerebellar granule neuron precursors
    Frederique Zindy
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 67:2676-84. 2007
    ..These results underscore the functional interplay between a network of specific genes that recurrently contribute to medulloblastoma formation...
  32. ncbi request reprint Clinical and molecular characteristics of malignant transformation of low-grade glioma in children
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 25:682-9. 2007
    ..To analyze the clinical and molecular characteristics of malignant transformation (MT) of low-grade glioma (LGG) in children...
  33. pmc Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas
    Jinghui Zhang
    Department of Computational Biology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Genet 45:602-12. 2013
    ..Focusing on the therapeutically challenging diffuse LGGs, our study of 151 tumors has discovered genetic alterations and potential therapeutic targets across the entire range of pediatric LGGs and LGGNTs...
  34. pmc Pten deletion causes mTorc1-dependent ectopic neuroblast differentiation without causing uniform migration defects
    Guo Zhu
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Development 139:3422-31. 2012
    ..Therefore, migration defects of Pten-null neurons might be secondary to ectopic differentiation...
  35. pmc Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups
    David W Ellison
    Department of Pathology MS 250, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Acta Neuropathol 121:381-96. 2011
    ....
  36. ncbi request reprint Medulloblastoma: signalling a change in treatment
    Richard J Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet Oncol 5:209-18. 2004
    ..Several pathways have been implicated in medulloblastoma formation, and knowledge of these is now being used to develop new ways of treating children with medulloblastoma...
  37. ncbi request reprint ERBB receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this disease
    Richard J Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA Richard
    Clin Cancer Res 8:3054-64. 2002
    ..This study was designed to investigate the biological and therapeutic significance of ERBB1, ERBB2, ERBB3, and ERBB4 in childhood ependymoma...
  38. ncbi request reprint ERBB1 is amplified and overexpressed in high-grade diffusely infiltrative pediatric brain stem glioma
    Richard J Gilbertson
    Brain Tumor Program, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Clin Cancer Res 9:3620-4. 2003
    ....
  39. ncbi request reprint ERBB2 in pediatric cancer: innocent until proven guilty
    Richard J Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, Tennessee 38105, USA
    Oncologist 10:508-17. 2005
    ..This review addresses the issues surrounding the identification of molecular targets in pediatric cancers by focusing on studies of the ERBB2 oncogene...
  40. doi request reprint Driving glioblastoma to drink
    Richard J Gilbertson
    Departments of Developmental Neurobiology and Oncology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA Electronic address
    Cell 157:289-90. 2014
    ..By screening for compounds that alter the phenotype of glioblastoma cells-an aggressive brain tumor-Kitambi et al. identify a potential new treatment of the disease and shed light on an unusual cell death mechanism...
  41. pmc Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032
    Giles W Robinson
    Giles W Robinson, Brent A Orr, Gang Wu, Tong Lin, Ibrahim Qaddoumi, Sue C Kaste, Michael Rusch, Sariah J Allen, Arzu Onar Thomas, Clinton F Stewart, James M Boyett, Richard J Gilbertson, David W Ellison, and Amar Gajjar, St Jude Children s Research Hospital, Memphis, TN Sridharan Gururangan and Annick Desjardins, Duke University Medical Center, Durham, NC Roger J Packer, Children s National Medical Center, Washington, DC Stewart Goldman, Ann and Robert H Lurie Children s Hospital of Chicago, Chicago, IL Michael D Prados, University of California San Francisco, San Francisco, CA Murali Chintagumpala, Texas Children s Cancer Center, Houston, TX Naoko Takebe, National Cancer Institute, Bethesda, MD Maryam Fouladi, Cincinnati Children s Hospital, Cincinnati, Department of Family Medicine
    J Clin Oncol 33:2646-54. 2015
    ..Two phase II studies assessed the efficacy of vismodegib, a sonic hedgehog (SHH) pathway inhibitor that binds smoothened (SMO), in pediatric and adult recurrent medulloblastoma (MB)...
  42. pmc Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer
    Si Ming Man
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell 162:45-58. 2015
    ..Therapeutic modulation of AIM2 expression and microbiota has the potential to prevent colorectal cancer. ..
  43. ncbi request reprint Phase I study of everolimus in pediatric patients with refractory solid tumors
    Maryam Fouladi
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Clin Oncol 25:4806-12. 2007
    ....
  44. pmc Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
    Gang Wu
    Department of Computational Biology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Genet 44:251-3. 2012
    ..3, or in the related HIST1H3B, encoding histone H3.1, that caused a p.Lys27Met amino acid substitution in each protein. An additional 14% of non-BS-PGs had somatic mutations in H3F3A causing a p.Gly34Arg alteration...
  45. ncbi request reprint The origins of medulloblastoma subtypes
    Richard J Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Annu Rev Pathol 3:341-65. 2008
    ..Definitive characterization of each medulloblastoma subtype will undoubtedly improve treatment of this disease and provide important insights to the origins of cancer...
  46. pmc Preclinical examination of clofarabine in pediatric ependymoma: intratumoral concentrations insufficient to warrant further study
    Yogesh T Patel
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA
    Cancer Chemother Pharmacol 75:897-906. 2015
    ..Therefore, clofarabine was de-prioritized as an agent to treat ependymoma, and further preclinical studies were not pursued. ..
  47. ncbi request reprint Continuous delivery of IFN-beta promotes sustained maturation of intratumoral vasculature
    Paxton V Dickson
    Department of Surgery, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Mol Cancer Res 5:531-42. 2007
    ..These results have significant implications for the planning of combination anticancer therapy...
  48. ncbi request reprint A perivascular niche for brain tumor stem cells
    Christopher Calabrese
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Cancer Cell 11:69-82. 2007
    ..We propose that brain CSCs are maintained within vascular niches that are important targets for therapeutic approaches...
  49. ncbi request reprint Brain tumors provide new clues to the source of cancer stem cells: does oncology recapitulate ontogeny?
    Richard J Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennesee 38105, USA
    Cell Cycle 5:135-7. 2006
    ..These data suggest strongly that ependymomas arise directly from transformed radial glia and they provide a novel method that could be used to map the cell of origin of other types of cancer...
  50. ncbi request reprint High-grade glioma: can we teach an old dogma new tricks?
    Richard J Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA
    Cancer Cell 9:147-8. 2006
    ..report an extensive study of the gene expression profiles of a large cohort of HGG. Their data provide new clues to the origins of this disease and suggest potential targets for novel therapies...
  51. ncbi request reprint Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial
    Amar Gajjar
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet Oncol 7:813-20. 2006
    ..We aimed to investigate the effectiveness of risk-adapted radiotherapy followed by a shortened period of dose-intense chemotherapy in children with medulloblastoma...
  52. pmc Mapping cancer origins
    Richard J Gilbertson
    Department of Developmental Neurobiology and Oncology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Cell 145:25-9. 2011
    ..5 million people each year. Poor understanding of cancer's diversity currently thwarts our goal of a cure for every patient, but recent integration of genomic and stem cell technologies promises a route through this impasse...
  53. ncbi request reprint Making a tumour's bed: glioblastoma stem cells and the vascular niche
    Richard J Gilbertson
    Department of Developmental Neurobiology and Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA
    Nat Rev Cancer 7:733-6. 2007
    ..These data have direct implications for cancer, highlighting the similarity between normal and malignant stem cells and identifying the tumour microenvironment as a target for new therapies...
  54. ncbi request reprint Molecular biology of medulloblastoma: will it ever make a difference to clinical management?
    Richard J Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale St, Memphis, TN 38105, USA
    J Neurooncol 75:273-8. 2005
    ..We review some of the reasons we have failed to translate knowledge of medulloblastoma disease biology to the clinic and look forward to the next generation of clinical and molecular studies that are seeking to correct this...
  55. ncbi request reprint Atypical teratoid/rhabdoid tumors (ATRT): improved survival in children 3 years of age and older with radiation therapy and high-dose alkylator-based chemotherapy
    Tanya M Tekautz
    Department of Hematology Oncology, Mail Stop 260, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    J Clin Oncol 23:1491-9. 2005
    ..To describe clinical features, therapeutic approaches, and prognostic factors in pediatric patients with atypical teratoid/rhabdoid tumors (ATRT) treated at St Jude Children's Research Hospital (SJCRH)...
  56. pmc Molecular insights into pediatric brain tumors have the potential to transform therapy
    Amar Gajjar
    Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee
    Clin Cancer Res 20:5630-40. 2014
    ..These novel insights will add impetus to translating these laboratory-based discoveries to newer therapies for children diagnosed with these tumors...
  57. ncbi request reprint To infinium, and beyond!
    Karen D Wright
    Department of Developmental Neurobiology and Oncology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Cancer Cell 17:419-20. 2010
    ..In this issue of Cancer Cell, Noushmehr et al., through The Cancer Genome Atlas (TCGA) project, provide one of the first integrated views of the GBM methylome, adding to our increasingly comprehensive understanding of this disease...
  58. ncbi request reprint Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations
    Margaret C Thompson
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 24:1924-31. 2006
    ..We hypothesized that gene expression profiling might be a more rapid and cost-effective method of identifying tumors that contain specific genetic abnormalities...
  59. ncbi request reprint Radial glia cells are candidate stem cells of ependymoma
    Michael D Taylor
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA
    Cancer Cell 8:323-35. 2005
    ....
  60. pmc The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation
    Tamar Uziel
    Department of Tumor Cell Biology and Genetics, Memphis, Tennessee 38105, USA
    Genes Dev 19:2656-67. 2005
    ..Methylation of INK4C (CDKN2C) was observed in four of 23 human MBs, and p18(INK4C) protein expression was extinguished in 14 of 73 cases. Hence, p18(INK4C) loss may contribute to MB formation in children...
  61. ncbi request reprint Mutational analysis of PDGFR-RAS/MAPK pathway activation in childhood medulloblastoma
    Richard J Gilbertson
    Northern Institute for Cancer Research, University of Newcastle, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK, and Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Eur J Cancer 42:646-9. 2006
    ....
  62. pmc Identification of interleukin-13 receptor alpha2 chain overexpression in situ in high-grade diffusely infiltrative pediatric brainstem glioma
    Bharat H Joshi
    Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Office of Cellular, Tissue, and Gene Therapies, Center for Biologics Evaluation and Research, U S Food and Drug Administration, Bethesda, MD, USA
    Neuro Oncol 10:265-74. 2008
    ..Both IHC and ISH represent robust methods to detect expression of the IL-13Ralpha2 receptor in BSG that could represent an important new drug target for treatment of this disease...
  63. ncbi request reprint What's new in neuro-oncology? Recent advances in medulloblastoma
    David W Ellison
    The Northern Institute for Cancer Research, University of Newcastle upon Tyne, The Medical School, Newcastle upon Tyne, UK
    Eur J Paediatr Neurol 7:53-66. 2003
  64. pmc Multifactorial analysis of predictors of outcome in pediatric intracranial ependymoma
    Lee Ridley
    Children s Brain Tumor Research Centre, University of Nottingham, Nottingham, UK
    Neuro Oncol 10:675-89. 2008
    ..Furthermore, telomerase reactivation and maintenance of telomeric repeats appear necessary for childhood ependymoma progression. These findings require corroboration in a clinical trial setting...
  65. ncbi request reprint Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling
    Janet C Lindsey
    Northern Institute for Cancer Research, The Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Carcinogenesis 25:661-8. 2004
    ..Furthermore, methylation observed in the normal cerebellum emphasises the requirement for appropriate control tissues when assessing the tumour-specificity of TSG hypermethylation...
  66. ncbi request reprint The TP53-ARF tumor suppressor pathway is frequently disrupted in large/cell anaplastic medulloblastoma
    Adrian J Frank
    Northern Institute for Cancer Research, University of Newcastle, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Brain Res Mol Brain Res 121:137-40. 2004
    ..Our data provide the first evidence that alterations within the TP53-ARF tumor suppressor pathway contribute to development of aggressive forms of medulloblastoma...
  67. pmc Pediatric phase I and pharmacokinetic study of erlotinib followed by the combination of erlotinib and temozolomide: a Children's Oncology Group Phase I Consortium Study
    Regina I Jakacki
    Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    J Clin Oncol 26:4921-7. 2008
    ..We conducted a phase I and pharmacokinetic study of the epidermal growth factor receptor (EGFR) inhibitor erlotinib as a single agent and in combination with temozolomide in children with refractory solid tumors...
  68. ncbi request reprint Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells
    Ichiro Nakano
    Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Neurosci Res 86:48-60. 2008
    ..These results demonstrate a critical role for MELK in the proliferation of brain tumors, including their stem cells, and suggest that MELK may be a compelling molecular target for treatment of high-grade brain tumors...
  69. ncbi request reprint Epigenetic inactivation of MCJ (DNAJD1) in malignant paediatric brain tumours
    Janet C Lindsey
    Northern Institute for Cancer Research, The Medical School, University of Newcastle, Newcastle upon Tyne, United Kingdom
    Int J Cancer 118:346-52. 2006
    ....
  70. ncbi request reprint A phase I study of 17-allylaminogeldanamycin in relapsed/refractory pediatric patients with solid tumors: a Children's Oncology Group study
    Brenda J Weigel
    University of Minnesota Cancer Center and Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Clin Cancer Res 13:1789-93. 2007
    ..To determine the recommended phase 2 dose, dose-limiting toxicities (DLT), pharmacokinetic profile, and pharmacodynamics of the heat shock protein (Hsp) 90 inhibitor, 17-allylaminogeldanamycin (17-AAG)...
  71. pmc Rethinking brain tumors: the fourth Mouse Models of Human Cancers Consortium nervous system tumors workshop
    Karlyne M Reilly
    Mouse Cancer Genetics Program, National Cancer Institute, Frederick, Maryland 21702, USA
    Cancer Res 68:5508-11. 2008
  72. ncbi request reprint PDGFRB is overexpressed in metastatic medulloblastoma
    Richard J Gilbertson
    Nat Genet 35:197-8. 2003