St. Jude Children's Research Hospital

Summary

Organization: St. Jude Children's Research Hospital
Country: USA

Top Publications

  1. ncbi Independent regulation of P53 stabilisation and activation after Rb deletion in primary epithelial cells
    Louise Treanor
    Division of Pathology, Queen s Medical Research Institute, 49 Little France Crescent, Edinburgh, EH16 4TJ Scotland, UK
    Int J Oncol 37:31-9. 2010
  2. ncbi Life and death during hematopoietic differentiation
    Joseph T Opferman
    Department of Biochemistry, St Jude Children s Research Hospital, 332 N Lauderdale Street D 4063C, Memphis, TN 38105, USA
    Curr Opin Immunol 19:497-502. 2007
  3. ncbi Central nervous system complications of sickle cell disease in children: an overview
    Winfred C Wang
    Department of Hematology Oncology, St Jude Children s Research Hospital Memphis, TN38105, USA
    Child Neuropsychol 13:103-19. 2007
  4. ncbi The cause and clinical significance of central tumor photopenia on thallium scintigraphy of pediatric osteosarcoma of the extremity
    M Beth McCarville
    Department of Radiological Sciences, Division of Diagnostic Imaging, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2974, USA
    AJR Am J Roentgenol 188:572-8. 2007
  5. ncbi PTEN enters the nuclear age
    Suzanne J Baker
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell 128:25-8. 2007
  6. ncbi A knowledge-guided active model method of cortical structure segmentation on pediatric MR images
    Zuyao Y Shan
    Division of Translational Imaging Research, Department of Radiological Sciences, St Jude Children s Research Hospital, and Department of Biomedical Engineering, The University of Memphis, Tennessee 381005, USA
    J Magn Reson Imaging 24:779-89. 2006
  7. ncbi Regression analysis of doubly censored failure time data with frailty
    Yang Jin Kim
    Department of Biostatistics, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, Tennessee 38105, USA
    Biometrics 62:458-64. 2006
  8. ncbi Ewing sarcoma-family tumors that arise after treatment of primary childhood cancer
    Sheri L Spunt
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Cancer 107:201-6. 2006
  9. ncbi Successive clinical trials for childhood acute myeloid leukemia at St Jude Children's Research Hospital, from 1980 to 2000
    R C Ribeiro
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Leukemia 19:2125-9. 2005
  10. ncbi Outcome of hematopoietic stem cell transplantation for pediatric patients with therapy-related acute myeloid leukemia or myelodysplastic syndrome
    Paul Woodard
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Pediatr Blood Cancer 47:931-5. 2006

Research Grants

Detail Information

Publications62

  1. ncbi Independent regulation of P53 stabilisation and activation after Rb deletion in primary epithelial cells
    Louise Treanor
    Division of Pathology, Queen s Medical Research Institute, 49 Little France Crescent, Edinburgh, EH16 4TJ Scotland, UK
    Int J Oncol 37:31-9. 2010
    ..A possible connection between the two pathways is discussed...
  2. ncbi Life and death during hematopoietic differentiation
    Joseph T Opferman
    Department of Biochemistry, St Jude Children s Research Hospital, 332 N Lauderdale Street D 4063C, Memphis, TN 38105, USA
    Curr Opin Immunol 19:497-502. 2007
    ..This review will address the apoptotic pathways that regulate these critical control points during hematopoiesis...
  3. ncbi Central nervous system complications of sickle cell disease in children: an overview
    Winfred C Wang
    Department of Hematology Oncology, St Jude Children s Research Hospital Memphis, TN38105, USA
    Child Neuropsychol 13:103-19. 2007
    ..However, definitive prophylaxis and treatment for most CNS complications of sickle cell disease have yet to be determined...
  4. ncbi The cause and clinical significance of central tumor photopenia on thallium scintigraphy of pediatric osteosarcoma of the extremity
    M Beth McCarville
    Department of Radiological Sciences, Division of Diagnostic Imaging, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2974, USA
    AJR Am J Roentgenol 188:572-8. 2007
    ....
  5. ncbi PTEN enters the nuclear age
    Suzanne J Baker
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell 128:25-8. 2007
    ..2007) and Trotman et al. (2007) describe how ubiquitination regulates PTEN stability and its nuclear localization. Additionally, Shen et al. (2007) report that a nuclear pool of PTEN helps to maintain chromosomal stability...
  6. ncbi A knowledge-guided active model method of cortical structure segmentation on pediatric MR images
    Zuyao Y Shan
    Division of Translational Imaging Research, Department of Radiological Sciences, St Jude Children s Research Hospital, and Department of Biomedical Engineering, The University of Memphis, Tennessee 381005, USA
    J Magn Reson Imaging 24:779-89. 2006
    ..To develop an automated method for quantification of cortical structures on pediatric MR images...
  7. ncbi Regression analysis of doubly censored failure time data with frailty
    Yang Jin Kim
    Department of Biostatistics, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, Tennessee 38105, USA
    Biometrics 62:458-64. 2006
    ..Simulation studies are performed to investigate finite sample properties of the proposed method and an illustrative example from an acquired immune deficiency syndrome (AIDS) cohort study is provided...
  8. ncbi Ewing sarcoma-family tumors that arise after treatment of primary childhood cancer
    Sheri L Spunt
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Cancer 107:201-6. 2006
    ..ESFT arising as a second cancer was reviewed and characterized at our childhood cancer center...
  9. ncbi Successive clinical trials for childhood acute myeloid leukemia at St Jude Children's Research Hospital, from 1980 to 2000
    R C Ribeiro
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Leukemia 19:2125-9. 2005
    ..We conclude that subtype-specific therapies are needed to replace the 'one size fits all' strategy of the past two decades...
  10. ncbi Outcome of hematopoietic stem cell transplantation for pediatric patients with therapy-related acute myeloid leukemia or myelodysplastic syndrome
    Paul Woodard
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Pediatr Blood Cancer 47:931-5. 2006
    ..Therapy-related myelodysplastic syndrome (t-MDS) and acute myeloid leukemia (t-AML) carry a poor prognosis. We analyzed the results of allogeneic HSCT in 38 children to determine which factors, if any, affected outcome...
  11. ncbi Magnetic resonance imaging of abdominal masses in the pediatric patient
    Fredric A Hoffer
    Department of Radiological Sciences, Division of Diagnostic Imaging, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38112, USA
    Semin Ultrasound CT MR 26:212-23. 2005
    ....
  12. ncbi Overt testicular disease at diagnosis of childhood acute lymphoblastic leukemia: lack of therapeutic role of local irradiation
    N Hijiya
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Leukemia 19:1399-403. 2005
    ..In conclusion, the prognostic impact of overt testicular disease has diminished. Irradiation appears to provide no survival advantage to this patient population...
  13. ncbi E3 ubiquitin ligases as regulators of membrane protein trafficking and degradation
    ALESSANDRA D'AZZO
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN, USA
    Traffic 6:429-41. 2005
    ..We emphasize the intricate network of interacting proteins that contribute to the substrate-E3 recognition and determine the substrate's cellular fate...
  14. ncbi Comparison of killer Ig-like receptor genotyping and phenotyping for selection of allogeneic blood stem cell donors
    Wing Leung
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 174:6540-5. 2005
    ..These results caution the use of genotyping alone for donor selection or leukemia-relapse prognostication because some KIRs may be expressed at a very low level...
  15. ncbi Making a tumour's bed: glioblastoma stem cells and the vascular niche
    Richard J Gilbertson
    Department of Developmental Neurobiology and Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA
    Nat Rev Cancer 7:733-6. 2007
    ..These data have direct implications for cancer, highlighting the similarity between normal and malignant stem cells and identifying the tumour microenvironment as a target for new therapies...
  16. pmc A fluid salt-bridging cluster and the stabilization of p53
    Thu Zar Lwin
    Hartwell Center for Bioinformatics and Biotechnology, Saint Jude Children s Research Hospital, 322 N Lauderdale St, Mail Stop 312, Memphis, TN 38105, USA
    J Mol Biol 373:1334-47. 2007
    ....
  17. ncbi Alternatively spliced human tissue factor promotes tumor growth and angiogenesis in a pancreatic cancer tumor model
    Jennifer E Hobbs
    The Division of Hematology Oncology of the Feinberg School of Medicine at Northwestern University, Chicago, IL, USA
    Thromb Res 120:S13-21. 2007
    ..asHTF is soluble due to the substitution of the transmembrane and cytoplasmic domains of exon 6 with a unique COOH-terminal domain...
  18. doi Multimethod adherence assessment in children with perinatally acquired HIV-1: the influence of off-schedule dosing in predicting biological markers
    Patricia A Garvie
    Department of Behavioral Medicine, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Pediatr Infect Dis J 29:372-4. 2010
    ..Off-schedule dosing predicted both health status markers, while the more common strategies did not. Findings support inclusion of off-schedule dosing concurrent with collection of biomarkers to assess adherence in children with HIV...
  19. pmc Effect of allopurinol versus urate oxidase on methotrexate pharmacokinetics in children with newly diagnosed acute lymphoblastic leukemia
    Kristine R Crews
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    Cancer 116:227-32. 2010
    ....
  20. pmc Locoregional tumor progression after radiation therapy influences overall survival in pediatric patients with neuroblastoma
    Atmaram S Pai Panandiker
    Division of Radiation Oncology, Department of Radiological Sciences, St Jude Children s Research Hospital, MS220, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    Int J Radiat Oncol Biol Phys 76:1161-5. 2010
    ..We conducted a retrospective review to identify factors that might predict for locoregional tumor control and its impact on overall survival...
  21. pmc Voxel-based analysis of T2 hyperintensities in white matter during treatment of childhood leukemia
    W E Reddick
    Division of Translational Imaging Research, St Jude Children s Research Hospital, Memphis, TN, USA
    AJNR Am J Neuroradiol 30:1947-54. 2009
    ..This study uses voxel-based analyses (VBA) of T2-weighted imaging of patients during treatment to identify which WM regions are preferentially damaged...
  22. pmc Factors associated with neurological recovery of brainstem function following postoperative conformal radiation therapy for infratentorial ependymoma
    Thomas E Merchant
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105 3678, USA
    Int J Radiat Oncol Biol Phys 76:496-503. 2010
    ..To identify risk factors associated with incomplete neurological recovery in pediatric patients with infratentorial ependymoma treated with postoperative conformal radiation therapy (CRT)...
  23. pmc Late mortality among 5-year survivors of childhood cancer: a summary from the Childhood Cancer Survivor Study
    Gregory T Armstrong
    Department of Epidemiology and Cancer Control, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 27:2328-38. 2009
    ....
  24. pmc Pharmacotherapy in sickle cell disease--state of the art and future prospects
    Jane Hankins
    Department of Hematology, St Jude Children s Research Hospital, Memphis, TN, USA
    Br J Haematol 145:296-308. 2009
    ....
  25. doi Total and active rabbit antithymocyte globulin (rATG;Thymoglobulin) pharmacokinetics in pediatric patients undergoing unrelated donor bone marrow transplantation
    Sandra K Call
    Department of Pharmaceutical Services, St Jude Children s Research Hospital, Memphis, Tennessee 38105 3678, USA
    Biol Blood Marrow Transplant 15:274-8. 2009
    ..These conclusions may not apply to patients with nonmalignant disorders...
  26. pmc Asymptomatic kidney stones in long-term survivors of childhood acute lymphoblastic leukemia
    S C Kaste
    Department of Radiological Sciences, Division of Diagnostic Imaging, University of Tennessee at Memphis, Memphis, TN, USA
    Leukemia 23:104-8. 2009
    ..Thus, kidney stones in childhood ALL survivors could herald the future deterioration of renal function and development of hypertension. Long-term follow-up imaging may be warranted in these patients to monitor for progressive morbidity...
  27. doi Bioisosteric phentolamine analogs as selective human alpha(2)- versus alpha(1)-adrenoceptor ligands
    Supriya A Bavadekar
    Department of Pharmacology, School of Pharmacy, University of Mississippi, University, MS 38677, United States
    Eur J Pharmacol 590:53-60. 2008
    ....
  28. doi Intervention steps for treating laryngospasm in pediatric patients
    Laura L Burgoyne
    Division of Anesthesiology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Paediatr Anaesth 18:297-302. 2008
    ..7/1000). However, there are no clinical data on the optimal type and sequence of therapeutic interventions. We therefore characterized the interventions used at St. Jude Children's Research Hospital...
  29. ncbi Neural correlates of a clinical continuous performance test
    Robert J Ogg
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Magn Reson Imaging 26:504-12. 2008
    ....
  30. ncbi The origins of medulloblastoma subtypes
    Richard J Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Annu Rev Pathol 3:341-65. 2008
    ..Definitive characterization of each medulloblastoma subtype will undoubtedly improve treatment of this disease and provide important insights to the origins of cancer...
  31. pmc A strategy to study tyrosinase transgenes in mouse melanocytes
    Alfonso Lavado
    Department of Molecular and Cellular Biology, Centro Nacional de Biotecnologia CNB CSIC, Campus de Cantoblanco, C Darwin, 3 28049 Madrid, Spain
    BMC Cell Biol 6:18. 2005
    ..It has been previously reported that it is possible to obtain and immortalize melanocyte cell cultures from postnatal mouse skin...
  32. ncbi Biology, clinical characteristics, and management of adrenocortical tumors in children
    Carlos Rodriguez-Galindo
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    Pediatr Blood Cancer 45:265-73. 2005
    ..Multi-institutional and prospective studies are necessary to further our understanding of the pathogenesis and to improve outcomes...
  33. ncbi Malignant breast tumor phospholipid profiles using (31)P magnetic resonance
    Thomas E Merchant
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Cancer Lett 176:159-67. 2002
    ..31)P MRS phospholipid profile data provide statistical correlations among histologic features and molecules known to play important roles in cellular communication, regulation, and processes unique to malignant tissues...
  34. pmc Characterization of H5N1 influenza viruses that continue to circulate in geese in southeastern China
    Robert G Webster
    Department of Virology and Molecular Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Virol 76:118-26. 2002
    ....
  35. ncbi Repressive adaptation in children with cancer: a replication and extension
    S Phipps
    Division of Behavioral Medicine, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Health Psychol 20:445-51. 2001
    ..These findings suggest a shift toward repressiveness in response to the diagnosis of cancer that is then maintained over time and necessitate further examination of the health consequences of adaptive style in this population...
  36. ncbi Pharmacogenomics: the inherited basis for interindividual differences in drug response
    W E Evans
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Annu Rev Genomics Hum Genet 2:9-39. 2001
    ..This chapter provides an overview of the current pharmacogenomics literature and offers insights for the potential impact of this field on the safe and effective use of medications...
  37. ncbi Minimizing the number of segments in a delivery sequence for intensity-modulated radiation therapy with a multileaf collimator
    J Dai
    Department of Radiation Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Med Phys 28:2113-20. 2001
    ..is used to calculate the complexity of an intensity matrix. Because no single variation is most efficient for all beams tested, we suggest implementing multiple variations of our algorithm...
  38. ncbi Cutting edge: culture with high doses of viral peptide induces previously unprimed CD8(+) T cells to produce cytokine
    J M Riberdy
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 167:2437-40. 2001
    ..However, at least for two influenza-derived epitopes, the avidity of the TCR-MHC peptide interaction appears to be insufficient to stabilize a tetrameric complex of MHC class I glycoprotein plus peptide on the lymphocyte surface...
  39. pmc Dissecting the host response to a gamma-herpesvirus
    P C Doherty
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Philos Trans R Soc Lond B Biol Sci 356:581-93. 2001
    ..Perhaps the main lesson learned to date is that all the components of immunity are likely to be important for the control of these complex viruses...
  40. ncbi The Stat family in cytokine signaling
    J N Ihle
    Department of Biochemistry, Howard Hughes Medical Institute, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA
    Curr Opin Cell Biol 13:211-7. 2001
    ....
  41. ncbi Concurrent translocations of MLL and CBFA2 (AML1) genes with new partner breakpoints in a child with secondary myelodysplastic syndrome after treatment of acute lymphoblastic leukemia
    S Mathew
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Chromosomes Cancer 28:227-32. 2000
    ..This report is the first to describe new partner breakpoints at 2p23 and 6p22 for MLL and CBFA2 genes, respectively, and concurrent rearrangements of these genes in a patient with secondary MDS...
  42. ncbi Isolation and characterization of vancomycin-tolerant Streptococcus pneumoniae from the cerebrospinal fluid of a patient who developed recrudescent meningitis
    J A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital Division of Infectious Diseases, Center, Memphis, Tennessee, USA
    J Infect Dis 181:369-73. 2000
    ..Because tolerance is a precursor phenotype to resistance and may lead to clinical failure of antibiotic therapy, these observations may have important implications for vancomycin use in infections caused by S. pneumoniae...
  43. ncbi Detection of minimal residual disease in acute leukemia by flow cytometry
    D Campana
    Department of Hematology Oncology, Medicine, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cytometry 38:139-52. 1999
    ..In this review, we discuss methodologic aspects and clinical results of flowcytometric detection of MRD in patients with acute leukemia...
  44. ncbi CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins
    C Kurschner
    Department of Developmental Neurobiology, Saint Jude Children s Research Hospital, Memphis, Tennessee, 38105, USA
    Mol Cell Neurosci 11:161-72. 1998
    ..The functional consequences of CIPP expression on Kir4.1 channels were studied using whole-cell voltage clamp techniques in Kir4.1 transfected COS-7 cells. On average, Kir4.1 current densities were doubled by cotransfection with CIPP...
  45. ncbi Neuropsychologic functioning of survivors of childhood medulloblastoma randomized to receive conventional or reduced-dose craniospinal irradiation: a Pediatric Oncology Group study
    R K Mulhern
    St Jude Children s Research Hospital, Department of Pediatrics, University Tennessee College of Medicine, Memphis, USA
    J Clin Oncol 16:1723-8. 1998
    ..4 gy...
  46. ncbi Paediatric embryonic brain tumours. biological and clinical relevance of molecular genetic abnormalities
    R Gilbertson
    Department of Developmental Neurobiology, Room D2006G, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    Eur J Cancer 38:675-85. 2002
    ..This review focuses on the principal molecular genetic abnormalities so far identified in embryonal brain tumours and discusses their biological and clinical relevance...
  47. ncbi Multi-component behavioral intervention to promote health protective behaviors in childhood cancer survivors: the protect study
    Melissa M Hudson
    Department of Hematology Oncology, St Jude Children s Research Hospital, and the Department of Pediatrics, University of Tennessee, Memphis, College of Medicine, Memphis, Tennessee 38105, USA
    Med Pediatr Oncol 39:2-1; discussion 2. 2002
    ..We initiated a controlled prospective trial to determine if a multi-component behavioral intervention could induce change in childhood cancer survivors' health knowledge, health perceptions, and practice of health-protective behaviors...
  48. ncbi Acute effects of irradiation on cognition: changes in attention on a computerized continuous performance test during radiotherapy in pediatric patients with localized primary brain tumors
    Thomas E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 53:1271-8. 2002
    ..To assess sustained attention, impulsivity, and reaction time during radiotherapy (RT) for pediatric patients with localized primary brain tumors...
  49. ncbi White matter lesions detected by magnetic resonance imaging after radiotherapy and high-dose chemotherapy in children with medulloblastoma or primitive neuroectodermal tumor
    Maryam Fouladi
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Clin Oncol 22:4551-60. 2004
    ....
  50. ncbi Severe cardiopulmonary complications consistent with systemic inflammatory response syndrome caused by leukemia cell lysis in childhood acute myelomonocytic or monocytic leukemia
    Nobuko Hijiya
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Pediatr Blood Cancer 44:63-9. 2005
    ..Life-threatening pulmonary complications that coincide with cell lysis during early chemotherapy and that mimic systemic inflammatory response syndrome (SIRS) have been reported in patients with acute myeloid leukemia (AML)...
  51. ncbi Can the genotoxicity of chemotherapy be predicted?
    Ching Hon Pui
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet 364:917-8. 2004
  52. ncbi Second neoplasms in pediatric patients with primary central nervous system tumors: the St. Jude Children's Research Hospital experience
    Alberto Broniscer
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 100:2246-52. 2004
    ..Details on second neoplasms (SNs) following pediatric central nervous system (CNS) tumors are scant, because of the rarity of such SNs. The goal of the current study was to investigate and characterize these rare SNs...
  53. ncbi Gabapentin to control seizures in children undergoing cancer treatment
    Raja B Khan
    Division of Neuro Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Child Neurol 19:97-101. 2004
    ..Only 8 children (7%) reported adverse effects, and the drug was discontinued in two. Gabapentin effectively controls seizures in children receiving chemotherapy and is well tolerated...
  54. ncbi Phase I and pharmacokinetic study of topotecan administered orally once daily for 5 days for 2 consecutive weeks to pediatric patients with refractory solid tumors
    Najat C Daw
    Department of Hematology Oncology, Mail Stop 260, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    J Clin Oncol 22:829-37. 2004
    ..We conducted a phase I trial of the injectable formulation of topotecan given orally once daily for 5 days for 2 consecutive weeks (qd x 5 x 2) in pediatric patients with refractory solid tumors...
  55. ncbi An Arf(GFP/GFP) reporter mouse reveals that the Arf tumor suppressor monitors latent oncogenic signals in vivo
    Charles J Sherr
    Howard Hughes Medical Institute, Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38117, USA
    Cell Cycle 3:239-40. 2004
    ..Studies of a knock-in mouse strain in which sequences encoding green fluorescent protein were substituted for those encoding p19Arf argue that the Arf gene responds to latent oncogenic signals in vivo to eliminate incipient cancer cells...
  56. ncbi Megadose transplantation of highly purified haploidentical stem cells: current results and future prospects
    Rupert Handgretinger
    Division of Stem Cell Transplantation, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    Pediatr Transplant 7:51-5. 2003
    ..We present the results obtained so far by CD34+ positive selection and discuss new techniques of graft engineering which might hopefully further improve the outcome of haploidentical stem cell transplantation...
  57. ncbi Stem cell plasticity: a new image of the bone marrow stem cell
    Edwin M Horwitz
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Curr Opin Pediatr 15:32-7. 2003
    ..Both animal models to carefully address outstanding issues and pilot clinical trials to explore the therapeutic potential will be key elements to advance science for the benefit of patients...
  58. ncbi Minimally invasive radiological diagnosis of pediatric hematological malignancies
    Bassen I Razzouk
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Pediatr Radiol 32:652. 2002
  59. ncbi Primary skeletal neoplasms: osteosarcoma and ewing sarcoma
    Fredric A Hoffer
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, 325 North Lauderdale, Memphis, TN 38105, USA
    Top Magn Reson Imaging 13:231-9. 2002
    ..Determination of response on follow-up static and dynamic contrast-enhanced magnetic resonance imaging and knowledge of optimal methods to determine recurrent tumor will improve the outcome for these children...
  60. ncbi A semi-parametric accelerated failure time cure model
    Chin Shang Li
    Department of Biostatistics, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Stat Med 21:3235-47. 2002
    ..An EM algorithm is developed to fit the model. The procedure is applied to a data set of tonsil cancer patients treated with radiation therapy...
  61. ncbi Preirradiation endocrinopathies in pediatric brain tumor patients determined by dynamic tests of endocrine function
    Thomas E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 54:45-50. 2002
    ..To prospectively evaluate pediatric patients with localized primary brain tumors for evidence of endocrinopathy before radiotherapy (RT)...
  62. ncbi Isolation of a cDNA encoding the chicken homologue of the human calcium-modulating cyclophilin ligand
    R J Bram
    Department of Experimental Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Gene 174:307-9. 1996
    ..The deduced amino acid sequences of chicken and human CAML show areas of extensive conservation, suggesting an evolutionarily important role in signaling...

Research Grants62

  1. SLEEP, FATIGUE, AND DEXAMETHOSONE IN CHILDHOOD CANCER
    Pamela Hinds; Fiscal Year: 2003
    ..Our study findings will explicate the relationship between sleep efficiency and fatigue, and between sleep, fatigue, and systemic exposure to dexamethasone. ..
  2. Voices of children and adolescents with incurable cancer on Phase I or II Trials
    Pamela S Hinds; Fiscal Year: 2010
    ..This study will allow us to measure direct symptom and quality of life reports of children and adolescents with incurable cancer who are receiving experimental drugs. ..
  3. Synergism Between Influenza Virus and Pneumococcus
    Jonathan McCullers; Fiscal Year: 2007
    ....
  4. 2nd Orthomyxoviruses Research Conference
    Jonathan McCullers; Fiscal Year: 2003
    ..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..
  5. Influenza-pneumococcal synergism: role of neuraminidase
    Jonathan McCullers; Fiscal Year: 2004
    ....
  6. Synergism Between Influenza Virus and Pneumococcus
    Jonathan McCullers; Fiscal Year: 2009
    ....
  7. 3rd Orthomyxoviruses Research Conference
    Jonathan McCullers; Fiscal Year: 2005
    ..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..
  8. Lethal synergism between influenza and pneumococcus
    Jonathan McCullers; Fiscal Year: 2003
    ....
  9. Psychosocial and Neurocognitive Consequences of Childhood Cancer
    Sean Phipps; Fiscal Year: 2006
    ..Publication of the conference proceedings will serve to summarize the current state of the field and to point towards new research agendas for the future. ..
  10. PSYCHOSOCIAL IMPACT OF PEDIATRIC BONE MARROW TRANSPLANT
    Sean Phipps; Fiscal Year: 2006
    ..Finally, analyses will explore hypotheses specific to the positive psychology model, testing the role of positive affect and dispositional optimism as mediators and moderators of the intervention on child and parent well being. ..
  11. MEASUREMENT OF ADAPTIVE STYLE IN CHILDREN WITH CANCER
    Sean Phipps; Fiscal Year: 2003
    ....
  12. Trauma and Growth in Pediatric Cancer
    Sean Phipps; Fiscal Year: 2010
    ....
  13. Evaluation of Cardiovascular Outcomes Among Childhood Cancer Survivors
    Melissa Hudson; Fiscal Year: 2009
    ..We expect the intervention to increase childhood cancer survivors' CV screening adherence, and therefore potentially significantly modify the morbidity and mortality of CV disease in this at-risk population. ..
  14. HEPATITIS C IN CHILDHOOD CANCER SURVIVORS
    Melissa Hudson; Fiscal Year: 2003
    ..abstract_text> ..
  15. Evaluation of Cardiovascular Outcomes Among Childhood Cancer Survivors
    MELISSA M contact HUDSON; Fiscal Year: 2010
    ..We expect the intervention to increase childhood cancer survivors'CV screening adherence, and therefore potentially significantly modify the morbidity and mortality of CV disease in this at-risk population. ..
  16. Tobacco Control Strategies for Medically At-Risk Youth
    Vida Tyc; Fiscal Year: 2005
    ..Working Group manuscripts that correspond to each objective will be published as a supplement to the journal, Pediatrics. ..
  17. Reduction of ETS Exposure in Pediatric Cancer Patients
    Vida Tyc; Fiscal Year: 2006
    ..Our planned clinical trial may verify the effectiveness of an important clinical service for this vulnerable population that can be adapted for other pediatric oncology settings. ..
  18. Protective Cell-Mediated Immunity Against Lethal H5N1 Influenza A Viruses
    Peter C Doherty; Fiscal Year: 2010
    ..These studies should allow us to develop a clear, mechanistic understanding of how to promote effective CMI against the H5N1 viruses. ..
  19. Protective Cell-Mediated Immunity Against Lethal H5N1 Influenza A Viruses
    Peter Doherty; Fiscal Year: 2007
    ..These studies should allow us to develop a clear, mechanistic understanding of how to promote effective CMI against the H5N1 viruses. ..
  20. Antileukemic effort of NK cells in HCT for pediatric AML
    Wing Leung; Fiscal Year: 2010
    ..Our goal is to optimize the pairing of unrelated donors and recipients of HCT, thereby improving survival of pediatric patients with AML who typically have a poor prognosis. ..
  21. Antileukemic effort of NK cells in HCT for pediatric AML
    Wing Leung; Fiscal Year: 2007
    ..Our goal is to optimize the pairing of unrelated donors and recipients of HCT, thereby improving survival of pediatric patients with AML who typically have a poor prognosis. ..
  22. Quantitative MR measure of MTX neurotoxicity in children
    WILBURN REDDICK; Fiscal Year: 2006
    ....
  23. Lapatinib in childhood CNS malignancies
    Maryam Fouladi; Fiscal Year: 2006
    ..These data will be used in the rational design of future phase I combination or frontline studies to improve the outcome in children with these poor prognosis tumors. ..
  24. Clinical trial of self complementary AAV8-mediated gene transfer for hemophilia B
    Andrew M Davidoff; Fiscal Year: 2010
    ....
  25. THE ANTI-APOPTOTIC ROLE OF HEATSHOCK PROTEIN 70 (HSP 70)
    Douglas Green; Fiscal Year: 2004
    ..Together, our studies will secure a mechanistic basis for the function of Hsp70 in the regulation of cell death and cell survival. ..
  26. Conference on Cellular Senescene and Cell Death
    Douglas Green; Fiscal Year: 2005
    ..The interconnections between these biological events and the overlapping principles that emerge represent an emerging field in biology and biomedical research. ..