R B Russell
Affiliation: SmithKline Beecham Pharmaceuticals
- Protein fold irregularities that hinder sequence analysisR B Russell
SmithKline Beecham Pharmaceuticals, Bioinformatics, New Frontiers Science Park North, Essex, UK
Curr Opin Struct Biol 8:364-71. 1998..Little attention has been paid, however, to the problems of detecting homology when domains are inserted or permuted. Here we review recent occurrences of these phenomena and discuss methods that permit their detection...
- Exon structure conservation despite low sequence similarity: a relic of dramatic events in evolution?M J Betts
Bioinformatics, GlaxoSmithKline, New Frontiers Science Park North, 3rd Avenue, Harlow, CM19 5AW, UK
EMBO J 20:5354-60. 2001..The results suggest ways to detect new and potentially very remote homologues, and to construct phylogenies for proteins with limited sequence similarity...