S K Gupta

Summary

Affiliation: SmithKline Beecham Pharmaceuticals
Country: USA

Publications

  1. ncbi request reprint Pharmacological evidence for complex and multiple site interaction of CXCR4 with SDF-1alpha: implications for development of selective CXCR4 antagonists
    S K Gupta
    Department of Cardiovascular Biology, Mail Code UW2511, Glaxo SmithKline Pharmaceuticals, King of Prussia, PA 19406, USA
    Immunol Lett 78:29-34. 2001
  2. ncbi request reprint CXCR4 undergoes complex lineage and inducing agent-dependent dissociation of expression and functional responsiveness to SDF-1alpha during myeloid differentiation
    S K Gupta
    Department of Cardiovascular Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Leukoc Biol 70:431-8. 2001
  3. ncbi request reprint Platelet agonist F11 receptor is a member of the immunoglobulin superfamily and identical with junctional adhesion molecule (JAM): regulation of expression in human endothelial cells and macrophages
    S K Gupta
    Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    IUBMB Life 50:51-6. 2000
  4. ncbi request reprint Cutting edge: CXCR4-Lo: molecular cloning and functional expression of a novel human CXCR4 splice variant
    S K Gupta
    Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA
    J Immunol 163:2368-72. 1999
  5. ncbi request reprint Modulation of CXCR4 expression and SDF-1alpha functional activity during differentiation of human monocytes and macrophages
    S K Gupta
    Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Leukoc Biol 66:135-43. 1999
  6. ncbi request reprint Molecular cloning of a novel chemokine receptor-like gene from early stage chick embryos
    S K Gupta
    Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA
    Biochem Mol Biol Int 44:673-81. 1998
  7. ncbi request reprint Molecular cloning of a gene from 'chromosome 3 specific' genomic library that encodes a novel CC-chemokine receptor like isotype
    S K Gupta
    SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19444, USA
    Biochem Mol Biol Int 40:551-60. 1996
  8. ncbi request reprint Chemokine receptors in human endothelial cells. Functional expression of CXCR4 and its transcriptional regulation by inflammatory cytokines
    S K Gupta
    Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Biol Chem 273:4282-7. 1998
  9. ncbi request reprint Cloning and relative expression analysis of rat stromal cell derived factor-1 (SDF-1)1: SDF-1 alpha mRNA is selectively induced in rat model of myocardial infarction
    K Pillarisetti
    Department of Cardiovascular Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    Inflammation 25:293-300. 2001
  10. ncbi request reprint Nucleotide sequence of cDNA encoding bonnet monkey (Macaca radiata) zona pellucida glycoprotein-ZP3
    S K Kolluri
    Gamete Antigen Laboratory, National Institute of Immunology, New Delhi, India
    Reprod Fertil Dev 7:1209-12. 1995

Collaborators

  • N Aiyar
  • P G Lysko
  • R A Thomas
  • E H Ohlstein
  • Nina Singh
  • A D Howard
  • P Dey
  • Sudip K Bandyopadhyay
  • Kai Fai Lee
  • Rameshwar K Sharma
  • R F Smith
  • R Kaul
  • U Brahmi
  • G K Gahlay
  • Partha Sarathi Majumder
  • S Chakravarty
  • Philip C N Chiu
  • M Samant
  • S Sundar
  • A Dube
  • R Garg
  • S Tiwari
  • A Sanyal
  • N Srivastava
  • N K Ganguly
  • K Joshi
  • H Vohra
  • A Rajwanshi
  • C K Govind
  • K Pillarisetti
  • C L Lee
  • P Bansal
  • Ronald T K Pang
  • Ben S T Wong
  • William S B Yeung
  • S B Sumitro
  • S Kadunganattil
  • A A Sahasrabuddhe
  • S Naik
  • P Tripathi
  • S Biswas
  • K Kumar
  • R Manoj Kumar
  • G P Sabarinath
  • J K Mohapatra
  • M Mittal
  • C Tosh
  • R Trivedi
  • D Hemadri
  • P Giridharan
  • M M Godbole
  • S Mukund
  • P Sheela
  • S S Thakral
  • B S Malik
  • R Santhanam
  • S Choudhury
  • S K Kolluri
  • K Banerjee
  • R Sarao
  • M A Arnaout
  • R J Dunn
  • M W Pierce
  • D G Tenen
  • V J Auld

Detail Information

Publications29

  1. ncbi request reprint Pharmacological evidence for complex and multiple site interaction of CXCR4 with SDF-1alpha: implications for development of selective CXCR4 antagonists
    S K Gupta
    Department of Cardiovascular Biology, Mail Code UW2511, Glaxo SmithKline Pharmaceuticals, King of Prussia, PA 19406, USA
    Immunol Lett 78:29-34. 2001
    ..Furthermore, these findings have important implications in the development and evaluation of CXCR4-selective small molecule antagonists for therapeutic use...
  2. ncbi request reprint CXCR4 undergoes complex lineage and inducing agent-dependent dissociation of expression and functional responsiveness to SDF-1alpha during myeloid differentiation
    S K Gupta
    Department of Cardiovascular Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Leukoc Biol 70:431-8. 2001
    ....
  3. ncbi request reprint Platelet agonist F11 receptor is a member of the immunoglobulin superfamily and identical with junctional adhesion molecule (JAM): regulation of expression in human endothelial cells and macrophages
    S K Gupta
    Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    IUBMB Life 50:51-6. 2000
    ..The data indicate that the F11 antigen is a novel receptor or cell adhesion molecule belonging to the immunoglobulin superfamily...
  4. ncbi request reprint Cutting edge: CXCR4-Lo: molecular cloning and functional expression of a novel human CXCR4 splice variant
    S K Gupta
    Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA
    J Immunol 163:2368-72. 1999
    ..Expression of CXCR4-Lo is noteworthy, as it may have differential affinity as a coreceptor for HIV strains in comparison with CXCR4. Furthermore, CXCR4-Lo may also provide a functional backup to CXCR4 during embryogenesis...
  5. ncbi request reprint Modulation of CXCR4 expression and SDF-1alpha functional activity during differentiation of human monocytes and macrophages
    S K Gupta
    Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Leukoc Biol 66:135-43. 1999
    ..GM-CSF had no effect on CXCR4 mRNA in HL-60 cells and does not cause its down-regulation in human macrophages...
  6. ncbi request reprint Molecular cloning of a novel chemokine receptor-like gene from early stage chick embryos
    S K Gupta
    Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA
    Biochem Mol Biol Int 44:673-81. 1998
    ....
  7. ncbi request reprint Molecular cloning of a gene from 'chromosome 3 specific' genomic library that encodes a novel CC-chemokine receptor like isotype
    S K Gupta
    SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19444, USA
    Biochem Mol Biol Int 40:551-60. 1996
    ..Further studies are underway to identify and clone the putative human homolog of this novel chemokine receptor...
  8. ncbi request reprint Chemokine receptors in human endothelial cells. Functional expression of CXCR4 and its transcriptional regulation by inflammatory cytokines
    S K Gupta
    Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Biol Chem 273:4282-7. 1998
    ..Taken together, these findings provide evidence of chemokine receptor expression in EC and offer an explanation for the action of chemokines like SDF-1alpha on the vascular endothelium...
  9. ncbi request reprint Cloning and relative expression analysis of rat stromal cell derived factor-1 (SDF-1)1: SDF-1 alpha mRNA is selectively induced in rat model of myocardial infarction
    K Pillarisetti
    Department of Cardiovascular Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    Inflammation 25:293-300. 2001
    ..Such modulation of SDF-1alpha mRNA expression may be indicative of its role in the inflammatory events in cardiovascular disease...
  10. ncbi request reprint Nucleotide sequence of cDNA encoding bonnet monkey (Macaca radiata) zona pellucida glycoprotein-ZP3
    S K Kolluri
    Gamete Antigen Laboratory, National Institute of Immunology, New Delhi, India
    Reprod Fertil Dev 7:1209-12. 1995
    ..These results have important implications for the use of bonnet monkey as an animal model for evaluation and development of contraceptive vaccine based on ZP3 for human use...
  11. ncbi request reprint Molecular cloning of the human fertilin beta subunit
    S K Gupta
    Department of Cellular and Molecular Biology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Biochem Biophys Res Commun 224:318-26. 1996
    ..The amino acid sequence at this position in human fertilin beta differs from the mouse, guinea pig and monkey sequence (mouse-QDE; human-FEE; monkey-FDE)...
  12. ncbi request reprint Simultaneous exposure of excess fluoride and calcium deficiency alters VDR, CaR, and calbindin D 9 k mRNA levels in rat duodenal mucosa
    S Tiwari
    Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, 226014, Lucknow, India
    Calcif Tissue Int 75:313-20. 2004
    ..We conclude that excess fluoride reduces the mRNA levels of VDR and D 9 k in the duodenal mucosa of rats, thereby possibly reducing calcium absorption. Calcium supplementation with simultaneous fluoride removal improves their expression...
  13. ncbi request reprint Degradation of 4-chlorophenol in UASB reactor under methanogenic conditions
    Partha Sarathi Majumder
    Centre for Environmental Science and Engineering, Indian Institute of Technology, Powai, Mumbai 400 076, India
    Bioresour Technol 99:4169-77. 2008
    ..Specific methanogenic activity of the sludge of control and test UASB reactor was 0.832 g CH(4) COD/g VSS d and 0.694 g CH(4) COD/g VSS d, respectively...
  14. ncbi request reprint Complete nucleotide sequence analysis of a vaccine strain and a field isolate of foot-and-mouth disease virus serotype Asia1 with an insertion in VP1 genomic region
    A Sanyal
    Project Directorate on Foot and Mouth Disease, Indian Veterinary Research Institute Campus, Mukteswar Kumaon, Nainital 263 138, Uttaranchal, India
    Acta Virol 48:159-66. 2004
    ..This study shows that in the gene pool of serotype Asia1 at least three groups of isolates/strains are present with respect to the length of VP1 protein...
  15. pmc Immunostimulatory cellular responses of cured Leishmania-infected patients and hamsters against the integral membrane proteins and non-membranous soluble proteins of a recent clinical isolate of Leishmania donovani
    R Garg
    Division of Parasitology, Central Drug Research Institute, Lucknow, India
    Clin Exp Immunol 140:149-56. 2005
    ..These results suggest that protective, immunostimulatory molecules are present in the IMP and NSP fractions, which may be exploited for development of a subunit vaccine for VL...
  16. ncbi request reprint Hematopoietic cells from gadd45a-deficient and gadd45b-deficient mice exhibit impaired stress responses to acute stimulation with cytokines, myeloablation and inflammation
    S K Gupta
    Department of Biochemistry, Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19104, USA
    Oncogene 25:5537-46. 2006
    ..These findings should aid in understanding the response of normal and malignant hematopoietic cells to physiological and chemical stressors including anticancer agents...
  17. ncbi request reprint Relevance of glycosylation of human zona pellucida glycoproteins for their binding to capacitated human spermatozoa and subsequent induction of acrosomal exocytosis
    S Chakravarty
    Gamete Antigen Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India
    Mol Reprod Dev 75:75-88. 2008
    ..These studies have revealed the binding profile of individual human zona protein to spermatozoa and further strengthened the importance of glycosylation of zona proteins for acrosomal exocytosis in spermatozoa...
  18. ncbi request reprint Proteophosphoglycan is differentially expressed in sodium stibogluconate-sensitive and resistant Indian clinical isolates of Leishmania donovani
    M Samant
    Divisions of Parasitology Central Drug Research Institute, Lucknow, India
    Parasitology 134:1175-84. 2007
    ..This study suggests the possibilities of involvement of PPG in drug-resistant mechanisms and of using PPG abundance as a marker for identifying drug-resistant clinical isolates in Indian kala azar...
  19. ncbi request reprint Update on zona pellucida glycoproteins based contraceptive vaccine
    S K Gupta
    Gamete Antigen Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 1100 67, India
    J Reprod Immunol 62:79-89. 2004
    ..Ongoing studies to delineate epitopes of ZP glycoproteins that will generate an immune response capable of inhibiting fertility without any untoward effects on ovarian functions will help in determining their feasibility for human use...
  20. ncbi request reprint Glycosylation of zona pellucida glycoprotein-3 is required for inducing acrosomal exocytosis in the bonnet monkey
    G K Gahlay
    Gamete Antigen Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 1100 67, India
    Cell Mol Biol (Noisy-le-grand) 49:389-97. 2003
    ..These results suggest that though the polypeptide backbone of ZP3 is sufficient for its binding to capacitated spermatozoa, yet glycosylation is required for induction of acrosomal exocytosis...
  21. ncbi request reprint Evaluation of the immunocontraceptive potential of Escherichia coli-expressed recombinant dog ZP2 and ZP3 in a homologous animal model
    N Srivastava
    Gamete Antigen Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India
    Reproduction 123:847-57. 2002
    ..These results, although preliminary, indicate that immunization with dZP3 may be a feasible proposition to control dog populations provided that adequate antibody titres are achieved...
  22. ncbi request reprint Flow cytometric immunophenotyping and comparison with immunocytochemistry in small round cell tumors
    U Brahmi
    Department of Cytopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    Anal Quant Cytol Histol 23:405-12. 2001
    ..CONCLUSION: FCI technique is sensitive, more objective and quantitative in comparison with manual absorbance-based microscopic detection of enzyme immunohistochemistry products. FCI may determine divergent differentiation in SRCTs...
  23. pmc Developmentally regulated alternative RNA splicing of rat brain sodium channel mRNAs
    R Sarao
    Centre for Research in Neuroscience, Montreal General Hospital, McGill University, Quebec, Canada
    Nucleic Acids Res 19:5673-9. 1991
    ..Alternative RNA splicing may modulate the RII/RIIA sodium channel properties during neuronal development...
  24. ncbi request reprint Role of immunocytochemistry and DNA flow cytometry in the fine-needle aspiration diagnosis of malignant small round-cell tumors
    U Brahmi
    Department of Cytology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    Diagn Cytopathol 24:233-9. 2001
    ..Further ancillary studies, e.g., electron microscopy, image analysis, and other molecular investigations, are required to further categorize these tumors more precisely for better clinical management of these cases...
  25. ncbi request reprint Purified and refolded recombinant bonnet monkey (Macaca radiata) zona pellucida glycoprotein-B expressed in Escherichia coli binds to spermatozoa
    C K Govind
    Gamete Antigen Laboratory, National Institute of Immunology, New Delhi 110 067, India
    Biol Reprod 64:1147-52. 2001
    ..These results suggest that nonglycosylated bmZPB binds to capacitated as well as acrosome-reacted spermatozoa in a nonhuman primate and may have a functional role during fertilization...
  26. ncbi request reprint A receptor in pituitary and hypothalamus that functions in growth hormone release
    A D Howard
    Merck Research Laboratories, Rahway, NJ 07065, USA
    Science 273:974-7. 1996
    ..On the basis of its pharmacological and molecular characterization, this GPC-R defines a neuroendocrine pathway for the control of pulsatile GH release and supports the notion that the GHSs mimic an undiscovered hormone...
  27. ncbi request reprint Localization of epitopes for monoclonal antibodies at the N-terminus of the porcine zona pellucida glycoprotein pZPC
    S K Gupta
    Gamete Antigen Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India
    Mol Reprod Dev 42:220-5. 1995
    ..These results, the first to define peptide epitopes of porcine zona glycoprotein, will assist in the design of an immunocontraceptive vaccine based on synthetic peptides corresponding to pZPC or its homologues in other species...
  28. pmc Amino acid sequence of the alpha subunit of human leukocyte adhesion receptor Mo1 (complement receptor type 3)
    M A Arnaout
    Renal Unit, Children s Hospital, Boston, Massachusetts
    J Cell Biol 106:2153-8. 1988
    ..Mo1 alpha, like p150, contains a unique 187-amino acid stretch NH2-terminal to the metal-binding domains. This region could be involved in some of the specific functions mediated by these leukocyte glycoproteins...
  29. doi request reprint Native human zona pellucida glycoproteins: purification and binding properties
    Philip C N Chiu
    Department of Obstetrics and Gynaecology, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, People s Republic of China
    Hum Reprod 23:1385-93. 2008
    ..Our current technology cannot generate recombinant human ZP (hZP) glycoproteins with native glycosylation...