Linda M Bradley
Affiliation: Sidney Kimmel Cancer Center
- Interleukin 7 regulates the survival and generation of memory CD4 cellsRobyn M Kondrack
Department of Immunology, The Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, CA 92121, USA
J Exp Med 198:1797-806. 2003..The results demonstrate that IL-7 can have previously unrecognized roles in the maintenance of memory in the CD4 cell population and in the survival of CD4 cells with a capacity to become memory cells...
- Availability of antigen-presenting cells can determine the extent of CD4 effector expansion and priming for secretion of Th2 cytokines in vivoLinda M Bradley
The Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
Eur J Immunol 32:2338-46. 2002..The results suggest that the level of APC engagement can not only determine the extent of effector expansion, but also the overall Th1/Th2 cytokine balance...
- Costimulation via OX40L expressed by B cells is sufficient to determine the extent of primary CD4 cell expansion and Th2 cytokine secretion in vivoPhyllis Jean Linton
The Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, CA 92121, USA
J Exp Med 197:875-83. 2003..The results suggest that without engagement of OX40L on B cells, CD4 cell responses to many protein Ag would be dominated by Th1 cytokines. These data have important implications for strategies to achieve optimal priming of CD4 subsets...
- CD4+ cell memory: the enigma of Th1 cellsLinda M Bradley
Division of Immunology, The Sidney Kimmel Cancer Center, 10 835 Altman Row, San Diego, CA 92121, USA
Trends Mol Med 9:186-8. 2003..These studies support a new paradigm, in which memory T cells are heterogeneous in terms of their stage of maturation and function as well as mechanisms of homeostatic control...
- Migration and T-lymphocyte effector functionLinda M Bradley
Division of Immunology, The Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, CA 92121, USA
Curr Opin Immunol 15:343-8. 2003..There are many unanswered questions about the developmental relationships and roles in protective immunity of antigen-experienced T cells that partition in different tissues...
- Withdrawal of stimulation may initiate the transition of effector to memory CD4 cellsJudith Harbertson
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Immunol 168:1095-102. 2002....
- Adaptive islet-specific regulatory CD4 T cells control autoimmune diabetes and mediate the disappearance of pathogenic Th1 cells in vivoSarah E Weber
Department of Immunology, Sidney Kimmel Cancer Center, San Diego, CA 92131, USA
J Immunol 176:4730-9. 2006....
- IL-7: maintaining T-cell memory and achieving homeostasisLinda M Bradley
Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, CA 92121, USA
Trends Immunol 26:172-6. 2005..In this Review, we discuss the role of IL-7 in the survival and homeostasis of naive and memory T cells and how that role is regulated by other factors...
- PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell ExhaustionRoberto Tinoco
Infectious and Inflammatory Disease Center and NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Research Institute, La Jolla, CA 92037, USA Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
Immunity 44:1190-203. 2016..Thus, PSGL-1 plays a fundamental role in balancing viral control and immunopathology and also functions to regulate T cell responses in the tumor microenvironment. ..
- Antigen-specific and non-specific CD4+ T cell recruitment and proliferation during influenza infectionTimothy J Chapman
Department of Microbiology and Immunology, David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, University of Rochester Medical Center, NY 14642, USA
Virology 340:296-306. 2005..These data show that, when primed, CD4(+) T cells may traffic to the lung in the absence of antigen, but do not proliferate. These results also document a useful tool for the study of CD4 T cells in influenza infection...
- Polyclonal adaptive regulatory CD4 cells that can reverse type I diabetes become oligoclonal long-term protective memory cellsElana Godebu
School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
J Immunol 181:1798-805. 2008....
- REGULATION OF HELPER T CELL MEMORYLinda Bradley; Fiscal Year: 2002..The proposed studies represents an integrated investigation of factors that will provide essential, basic information about the regulation of CD4 memory. ..