Russell B Williams

Summary

Affiliation: Sequoia Sciences
Country: USA

Publications

  1. doi request reprint Isolation of apoptosis-inducing stilbenoids from four members of the Orchidaceae family
    Russell B Williams
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, St Louis, Missouri, USA
    Planta Med 78:160-5. 2012
  2. pmc Cytotoxic and antibacterial beilschmiedic acids from a Gabonese species of Beilschmiedia
    Russell B Williams
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, 1912 Innerbelt Business Center Drive, St Louis, Missouri 63114, USA
    J Nat Prod 75:1319-25. 2012
  3. doi request reprint Antibiotic indole sesquiterpene alkaloid from Greenwayodendron suaveolens with a new natural product framework
    Russell B Williams
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, 1912 Innerbelt Business Center Drive, St Louis, Missouri 63114, USA
    J Nat Prod 73:1008-11. 2010
  4. pmc Polyoxygenated cyclohexene derivatives from Monanthotaxis congoensis
    Courtney M Starks
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, St Louis, MO 63114, United States
    Phytochemistry 74:185-9. 2012
  5. doi request reprint Antibacterial clerodane diterpenes from Goldenrod (Solidago virgaurea)
    Courtney M Starks
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences Inc, 1912 Innerbelt Business Center Drive, St Louis, MO 63114, USA
    Phytochemistry 71:104-9. 2010
  6. doi request reprint Acetylated dammarane-type bisdesmosides from Combretum inflatum
    Russell B Williams
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, 1912 Innerbelt Business Center Drive, St Louis, Missouri 63114, United States
    J Nat Prod 76:1592-7. 2013
  7. doi request reprint Dammarane-type triterpene glycosides from Oncoba manii active against methicillin-resistant Staphylococcus aureus
    Eliane Garo
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, Saint Louis, Missouri 63114, USA
    Planta Med 75:541-3. 2009
  8. pmc Phenylpropanoids from Phragmipedium calurum and their antiproliferative activity
    Courtney M Starks
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, 1912 Innerbelt Business Center Drive, St Louis, MO 63114, United States
    Phytochemistry 82:172-5. 2012
  9. doi request reprint Antibacterial chromene and chromane stilbenoids from Hymenocardia acida
    Courtney M Starks
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, 1912 Innerbelt Business Center Drive, St Louis, MO 63114, United States Electronic address
    Phytochemistry 98:216-22. 2014
  10. doi request reprint Digging Deep for New Compounds from the Compass Plant, Silphium laciniatum
    Russell B Williams
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, 1912 Innerbelt Business Center Drive, St Louis, Missouri 63114, United States
    J Nat Prod 78:2074-86. 2015

Collaborators

Detail Information

Publications14

  1. doi request reprint Isolation of apoptosis-inducing stilbenoids from four members of the Orchidaceae family
    Russell B Williams
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, St Louis, Missouri, USA
    Planta Med 78:160-5. 2012
    ..Based on these results, a portion of the extract from a commercially available Oncidium sp. was chemically modified in an attempt to obtain additional phenanthraquinones...
  2. pmc Cytotoxic and antibacterial beilschmiedic acids from a Gabonese species of Beilschmiedia
    Russell B Williams
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, 1912 Innerbelt Business Center Drive, St Louis, Missouri 63114, USA
    J Nat Prod 75:1319-25. 2012
    ..This is the first report of cytotoxic activity for the endiandric/beilschmiedic acid class of compounds...
  3. doi request reprint Antibiotic indole sesquiterpene alkaloid from Greenwayodendron suaveolens with a new natural product framework
    Russell B Williams
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, 1912 Innerbelt Business Center Drive, St Louis, Missouri 63114, USA
    J Nat Prod 73:1008-11. 2010
    ..Pentacyclindole (1) and polyalthenol (4) showed activity against clinical isolates of Staphylococcus aureus with polyalthenol (4) demonstrating a MIC(90) of 4 microg/mL...
  4. pmc Polyoxygenated cyclohexene derivatives from Monanthotaxis congoensis
    Courtney M Starks
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, St Louis, MO 63114, United States
    Phytochemistry 74:185-9. 2012
    ..Structures were determined using NMR, MS, and optical rotation analyses. One compound displayed moderate antiproliferative activity against NCI-H460 and M14 cancer cells...
  5. doi request reprint Antibacterial clerodane diterpenes from Goldenrod (Solidago virgaurea)
    Courtney M Starks
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences Inc, 1912 Innerbelt Business Center Drive, St Louis, MO 63114, USA
    Phytochemistry 71:104-9. 2010
    ..The structures were determined by NMR spectroscopic analysis. Several displayed moderate antibacterial activity against Staphylococcus aureus...
  6. doi request reprint Acetylated dammarane-type bisdesmosides from Combretum inflatum
    Russell B Williams
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, 1912 Innerbelt Business Center Drive, St Louis, Missouri 63114, United States
    J Nat Prod 76:1592-7. 2013
    ..Compounds 3-7 reduced the growth of MRSA at 16 μg/mL by 71-45%, and compound 7 had an IC₅₀ value of 3.9 μM in NCI-H460...
  7. doi request reprint Dammarane-type triterpene glycosides from Oncoba manii active against methicillin-resistant Staphylococcus aureus
    Eliane Garo
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, Saint Louis, Missouri 63114, USA
    Planta Med 75:541-3. 2009
    ..Compounds 1 and 2 inhibited the growth of methicillin-resistant Staphylococcus aureus (MRSA)...
  8. pmc Phenylpropanoids from Phragmipedium calurum and their antiproliferative activity
    Courtney M Starks
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, 1912 Innerbelt Business Center Drive, St Louis, MO 63114, United States
    Phytochemistry 82:172-5. 2012
    ..They were evaluated for antiproliferative activity against multiple human cancer cell lines, and two displayed moderate activity against several cell lines...
  9. doi request reprint Antibacterial chromene and chromane stilbenoids from Hymenocardia acida
    Courtney M Starks
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, 1912 Innerbelt Business Center Drive, St Louis, MO 63114, United States Electronic address
    Phytochemistry 98:216-22. 2014
    ..None had IC50 values <20 μM in antiproliferation assays against several human cancer cell lines...
  10. doi request reprint Digging Deep for New Compounds from the Compass Plant, Silphium laciniatum
    Russell B Williams
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, 1912 Innerbelt Business Center Drive, St Louis, Missouri 63114, United States
    J Nat Prod 78:2074-86. 2015
    ..laciniatum specimen has led to the identification of 15 new terpenoids (3-8, 10-17, and 22), which were screened for cytotoxic activity in the NCI-H460 human large-cell lung carcinoma cell line. ..
  11. pmc Novel pentadecenyl tetrazole enhances susceptibility of methicillin-resistant Staphylococcus aureus biofilms to gentamicin
    Krista M Olson
    Sequoia Sciences, 1912 Innerbelt Business Center Drive, St Louis, MO 63114, USA
    Antimicrob Agents Chemother 55:3691-5. 2011
    ..This novel combination also exhibits synergistic effects on MRSA planktonic cells. This plant-derived compound reveals promise for its effectiveness and warrants further lead optimization as an antibiotic and aminoglycoside potentiator...
  12. doi request reprint Diterpenes from the endangered goldenrod Solidago shortii
    Russell B Williams
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, 1912 Innerbelt Business Center Drive, St Louis, Missouri 63114, United States
    J Nat Prod 77:1438-44. 2014
    ....
  13. pmc Evolution of Efficient Modular Polyketide Synthases by Homologous Recombination
    Joseph A Chemler
    Sequoia Sciences, Inc, 1912 Innerbelt Business Center Drive, Saint Louis, Missouri 63114, United States
    J Am Chem Soc 137:10603-9. 2015
    ..This method permits the engineering of PKS pathways as modular building blocks for the production of new antibiotic-like molecules. ..
  14. doi request reprint Dereplication of natural products using minimal NMR data inputs
    Russell B Williams
    Sequoia Sciences, Inc, 1912 Innerbelt Business Center Drive, St Louis, MO 63114, USA
    Org Biomol Chem 13:9957-62. 2015
    ..The strategy is an application of computer-assisted structure elucidation using ACD/Structure Elucidator and data obtained from the ChemSpider database hosted by the Royal Society of Chemistry. ..