S Wang

Summary

Affiliation: Schering-Plough Research Institute
Country: USA

Publications

  1. ncbi 8th Annual International Conference on Obesity and Non-Insulin Dependent Diabetes Mellitus: novel drug developments
    S Wang
    Schering Plough Research Institute, Kenilworth, NJ, USA
    Expert Opin Investig Drugs 8:1117-25. 1999
  2. ncbi Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes
    S Wang
    Department of CNS CV Biological Research, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Biol Chem 272:31949-52. 1997
  3. ncbi Molecular cloning and pharmacological characterization of a new galanin receptor subtype
    S Wang
    The Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    Mol Pharmacol 52:337-43. 1997
  4. ncbi Genomic organization and functional characterization of the mouse GalR1 galanin receptor
    S Wang
    Department of CNS CV Biological Research, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    FEBS Lett 411:225-30. 1997
  5. ncbi The GalR2 galanin receptor mediates galanin-induced jejunal contraction, but not feeding behavior, in the rat: differentiation of central and peripheral effects of receptor subtype activation
    S Wang
    Department of CNS CV Biological Research, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    FEBS Lett 434:277-82. 1998
  6. ncbi Differential intracellular signaling of the GalR1 and GalR2 galanin receptor subtypes
    S Wang
    Department of CNS CV Biological Research, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    Biochemistry 37:6711-7. 1998
  7. ncbi A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization
    S Wang
    Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Biol Chem 275:40686-94. 2000
  8. ncbi 9th International Conference on Obesity, NIDDM, adipogenesis and insulin resistance
    S Wang
    Schering Plough Research Institute, Kenilworth, UK
    Expert Opin Investig Drugs 9:1673-8. 2000
  9. ncbi Identification of a novel neuromedin U receptor subtype expressed in the central nervous system
    L Shan
    Human Genome Research and Cardiovascular Central Nervous System Research, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Biol Chem 275:39482-6. 2000
  10. ncbi The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization
    L Pang
    Department of CNS CV Biological Research, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Neurochem 71:2252-9. 1998

Collaborators

Detail Information

Publications68

  1. ncbi 8th Annual International Conference on Obesity and Non-Insulin Dependent Diabetes Mellitus: novel drug developments
    S Wang
    Schering Plough Research Institute, Kenilworth, NJ, USA
    Expert Opin Investig Drugs 8:1117-25. 1999
    ....
  2. ncbi Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes
    S Wang
    Department of CNS CV Biological Research, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Biol Chem 272:31949-52. 1997
    ..Northern blot analysis showed expression in heart, spleen, and testis. Unlike GalR1 and GalR2, no expression of GalR3 was detectable in the brain, suggesting that GalR3 may mediate some of the peripheral functions of galanin...
  3. ncbi Molecular cloning and pharmacological characterization of a new galanin receptor subtype
    S Wang
    The Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    Mol Pharmacol 52:337-43. 1997
    ..The identification of galanin(2-29) as a receptor-specific ligand should enhance the understanding of specificity of galanin-receptor interactions...
  4. ncbi Genomic organization and functional characterization of the mouse GalR1 galanin receptor
    S Wang
    Department of CNS CV Biological Research, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    FEBS Lett 411:225-30. 1997
    ..Functional analysis of the encoded cDNA revealed active ligand binding and intracellular signaling. The expression is detected in brain, spinal cord, heart and skeletal muscle...
  5. ncbi The GalR2 galanin receptor mediates galanin-induced jejunal contraction, but not feeding behavior, in the rat: differentiation of central and peripheral effects of receptor subtype activation
    S Wang
    Department of CNS CV Biological Research, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    FEBS Lett 434:277-82. 1998
    ..The action profile for food intake in rats excluded GalR2, GalR3 and the putative pituitary galanin receptor as the 'feeding receptor', suggesting that either GalR1 or an unidentified GalR is responsible for mediating this function...
  6. ncbi Differential intracellular signaling of the GalR1 and GalR2 galanin receptor subtypes
    S Wang
    Department of CNS CV Biological Research, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    Biochemistry 37:6711-7. 1998
    ....
  7. ncbi A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization
    S Wang
    Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Biol Chem 275:40686-94. 2000
    ..The discovery of this new receptor should aid in further understanding the roles of LTB(4) in pathologies in these tissues and may provide a tool in identification of specific antagonists/agonists for potential therapeutic treatments...
  8. ncbi 9th International Conference on Obesity, NIDDM, adipogenesis and insulin resistance
    S Wang
    Schering Plough Research Institute, Kenilworth, UK
    Expert Opin Investig Drugs 9:1673-8. 2000
    ..Below are meeting highlights closely related to new drug developments and drug target identification in these therapeutic areas...
  9. ncbi Identification of a novel neuromedin U receptor subtype expressed in the central nervous system
    L Shan
    Human Genome Research and Cardiovascular Central Nervous System Research, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Biol Chem 275:39482-6. 2000
    ..Based on these data, we conclude that NmU-R2 is a novel neuromedin U receptor subtype that is likely to mediate central nervous system-specific neuromedin U effects...
  10. ncbi The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization
    L Pang
    Department of CNS CV Biological Research, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Neurochem 71:2252-9. 1998
    ..Thus, the galanin receptor encoded in the cloned mouse GalR gene is the type 2 galanin receptor and is active in both ligand binding and signaling assays...
  11. ncbi Evidence for hydrophobic interaction between galanin and the GalR1 galanin receptor and GalR1-mediated ligand internalization: fluorescent probing with a fluorescein-galanin
    S Wang
    Department of CNS CV Biological Research, Schering Plough Research Institute, Kenilworth, New Jersey 07033
    Biochemistry 37:9528-35. 1998
    ....
  12. ncbi Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, mch-r2
    S Wang
    Departments of Human Genomics and Central Nervous System Biology, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Biol Chem 276:34664-70. 2001
    ..Blot hybridization revealed exclusive expression of MCH-R2 mRNA in several distinct brain regions, particularly in the cortical area, suggesting the involvement of MCH-R2 in the central regulation of MCH-mediated functions...
  13. ncbi Identification of a human gastrointestinal tract and immune system receptor for the peptide neuromedin U
    J A Hedrick
    Human Genome Research, Schering Plough Research Institute, Kenilworth, New Jersey 07033 1300, USA
    Mol Pharmacol 58:870-5. 2000
    ..In addition, we show that whereas neuromedin U is expressed by monocytes and dendritic cells, GPR66/FM-3 is expressed by T cells and NK cells. These data suggest a previously unrecognized role for NmU as an immunoregulatory molecule...
  14. ncbi Cloning and characterization of a novel human histamine receptor
    K L Morse
    Department of Human Genomics Research, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Pharmacol Exp Ther 296:1058-66. 2001
    ..In both of these assays, SP9144 exhibited evidence of constitutive activation. Taken together, these data demonstrate that SP9144 is a unique, fourth histamine receptor subtype...
  15. ncbi Purification and cloning of amyloid precursor protein beta-secretase from human brain
    S Sinha
    Elan Pharmaceuticals, South San Francisco, California 94080, USA
    Nature 402:537-40. 1999
    ..Cloning and expression of the enzyme reveals that human brain beta-secretase is a new membrane-bound aspartic proteinase...
  16. ncbi p53 gene mutations are uncommon but p53 is commonly expressed in anaplastic large-cell lymphoma
    G Z Rassidakis
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Leukemia 19:1663-9. 2005
    ..78 vs 0.91%, P = 0.0003). We conclude that the p53 gene is rarely mutated in ALK+ and ALK- ALCL tumors. Nevertheless, wild-type p53 gene product is commonly overexpressed in ALCL and may be functional in a subset of these tumors...
  17. ncbi Differentially expressed cDNAs in PLCbeta3-induced tumor suppression in a human endocrine pancreatic tumor cell line: activation of the human mismatch repair protein 3 gene
    P Stalberg
    Endocrine Oncology Unit, Department of Medical Sciences, University Hospital, Uppsala, 751 85, Sweden
    Biochem Biophys Res Commun 281:227-31. 2001
    ..Differential expression of these genes may contribute to the PLCB3-induced tumor suppression of neuroendocrine tumor cell lines...
  18. ncbi Prostate short-chain dehydrogenase reductase 1 (PSDR1): a new member of the short-chain steroid dehydrogenase/reductase family highly expressed in normal and neoplastic prostate epithelium
    B Lin
    Departments of Molecular Biotechnology, University of Washington, Seattle 98195, USA
    Cancer Res 61:1611-8. 2001
    ..These results identify a new gene involved in the androgen receptor-regulated gene network of the human prostate that may play a role in the pathogenesis of prostate carcinoma...
  19. ncbi Cloning and characterization of KLHL5, a novel human gene encoding a kelch-related protein with a BTB domain
    S Wang
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, People s Republic of China
    Biochem Genet 39:227-38. 2001
    ..Northern blot analysis reveals a single transcript. It is abundantly expressed in ovary, adrenal gland, and thyroid and less abundantly expressed in trachea, prostate, testis, lymph node, and spinal cord. KLHL5 was mapped to 4p13-4p15.1...
  20. ncbi Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS
    S Wang
    Department of Immunology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, MN 55905, USA
    Blood 96:2808-13. 2000
    ..The results indicate that B7-H2 is a putative ligand for the ICOS T-cell molecule. (Blood. 2000;96:2808-2813)..
  21. ncbi Molecular cloning and characterization of a cDNA encoding mouse phospholipase C-beta3
    S Wang
    Department of Internal Medicine, Uppsala University Hospital, S 751 85 Uppsala, Sweden
    Biochim Biophys Acta 1393:173-8. 1998
    ..The observation of PLC-beta3 nuclear localization suggests that PLC-beta3 may have intranuclear functions...
  22. ncbi Specific targeting of folate-dendrimer MRI contrast agents to the high affinity folate receptor expressed in ovarian tumor xenografts
    S D Konda
    Biomedical Magnetic Resonance Laboratory, College of Medicine, University of Illinois, Urbana, IL 61801, USA
    MAGMA 12:104-13. 2001
    ..Results suggest that a macromolecular, dendrimeric MRI agent with high molecular relaxivities (1646 mM(-1) s(-1)) can be used in specifically targeting the hFR on tumor cells and ovarian tumors...
  23. ncbi Isolation and characterization of mouse MUC18 cDNA gene, and correlation of MUC18 expression in mouse melanoma cell lines with metastatic ability
    H Yang
    Departments of Microbiology and Immunology, Emory University School of Medicine, GA 30322, Atlanta, USA
    Gene 265:133-45. 2001
    ..Most biological functions of the muMUC18 may be similar to the huMUC18...
  24. ncbi Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta
    Y R Hong
    Graduate Institute of Biochemistry, Kaohsiung Medical University, Taiwan
    Biochim Biophys Acta 1492:513-6. 2000
    ..Our findings suggest that hNinein may be involved in the formation of centrosome matrix and interacts with the GSK-3beta, implying that it may also be regulated by GSK-3beta phosphorylation signaling...
  25. ncbi Cloning, expression and chromosomal mapping of human lysosomal sialidase and characterization of mutations in sialidosis
    A V Pshezhetsky
    Departement de Pediatrie, Hopital Sainte Justine, Universite de Montreal, Quebec, Canada
    Nat Genet 15:316-20. 1997
    ..We mapped the lysosomal sialidase gene to human chromosome 6 (6p21.3), which is consistent with the previous chromosomal assignment of this gene in proximity to the HLA locus...
  26. pmc Vaccinia virus morphogenesis is blocked by temperature-sensitive mutations in the F10 gene, which encodes protein kinase 2
    S Wang
    Program in Molecular Biology, Sloan Kettering Institute, New York, New York 10021, USA
    J Virol 69:6376-88. 1995
    ..These findings suggest that protein phosphorylation plays an essential role at an early stage of virion assembly...
  27. ncbi Human mitochondrial HMG CoA synthase: liver cDNA and partial genomic cloning, chromosome mapping to 1p12-p13, and possible role in vertebrate evolution
    Y Boukaftane
    Service de Genetique Medicale, Hopital Sainte Justine, Montreal, Quebec, Canada
    Genomics 23:552-9. 1994
    ....
  28. ncbi Cloning and characterization of a Saccharomyces cerevisiae gene encoding the low molecular weight protein-tyrosine phosphatase
    K Ostanin
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907 1393, USA
    J Biol Chem 270:18491-9. 1995
    ..cerevisiae...
  29. ncbi 3-Hydroxy-3-methylglutaryl coenzyme A lyase (HL): cloning and characterization of a mouse liver HL cDNA and subchromosomal mapping of the human and mouse HL genes
    S Wang
    Service de Genetique Medicale, Hopital Sainte Justine, Montreal, Quebec, Canada
    Mamm Genome 4:382-7. 1993
    ..6 +/- 3.6 cM-Hmgcl-7.3 +/- 2.3 cM-Xmv-8-1.5 +/- 1.0 cM-Gpd-1. The human HL locus (HMGCL) was mapped to distal Chr 1p by analysis of a human-hamster hybrid cell panel and by in situ hybridization...
  30. ncbi cDNA cloning and expression of stress-inducible rat hsp70 in normal and injured rat brain
    F M Longo
    Department of Neurology V127, University of California, San Francisco
    J Neurosci Res 36:325-35. 1993
    ..Since there are at least five human and six mouse inducible hsp70 genes known, many other rat hsp70 genes probably exist that could function in different cells or organelles or be induced under different circumstances...
  31. pmc Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor
    S Wang
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755
    Mol Cell Biol 13:3324-39. 1993
    ..Association of the CBF beta subunits does not extend the phosphate contacts in the binding site. We propose that CBF beta is a non-DNA-binding subunit of CBF and does not contact DNA directly...
  32. ncbi A novel G protein-coupled P2 purinoceptor (P2Y3) activated preferentially by nucleoside diphosphates
    T E Webb
    Molecular Neurobiology Unit, Royal Free Hospital School of Medicine, London, UK
    Mol Pharmacol 50:258-65. 1996
    ..The results indicated that P2Y3 is a previously unknown P2 purinoceptor subtype with a preference for nucleoside diphosphates...
  33. ncbi Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase
    X S Wang
    Amgen Inc, Boulder, Colorado 80301, USA
    J Biol Chem 272:23668-74. 1997
    ..Taken together, these data indicate that p38delta is a new member of the p38 MAPK family and that p38delta likely has functions distinct from that of p38alpha...
  34. ncbi Molecular cloning and characterization of a cDNA encoding the rat interleukin-8 receptor
    A E Gobl
    Department of Internal Medicine, University Hospital, Uppsala, Sweden
    Biochim Biophys Acta 1326:171-7. 1997
    ..IL-8R mRNA containing cells were predominately found in the mantle zone of the germinal center. These cells were identified as B lymphocytes using the OX-33 monoclonal antibody...
  35. pmc HMG CoA lyase deficiency: identification of five causal point mutations in codons 41 and 42, including a frequent Saudi Arabian mutation, R41Q
    G A Mitchell
    Service de Genetique Medicale, Hopital Sainte Justine, Montreal, Quebec H3T 1C5, Canada
    Am J Hum Genet 62:295-300. 1998
    ..Codons 41 and 42 are important for normal HL catalysis and account for a disproportionate 21 (26%) of 82 of mutant alleles in our group of HL-deficient probands...
  36. ncbi The human connexin32 gene is transcribed from two tissue-specific promoters
    I M Neuhaus
    Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Florida 33101, USA
    Biosci Rep 16:239-48. 1996
    ..CMTX1 patients with a normal cx32 coding region are expected to have mutations in this newly described promoter P2 rather than the known promoter P1...
  37. ncbi Esophagin cDNA cloning and characterization: a tissue-specific member of the small proline-rich protein family that is not expressed in esophageal tumors
    J M Abraham
    Department of Medicine Gastroenterology Division, University of Maryland School of Medicine, Baltimore 21201, USA
    Cell Growth Differ 7:855-60. 1996
    ..Esophagin constitutes the newest and largest member of this small proline-rich gene family and is associated with differentiation and the benign phenotype of the human esophageal epithelial cell...
  38. ncbi Increased fatty acid oxidation in transgenic mice overexpressing UCP3 in skeletal muscle
    S Wang
    Clore Laboratory, University of Buckingham, Buckingham, UK
    Diabetes Obes Metab 5:295-301. 2003
    ..To determine the rates of substrate oxidation by skeletal muscle in vitro as well as tissue-specific glucose uptake in vivo in transgenic mice overexpressing uncoupling protein-3 (UCP3) in skeletal muscle...
  39. pmc Age-related bias in function of natural killer T cells and granulocytes after stress: reciprocal association of steroid hormones and sympathetic nerves
    K Sagiyama
    Department of Immunology, Niigata University School of Medicine, Niigata, Japan
    Clin Exp Immunol 135:56-63. 2004
    ....
  40. ncbi Polyphosphoramidate gene carriers: effect of charge group on gene transfer efficiency
    J Wang
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Gene Ther 11:1001-10. 2004
    ..These results establish that PPA gene carriers with primary amino group side chains are more potent than those with secondary, tertiary or quaternary amino groups in vitro and in the intrathecal gene delivery model...
  41. ncbi [Effects of blood transfusion on cellular immuno-function in patients with laryngeal carcinoma]
    J Wang
    Department of Otolaryngology, First People's Hospital, Shanghai 200080
    Lin Chuang Er Bi Yan Hou Ke Za Zhi 15:103-5. 2001
    ..05). CONCLUSION: While cellular immunofunction is generally low in patients with laryngeal carcinoma, allotransfusion will reduce further. It makes contribution to spreading and metastasis of carcinoma easier...
  42. ncbi A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33
    G Whitney
    Inflammation and Pulmonary Drug Discovery Department, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA
    Eur J Biochem 268:6083-96. 2001
    ..This is very similar to CD33, which also binds the phosphatases SHP-1 and SHP-2, therefore siglec-10, as CD33, may be characterized as an inhibitory receptor...
  43. ncbi Leukotriene A4 hydrolase as a target for cancer prevention and therapy
    X Chen
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, New Jersey 08854, USA
    Curr Cancer Drug Targets 4:267-83. 2004
    ..g., cyclooxygenase 2 inhibitors) in cancer prevention and treatment trials to test their effectiveness...
  44. ncbi Proteinase inhibitor 9, an inhibitor of granzyme B-mediated apoptosis, is a primary estrogen-inducible gene in human liver cells
    H Kanamori
    Department of Biochemistry, University of Illinois, Urbana, Illinois 61801, USA
    J Biol Chem 275:5867-73. 2000
    ..Mutational inactivation of three potential imperfect estrogen response elements in the PI-9 5'-flanking region had no effect on moxestrol estrogen receptor induction...
  45. ncbi Synthesis and characterization of thermoset biodegradable elastomers based on star-poly(epsilon-caprolactone-co-D,L-lactide)
    B Amsden
    Department of Chemical Engineering, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Biomacromolecules 5:1399-404. 2004
    ..The results demonstrate a means of predictably altering the elastomer physical properties by adjusting the star copolymer prepolymer initial molecular weight and monomer ratio...
  46. ncbi Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome
    A Patapoutian
    Division of Biology 156 29, California Institute of Technology, Pasadena 91125, USA
    Development 121:3347-58. 1995
    ..Finally, a later and relatively mild phenotype was detected in intercostal muscles of newborn animals...
  47. ncbi Low molecular weight polyethylenimines linked by beta-cyclodextrin for gene transfer into the nervous system
    G P Tang
    Institute of Bioengineering and Nanotechnology, Singapore
    J Gene Med 8:736-44. 2006
    ..In the present study we developed and tested a new PEI polymer synthesized by linking less toxic, low molecular weight (MW) PEIs with a commonly used, biocompatible drug carrier, beta-cyclodextrin (CyD)...
  48. ncbi Transient appearance of hepatic natural killer cells with high cytotoxicity and unique phenotype in very young mice
    X Bai
    Department of Immunology, Niigata University School of Medicine, Niigata, Japan
    Scand J Immunol 63:275-81. 2006
    ..Namely, liver NK cells in very young mice temporarily show the highest NK cytotoxicity and a unique activated phenotype. Physiological meaning of the present phenomenon was discussed...
  49. ncbi "HAIRY CANOLA"--Arabidopsis GL3 induces a dense covering of trichomes on Brassica napus seedlings
    M Y Gruber
    Agriculture and Agri Food Canada, Saskatoon Research Centre, 107 Science Place, Saskatoon, SK S7N 0X2, Canada
    Plant Mol Biol 60:679-98. 2006
    ..napus may be regulated differently from Arabidopsis. They also imply that insertion of GL3 into Brassica species under a tissue-specific promoter has strong potential for developing insect-resistant crop plants...
  50. ncbi GAL4-NF-kappaB fusion protein augments transgene expression from neuronal promoters in the rat brain
    B H Liu
    Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, 138669, Singapore
    Mol Ther 14:872-82. 2006
    ..This approach should be suitable for constructing powerful and stable gene expression systems based on weak cell-specific promoters in neuronal phenotypes...
  51. ncbi Extracellular hmgb1 functions as an innate immune-mediator implicated in murine cardiac allograft acute rejection
    Y Huang
    Laboratory of Transplantation, Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Am J Transplant 7:799-808. 2007
    ..The enhanced graft survival is associated with reduced allograft expression of TNFalpha, IFNgamma and Hmgb1 and impaired Th1 immune response...
  52. ncbi Nephrin is expressed in the pancreatic beta cells
    T Palmen
    Haartman Institute, Division of Bacteriology and Immunology, University of Helsinki, and Helsinki University Central Hospital Helsinki, Finland
    Diabetologia 44:1274-80. 2001
    ..The aim of this study was to describe the expression of nephrin mRNA and protein in human pancreas as well as identify the nephrin-expressing cell types...
  53. ncbi Differential expression and functional analysis of Pitx2 isoforms in regulation of heart looping in the chick
    X Yu
    Department of Cell and Molecular Biology, Molecular and Cell Biology Graduate Program and Center for Bioenvironmetal Research, Tulane University, New Orleans, LA 70118, USA
    Development 128:1005-13. 2001
    ..The results thus demonstrate that Pitx2c plays a crucial role in the left-right axis determination and rightward heart looping during chick embryogenesis...
  54. ncbi In vivo requirement for the paired domain and homeodomain of the paired segmentation gene product
    C Bertuccioli
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Development 122:2673-85. 1996
    ....
  55. ncbi Identification and analysis of the human and murine putative chromatin structure regulator SUPT6H and Supt6h
    P W Chiang
    Department of Pediatrics, University of Michigan Medical Center, Ann Arbor 48109, USA
    Genomics 34:328-33. 1996
    ..These data indicate that SUPT6H and Supt6h are functionally analogous to SPT6 and emb-5 and may therefore regulate transcription through establishment or maintenance of chromatin structure...
  56. pmc beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain
    M J Caloca
    Center for Experimental Therapeutics, Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    Proc Natl Acad Sci U S A 96:11854-9. 1999
    ..Our results demonstrate that beta2-chimaerin is a high affinity receptor for DAG through binding to its C1 domain and supports the emerging concept that multiple pathways transduce signaling through DAG and the phorbol esters...
  57. ncbi 3-Hydroxy-3-methylglutaryl coenzyme A lyase (HL). Cloning of human and chicken liver HL cDNAs and characterization of a mutation causing human HL deficiency
    G A Mitchell
    Section de Génétique Médicale, Hopital Ste Justine, Montreal, Quebec, Canada
    J Biol Chem 268:4376-81. 1993
    ..S69fs(-2) was not present in 12 other HL-deficient patients of 10 other ethnic origins, showing that HL deficiency is genetically heterogeneous...
  58. ncbi Mutations in the connexin 32 gene in X-linked dominant Charcot-Marie-Tooth disease (CMTX1)
    N Fairweather
    Department of Molecular and Cell Biology, University of Aberdeen, Medical School, UK
    Hum Mol Genet 3:29-34. 1994
    ..These findings are consistent with the disease CMTX1 being the result of mutations affecting the gene connexin 32 (Cx32)...
  59. pmc Amino acid sequence for the peptide extension on the prolipoprotein of the Escherichia coli outer membrane
    S Inouye
    Proc Natl Acad Sci U S A 74:1004-8. 1977
    ..The significance of the amino acid sequence is discussed in terms of the mechanism of biosynthesis and assembly of the lipoprotein in the E. coli outer membrane...
  60. ncbi Identification and functional characterization of DR6, a novel death domain-containing TNF receptor
    G Pan
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA
    FEBS Lett 431:351-6. 1998
    ..DR6 interacts with TRADD, which has previously been shown to associate with TNFR1. Furthermore, ectopic expression of DR6 in mammalian cells induces apoptosis and activation of both NF-kappaB and JNK...
  61. ncbi Characterization of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 ORF57 promoter
    W Duan
    School of Biological Sciences, University of Nebraska, Lincoln, Nebraska, USA
    Arch Virol 146:403-13. 2001
    ..Our study on the regulation of ORF57 expression by ORF50 provides the basis for further studies on the regulation of HHV-8 lytic gene expression...
  62. pmc Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells
    P E Paz
    Onyx Pharmaceuticals, 3031 Research Drive, Richmond, CA 94806, USA
    Biochem J 356:461-71. 2001
    ..Furthermore, by expression of LAT mutants in LAT-deficient T cells, we demonstrate that Tyr(191) and Tyr(171) are required for T-cell activation and Tyr(132) is required for the activation of PLCgamma1 and Ras signalling pathways...
  63. pmc The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling
    K Lin
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:11196-200. 1997
    ..Interestingly, Frzb-1 does not block Wnt-5A signaling in a Xenopus functional assay, even though Wnt-5A coimmunoprecipitates with Frzb-1, suggesting that coimmunoprecipitation does not necessarily imply inhibition of Wnt function...
  64. ncbi Protein kinase C epsilon-Src modules direct signal transduction in nitric oxide-induced cardioprotection: complex formation as a means for cardioprotective signaling
    T M Vondriska
    Department of Physiology, Division of Cardiology, University of Louisville, Louisville, KY, USA
    Circ Res 88:1306-13. 2001
    ....
  65. ncbi Cloning of rat grp75, an hsp70-family member, and its expression in normal and ischemic brain
    S M Massa
    Department of Neurology, University of California, San Francisco, USA
    J Neurosci Res 40:807-19. 1995
    ..However, when the injury is extensive, hsr is upregulated in neurons outside the ischemic area. The induction of grp75 may represent a sensitive marker of metabolically compromised tissue...
  66. ncbi Functional interaction of Jun and homeodomain proteins
    L K Schaefer
    Department of Neurosurgery, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 276:43074-82. 2001
    ..We conclude that the functional interaction between members of the Jun and homeodomain families of transcription factors could play a critical role in regulating developmental and differentiation programs...
  67. ncbi Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 ORF50 gene product contains a potent C-terminal activation domain which activates gene expression via a specific target sequence
    S Wang
    Nebraska Center for Virology School of Biological Sciences, University of Nebraska, Lincoln 68588-0666, USA
    Arch Virol 146:1415-26. 2001
    ..How the ART activation domain activates ORF57 and K8 gene expression through the 16-bp consensus sequence remains to be determined...
  68. pmc Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice
    R E Young
    Cardiovascular Medicine Unit, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK
    Br J Pharmacol 151:628-37. 2007
    ..The present study aimed to address this issue by using both an NE inhibitor (ONO-5046) and NE deficient (NE(-/-)) mice...