Ruth Santacreu

Summary

Country: USA

Publications

  1. pmc Association between Pre-Transplant Serum Malondialdehyde Levels and Survival One Year after Liver Transplantation for Hepatocellular Carcinoma
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, S N, La Laguna, Santa Cruz de Tenerife 38320, Spain
    Int J Mol Sci 17:500. 2016
  2. pmc Association between Interleukin-6 Promoter Polymorphism (-174 G/C), Serum Interleukin-6 Levels and Mortality in Severe Septic Patients
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, S N, La Laguna, 38320 Santa Cruz de Tenerife, Spain
    Int J Mol Sci 17:. 2016
  3. pmc Prognostic Value of Serum Caspase-Cleaved Cytokeratin-18 Levels before Liver Transplantation for One-Year Survival of Patients with Hepatocellular Carcinoma
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s n La Laguna, Tenerife 38320, Spain
    Int J Mol Sci 17:. 2016
  4. doi request reprint Chlorhexidine-silver sulfadiazine-impregnated venous catheters are efficient even at subclavian sites without tracheostomy
    Leonardo Lorente
    Department of Critical Care, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain Electronic address
    Am J Infect Control 44:1526-1529. 2016
  5. pmc Serum Levels of Substance P and Mortality in Patients with a Severe Acute Ischemic Stroke
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s n La Laguna, Tenerife 38320, Spain
    Int J Mol Sci 17:. 2016
  6. doi request reprint Serum caspase 3 levels are associated with early mortality in severe septic patients
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s n La Laguna, 38320, Tenerife, Spain Electronic address
    J Crit Care 34:103-6. 2016
  7. pmc Association between total antioxidant capacity and mortality in ischemic stroke patients
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, S N, 38320, La Laguna, Santa Cruz de Tenerife, Spain
    Ann Intensive Care 6:39. 2016
  8. doi request reprint Septic patients with mitochondrial DNA haplogroup JT have higher respiratory complex IV activity and survival rate
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, S N, La Laguna 38320, Santa Cruz de Tenerife, Spain Electronic address
    J Crit Care 33:95-9. 2016
  9. doi request reprint Association between serum substance P levels and mortality in patients with severe sepsis
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, La Laguna, Tenerife, Spain Electronic address
    J Crit Care 30:924-8. 2015
  10. doi request reprint Decrease of oxidative phosphorylation system function in severe septic patients
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s n La Laguna, 38320, Santa Cruz de Tenerife, Spain Electronic address
    J Crit Care 30:935-9. 2015

Collaborators

  • Jose Blanquer
  • Jose A Paramo
  • Josune Orbe
  • Nicolás Serrano
  • M J Ramos
  • Antonio Gonzalez
  • Nerea Varo
  • Maria Lecuona
  • C Garcia
  • Jose R Perez
  • Alberto Dominguez-Rodriguez
  • A Rodriguez
  • J Rello
  • J Martinez
  • J Valles
  • M A Rodriguez
  • Stijn I Blot
  • M Martin
  • Leonardo Lorente
  • Alejandro Jimenez
  • Maria L Mora
  • Jordi Sole-Violan
  • L Lorente
  • César Díaz
  • Lorenzo Labarta
  • José Ferreres
  • Juan M Borreguero-León
  • Luis Ramos
  • Mónica Argüeso
  • M L Mora
  • A Jimenez
  • Pedro Abreu-Gonzalez
  • Antonio Sierra
  • Juan J Cáceres
  • Teresa Almeida
  • Eduardo Ruiz-Pesini
  • Julio Montoya
  • Jose A Rodriguez
  • Antonia Pérez-Cejas
  • Judith Cabrera
  • Lisset Lorenzo
  • José Luis Iribarren
  • Juan José Jiménez
  • Marta Riaño-Ruiz
  • Sergio T Rodríguez
  • Mariano Hernandez
  • Lorena Raja
  • Juan J Jimenez
  • Jose L Iribarren
  • Juan María Borreguero-León
  • Esther López-Gallardo
  • I Roca
  • Ruth Iceta
  • Santiago Lubillo
  • Ysamar Barrios
  • José M Ferrer-Agüero
  • Maria C Llimiñana
  • Dácil Díaz
  • Pablo Sanz
  • Manuel A Barrera
  • Ester López-Gallardo
  • Sara Diosdado
  • Oswaldo Gonzalez
  • Lucía Marca
  • Agustín F González-Rivero
  • Ramón Galván
  • N Lafuente
  • E Pastor
  • A Sierra
  • S Palmero
  • C Naranjo
  • M T Brouard
  • J J Jimenez
  • Felipe Belmonte
  • R Galvan
  • J Castedo
  • Juan J Jimenez Rivera
  • Melitón Santana
  • Rafael Martinez
  • Rosalia Perez
  • Juan Castedo
  • Maitane Brouard
  • Ibrahim Nassar
  • Elisa Borja
  • Javier Padilla
  • Antonia M Moreno
  • Thais de la Cruz
  • Eva Hurtado
  • Silvia Ramos
  • Manuel Buitrago

Detail Information

Publications74

  1. pmc Association between Pre-Transplant Serum Malondialdehyde Levels and Survival One Year after Liver Transplantation for Hepatocellular Carcinoma
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, S N, La Laguna, Santa Cruz de Tenerife 38320, Spain
    Int J Mol Sci 17:500. 2016
    ..580 to infinite; p = 0.007) adjusting for age of the deceased donor. The main finding of our study was that there is an association between serum MDA levels before LT for HCC and 1-year survival after LT. ..
  2. pmc Association between Interleukin-6 Promoter Polymorphism (-174 G/C), Serum Interleukin-6 Levels and Mortality in Severe Septic Patients
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, S N, La Laguna, 38320 Santa Cruz de Tenerife, Spain
    Int J Mol Sci 17:. 2016
    ..28; 95% CI = 0.074-1.037; p = 0.06). The most important results of our study were that CC might be a favorable genotype in septic patients showing lower serum IL-6 levels and lower risk of death within 30 days...
  3. pmc Prognostic Value of Serum Caspase-Cleaved Cytokeratin-18 Levels before Liver Transplantation for One-Year Survival of Patients with Hepatocellular Carcinoma
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s n La Laguna, Tenerife 38320, Spain
    Int J Mol Sci 17:. 2016
    ..001). The new finding of our study was that serum levels of CCCK-18 before LT in patients with HCC could be used as prognostic biomarker of survival. ..
  4. doi request reprint Chlorhexidine-silver sulfadiazine-impregnated venous catheters are efficient even at subclavian sites without tracheostomy
    Leonardo Lorente
    Department of Critical Care, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain Electronic address
    Am J Infect Control 44:1526-1529. 2016
    ..That was the objective of this study...
  5. pmc Serum Levels of Substance P and Mortality in Patients with a Severe Acute Ischemic Stroke
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s n La Laguna, Tenerife 38320, Spain
    Int J Mol Sci 17:. 2016
    ..541-18.470; p = 0.008) after controlling for age and GCS. Thus, the major novel finding of our study was the association between serum levels of SP and mortality in patients suffering from severe acute ischemic stroke. ..
  6. doi request reprint Serum caspase 3 levels are associated with early mortality in severe septic patients
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s n La Laguna, 38320, Tenerife, Spain Electronic address
    J Crit Care 34:103-6. 2016
    ..However, an association between serum caspase 3 levels at moment of severe sepsis diagnosis and mortality in septic patients has not been previously demonstrated, and this was the main objective of the present study...
  7. pmc Association between total antioxidant capacity and mortality in ischemic stroke patients
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, S N, 38320, La Laguna, Santa Cruz de Tenerife, Spain
    Ann Intensive Care 6:39. 2016
    ..The objective of this study was to examine the relationship of TAC with 30-day mortality after severe ischemic stroke...
  8. doi request reprint Septic patients with mitochondrial DNA haplogroup JT have higher respiratory complex IV activity and survival rate
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, S N, La Laguna 38320, Santa Cruz de Tenerife, Spain Electronic address
    J Crit Care 33:95-9. 2016
    ..However, the association between mtDNA haplogroup, OXPHOS capacity at diagnosis of severe sepsis, and survival has been not previously reported, and that was the objective of the present study...
  9. doi request reprint Association between serum substance P levels and mortality in patients with severe sepsis
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, La Laguna, Tenerife, Spain Electronic address
    J Crit Care 30:924-8. 2015
    ..The main goal of this study was to determine a possible relationship between serum SP levels and patient outcome in the largest cohort of severe septic patients analyzed so far...
  10. doi request reprint Decrease of oxidative phosphorylation system function in severe septic patients
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s n La Laguna, 38320, Santa Cruz de Tenerife, Spain Electronic address
    J Crit Care 30:935-9. 2015
    ..Thus, the objective of this study was to compare platelet respiratory complex IV (CIV) activity between severe septic patients and healthy individuals in a larger series (including 198 severe septic patients and 96 healthy controls)...
  11. doi request reprint Serum melatonin levels are associated with mortality in severe septic patients
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s n La Laguna, 38320, Santa Cruz de Tenerife, Spain Electronic address
    J Crit Care 30:860.e1-6. 2015
    ..Thus, the objective of this study was to determine whether serum melatonin levels are associated with severity, oxidant and inflammatory state, and mortality in a large series of septic patients...
  12. doi request reprint Efficiency of chlorhexidine-silver sulfadiazine-impregnated venous catheters at subclavian sites
    Leonardo Lorente
    Department of Critical Care, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain Electronic address
    Am J Infect Control 43:711-4. 2015
    ..This study determined the cost of a CVC, diagnosis of CRBSI, and antimicrobial agents to treat CRBSI; we did not consider the cost of increased hospital stay...
  13. pmc Association between Serum Soluble CD154 Levels and Mortality in Patients with Malignant Middle Cerebral Artery Infarction
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, La Laguna 38320, Spain
    Int J Mol Sci 16:12147-58. 2015
    ..However, the association between circulating sCD154 levels and mortality in ischemic stroke patients has not been reported, and was the focus of this study...
  14. pmc Serum tissue inhibitor of matrix metalloproteinase-1 levels are associated with mortality in patients with malignant middle cerebral artery infarction
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s n La Laguna, 38320, Santa Cruz de Tenerife, Spain
    BMC Neurol 15:111. 2015
    ..In addition, to our knowledge, serum MMP-9, MMP-10 and TIMP-1 levels in patients with malignant middle cerebral artery infarction (MMCAI) for mortality prediction have not been studied, and these were the objectives of this study...
  15. pmc Serum substance P levels are associated with severity and mortality in patients with severe traumatic brain injury
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s n La Laguna, 38320, Tenerife, Spain
    Crit Care 19:192. 2015
    ..Thus, the main goal of the present study was to determine whether serum SP levels are associated with injury severity and mortality in patients with severe TBI...
  16. pmc Total antioxidant capacity is associated with mortality of patients with severe traumatic brain injury
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s n La Laguna, 38320, Santa Cruz de Tenerife, Spain
    BMC Neurol 15:115. 2015
    ..Thus, the objective of this study was to determine whether there is an association between circulating TAC, peroxidation state and mortality in patients with severe TBI...
  17. pmc Serum caspase-3 levels and mortality are associated in patients with severe traumatic brain injury
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s n La Laguna, 38320, Santa Cruz de Tenerife, Spain
    BMC Neurol 15:228. 2015
    ....
  18. doi request reprint Chlorhexidine-silver sulfadiazine- or rifampicin-miconazole-impregnated venous catheters decrease the risk of catheter-related bloodstream infection similarly
    Leonardo Lorente
    Department of Critical Care, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain Electronic address
    Am J Infect Control 44:50-3. 2016
    ....
  19. doi request reprint Serum soluble CD40 Ligand levels are associated with severity and mortality of brain trauma injury patients
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s n La Laguna 38320, Santa Cruz de Tenerife, Spain Electronic address
    Thromb Res 134:832-6. 2014
    ..Thus, the objective of this study was to determine whether serum sCD40L levels are associated with severity and mortality in patients with severe TBI...
  20. doi request reprint Subglottic secretion drainage and continuous control of cuff pressure used together save health care costs
    Leonardo Lorente
    Department of Critical Care, University Hospital of the Canary Islands, La Laguna, Tenerife, Spain Electronic address
    Am J Infect Control 42:1101-5. 2014
    ..The objective of this study was to determine whether the simultaneous use of these 2 preventive measures for VARI could save health care costs...
  21. doi request reprint Cost/benefit analysis of chlorhexidine-silver sulfadiazine-impregnated venous catheters for femoral access
    Leonardo Lorente
    Department of Critical Care, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, Spain Electronic address
    Am J Infect Control 42:1130-2. 2014
    ....
  22. doi request reprint Association between serum total antioxidant capacity and mortality in severe septic patients
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, Spain Electronic address
    J Crit Care 30:217.e7-12. 2015
    ..We aimed at assessing a possible relationship between TAC serum levels and mortality using a large cohort of patients with severe sepsis...
  23. doi request reprint Sustained high plasma plasminogen activator inhibitor-1 levels are associated with severity and mortality in septic patients
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, Spain Electronic address
    Thromb Res 134:182-6. 2014
    ..However, some questions remain unanswered, such as whether there is an association between plasma PAI-1 levels and sepsis severity and mortality, and inflammation state during the first week...
  24. pmc Severe septic patients with mitochondrial DNA haplogroup JT show higher survival rates: a prospective, multicenter, observational study
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, Spain
    PLoS ONE 8:e73320. 2013
    ....
  25. pmc Association between serum tissue inhibitor of matrix metalloproteinase-1 levels and mortality in patients with severe brain trauma injury
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain
    PLoS ONE 9:e94370. 2014
    ..Thus, the aim of this study was to determine whether serum TIMP-1 and MMP-9 levels are associated with mortality in patients with severe TBI...
  26. pmc Association of sepsis-related mortality with early increase of TIMP-1/MMP-9 ratio
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, Spain
    PLoS ONE 9:e94318. 2014
    ....
  27. doi request reprint Chlorhexidine-silver sulfadiazine-impregnated venous catheters save costs
    Leonardo Lorente
    Department of Critical Care, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain Electronic address
    Am J Infect Control 42:321-4. 2014
    ..However, in these analyses, the CVC-related cost included the increase of hospital stay...
  28. doi request reprint Lesser incidence of accidental catheter removal with femoral versus radial arterial access
    L Lorente
    Department of Intensive Care, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, Spain
    Med Intensiva 37:316-9. 2013
    ..Few data are available on accidental arterial catheter removal, and no studies have been found comparing the incidence of ACR between different arterial catheter sites...
  29. pmc Prognostic value of malondialdehyde serum levels in severe sepsis: a multicenter study
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, Spain
    PLoS ONE 8:e53741. 2013
    ..We wished to determine whether malondialdehyde (MDA) serum levels were associated with severity and 30-day mortality in a large series of patients with sepsis...
  30. ncbi request reprint Ventilator-associated pneumonia with or without toothbrushing: a randomized controlled trial
    L Lorente
    Department of Critical Care, Hospital Universitario de Canarias, Ofra s n La Cuesta, La Laguna, 38320 Santa Cruz de Tenerife, Spain
    Eur J Clin Microbiol Infect Dis 31:2621-9. 2012
    ..87, 95 % confidence interval [CI] = 0.469-1.615; p = 0.75). Adding manual toothbrushing to chlorhexidine oral care does not help to prevent VAP in critical care patients on mechanical ventilation...
  31. doi request reprint Rifampicin-miconazole-impregnated catheters save cost in jugular venous sites with tracheostomy
    L Lorente
    Department of Critical Care, Hospital Universitario de Canarias, Ofra s n La Cuesta, La Laguna, 38320, Santa Cruz de Tenerife, Spain
    Eur J Clin Microbiol Infect Dis 31:1833-6. 2012
    ..The results of our study may contribute to clinical decision-making and selection of those patients who could benefit from the use of antimicrobial-impregnated catheters...
  32. pmc Survival and mitochondrial function in septic patients according to mitochondrial DNA haplogroup
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, La Laguna 38320, Santa Cruz de Tenerife, Spain
    Crit Care 16:R10. 2012
    ..Given that COX catalytic subunits are encoded by mtDNA, the objective of the present study was to explore whether mtDNA population genetic variation could affect COX activity and quantity and favors sepsis survival...
  33. doi request reprint Lower catheter-related bloodstream infection in arterial than in venous femoral catheter
    L Lorente
    Department of Intensive Care, Hospital Universitario de Canarias, 38320, La Laguna, Tenerife
    Eur J Clin Microbiol Infect Dis 31:487-90. 2012
    ..The novel finding of our study is that the risk of CRBSI was higher in venous than in arterial femoral catheters. Thus, special approaches to prevent CRBSI might play a more important role in venous than in arterial catheters...
  34. pmc Factors associated with excessive bleeding in cardiopulmonary bypass patients: a nested case-control study
    Juan J Jimenez Rivera
    Intensive Care Unit, University Hospital of Canary Islands, La Laguna, Spain
    J Cardiothorac Surg 2:17. 2007
    ..Less than 50% of patients undergoing re-intervention exhibit surgical sources of bleeding. We studied clinical and genetic factors associated with EB...
  35. pmc Tranexamic acid attenuates inflammatory response in cardiopulmonary bypass surgery through blockade of fibrinolysis: a case control study followed by a randomized double-blind controlled trial
    Juan J Jimenez
    Intensive Care Department, Hospital Universitario de Canarias, Ofra s n La Cuesta, La Laguna, 38320, Spain
    Crit Care 11:R117. 2007
    ..Tranexamic acid (TA) reduces fibrinolysis and blood loss after cardiopulmonary bypass (CPB). However, its effects on IR and vasoplegic shock (VS) are not well known and elucidating these effects was the main objective of this study...
  36. doi request reprint Higher arterial catheter-related infection rates in femoral than in dorsalis pedis access
    L Lorente
    Department of Intensive Care, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain
    J Hosp Infect 74:365-9. 2010
    ..6; 95% confidence interval: 1.37-infinite; P=0.01). These results suggest that dorsalis pedis arterial access should be used in preference to femoral arterial access in order to reduce the risk of ACRI...
  37. pmc Arterial catheter-related infection of 2,949 catheters
    Leonardo Lorente
    Department of Intensive Care, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain
    Crit Care 10:R83. 2006
    ..The objective of the present study was to analyze the incidence of catheter-related local infection (CRLI) and catheter-related bloodstream infection (CRBSI) of arterial catheters according to different access sites...
  38. ncbi request reprint Catheter-related infection in critically ill patients
    Leonardo Lorente
    Department of Intensive Care, Hospital Universitario de Canarias, Ofra s n La Cuesta, 38320 La Laguna, Santa Cruz de Tenerife, Spain
    Intensive Care Med 30:1681-4. 2004
    ..To describe the incidence of the catheter-related local infection (CRLI) and catheter-related bloodstream infection (CRBSI) of central venous catheters (CVCs) and arterial catheters (ACs)...
  39. doi request reprint Catheter-related bacteremia from femoral and central internal jugular venous access
    L Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra s n La Cuesta, La Laguna, Santa Cruz de Tenerife, Spain
    Eur J Clin Microbiol Infect Dis 27:867-71. 2008
    ..93; 95% confidence interval: 1.03-3.73; P = 0.04). Central internal jugular venous access could be considered a safer route of venous access than femoral access in minimizing the risk of central venous catheter-related bacteremia...
  40. ncbi request reprint Comparison of clinical cure rates in adults with ventilator-associated pneumonia treated with intravenous ceftazidime administered by continuous or intermittent infusion: a retrospective, nonrandomized, open-label, historical chart review
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias Ofra s n, La Cuesta, La Laguna 38320, Tenerife, Spain
    Clin Ther 29:2433-9. 2007
    ..Beta-lactam antibiotics are reported to exhibit time-dependent bactericidal activity. However, there are limited data on the clinical efficacy of ceftazidime administered by continuous infusion...
  41. ncbi request reprint Evidence on measures for the prevention of ventilator-associated pneumonia
    L Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, C Ofra s n, La Laguna, Tenerife, 38320, Spain
    Eur Respir J 30:1193-207. 2007
    ..The present review article is useful for identifying evidence-based processes that can be modified to improve patients' safety...
  42. ncbi request reprint Influence of an endotracheal tube with polyurethane cuff and subglottic secretion drainage on pneumonia
    Leonardo Lorente
    Department of Critical Care, Hospital Universitario de Canarias, Ofra s n, La Cuesta, La Laguna 38320, Santa Cruz de Tenerife, Spain
    Am J Respir Crit Care Med 176:1079-83. 2007
    ....
  43. ncbi request reprint Microorganisms responsible for intravascular catheter-related bloodstream infection according to the catheter site
    Leonardo Lorente
    Department of Intensive Care and Research Unit, Hospital Universitario de Canarias, Tenerife, Spain
    Crit Care Med 35:2424-7. 2007
    ..We therefore compared the proportion of IVC-RBSI due to Gram-negative bacteria and yeasts according to catheter site...
  44. ncbi request reprint Internal jugular venous catheter-related bacteremia according to central and posterior accesses
    Leonardo Lorente
    Hospital Universitario de Canarias, Intensive Care Unit, Ofra s n, La Cuesta, La Laguna, 38320 Santa Cruz de Tenerife, Spain
    Intensive Care Med 33:1071-5. 2007
    ..Although there are many studies about central venous catheter-related infection, we have not found any analysis of the incidence of internal jugular venous catheter-related bacteremia associated with different accesses...
  45. pmc Ventilator-associated pneumonia using a heated humidifier or a heat and moisture exchanger: a randomized controlled trial [ISRCTN88724583]
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain
    Crit Care 10:R116. 2006
    ..The aim of this study was to determine the incidence of VAP associated with HHs or HMEs...
  46. ncbi request reprint Tracheal suction by closed system without daily change versus open system
    Leonardo Lorente
    Department of Critical Care, Hospital Universitario de Canarias, Ofra s n, La Cuesta, La Laguna, 38320, Santa Cruz de Tenerife, Spain
    Intensive Care Med 32:538-44. 2006
    ..However, is it necessary to change the closed system daily?..
  47. ncbi request reprint Meropenem by continuous versus intermittent infusion in ventilator-associated pneumonia due to gram-negative bacilli
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Tenerife, Spain
    Ann Pharmacother 40:219-23. 2006
    ..However, limited data exist on the clinical efficacy of meropenem administered by continuous infusion...
  48. pmc Central venous catheter-related infection in a prospective and observational study of 2,595 catheters
    Leonardo Lorente
    Department of Intensive Care, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, Spain
    Crit Care 9:R631-5. 2005
    ..The objective of this study was to analyze the incidence of catheter-related local infection (CRLI) and catheter-related bloodstream infection (CRBSI) with central venous catheters (CVCs) according to different access sites...
  49. pmc Accidental catheter removal in critically ill patients: a prospective and observational study
    Leonardo Lorente
    Staff Intensivist, Department of Intensive Care, Hospital Universitario de Canarias, Tenerife, Spain
    Crit Care 8:R229-33. 2004
    ..The objective of the present study was to analyze the incidence of ACR for all types of catheters in the ICU...
  50. doi request reprint The use of rifampicin-miconazole-impregnated catheters reduces the incidence of femoral and jugular catheter-related bacteremia
    Leonardo Lorente
    Department of Critical Care, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, Spain
    Clin Infect Dis 47:1171-5. 2008
    ..In previous studies, we have found a higher incidence of central venous catheter-related bacteremia among patients with femoral and central jugular accesses than among patients with other venous accesses...
  51. ncbi request reprint The management of acute lower respiratory tract infection
    L Lorente
    Department of Critical Care, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain
    Minerva Med 99:459-81. 2008
    ....
  52. doi request reprint Clinical cure of ventilator-associated pneumonia treated with piperacillin/tazobactam administered by continuous or intermittent infusion
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra s n, La Cuesta, La Laguna 38320, Tenerife, Spain
    Int J Antimicrob Agents 33:464-8. 2009
    ....
  53. doi request reprint Lower arterial catheter-related infection in brachial than in femoral access
    Leonardo Lorente
    Department of Intensive Care, Hospital Universitario de Canarias, Ofra s n, La Laguna, Santa Cruz de Tenerife, Spain
    Am J Infect Control 38:e40-2. 2010
    ..08 vs 0 per 1000 catheter-days, respectively; odds ratio, 6.18; 95% confidence interval: 1.11-infinite; P = .02). Thus, arterial brachial access should be used in preference to femoral access...
  54. doi request reprint Influence of tracheostomy on the incidence of catheter-related bloodstream infection in the catheterization of jugular vein by posterior access
    L Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra s n La Cuesta, La Laguna, 38320 Santa Cruz de Tenerife, Spain
    Eur J Clin Microbiol Infect Dis 30:1049-51. 2011
    ..24 vs 0 episodes of CRBSI per 1,000 catheter-day; odds ratio = 23.92; 95% CI = 1.86-infinite; p = 0.008). Thus, the presence of tracheostomy is a risk factor of CRBSI on the catheterization of jugular vein by posterior access...
  55. pmc Association between serum soluble CD40 ligand levels and mortality in patients with severe sepsis
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, S N, La Laguna 38320, Santa Cruz de Tenerife, Spain
    Crit Care 15:R97. 2011
    ..Thus, the aim of this study was to determine whether circulating sCD40L levels could be a marker of adverse outcome in a large cohort of patients with severe sepsis...
  56. doi request reprint Lower incidence of catheter-related bloodstream infection in cubital than in femoral artery access
    Leonardo Lorente
    Department of Intensive Care, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain
    Scand J Infect Dis 43:814-7. 2011
    ..However the development of randomized controlled trials is necessary before this conclusion can be definitively established. In addition, it is necessary to consider other potential mechanical complications when decision-making...
  57. doi request reprint Platelet cytochrome c oxidase activity and quantity in septic patients
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, Spain
    Crit Care Med 39:1289-94. 2011
    ..The objective was to evaluate the relationship between cytochrome c oxidase activities and quantities and 6-month survival in a larger series of septic patients using a less invasive method (circulating platelets)...
  58. doi request reprint [Femoral venous catheterization. Does it really need to be avoided?]
    L Lorente
    Unidad de Cuidados Intensivos, Hospital Universitario de Canarias, La Laguna, Tenerife, Espana
    Med Intensiva 33:442-9. 2009
    ..a decrease in the incidence of CVCBSI, but an increase in the rate of mechanical complications as pneumothorax and/or hemothorax? 2) Couldn't antimicrobial-impregnated CVCs be used to prevent CVCBSI when the femoral venous access is used?..
  59. pmc Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, 38320 Santa Cruz de Tenerife, Spain
    Crit Care 13:R158. 2009
    ..The objective of this study was to determine the predictive value of MMP-9, MMP-10, and TIMP-1 on clinical severity and mortality in a large series of patients with severe sepsis...
  60. doi request reprint Influence of tracheostomy on the incidence of central venous catheter-related bacteremia
    L Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra s n La Cuesta, La Laguna, 38320 Santa Cruz de Tenerife, Spain
    Eur J Clin Microbiol Infect Dis 28:1141-5. 2009
    ..001). Besides, we found a higher incidence of CRB in patients with tracheostomy using the jugular access compared to subclavian access (21.64 vs. 5.11 per 1,000 catheter-days; OR = 4.23; 95% CI = 1.44-infinite; P = 0.0097)...
  61. doi request reprint Lower associated costs using rifampicin-miconazole‒impregnated catheters compared with standard catheters
    Leonardo Lorente
    Department of Critical Care, Hospital of the University of Canarias, Santa Cruz de Tenerife, Spain
    Am J Infect Control 39:895-7. 2011
    ..001). Our data indicate that the use of rifampicin-miconazole-impregnated catheters can save associated costs...
  62. ncbi request reprint Ventilator-associated pneumonia using a closed versus an open tracheal suction system
    Leonardo Lorente
    Department of Critical Care, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain
    Crit Care Med 33:115-9. 2005
    ..The aim of this study was to analyze the prevalence of ventilator-associated pneumonia (VAP) using a closed-tracheal suction system vs. an open system...
  63. doi request reprint Lower incidence of catheter-related bloodstream infection in subclavian venous access in the presence of tracheostomy than in femoral venous access: prospective observational study
    L Lorente
    Intensive Care Unit Research Unit of the Hospital Universitario de Canarias, Tenerife, Spain
    Clin Microbiol Infect 17:870-2. 2011
    ..In this study, we found lower CRBSI in subclavian venous access in the presence of tracheostomy than in femoral venous access (3.9 vs. 10.1 CRBSI per 1000 catheter-days; odds ratio = 0.39; 95% confidence interval ≤0.001-0.91; p 0.03)...
  64. ncbi request reprint Periodically changing ventilator circuits is not necessary to prevent ventilator-associated pneumonia when a heat and moisture exchanger is used
    Leonardo Lorente
    Department of Critical Care, Hospital Universitario de Canarias, La Laguna, Spain
    Infect Control Hosp Epidemiol 25:1077-82. 2004
    ..The Centers for Disease Control and Prevention recommended not changing the circuits periodically...
  65. ncbi request reprint Bacterial filters in respiratory circuits: an unnecessary cost?
    Leonardo Lorente
    Department of Critical Care, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain
    Crit Care Med 31:2126-30. 2003
    ..To evaluate the efficacy of bacterial filters (BF) to decrease pneumonia associated with mechanical ventilation (MV)...
  66. ncbi request reprint Prolonged intubation rates after coronary artery bypass surgery and ICU risk stratification score
    Nicolás Serrano
    Hospital Universitario de Canarias, Critical Care Department, Universidad de La Laguna, 38320 La Laguna, Tenerife, Spain
    Chest 128:595-601. 2005
    ..To determine prolonged intubation rates among patients undergoing coronary artery bypass graft (CABG) surgery, and to evaluate the ability of the Intensive Care Unit Risk Stratification Score (ICURSS) model to predict these events...
  67. doi request reprint [Pandemic influenza A in the ICU: experience in Spain and Latin America. GETGAG/SEMICYUC/(Spanish Working Group on Severe Pandemic Influenza A/SEMICYUC)]
    A Rodriguez
    Unidad de Cuidados Intensivos, Hospital Joan XXIII, CIBER Enfermedades Respiratorias, IISPV, Tarragona, Espana
    Med Intensiva 34:87-94. 2010
    ..It has spread very rapidly since the first cases were diagnosed in Mexico with the subsequent spread of the virus throughout the Southern Cone and Europe during the summer season...
  68. doi request reprint New issues and controversies in the prevention of ventilator-associated pneumonia
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain
    Am J Respir Crit Care Med 182:870-6. 2010
    ..More research is necessary to clarify the role of continuous cuff pressure monitoring, removal of biofilm formation in the endotracheal tubes, and routine saline instillation before tracheal suctioning...
  69. ncbi request reprint Equivalence of posterior internal jugular and subclavian accesses in the incidence of central venous catheter related bacteremia
    Leonardo Lorente
    Intensive Care Med 33:2230-1. 2007
  70. ncbi request reprint The micro-organism responsible for central venous catheter related bloodstream infection depends on catheter site
    Leonardo Lorente
    Intensive Care Med 32:1449-50. 2006
  71. doi request reprint Microorganisms responsible for femoral catheter-related bloodstream infection
    Leonardo Lorente
    Crit Care Med 36:657-8. 2008
  72. ncbi request reprint The catheter site influences in the micro-organism responsible of arterial catheter-related infection
    Leonardo Lorente
    Intensive Care Med 32:1919-20. 2006