Gina L C Yosten

Summary

Affiliation: Saint Louis University
Country: USA

Publications

  1. doi request reprint The Physiology of Proinsulin C-Peptide: Unanswered Questions and a Proposed Model
    Gina L C Yosten
    Department of Pharmacological and Physiological Science, St Louis University School of Medicine, St Louis, Missouri and
    Physiology (Bethesda) 30:327-32. 2015
  2. pmc Physiological effects and therapeutic potential of proinsulin C-peptide
    Gina L C Yosten
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, Missouri
    Am J Physiol Endocrinol Metab 307:E955-68. 2014
  3. pmc Neural circuitry underlying the central hypertensive action of nesfatin-1: melanocortins, corticotropin-releasing hormone, and oxytocin
    Gina L C Yosten
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, Saint Louis, Missouri
    Am J Physiol Regul Integr Comp Physiol 306:R722-7. 2014
  4. doi request reprint Evidence for an interaction between proinsulin C-peptide and GPR146
    Gina L C Yosten
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 S Grand Boulevard, Saint Louis, Missouri 63104, USA
    J Endocrinol 218:B1-8. 2013
  5. ncbi request reprint Evidence for an interaction between proinsulin C-peptide and GPR146
    Gina L C Yosten
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 S Grand Boulevard, Saint Louis, Missouri 63104, USA
    J Endocrinol 218:B1-8. 2013
  6. doi request reprint Novel neuropeptides in the control of food intake: neuronostatin and nesfatin-1
    Gina L C Yosten
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, Saint Louis, Missouri, USA
    Vitam Horm 92:1-25. 2013
  7. pmc Pressor doses of vasopressin result in only transient elevations in plasma peptide levels
    Gina L C Yosten
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, Saint Louis, MO 63104, United States
    Peptides 33:342-5. 2012
  8. doi request reprint Evidence for a role of endogenous nesfatin-1 in the control of water drinking
    G L C Yosten
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    J Neuroendocrinol 24:1078-84. 2012
  9. pmc Nesfatin-1 exerts cardiovascular actions in brain: possible interaction with the central melanocortin system
    Gina L C Yosten
    Saint Louis Univ, Dept of Pharmacological and Physiological Science, 1402 S Grand Blvd, St Louis, MO 63104, USA
    Am J Physiol Regul Integr Comp Physiol 297:R330-6. 2009
  10. pmc The anorexigenic and hypertensive effects of nesfatin-1 are reversed by pretreatment with an oxytocin receptor antagonist
    Gina L C Yosten
    Department of Pharmacological and Physiological Science, Saint Louis University, Saint Louis, Missouri 63104, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1642-7. 2010

Collaborators

Detail Information

Publications25

  1. doi request reprint The Physiology of Proinsulin C-Peptide: Unanswered Questions and a Proposed Model
    Gina L C Yosten
    Department of Pharmacological and Physiological Science, St Louis University School of Medicine, St Louis, Missouri and
    Physiology (Bethesda) 30:327-32. 2015
    ..In this review, we address the existence of the C-peptide receptor, the interaction between C-peptide and insulin, and the potential physiological significance of proinsulin C-peptide. ..
  2. pmc Physiological effects and therapeutic potential of proinsulin C-peptide
    Gina L C Yosten
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, Missouri
    Am J Physiol Endocrinol Metab 307:E955-68. 2014
    ..Finally, a hypothesis is offered concerning the relationship between C-peptide and the development of microvascular complications of diabetes. ..
  3. pmc Neural circuitry underlying the central hypertensive action of nesfatin-1: melanocortins, corticotropin-releasing hormone, and oxytocin
    Gina L C Yosten
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, Saint Louis, Missouri
    Am J Physiol Regul Integr Comp Physiol 306:R722-7. 2014
    ....
  4. doi request reprint Evidence for an interaction between proinsulin C-peptide and GPR146
    Gina L C Yosten
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 S Grand Boulevard, Saint Louis, Missouri 63104, USA
    J Endocrinol 218:B1-8. 2013
    ..These data indicate that GPR146 is likely a part of the C-peptide signaling complex and provide a platform for the elucidation of the C-peptide signalosome. ..
  5. ncbi request reprint Evidence for an interaction between proinsulin C-peptide and GPR146
    Gina L C Yosten
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 S Grand Boulevard, Saint Louis, Missouri 63104, USA
    J Endocrinol 218:B1-8. 2013
    ..These data indicate that GPR146 is likely a part of the C-peptide signaling complex and provide a platform for the elucidation of the C-peptide signalosome...
  6. doi request reprint Novel neuropeptides in the control of food intake: neuronostatin and nesfatin-1
    Gina L C Yosten
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, Saint Louis, Missouri, USA
    Vitam Horm 92:1-25. 2013
    ....
  7. pmc Pressor doses of vasopressin result in only transient elevations in plasma peptide levels
    Gina L C Yosten
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, Saint Louis, MO 63104, United States
    Peptides 33:342-5. 2012
    ..Thus we conclude that small increases in circulating vasopressin levels can result in significant elevations in mean arterial pressure at least in the conscious rat...
  8. doi request reprint Evidence for a role of endogenous nesfatin-1 in the control of water drinking
    G L C Yosten
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    J Neuroendocrinol 24:1078-84. 2012
    ..The results obtained in the present study suggest that locally produced nesfatin-1 may be an important component of the hypothalamic mechanisms controlling fluid and electrolyte homeostasis...
  9. pmc Nesfatin-1 exerts cardiovascular actions in brain: possible interaction with the central melanocortin system
    Gina L C Yosten
    Saint Louis Univ, Dept of Pharmacological and Physiological Science, 1402 S Grand Blvd, St Louis, MO 63104, USA
    Am J Physiol Regul Integr Comp Physiol 297:R330-6. 2009
    ..Thus we have identified a novel action of nesfatin-1, in addition to its anorexigenic effects, to stimulate autonomic nervous system activity...
  10. pmc The anorexigenic and hypertensive effects of nesfatin-1 are reversed by pretreatment with an oxytocin receptor antagonist
    Gina L C Yosten
    Department of Pharmacological and Physiological Science, Saint Louis University, Saint Louis, Missouri 63104, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1642-7. 2010
    ....
  11. pmc The melanocortins, not oxytocin, mediate the anorexigenic and antidipsogenic effects of neuronostatin
    Gina L C Yosten
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 S Grand Boulevard, Saint Louis, MO 63104, USA
    Peptides 31:1711-4. 2010
    ..Neuronostatin-induced anorexia was not reversed by pretreatment with the oxytocin receptor antagonist, OVT, suggesting that neuronostatin acts through a unique subset of POMC neurons that do not signal via central oxytocin receptors...
  12. pmc Neuronostatin acts in brain to biphasically increase mean arterial pressure through sympatho-activation followed by vasopressin secretion: the role of melanocortin receptors
    Gina L C Yosten
    Dept of Pharmacological and Physiological Science, Saint Louis University, St Louis, MO 63104, USA
    Am J Physiol Regul Integr Comp Physiol 300:R1194-9. 2011
    ....
  13. pmc Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic α-cells
    Mollisa M Elrick
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, Missouri
    Am J Physiol Regul Integr Comp Physiol 310:R143-55. 2016
    ....
  14. pmc Evidence for an interaction of neuronostatin with the orphan G protein-coupled receptor, GPR107
    Gina L C Yosten
    Department of Pharmacological and Physiological Science, Saint Louis Univ School of Medicine, 1402 S Grand Blvd, St Louis, MO 63104, USA
    Am J Physiol Regul Integr Comp Physiol 303:R941-9. 2012
    ..Thus, GPR107 is a promising candidate receptor for neuronostatin, and neuronostatin, interacting with GPR107, may play an important role in the central control of cardiovascular function...
  15. doi request reprint Obestatin inhibits vasopressin secretion: evidence for a physiological action in the control of fluid homeostasis
    Willis K Samson
    Department of Pharmacological and Physiological Science, Saint Louis University, 1402 South Grand Boulevard, St Louis, Missouri 63104, USA
    J Endocrinol 196:559-64. 2008
    ..We conclude that this product of post-translational processing of the ghrelin prohormone may be an important contributor to the physiologic regulation of fluid and electrolyte homeostasis...
  16. pmc Hypoglycemia unawareness prevention: Targeting glucagon production
    Willis K Samson
    Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St Louis, MO 63104, United States Electronic address
    Physiol Behav 162:147-50. 2016
    ..We hypothesize that this hormone, called neuronostatin, may be effective as a co-therapy with insulin to prevent repeated, potentially fatal episodes of recurrent hypoglycemia. ..
  17. pmc Understanding peptide biology: The discovery and characterization of the novel hormone, neuronostatin
    Gina L C Yosten
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, USA
    Peptides 72:192-5. 2015
    ..More importantly, we detail our deductive reasoning strategy for the identification of a neuronostatin receptor and our progress in establishing the physiological relevance of the peptide. ..
  18. pmc Neuronostatin encoded by the somatostatin gene regulates neuronal, cardiovascular, and metabolic functions
    Willis K Samson
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Biol Chem 283:31949-59. 2008
    ..Our findings demonstrate diverse neuronal, neuroendocrine, and cardiovascular actions of a somatostatin gene-encoded hormone and provide the basis to investigate the physiological roles of this endogenously produced brain/gut peptide...
  19. ncbi request reprint Cardiovascular and antidipsogenic effects of nesfatin-1
    Gina L C Yosten
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104 USA
    Curr Pharm Des 19:6973-5. 2013
    ....
  20. pmc Neuronostatin inhibits glucose-stimulated insulin secretion via direct action on the pancreatic α-cell
    Alison S Salvatori
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, Missouri and
    Am J Physiol Endocrinol Metab 306:E1257-63. 2014
    ..These studies suggest that neuronostatin participates in maintaining glucose homeostasis through cell-cell interactions between α-cells and β-cells in the endocrine pancreas, leading to attenuation in insulin secretion. ..
  21. pmc Neuropeptide W increases mean arterial pressure as a result of behavioral arousal
    Alicia T Pate
    Department of Pharmacological and Physiological Science, Saint Louis University, St Louis, Missouri
    Am J Physiol Regul Integr Comp Physiol 305:R804-10. 2013
    ..Our results suggest that NPW increased MAP secondary to increased behavioral arousal...
  22. pmc Hypothalamic action of phoenixin to control reproductive hormone secretion in females: importance of the orphan G protein-coupled receptor Gpr173
    Lauren M Stein
    Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St Louis, Missouri and
    Am J Physiol Regul Integr Comp Physiol 311:R489-96. 2016
    ..These studies are the first to demonstrate a functional relationship between PNX and Gpr173 in reproductive physiology and identify a potential therapeutic target for ovulatory dysfunction. ..
  23. pmc Adropin acts in brain to inhibit water drinking: potential interaction with the orphan G protein-coupled receptor, GPR19
    Lauren M Stein
    Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St Louis, Missouri
    Am J Physiol Regul Integr Comp Physiol 310:R476-80. 2016
    ....
  24. pmc A 5'-upstream short open reading frame encoded peptide regulates angiotensin type 1a receptor production and signalling via the β-arrestin pathway
    Gina L C Yosten
    Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St Louis, MO, USA
    J Physiol 594:1601-5. 2016
    ....
  25. doi request reprint Low O2-induced ATP release from erythrocytes of humans with type 2 diabetes is restored by physiological ratios of C-peptide and insulin
    Jennifer P Richards
    Department of Pharmacological and Physiological Science, Saint Louis University, St Louis, Missouri
    Am J Physiol Regul Integr Comp Physiol 307:R862-8. 2014
    ..These results suggest that the addition of C-peptide to the treatment regimen for type 2 diabetes could have beneficial effects on tissue oxygenation, which would help to ameliorate the concomitant peripheral vascular disease...