Sarah L George
Affiliation: Saint Louis University
- The GB virus C (GBV-C) NS3 serine protease inhibits HIV-1 replication in a CD4+ T lymphocyte cell line without decreasing HIV receptor expressionSarah L George
Division of Infectious Diseases, Department of Internal Medicine, St Louis University, St Louis, Missouri, United States of America
PLoS ONE 7:e30653. 2012..Two GBV-C proteins, NS5A and E2, have been shown previously to inhibit HIV replication in vitro. We investigated whether the GBV-C NS3 serine protease affects HIV replication...
- What you need to know about GB virus CSarah L George
Division of Infectious Diseases, Saint Louis University School of Medicine, FDT 8N, 3635 Vista Avenue, St Louis, MO 63110, USA
Curr Gastroenterol Rep 7:54-62. 2005..GBV-C E2 protein in serum has also been associated with prolonged survival in HIV infection; recent evidence indicates that GBV-C E2 protein may neutralize HIV infection in vitro...
- Clinical, virologic, histologic, and biochemical outcomes after successful HCV therapy: a 5-year follow-up of 150 patientsSarah L George
Department of Internal Medicine, Division of Gastroenterology, Saint Louis University Liver Center, St Louis, MO, USA
Hepatology 49:729-38. 2009..No patient had conclusive evidence of virologic relapse. Three patients had persistently elevated alanine aminotransferase levels; two of these had new liver disease...
- GB virus C replicates in primary T and B lymphocytesSarah L George
Research Service and Department of Internal Medicine, Saint Louis University Hospital and St Louis Veterans Affairs Medical Center, MO 63110, USA
J Infect Dis 193:451-4. 2006....
- Hepatitis C virus viremia in HIV-infected individuals with negative HCV antibody testsSarah L George
Department of Internal Medicine, Iowa City Veterans Administration Medical Center, University of Iowa, College of Medicine, 52242, USA
J Acquir Immune Defic Syndr 31:154-62. 2002....
- Inhibition of HIV-1 replication by GB virus C infection through increases in RANTES, MIP-1alpha, MIP-1beta, and SDF-1Jinhua Xiang
Research Service and Department of Internal Medicine, Iowa City VA Medical Center and University of Iowa, Iowa City, IA, USA
Lancet 363:2040-6. 2004..This study provides insight into the epidemiological association between GBV-C infection and longer survival in HIV-infected individuals...
- Human pegivirus (GB virus C) NS3 protease activity inhibits induction of the type I interferon response and is not inhibited by HCV NS3 protease inhibitorsAdnan Y Chowdhury
Saint Louis University School of Medicine, Department of Molecular Microbiology and Immunology, St Louis, MO, USA Saint Louis University School of Medicine, Department of Internal Medicine, Division of Infectious Diseases, Allergy and Immunology, St Louis, MO, USA Electronic address
Virology 456:300-9. 2014..Our results also imply that HCV protease inhibitors should not interfere with the beneficial effects of HPgV in HPgV/HCV/HIV infected patients. ..
- Recombinant hepatitis C virus-like particles expressed by baculovirus: utility in cell-binding and antibody detection assaysJinhua Xiang
Department of Internal Medicine, Iowa City Veterans Administration Medical Center, Iowa City, Iowa, USA
J Med Virol 68:537-43. 2002..In addition, HCV VLPs seem useful for evaluating HCV-cell interactions...
- Clinical isolates of GB virus type C vary in their ability to persist and replicate in peripheral blood mononuclear cell culturesSarah L George
Departments of Internal Medicine and Research, Iowa City VA Medical Center, University of Iowa, and the Helen C Levitt Center for Viral Pathogenesis, Iowa City, IA 52242, USA
Virology 316:191-201. 2003..Since GBV-C appears to inhibit HIV replication in a coinfection model, these studies should facilitate determination of the mechanism of this interaction...
- Persistent GB virus C infection is associated with decreased HIV-1 disease progression in the Amsterdam Cohort StudySarah L George
J Infect Dis 191:2156-7; author reply 2158-60. 2005