Chung S Yang

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. ncbi Cancer Preventive Activities of Tea Catechins
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Molecules 21:. 2016
  2. doi Effects of Tea Catechins on Cancer Signaling Pathways
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA International Joint Research Laboratory of Tea Chemistry and Health Effects, Anhui Agricultural University, Hefei, PR China Electronic address
    Enzymes 36:195-221. 2014
  3. pmc Cancer prevention by tocopherols and tea polyphenols
    Chung S Yang
    Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, United States Electronic address
    Cancer Lett 334:79-85. 2013
  4. doi Combination of chemopreventive agents in nanoparticles for cancer prevention
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020
    Cancer Prev Res (Phila) 6:1011-4. 2013
  5. doi Prevention of chronic diseases by tea: possible mechanisms and human relevance
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Annu Rev Nutr 33:161-81. 2013
  6. pmc Cancer therapy combination: green tea and a phosphodiesterase 5 inhibitor?
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, 164 Frelinghuysen Road, Piscataway, New Jersey 08854 8020, USA
    J Clin Invest 123:556-8. 2013
  7. doi The effects of green tea polyphenols on drug metabolism
    Chung S Yang
    The State University of New Jersey, Ernest Mario School of Pharmacy, Department of Chemical Biology, Rutgers, Piscataway, NJ 08854 8020, USA
    Expert Opin Drug Metab Toxicol 8:677-89. 2012
  8. pmc Does vitamin E prevent or promote cancer?
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, 08854, USA
    Cancer Prev Res (Phila) 5:701-5. 2012
  9. ncbi Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxib
    Ning Li
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Clin Cancer Res 11:2089-96. 2005
  10. ncbi Inhibition of intestinal tumorigenesis in Apc(min/+) mice by green tea polyphenols (polyphenon E) and individual catechins
    Xingpei Hao
    Department of Chemical Biology, Ernest Mario School of Pharmacy Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Nutr Cancer 59:62-9. 2007

Collaborators

Detail Information

Publications94

  1. ncbi Cancer Preventive Activities of Tea Catechins
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Molecules 21:. 2016
    ..The potential and possible problems in the application of tea and tea-derived products for cancer prevention are discussed...
  2. doi Effects of Tea Catechins on Cancer Signaling Pathways
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA International Joint Research Laboratory of Tea Chemistry and Health Effects, Anhui Agricultural University, Hefei, PR China Electronic address
    Enzymes 36:195-221. 2014
    ..More weight is put on studies in vivo over experiments in vitro. It also discusses key issues involved in extrapolating results from cell line studies to mechanistic insights in vivo. ..
  3. pmc Cancer prevention by tocopherols and tea polyphenols
    Chung S Yang
    Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, United States Electronic address
    Cancer Lett 334:79-85. 2013
    ..The cancer preventive activity of green tea in humans, however, has not been conclusively demonstrated and remains to be further investigated. ..
  4. doi Combination of chemopreventive agents in nanoparticles for cancer prevention
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020
    Cancer Prev Res (Phila) 6:1011-4. 2013
    ..Also discussed is the importance of measuring tissue levels of the chemopreventive agents to understand the mode of action of these nanoparticles and to avoid toxicity...
  5. doi Prevention of chronic diseases by tea: possible mechanisms and human relevance
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Annu Rev Nutr 33:161-81. 2013
    ..It also discusses other health effects and possible side effects of tea consumption. This article provides a critical assessment of the health effects of tea consumption and suggests new directions for research in this area. ..
  6. pmc Cancer therapy combination: green tea and a phosphodiesterase 5 inhibitor?
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, 164 Frelinghuysen Road, Piscataway, New Jersey 08854 8020, USA
    J Clin Invest 123:556-8. 2013
    ..This is a provocative observation with important implications for cancer therapy. It also raises several issues for further investigation, such as the mechanism by which EGCG specifically activates 67LR...
  7. doi The effects of green tea polyphenols on drug metabolism
    Chung S Yang
    The State University of New Jersey, Ernest Mario School of Pharmacy, Department of Chemical Biology, Rutgers, Piscataway, NJ 08854 8020, USA
    Expert Opin Drug Metab Toxicol 8:677-89. 2012
    ..Although tea consumption is considered to be innocuous, the potential interactions between tea polyphenols and drugs have been demonstrated in studies in vitro and in vivo...
  8. pmc Does vitamin E prevent or promote cancer?
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, 08854, USA
    Cancer Prev Res (Phila) 5:701-5. 2012
    ....
  9. ncbi Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxib
    Ning Li
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Clin Cancer Res 11:2089-96. 2005
    ..However, it is unknown whether the 5-lipoxygenase (5-Lox) pathway contributes to oral carcinogenesis, and whether combination of inhibitors of both pathways may have synergistic or additive effects of chemoprevention...
  10. ncbi Inhibition of intestinal tumorigenesis in Apc(min/+) mice by green tea polyphenols (polyphenon E) and individual catechins
    Xingpei Hao
    Department of Chemical Biology, Ernest Mario School of Pharmacy Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Nutr Cancer 59:62-9. 2007
    ..The results suggest that these molecular events contribute to the cancer prevention activity of EGCG and PPE. Furthermore, diet appears to be a better route of administration for PPE than drinking fluid...
  11. pmc A gamma-tocopherol-rich mixture of tocopherols inhibits colon inflammation and carcinogenesis in azoxymethane and dextran sulfate sodium-treated mice
    Jihyeung Ju
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA
    Cancer Prev Res (Phila) 2:143-52. 2009
    ....
  12. ncbi Delivery of tea polyphenols to the oral cavity by green tea leaves and black tea extract
    Mao Jung Lee
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA
    Cancer Epidemiol Biomarkers Prev 13:132-7. 2004
    ..These results indicate that tea leaves can be used as a convenient, slow-release source of catechins and theaflavins and provide information for the possible use of tea in the prevention of oral cancer and dental caries...
  13. pmc A gamma-tocopherol-rich mixture of tocopherols inhibits chemically induced lung tumorigenesis in A/J mice and xenograft tumor growth
    Gang Lu
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Carcinogenesis 31:687-94. 2010
    ..These results demonstrate the inhibitory effect of gamma-TmT against lung tumorigenesis and the growth of xenograft tumors of human lung cancer cells. The inhibitory activity may be due mainly to the actions of delta-T and gamma-T...
  14. pmc Dietary tocopherols inhibit PhIP-induced prostate carcinogenesis in CYP1A-humanized mice
    Jayson X Chen
    Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Piscataway, NJ, USA Joint Graduate Program in Toxicology, Piscataway, NJ, USA
    Cancer Lett 371:71-8. 2016
    ..2% in diet) showed that δ-T was more effective than γ-T or α-T in preventing mPIN formations and p-AKT elevation. These results indicate that γ-TmT and δ-T could be effective preventive agents of prostate cancer. ..
  15. pmc Dietary tocopherols inhibit cell proliferation, regulate expression of ERα, PPARγ, and Nrf2, and decrease serum inflammatory markers during the development of mammary hyperplasia
    Amanda K Smolarek
    Department of Pharmacology and Toxicology, Rutgers, The State University of New Jersey, Piscataway, New Jersey
    Mol Carcinog 52:514-25. 2013
    ....
  16. ncbi Inhibition of adenoma progression to adenocarcinoma in a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis model in A/J mice by tea polyphenols and caffeine
    Gang Lu
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 16445 0687, USA
    Cancer Res 66:11494-501. 2006
    ..This effect is closely associated with decreased cell proliferation, enhanced apoptosis, and lowered levels of c-Jun and Erk1/2 phosphorylation...
  17. pmc Pro-oxidative activities and dose-response relationship of (-)-epigallocatechin-3-gallate in the inhibition of lung cancer cell growth: a comparative study in vivo and in vitro
    Guang Xun Li
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Carcinogenesis 31:902-10. 2010
    ..Although EGCG is generally considered to be an antioxidant, the present study demonstrates the pro-oxidative activities of EGCG in vivo and in vitro in the described experimental system...
  18. pmc The major green tea polyphenol, (-)-epigallocatechin-3-gallate, inhibits obesity, metabolic syndrome, and fatty liver disease in high-fat-fed mice
    Mousumi Bose
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Nutr 138:1677-83. 2008
    ..Short-term EGCG treatment appeared to reverse preexisting high-fat-induced metabolic pathologies in obese mice. These effects may be mediated by decreased lipid absorption, decreased inflammation, and other mechanisms...
  19. ncbi Inhibition of intestinal tumorigenesis in Apcmin/+ mice by (-)-epigallocatechin-3-gallate, the major catechin in green tea
    Jihyeung Ju
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Cancer Res 65:10623-31. 2005
    ....
  20. ncbi Peracetylation as a means of enhancing in vitro bioactivity and bioavailability of epigallocatechin-3-gallate
    Joshua D Lambert
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Drug Metab Dispos 34:2111-6. 2006
    ..4- and 6.0-fold, respectively). These data suggest that acetylation represents a means of increasing the biological potency in vitro, increasing the bioavailability of EGCG in vivo, and may improve cancer-preventive activity...
  21. doi Deleterious effects of high concentrations of (-)-epigallocatechin-3-gallate and atorvastatin in mice with colon inflammation
    Fei Guan
    Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA
    Nutr Cancer 64:847-55. 2012
    ..5% EGCG also increased serum levels of leukotriene B4 and prostaglandin E2. These results suggest that, in mice bearing colon inflammation, high concentrations of EGCG and ATST enhance colon bleeding and may promote colon carcinogenesis...
  22. ncbi Promoter hypermethylation and inactivation of O(6)-methylguanine-DNA methyltransferase in esophageal squamous cell carcinomas and its reactivation in cell lines
    Ming Zhu Fang
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Int J Oncol 26:615-22. 2005
    ....
  23. pmc Atorvastatin and celecoxib in combination inhibits the progression of androgen-dependent LNCaP xenograft prostate tumors to androgen independence
    Xi Zheng
    Department of Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, 08854, USA
    Cancer Prev Res (Phila) 3:114-24. 2010
    ..Our results indicate that administration of a combination of atorvastatin and celecoxib may be an effective strategy for the prevention of prostate cancer progression from androgen dependence to androgen independence...
  24. ncbi Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenase
    Jungil Hong
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Carcinogenesis 25:1671-9. 2004
    ..These activities may contribute to the anti-inflammatory and anticarcinogenic actions of curcumin and its analogs...
  25. doi Synergistic inhibition of lung tumorigenesis by a combination of green tea polyphenols and atorvastatin
    Gang Lu
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Clin Cancer Res 14:4981-8. 2008
    ....
  26. pmc Synergistic actions of atorvastatin with gamma-tocotrienol and celecoxib against human colon cancer HT29 and HCT116 cells
    Zhihong Yang
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA
    Int J Cancer 126:852-63. 2010
    ..The synergistic action of these three compounds was also illustrated by their induction of G(0)/G(1) phase cell cycle arrest and apoptosis...
  27. ncbi Effects of garcinol and its derivatives on intestinal cell growth: Inhibitory effects and autoxidation-dependent growth-stimulatory effects
    Jungil Hong
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, The State University of New Jersey, Piscataway, NJ 08854, USA
    Free Radic Biol Med 42:1211-21. 2007
    ..It remains to be determined whether the currently observed stimulatory and inhibitory effects of garcinol on colon cell growth occur in vivo...
  28. pmc Effect of genistein on the bioavailability and intestinal cancer chemopreventive activity of (-)-epigallocatechin-3-gallate
    Joshua D Lambert
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Carcinogenesis 29:2019-24. 2008
    ..These results further show the need for careful cancer prevention studies in animal models and for caution when interpreting data from in vitro studies...
  29. pmc δ- and γ-tocopherols, but not α-tocopherol, inhibit colon carcinogenesis in azoxymethane-treated F344 rats
    Fei Guan
    Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Cancer Prev Res (Phila) 5:644-54. 2012
    ..Our study provides the first evidence for the much higher cancer preventive activity of δ-T and γ-T than α-T in a chemically induced colon carcinogenesis model. It further suggests that δ-T is more effective than γ-T...
  30. doi Effects of combination of calcium and aspirin on azoxymethane-induced aberrant crypt foci formation in the colons of mice and rats
    Yingying Liu
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
    Nutr Cancer 60:660-5. 2008
    ..These results indicate that the combination of calcium and aspirin did not produce a synergistic effect on the ACF formation in AOM-treated mice and rats...
  31. ncbi Modulation of arachidonic acid metabolism and nitric oxide synthesis by garcinol and its derivatives
    Jungil Hong
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Carcinogenesis 27:278-86. 2006
    ..These activities may contribute to the anti-inflammatory and anticarcinogenic actions of garcinol and its derivatives...
  32. ncbi Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy
    Ming Zhu Fang
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
    Clin Cancer Res 11:7033-41. 2005
    ..To determine whether other polyphenolic compounds have similar activities, we studied the effects of soy isoflavones on DNA methylation...
  33. doi The antioxidant and anti-inflammatory activities of tocopherols are independent of Nrf2 in mice
    Guangxun Li
    Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Free Radic Biol Med 52:1151-8. 2012
    ....
  34. ncbi Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines
    Ming Zhu Fang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Cancer Res 63:7563-70. 2003
    ....
  35. ncbi Mechanism of action of (-)-epigallocatechin-3-gallate: auto-oxidation-dependent inactivation of epidermal growth factor receptor and direct effects on growth inhibition in human esophageal cancer KYSE 150 cells
    Zhe Hou
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
    Cancer Res 65:8049-56. 2005
    ..In future studies of EGCG and other polyphenolic compounds in cell culture, SOD may be added to stabilize EGCG and to avoid possible artifacts...
  36. pmc Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer
    Tin Oo Khor
    Center for Cancer Prevention Research and Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Cancer Prev Res (Phila) 1:187-91. 2008
    ..Our findings show that Nrf2 plays a critical role in protecting against inflammation-associated colorectal cancer...
  37. ncbi Enzymatic synthesis of tea theaflavin derivatives and their anti-inflammatory and cytotoxic activities
    Shengmin Sang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Bioorg Med Chem 12:459-67. 2004
    ..7 cells. Their cytotoxic activities against KYSE 150 and 510 human esophageal squamous cell carcinoma and HT 29 human colon cancer cells were also evaluated...
  38. pmc Voluntary exercise inhibits intestinal tumorigenesis in Apc(Min/+) mice and azoxymethane/dextran sulfate sodium-treated mice
    Jihyeung Ju
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    BMC Cancer 8:316. 2008
    ..The present study investigated the effects of voluntary exercise on intestinal tumor formation in two different animal models, Apc(Min/+) mice and azoxymethane (AOM)/dextran sulfate sodium (DSS)-treated mice...
  39. doi Inhibition of progression of androgen-dependent prostate LNCaP tumors to androgen independence in SCID mice by oral caffeine and voluntary exercise
    Xi Zheng
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Nutr Cancer 64:1029-37. 2012
    ..Our results indicate that oral administration of caffeine in combination with voluntary exercise may be an effective strategy for the prevention of prostate cancer progression from androgen dependence to androgen independence...
  40. ncbi Dose-dependent levels of epigallocatechin-3-gallate in human colon cancer cells and mouse plasma and tissues
    Joshua D Lambert
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, NJ 08854 8020, USA
    Drug Metab Dispos 34:8-11. 2006
    ..The present study provides information with respect to what concentrations of EGCG are achievable in mice and may guide dose selection for future cancer chemoprevention studies with EGCG...
  41. pmc Mixed tocopherols prevent mammary tumorigenesis by inhibiting estrogen action and activating PPAR-gamma
    Hong Jin Lee
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Clin Cancer Res 15:4242-9. 2009
    ..In the present study, we investigated the inhibitory effect of a tocopherol mixture rich in gamma- and delta-tocopherols against mammary tumorigenesis...
  42. ncbi Stability of tea polyphenol (-)-epigallocatechin-3-gallate and formation of dimers and epimers under common experimental conditions
    Shengmin Sang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, 164 Frelinghuysen Road, Piscataway, New Jersey 08854 8020, USA
    J Agric Food Chem 53:9478-84. 2005
    ..In future studies with EGCG, its stability should be considered in order to avoid possible artifacts...
  43. pmc Cancer prevention by tea and tea polyphenols
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Phar macy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Asia Pac J Clin Nutr 17:245-8. 2008
    ..Human intervention trials and large prospective studies are needed to further assess the cancer preventive activities of tea constituents...
  44. doi Combination of atorvastatin and celecoxib synergistically induces cell cycle arrest and apoptosis in colon cancer cells
    Hang Xiao
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Int J Cancer 122:2115-24. 2008
    ..The present work suggests the possible therapeutic application of this combination and provides leads for mechanistic and biomarker investigations in clinical trials...
  45. ncbi Dietary polyphenols may affect DNA methylation
    Mingzhu Fang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    J Nutr 137:223S-228S. 2007
    ..On the other hand, the consumption of excessive amounts of polyphenols in dietary supplements may affect DNA methylation status. All these possibilities remain to be examined...
  46. pmc δ-tocopherol is more active than α - or γ -tocopherol in inhibiting lung tumorigenesis in vivo
    Guang Xun Li
    Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA
    Cancer Prev Res (Phila) 4:404-13. 2011
    ....
  47. ncbi Effects of green tea and high-fat diet on arachidonic acid metabolism and aberrant crypt foci formation in an azoxymethane-induced colon carcinogenesis mouse model
    Jihyeung Ju
    Graduate Program of Food Science, Rutgers, The State University of New Jersey, New Brunswick, NJ 08854, USA
    Nutr Cancer 46:172-8. 2003
    ..Green tea inhibits ACF formation in mice on a high corn oil diet, suggesting its possible inhibitory effect on colon carcinogenesis in populations such as those in Western countries that consume high amounts of fat...
  48. doi Nrf2 knockout enhances intestinal tumorigenesis in Apc(min/+) mice due to attenuation of anti-oxidative stress pathway while potentiates inflammation
    Ka Lung Cheung
    Graduate Program in Pharmaceutical Science, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey Center for Cancer Prevention Research, Rutgers, The State University of New Jersey, Piscataway, New Jersey
    Mol Carcinog 53:77-84. 2014
    ....
  49. doi Bioavailability issues in studying the health effects of plant polyphenolic compounds
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Mol Nutr Food Res 52:S139-51. 2008
    ..Further research on both the biological activity and bioavailability of dietary polyphenols is needed to properly assess their usefulness for the prevention and treatment of disease...
  50. pmc Murine prostate cancer inhibition by dietary phytochemicals--curcumin and phenyethylisothiocyanate
    Avantika Barve
    Graduate Program in Pharmaceutical Sciences, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Pharm Res 25:2181-9. 2008
    ..Hence, this study was undertaken to examine the potential chemopreventive properties of the two agents against transgenic adenocarcinoma of the mouse prostate...
  51. doi Epigenetic reactivation of Nrf2 in murine prostate cancer TRAMP C1 cells by natural phytochemicals Z-ligustilide and Radix angelica sinensis via promoter CpG demethylation
    Zheng Yuan Su
    Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, United States
    Chem Res Toxicol 26:477-85. 2013
    ..Epigenetic modifications of genes, including Nrf2, may therefore contribute to the overall health benefits of RAS, including the anticancer effect of RAS and its bioactive component, Lig...
  52. doi Mechanistic issues concerning cancer prevention by tea catechins
    Chung S Yang
    Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Mol Nutr Food Res 55:819-31. 2011
    ..This article discusses the key issues involved in extrapolating results from cell line studies to mechanistic information in vivo and in translating animal studies to human cancer prevention...
  53. ncbi Over-expression of gastrin-releasing peptide in human esophageal squamous cell carcinomas
    Ming Zhu Fang
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Carcinogenesis 25:865-71. 2004
    ..GRP (1 mM) also increased cyclooxygenase-2 protein expression by 3.4-fold. This is the first demonstration that GRP is over-expressed in ESCC, and its over-expression may play a role in ESCC development and growth...
  54. pmc Increased growth inhibitory effects on human cancer cells and anti-inflammatory potency of shogaols from Zingiber officinale relative to gingerols
    Shengmin Sang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, 164 Frelinghuysen Road, Piscataway, New Jersey 08854 8020, USA
    J Agric Food Chem 57:10645-50. 2009
    ..In addition, we found that [6]-shogaol had much stronger inhibitory effects on arachidonic acid release and nitric oxide (NO) synthesis than [6]-gingerol...
  55. ncbi Synthesis and biological activity of the tea catechin metabolites, M4 and M6 and their methoxy-derivatives
    Joshua D Lambert
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Bioorg Med Chem Lett 15:873-6. 2005
    ..The possible antiinflammatory activity of 1 and its trimethoxy derivative was also evaluated. Neither compound inhibited the release of arachidonic acid, although 1 inhibited NO production by 50% at 20 microM...
  56. ncbi Biotransformation of green tea polyphenols and the biological activities of those metabolites
    Joshua D Lambert
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Mol Pharm 4:819-25. 2007
    ..We hope this article will spark research efforts on some of the important questions regarding tea polyphenol bioavailability, biotransformation, and the biological activities of tea catechin metabolites...
  57. ncbi Epigallocatechin-3-gallate is absorbed but extensively glucuronidated following oral administration to mice
    Joshua D Lambert
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Nutr 133:4172-7. 2003
    ..This is the first report of the pharmacokinetic parameters of EGCG in mice. Such information provides a basis for understanding the bioavailability of EGCG in mice and should aid in understanding the cancer preventive activity of EGCG...
  58. pmc Effect of alpha-tocopherol, N-acetylcysteine and omeprazole on esophageal adenocarcinoma formation in a rat surgical model
    Jing Hao
    Department of Chemical Biology, Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 0789, USA
    Int J Cancer 124:1270-5. 2009
    ..Our results suggest that supplementation with alpha-tocopherol inhibits the development of EAC in the rat EGDA model and similar inhibitory effect can be achieved when a lower dose of alpha-tocopherol is used in combination with NAC...
  59. ncbi Administration of green tea or caffeine enhances the disappearance of UVB-induced patches of mutant p53 positive epidermal cells in SKH-1 mice
    Yao Ping Lu
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Carcinogenesis 26:1465-72. 2005
    ..Our studies indicate that the chemopreventive effect of caffeine or green tea may occur by a proapoptotic effect preferentially in early precancerous lesions...
  60. pmc Inhibitory effects of different forms of tocopherols, tocopherol phosphates, and tocopherol quinones on growth of colon cancer cells
    Sonia C Dolfi
    Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United States
    J Agric Food Chem 61:8533-40. 2013
    ....
  61. ncbi Characterization of genetic alteration patterns in human esophageal squamous cell carcinoma using selected microsatellite markers spanning multiple loci
    Yuyang Christine Cai
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Int J Oncol 30:1059-67. 2007
    ..The results demonstrate the degree of genetic alterations at different loci of the chromosomes. Some of the microsatellite markers may be useful for the early detection of ESCC...
  62. ncbi Hypermethylation-associated inactivation of retinoic acid receptor beta in human esophageal squamous cell carcinoma
    Yimin Wang
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
    Clin Cancer Res 9:5257-63. 2003
    ..The purpose of this study was to investigate the mechanism of altered retinoic acid receptor beta (RARbeta) expression during esophageal squamous carcinogenesis...
  63. ncbi Tea polyphenol (-)-epigallocatechin-3-gallate: a new trapping agent of reactive dicarbonyl species
    Shengmin Sang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, 164 Frelinghuysen Road, Piscataway, New Jersey 08854 8020, USA
    Chem Res Toxicol 20:1862-70. 2007
    ..The purified mono-MGO adducts of EGCG in this study can be used as standards for further in vivo studies on the possible trapping of reactive dicarbonyl species by EGCG...
  64. pmc Dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced prostate carcinogenesis in CYP1A-humanized mice
    Guangxun Li
    Department of Chemical Biology, Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Cancer Prev Res (Phila) 5:963-72. 2012
    ..This dietary carcinogen-induced prostate cancer model, recapitulating important features of early human prostate carcinogenesis, constitutes a new experimental system for prostate cancer research...
  65. ncbi Overexpression of 5-lipoxygenase in rat and human esophageal adenocarcinoma and inhibitory effects of zileuton and celecoxib on carcinogenesis
    Xiaoxin Chen
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Clin Cancer Res 10:6703-9. 2004
    ....
  66. ncbi Glucuronides of tea catechins: enzymology of biosynthesis and biological activities
    Hong Lu
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Drug Metab Dispos 31:452-61. 2003
    ..These results provide foundations for understanding the biotransformation and biological activities of tea catechins...
  67. ncbi Stimulatory effect of oral administration of tea, coffee or caffeine on UVB-induced apoptosis in the epidermis of SKH-1 mice
    Allan H Conney
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Toxicol Appl Pharmacol 224:209-13. 2007
    ..Further studies are needed to determine mechanisms of these effects of caffeine and to determine the effects of caffeine administration on sunlight-induced actinic keratoses and squamous cell carcinomas in humans...
  68. pmc Cancer-preventive activities of tocopherols and tocotrienols
    Jihyeung Ju
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Carcinogenesis 31:533-42. 2010
    ..Based on this information, we propose that a gamma-tocopherol-rich mixture of tocopherols is a very promising cancer-preventive agent and warrants extensive future research...
  69. pmc Antioxidative and anti-carcinogenic activities of tea polyphenols
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Arch Toxicol 83:11-21. 2009
    ..Finally, we discuss the effects of tea consumption on cancer risk in humans. It is our aim to raise some of the unanswered questions regarding cancer prevention by tea and to stimulate further research in this area...
  70. ncbi Wheat bran oil and its fractions inhibit human colon cancer cell growth and intestinal tumorigenesis in Apc(min/+) mice
    Shengmin Sang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, 164 Frelinghuysen Road, Piscataway, New Jersey 08854 8020, USA
    J Agric Food Chem 54:9792-7. 2006
    ..The current results demonstrate, for the first time, the intestinal cancer preventive activity of WB oil. The active ingredients, however, remain to be identified...
  71. pmc N-Acetylcysteine enhances the lung cancer inhibitory effect of epigallocatechin-3-gallate and forms a new adduct
    Joshua D Lambert
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Free Radic Biol Med 44:1069-74. 2008
    ..The present results show that under cell culture conditions, EGCG and NAC interact to form a previously unreported adduct, EGCG-2'-NAC, which may contribute to enhancement of EGCG-mediated cell killing...
  72. ncbi Gene expression changes induced by green tea polyphenol (-)-epigallocatechin-3-gallate in human bronchial epithelial 21BES cells analyzed by DNA microarray
    Ragini Vittal
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Mol Cancer Ther 3:1091-9. 2004
    ..The elucidation of gene expression changes between H2O2-dependent and H2O2-independent responses helps us better understand the cancer chemopreventive and anticancer actions of EGCG...
  73. ncbi Green tea polyphenols: antioxidative and prooxidative effects
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, Piscataway, NJ 08854 8020, USA
    J Nutr 134:3181S. 2004
  74. pmc Inhibition of carcinogenesis by tea constituents
    Jihyeung Ju
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Semin Cancer Biol 17:395-402. 2007
    ..Human intervention trials are warranted to determine the possible prevention of cancer of specific sites by preparation of tea constituents...
  75. ncbi Benzotropolone inhibitors of estradiol methylation: kinetics and in silico modeling studies
    Joshua D Lambert
    Department of Chemical Biology Rutgers, Ernest Mario School of Pharmacy, The State University of New Jersey, 164 Frelinghuysen Rd, Piscataway, NJ 08854, USA
    Bioorg Med Chem 13:2501-7. 2005
    ..Further studies are needed to determine the impact in vivo of COMT inhibition by these compounds...
  76. doi Cancer prevention by tea: Evidence from laboratory studies
    Chung S Yang
    Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Pharmacol Res 64:113-22. 2011
    ..Nevertheless, the molecular mechanisms of inhibition of carcinogenesis in animals and humans remain to be further investigated. Future research directions in this area are discussed...
  77. ncbi Mechanisms of cancer prevention by tea constituents
    Joshua D Lambert
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Nutr 133:3262S-3267S. 2003
    ..Such discussion, it is hoped, will clarify some misunderstandings of cancer prevention by tea and stimulate new research efforts...
  78. ncbi Mixed tocopherols inhibit N-methyl-N-nitrosourea-induced mammary tumor growth in rats
    Nanjoo Suh
    Department of Chemical Biology, The State University of New Jersey, Piscataway, NJ 08854, USA
    Nutr Cancer 59:76-81. 2007
    ..The treatment increased the serum levels of gamma- and delta-tocopherols without affecting the body weight. The results of this study suggest that mixed tocopherols may be safe and effective agents for the prevention of breast cancer...
  79. doi Apple polyphenols, phloretin and phloridzin: new trapping agents of reactive dicarbonyl species
    Xi Shao
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Chem Res Toxicol 21:2042-50. 2008
    ..Our results suggest that dietary flavonoids that have the same A ring structure as phloretin may have the potential to trap reactive dicarbonyl species and therefore inhibit the formation of AGEs...
  80. ncbi Inhibition of human liver catechol-O-methyltransferase by tea catechins and their metabolites: structure-activity relationship and molecular-modeling studies
    Dapeng Chen
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Biochem Pharmacol 69:1523-31. 2005
    ..These results provide mechanistic insight into the inhibition of COMT by commonly consumed tea catechins...
  81. pmc Effects of green tea polyphenol (-)-epigallocatechin-3-gallate on newly developed high-fat/Western-style diet-induced obesity and metabolic syndrome in mice
    Yu Kuo Chen
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United States
    J Agric Food Chem 59:11862-71. 2011
    ..The beneficial effects of EGCG are associated with decreased lipid absorption and reduced levels of inflammatory cytokines...
  82. pmc Inhibition of inflammation and carcinogenesis in the lung and colon by tocopherols
    Chung S Yang
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Rutgers, The State University of New Jersey, New Jersey, USA
    Ann N Y Acad Sci 1203:29-34. 2010
    ..These results demonstrate the antioxidative, anti-inflammatory, and anticarcinogenic activities of tocopherols...
  83. pmc Rapid induction of colon carcinogenesis in CYP1A-humanized mice by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate
    Connie Cheung
    Department of Chemical Biology, Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Carcinogenesis 32:233-9. 2011
    ..These results illustrate that PhIP and DSS combination produces rapid colon carcinogenesis in hCYP1A-mice and this is an effective model to mimic human colon carcinogenesis...
  84. pmc Analysis of multiple metabolites of tocopherols and tocotrienols in mice and humans
    Yang Zhao
    Department of Chemical Biology, Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey 08854, USA
    J Agric Food Chem 58:4844-52. 2010
    ..Urinary metabolites may serve as useful biomarkers for the nutritional assessment of vitamin E...
  85. pmc The pak4 protein kinase plays a key role in cell survival and tumorigenesis in athymic mice
    Yingying Liu
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Mol Cancer Res 6:1215-24. 2008
    ..This makes it an attractive candidate for drug therapy for different types of cancer...
  86. pmc Inhibition of lung cancer growth in mice by dietary mixed tocopherols
    Joshua D Lambert
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA
    Mol Nutr Food Res 53:1030-5. 2009
    ..Further studies are needed to determine the underlying mechanisms for this anticancer activity, and to determine if such activity occurs in other models of cancer...
  87. pmc A γ-tocopherol-rich mixture of tocopherols maintains Nrf2 expression in prostate tumors of TRAMP mice via epigenetic inhibition of CpG methylation
    Ying Huang
    Department of Pharmaceutics, Center for Cancer Prevention Research, Earnest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA
    J Nutr 142:818-23. 2012
    ....
  88. doi Green tea and cancer prevention
    Chung S Yang
    Department of Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
    Nutr Cancer 62:931-7. 2010
    ..This article reviews data on the cancer preventive activities of green tea polyphenols, possible mechanisms involved, and the relationship between green tea consumption and human cancer risk...
  89. pmc Cancer prevention by tea: animal studies, molecular mechanisms and human relevance
    Chung S Yang
    Susan Lehman Cullman Laboratory of Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Nat Rev Cancer 9:429-39. 2009
    ..Here, we review these biological activities and existing data relating tea consumption to human cancer risk in an attempt to understand the potential use of tea for cancer prevention...
  90. pmc Green tea polyphenol EGCG suppresses lung cancer cell growth through upregulating miR-210 expression caused by stabilizing HIF-1α
    Hong Wang
    Susan L Cullman Laboratory for Cancer Research, Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy at Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Carcinogenesis 32:1881-9. 2011
    ..In summary, our results demonstrated, for the first time, the elevation of miR-210 by EGCG in lung cancer cell lines and this is mediated by the stabilization of HIF-1α. This event contributes to the anticancer activity of EGCG...
  91. pmc Gastroesophageal reflux leads to esophageal cancer in a surgical model with mice
    Jing Hao
    Department of Chemical Biology, Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    BMC Gastroenterol 9:59. 2009
    ..However, use of this rat model for mechanistic and chemopreventive studies is limited due to lack of genetically modified rat strains. Therefore, a mouse model of esophageal adenocarcinoma is needed...
  92. pmc Curcumin induces the differentiation of myeloid-derived suppressor cells and inhibits their interaction with cancer cells and related tumor growth
    Shui Ping Tu
    Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 Phone 1 732 445 3400 ext 279 Fax 1 732 445 3421 and Chung S Yang
    Cancer Prev Res (Phila) 5:205-15. 2012
    ..The induction of MDSC differentiation and inhibition of the interaction of MDSCs with cancer cells are potential strategies for cancer prevention and therapy. Cancer Prev Res; 5(2); 205-15. ©2011 AACR...
  93. pmc Metabolism of tocotrienols in animals and synergistic inhibitory actions of tocotrienols with atorvastatin in cancer cells
    Zhihong Yang
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ, 08854, USA
    Genes Nutr 7:11-8. 2012
    ..It remains to be determined whether such a synergy occurs in vivo...
  94. pmc Structural identification of novel glucoside and glucuronide metabolites of (-)-epigallocatechin-3-gallate in mouse urine using liquid chromatography/electrospray ionization tandem mass spectrometry
    Shengmin Sang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Rapid Commun Mass Spectrom 22:3693-9. 2008
    ..To our knowledge, this is the first report of the identification of a glucoside metabolite of EGCG in mammals. Our results indicate that glucosidation represents a novel pathway in the metabolism of EGCG in mice...