DIPAK SARKAR

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. pmc Regulation of cancer progression by β-endorphin neuron
    Dipak K Sarkar
    Rutgers Endocrine Program, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA
    Cancer Res 72:836-40. 2012
  2. pmc Mu-opioid receptor and delta-opioid receptor differentially regulate microglial inflammatory response to control proopiomelanocortin neuronal apoptosis in the hypothalamus: effects of neonatal alcohol.
    Pallavi Shrivastava
    J Neuroinflammation 14:83. 2017
  3. doi request reprint Fetal alcohol exposure increases susceptibility to carcinogenesis and promotes tumor progression in prostate gland
    Dipak K Sarkar
    Endocrinology Program and Department of Animal Sciences, Rutgers, The State University of New Jersey, 67 Poultry Farm Road, New Brunswick, NJ, 08901, USA
    Adv Exp Med Biol 815:389-402. 2015
  4. pmc Roles of dopamine 2 receptor isoforms and g proteins in ethanol regulated prolactin synthesis and lactotropic cell proliferation
    Amitabha Sengupta
    Endocrine Program, Department of Animal Sciences, Rutgers University, New Brunswick, NJ, USA
    PLoS ONE 7:e45593. 2012
  5. doi request reprint Beta-endorphin neuron regulates stress response and innate immunity to prevent breast cancer growth and progression
    Dipak K Sarkar
    Endocrinology Program and Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA
    Vitam Horm 93:263-76. 2013
  6. pmc Dopamine, dopamine D2 receptor short isoform, transforming growth factor (TGF)-beta1, and TGF-beta type II receptor interact to inhibit the growth of pituitary lactotropes
    D K Sarkar
    Endocrinology Program, Biomedical Division of the Center of Alcohol Studies and Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick 08901, USA
    Endocrinology 146:4179-88. 2005
  7. ncbi request reprint Role of estrogen in alcohol promotion of breast cancer and prolactinomas
    D K Sarkar
    Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901 8525, USA
    Alcohol Clin Exp Res 25:230S-236S. 2001
  8. pmc Genesis of prolactinomas: studies using estrogen-treated animals
    Dipak K Sarkar
    Endocrine Program, Biomedical Division, Center of Alcohol Studies and Department of Animal Sciences, Rutgers The State University of New Jersey, 84 Lipman Drive, New Brunswick, NJ 08901, USA
    Front Horm Res 35:32-49. 2006
  9. pmc Changes in thrombospondin-1 levels in the endothelial cells of the anterior pituitary during estrogen-induced prolactin-secreting pituitary tumors
    Abby J Sarkar
    Endocrinology Program and Department of Animal Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, New Jersey 08901, USA
    J Endocrinol 192:395-403. 2007
  10. ncbi request reprint Alcohol exposure during the developmental period induces beta-endorphin neuronal death and causes alteration in the opioid control of stress axis function
    Dipak K Sarkar
    Endocrinology Program, Rutgers The State University of New Jersey, 84 Lipman Drive, New Brunswick, NJ 08901, USA
    Endocrinology 148:2828-34. 2007

Research Grants

  1. OPIOID AND ALCOHOL REGULATED IMMUNE FUNCTION
    DIPAK SARKAR; Fiscal Year: 2002
  2. CONSTRUCTION OF BIOLOGY RESEARCH FACILITY
    DIPAK SARKAR; Fiscal Year: 2002
  3. ESTROGEN MITOGENIC ACTION IN THE PITUITARY
    DIPAK SARKAR; Fiscal Year: 2003
  4. ROLE OF OPIATES IN ALCOHOL-INDUCED NEUROTOXICITY
    DIPAK SARKAR; Fiscal Year: 2009
  5. Biology of the NK cell cytolytic activity rhythm
    DIPAK KUMAR SARKAR; Fiscal Year: 2010
  6. Fetal Alcohol Effects on Circadian clocks and POMC
    DIPAK KUMAR SARKAR; Fiscal Year: 2010

Collaborators

  • K W Singletary
  • J G Liehr
  • GARY MEADOWS
  • Xiaodong Cheng
  • Nadka I Boyadjieva
  • Kirti Chaturvedi
  • Alvaro Arjona
  • Cui Ping Chen
  • Nadka Boyadjieva
  • Madhavi Dokur
  • Juan P Advis
  • Peter Kuhn
  • Souichi Oomizu
  • Pallavi Shrivastava
  • Abby J Sarkar
  • Alok De
  • Michael M Poplawski
  • Amitabha Sengupta
  • Kristine N Willoughby
  • Nurul Kabir
  • Miguel A Cabrera
  • Tina Franklin
  • Lucy G Chastain
  • Shaima Jabbar
  • Maria Ortiguela
  • Lian Sheng Liu
  • Cui P Chen

Detail Information

Publications47

  1. pmc Regulation of cancer progression by β-endorphin neuron
    Dipak K Sarkar
    Rutgers Endocrine Program, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA
    Cancer Res 72:836-40. 2012
    ..Thus, β-endorphin cell therapy may offer some therapeutic value in cancer prevention...
  2. pmc Mu-opioid receptor and delta-opioid receptor differentially regulate microglial inflammatory response to control proopiomelanocortin neuronal apoptosis in the hypothalamus: effects of neonatal alcohol.
    Pallavi Shrivastava
    J Neuroinflammation 14:83. 2017
    ..Additionally, these results identify a protective effect of a DOR agonist against the pro-inflammatory and neurotoxic action of ethanol...
  3. doi request reprint Fetal alcohol exposure increases susceptibility to carcinogenesis and promotes tumor progression in prostate gland
    Dipak K Sarkar
    Endocrinology Program and Department of Animal Sciences, Rutgers, The State University of New Jersey, 67 Poultry Farm Road, New Brunswick, NJ, 08901, USA
    Adv Exp Med Biol 815:389-402. 2015
    ..Furthermore, I will discuss the additional possibility of the involvement of impaired stress regulation and resulting immune incompetence in the increased prostatic neoplasia in the fetal alcohol exposed offspring. ..
  4. pmc Roles of dopamine 2 receptor isoforms and g proteins in ethanol regulated prolactin synthesis and lactotropic cell proliferation
    Amitabha Sengupta
    Endocrine Program, Department of Animal Sciences, Rutgers University, New Brunswick, NJ, USA
    PLoS ONE 7:e45593. 2012
    ..These results suggest that ethanol via the inhibitory action on D2S receptor activity suppresses Gi3 repression of Gs expression resulting in stimulation of PRL synthesis and cell proliferation in lactotropes...
  5. doi request reprint Beta-endorphin neuron regulates stress response and innate immunity to prevent breast cancer growth and progression
    Dipak K Sarkar
    Endocrinology Program and Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA
    Vitam Horm 93:263-76. 2013
    ....
  6. pmc Dopamine, dopamine D2 receptor short isoform, transforming growth factor (TGF)-beta1, and TGF-beta type II receptor interact to inhibit the growth of pituitary lactotropes
    D K Sarkar
    Endocrinology Program, Biomedical Division of the Center of Alcohol Studies and Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick 08901, USA
    Endocrinology 146:4179-88. 2005
    ..The constitutive expression of D2 receptor short isoform also reduced the tumor cell growth rate. These data suggest that a TGFbeta1 system may mediate, in part, the growth-inhibitory action of dopamine on lactotropes...
  7. ncbi request reprint Role of estrogen in alcohol promotion of breast cancer and prolactinomas
    D K Sarkar
    Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901 8525, USA
    Alcohol Clin Exp Res 25:230S-236S. 2001
    ..Liehr; (2) Alcohol and breast cancer: Studies using animals, by Keith W. Singletary; and (3) Evaluation of the role of estrogen in mediation of ethanol effect on prolactinoma: Studies using animals, by Dipak K. Sarkar...
  8. pmc Genesis of prolactinomas: studies using estrogen-treated animals
    Dipak K Sarkar
    Endocrine Program, Biomedical Division, Center of Alcohol Studies and Department of Animal Sciences, Rutgers The State University of New Jersey, 84 Lipman Drive, New Brunswick, NJ 08901, USA
    Front Horm Res 35:32-49. 2006
    ..The downstream signaling that governs lactotropic cell proliferation involves activation of the MAP kinase p44/42-dependent pathway...
  9. pmc Changes in thrombospondin-1 levels in the endothelial cells of the anterior pituitary during estrogen-induced prolactin-secreting pituitary tumors
    Abby J Sarkar
    Endocrinology Program and Department of Animal Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, New Jersey 08901, USA
    J Endocrinol 192:395-403. 2007
    ..These results suggest that locally produced TSP-1 may regulate estrogen angiogenic action on the pituitary...
  10. ncbi request reprint Alcohol exposure during the developmental period induces beta-endorphin neuronal death and causes alteration in the opioid control of stress axis function
    Dipak K Sarkar
    Endocrinology Program, Rutgers The State University of New Jersey, 84 Lipman Drive, New Brunswick, NJ 08901, USA
    Endocrinology 148:2828-34. 2007
    ....
  11. pmc Ethanol alters production and secretion of estrogen-regulated growth factors that control prolactin-secreting tumors in the pituitary
    Dipak K Sarkar
    Program of Endocrinology, Center of Alcohol Studies and Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, USA
    Alcohol Clin Exp Res 31:2101-5. 2007
    ....
  12. pmc Cyclic adenosine monophosphate differentiated beta-endorphin neurons promote immune function and prevent prostate cancer growth
    Dipak K Sarkar
    Endocrine Program and Neurotoxicology Laboratories, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA
    Proc Natl Acad Sci U S A 105:9105-10. 2008
    ....
  13. doi request reprint Hyperprolactinemia following chronic alcohol administration
    Dipak K Sarkar
    Endocrine Program, Biomedical Division of the Center of Alcohol Studies and Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901 8525, USA
    Front Horm Res 38:32-41. 2010
    ..A coordinated suppression of D2 receptor- and TbetaRII receptor-mediated signaling as well as enhancement of bFGF activity might be critical for ethanol action on PRL production and cell proliferation in lactotropes...
  14. pmc Transplantation of β-endorphin neurons into the hypothalamus promotes immune function and restricts the growth and metastasis of mammary carcinoma
    Dipak K Sarkar
    Rutgers Endocrine Program, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA
    Cancer Res 71:6282-91. 2011
    ..Together, our findings establish a protective role for BEP against the growth and metastasis of mammary tumor cells by altering autonomic nervous system activities that enhance innate immune function...
  15. pmc Alteration in G proteins and prolactin levels in pituitary after ethanol and estrogen treatment
    Kirti Chaturvedi
    Endocrine Program, Center of Alcohol Studies and Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA
    Alcohol Clin Exp Res 32:806-13. 2008
    ..The present study was conducted to determine the changes in the pituitary levels of G proteins during the tumor development following alcohol and ethanol treatments...
  16. doi request reprint Ethanol induces apoptotic death of beta-endorphin neurons in the rat hypothalamus by a TGF-beta 1-dependent mechanism
    Peter Kuhn
    Endocrine Program, Center of Alcohol Studies and Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, USA
    Alcohol Clin Exp Res 32:706-14. 2008
    ....
  17. pmc Isolation and characterization of rat pituitary endothelial cells
    Kirti Chaturvedi
    Endocrinology Program, Biomedical Division of the Center of Alcohol Studies and Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA
    Neuroendocrinology 83:387-93. 2006
    ..These results suggest that a magnetic separation technique can be used for enrichment of pituitary-derived endothelial cells for determination of cellular mechanisms governing the vascularization in the pituitary...
  18. ncbi request reprint Prenatal ethanol exposure alters the expression of period genes governing the circadian function of beta-endorphin neurons in the hypothalamus
    Cui Ping Chen
    Endocrine Program, Biomedical Division of the Center of Alcohol Studies and Department of Animal Sciences, The State University of New Jersey, New Brunswick, New Jersey 08901 8525, USA
    J Neurochem 97:1026-33. 2006
    ..These data suggest for the first time that fetal exposure to ethanol significantly alters the clock mechanisms governing the circadian function of beta-endorphin neurons...
  19. ncbi request reprint Ethanol induces apoptotic death of developing beta-endorphin neurons via suppression of cyclic adenosine monophosphate production and activation of transforming growth factor-beta1-linked apoptotic signaling
    Cui Ping Chen
    Endocrinology Program and Department of Animal Sciences, 84 Lipman Dr, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA
    Mol Pharmacol 69:706-17. 2006
    ....
  20. pmc Transforming growth factor-beta3 increases gap-junctional communication among folliculostellate cells to release basic fibroblast growth factor
    Nurul Kabir
    Endocrinology Program and Department of Animal Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, New Jersey 08901, USA
    Endocrinology 146:4054-60. 2005
    ..Taken together, these results suggest that TGFbeta3 may act on FS cells to increase gap-junctional communication to maximize its effect on bFGF secretion...
  21. pmc Role of protein kinase C-Ras-MAPK p44/42 in ethanol and transforming growth factor-beta3-induced basic fibroblast growth factor release from folliculostellate cells
    Kirti Chaturvedi
    Endocrinology Program and Department of Animal Science, Rutgers, The State University of New Jersey, New Brunswick, USA
    J Pharmacol Exp Ther 314:1346-52. 2005
    ..These data suggest that the PKC-activated Ras-dependent MAPK p44/42 pathway is involved in the cross talk between TGF-beta3 and ethanol to increase bFGF release from FS cells...
  22. ncbi request reprint Ethanol induces hyperprolactinemia by increasing prolactin release and lactotrope growth in female rats
    Alok De
    Program of Endocrinology, Center of Alcohol Studies and Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901 8525, USA
    Alcohol Clin Exp Res 26:1420-9. 2002
    ..This study investigated whether increased pituitary production of prolactin, which leads to alcohol-induced hyperprolactinemia, results from an increase in cell number and/or cell production of prolactin in the pituitary...
  23. pmc Ethanol and estradiol modulate alternative splicing of dopamine D2 receptor messenger RNA and abolish the inhibitory action of bromocriptine on prolactin release from the pituitary gland
    Souichi Oomizu
    Endocrinology Program, Biomedical Division, Center of Alcohol Studies and Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, 08901, USA
    Alcohol Clin Exp Res 27:975-80. 2003
    ..Previously we have shown that ethanol increases PRL release both in vivo and in vitro. How ethanol increases PRL release is not well understood...
  24. pmc Folliculostellate cells determine the susceptibility of lactotropes to estradiol's mitogenic action
    Souichi Oomizu
    Endocrinology Program, Rutgers, Biomedical Divison of the Center for Alcohol Studies, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, USA
    Endocrinology 145:1473-80. 2004
    ..These data suggest that cell-cell interaction between FS cells and lactotropes regulates estradiol's mitogenic action on lactotropes and also determines lactotrope susceptibility to the steroid...
  25. ncbi request reprint Role of protein kinase C in control of ethanol-modulated beta-endorphin release from hypothalamic neurons in primary cultures
    Alok De
    Department of Animal Sciences, Rutgers, The State University of New Jersey, Cook College, New Brunswick, New Jersey 08901 8525, USA
    J Pharmacol Exp Ther 301:119-28. 2002
    ..These data provide evidence for the first time that ethanol-regulated IR-beta-EP secretion is controlled by the PKC system, possibly involving PKC-delta and PKC-epsilon isoenzymes...
  26. ncbi request reprint Role of beta-endorphin, corticotropin-releasing hormone, and autonomic nervous system in mediation of the effect of chronic ethanol on natural killer cell cytolytic activity
    Nadka Boyadjieva
    Endocrine Program, Center of Alcohol Studies and Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA
    Alcohol Clin Exp Res 30:1761-7. 2006
    ..In the present study, we evaluated the roles of beta-EP neurons, corticotropin releasing hormone (CRH) neurons, and the autonomic nervous system (ANS) in regulation of the ethanol effect on splenic NK cell cytolytic function...
  27. ncbi request reprint Vasoactive intestinal peptide and corticotropin-releasing hormone increase beta-endorphin release and proopiomelanocortin messenger RNA levels in primary cultures of hypothalamic cells: effects of acute and chronic ethanol treatment
    Michael M Poplawski
    Endocrinology Program, Center of Alcohol Studies and Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901 8525, USA
    Alcohol Clin Exp Res 29:648-55. 2005
    ..Whether these neuropeptides affect beta-EP neuronal function in the presence or absence of ethanol has not previously been determined...
  28. pmc Involvement of protein kinase C-dependent mitogen-activated protein kinase p44/42 signaling pathway for cross-talk between estradiol and transforming growth factor-beta3 in increasing basic fibroblast growth factor in folliculostellate cells
    Kirti Chaturvedi
    Endocrinology Program, Biomedical Division of the Center of Alcohol Studies and Department of Animal Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, NJ 08901, USA
    Endocrinology 145:706-15. 2004
    ..These data suggest that an estradiol receptor-independent protein kinase C- activated Ras-dependent MAPK pathway is involved in the cross-talk between TGF-beta3 and estradiol to increase bFGF production and/or release from FS cells...
  29. ncbi request reprint Modulation of hypothalamic beta-endorphin-regulated expression of natural killer cell cytolytic activity regulatory factors by ethanol in male Fischer-344 rats
    Madhavi Dokur
    Endocrinology Program, Center of Alcohol Studies and Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901 8525, USA
    Alcohol Clin Exp Res 28:1180-6. 2004
    ....
  30. pmc Beta-endorphin neuronal cell transplant reduces corticotropin releasing hormone hyperresponse to lipopolysaccharide and eliminates natural killer cell functional deficiencies in fetal alcohol exposed rats
    Nadka I Boyadjieva
    Endocrine Program, Department of Animal Sciences, Rutgers The State University of New Jersey, New Brunswick, NJ 08901, USA
    Alcohol Clin Exp Res 33:931-7. 2009
    ..Hence, we determined whether in vitro differentiated BEP neurons could be used for reversing the compromised stress response and immune function in fetal alcohol exposed rats...
  31. ncbi request reprint Beta-endorphin modulation of interferon-gamma, perforin and granzyme B levels in splenic NK cells: effects of ethanol
    Madhavi Dokur
    Endocrine Program, Biomedical Division of the Center of Alcohol Studies and Department of Animal Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, NJ 08901 8525, USA
    J Neuroimmunol 166:29-38. 2005
    ..These results suggest that beta-EP and ethanol interact to regulate NK cell functions...
  32. ncbi request reprint Beta-endorphin modulation of lymphocyte proliferation: effects of ethanol
    Nadka I Boyadjieva
    Endocrinology Program, Center of Alcohol Studies, Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick 08901 8525, USA
    Alcohol Clin Exp Res 26:1719-27. 2002
    ..In this study, we investigated whether ethanol treatment for 1 to 4 weeks reduces the proliferation of other lymphocyte subsets and whether beta-EP regulates ethanol's effect on lymphocyte proliferation...
  33. ncbi request reprint Ethanol suppression of the hypothalamic proopiomelanocortin level and the splenic NK cell cytolytic activity is associated with a reduction in the expression of proinflammatory cytokines but not anti-inflammatory cytokines in neuroendocrine and immune cel
    Cui Ping Chen
    Endocrine Program, Center of Alcohol Studies and Department of Animal Sciences, Rutgers The State University of New Jersey, 84 Lipman Drive, New Brunswick, NJ, USA
    Alcohol Clin Exp Res 30:1925-32. 2006
    ..The effects of ethanol on the proinflammatory and anti-inflammatory cytokines known to control beta-endorphin neuronal and NK cell functions during immune challenges have not been determined...
  34. ncbi request reprint Opioid antagonist naltrexone disrupts feedback interaction between mu and delta opioid receptors in splenocytes to prevent alcohol inhibition of NK cell function
    Nadka I Boyadjieva
    Program of Endocrinology, Center of Alcohol Studies, Department of Animal Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, NJ 08901, USA
    J Immunol 173:42-9. 2004
    ..We conclude that naltrexone, which has been shown to be a promising agent for the clinical management of alcoholism, may have potential use in the treatment of immune deficiency in alcoholic and nonalcoholic patients...
  35. ncbi request reprint Chronic ethanol consumption impairs the circadian rhythm of pro-opiomelanocortin and period genes mRNA expression in the hypothalamus of the male rat
    Cui Ping Chen
    Endocrine Program, Center of Alcohol Studies and Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901 8525, USA
    J Neurochem 88:1547-54. 2004
    ..Our findings identified the vulnerability of the body's clock machinery and its opioidergic system to chronic alcohol drinking...
  36. pmc Opioid-like activity of naltrexone on natural killer cell cytolytic activity and cytokine production in splenocytes: effects of alcohol
    Nadka I Boyadjieva
    Department of Animal Sciences, Rutgers, The State University of New Jersey, Center of Alcohol Studies, New Brunswick, New Jersey 08901, USA
    J Interferon Cytokine Res 30:15-22. 2010
    ..Furthermore, these results identify the potential of the use of naltrexone in the treatment of immune deficiency in alcoholic and non-alcoholic patients...
  37. pmc Mediation of basic fibroblast growth factor-induced lactotropic cell proliferation by Src-Ras-mitogen-activated protein kinase p44/42 signaling
    Kirti Chaturvedi
    Endocrinology Program and Department of Animal Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, New Jersey 08901, USA
    Endocrinology 146:1948-55. 2005
    ..These data suggest that bFGF induction of lactotropic cell proliferation is possibly mediated by activation of Src kinase, Ras p21, and MAPK p44/42...
  38. ncbi request reprint Role of nitric oxide in alcohol alteration of beta-endorphin release from hypothalamic cells in primary cultures
    Nadka I Boyadjieva
    Center for Alcohol Studies and Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick 08901 8525, USA
    Alcohol Clin Exp Res 27:1813-8. 2003
    ..Nitric oxide (NO) mediates many pharmacological actions of ethanol. NO's role in regulating ethanol action on hypothalamic beta-endorphin (beta-EP) neurons is not established...
  39. ncbi request reprint Reduction of perforin, granzyme B, and cytokine interferon gamma by ethanol in male Fischer 344 rats
    Madhavi Dokur
    Endocrinology Program, Center of Alcohol Studies, Rutgers, The State University of New Jersey, New Brunswick, USA
    Alcohol Clin Exp Res 27:670-6. 2003
    ....
  40. ncbi request reprint Circadian oscillations of clock genes, cytolytic factors, and cytokines in rat NK cells
    Alvaro Arjona
    Endocrinology Program, Center of Alcohol Studies and Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA
    J Immunol 174:7618-24. 2005
    ..Moreover, the circadian expression of cytolytic factors and cytokines in NK cells reported in this study emphasizes the circadian nature of NK cell function...
  41. ncbi request reprint Catecholaminergic control of NK cell cytolytic activity regulatory factors in the spleen
    Madhavi Dokur
    Endocrinology Program, Biomedical Division at the Center of Alcohol Studies and Department of Animal Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, NJ 08901 8525, USA
    J Neuroimmunol 151:148-57. 2004
    ..These data suggest that NE and beta-adrenergic agonists may inhibit NK cell cytolytic activity by regulating the production of perforin, granzyme B, and IFN-gamma in splenocytes...
  42. ncbi request reprint Circadian rhythms of granzyme B, perforin, IFN-gamma, and NK cell cytolytic activity in the spleen: effects of chronic ethanol
    Alvaro Arjona
    Program of Endocrinology, Center of Alcohol Studies, Department of Animal Sciences, Rutgers, State University of New Jersey, New Brunswick, NJ 08901, USA
    J Immunol 172:2811-7. 2004
    ..These findings identify the circadian functions of splenic NK cells and show the vulnerability of these rhythms to chronic ethanol...
  43. ncbi request reprint Are circadian rhythms the code of hypothalamic-immune communication? Insights from natural killer cells
    Alvaro Arjona
    Endocrinology Program, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, NJ 08901, USA
    Neurochem Res 33:708-18. 2008
    ..In this overview, we summarize the findings demonstrating that Natural Killer (NK) cell function is under circadian control...
  44. ncbi request reprint Fetal ethanol exposure disrupts the daily rhythms of splenic granzyme B, IFN-gamma, and NK cell cytotoxicity in adulthood
    Alvaro Arjona
    Endocrine Program, Biomedical Division of the Center of Alcohol Studies and Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, USA
    Alcohol Clin Exp Res 30:1039-44. 2006
    ..Although ethanol is known to be a potent toxin for many systems in the developing fetus, including the immune system, the long-term effects of fetal ethanol exposure on circadian immune function have not been explored...
  45. ncbi request reprint Neonatally administered tert-octylphenol affects onset of puberty and reproductive development in female rats
    Kristine N Willoughby
    Endocrinology Program and Department of Animal Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, NJ 08901, USA
    Endocrine 26:161-8. 2005
    ..These data suggest that exposure to OP during the critical period of sexual brain differentiation affects the onset of puberty and reproductive development...
  46. ncbi request reprint Evidence supporting a circadian control of natural killer cell function
    Alvaro Arjona
    Endocrinology Program and Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA
    Brain Behav Immun 20:469-76. 2006
    ..Taken together, these results provide evidence supporting that NK cell function is under circadian regulation...

Research Grants6

  1. OPIOID AND ALCOHOL REGULATED IMMUNE FUNCTION
    DIPAK SARKAR; Fiscal Year: 2002
    ....
  2. CONSTRUCTION OF BIOLOGY RESEARCH FACILITY
    DIPAK SARKAR; Fiscal Year: 2002
    ..abstract_text> ..
  3. ESTROGEN MITOGENIC ACTION IN THE PITUITARY
    DIPAK SARKAR; Fiscal Year: 2003
    ..Such knowledge should be important in understanding prolactinoma because increased proliferation is an early step in cell transformation. ..
  4. ROLE OF OPIATES IN ALCOHOL-INDUCED NEUROTOXICITY
    DIPAK SARKAR; Fiscal Year: 2009
    ....
  5. Biology of the NK cell cytolytic activity rhythm
    DIPAK KUMAR SARKAR; Fiscal Year: 2010
    ..The proposed series of studies should enhance our knowledge of the physiological mechanisms orchestrating NK cell circadian function. ..
  6. Fetal Alcohol Effects on Circadian clocks and POMC
    DIPAK KUMAR SARKAR; Fiscal Year: 2010
    ..This information should help to develop therapeutic strategies in managing sleep-wake disturbances and the resultant health consequences in FAE offspring. ..