Ah Ng Tony Kong

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. pmc Natural compound-derived epigenetic regulators targeting epigenetic readers, writers and erasers
    Anne Yuqing Yang
    Rutgers, The State University of New Jersey, Ernest Mario School of Pharmacy, Room 228, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Curr Top Med Chem 16:697-713. 2016
  2. pmc The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains
    J H Kim
    Graduate Program in Pharmaceutical Science, Rutgers, The State University of New Jersey, Piscataway, NJ, USA
    Oncogene 32:514-27. 2013
  3. doi Requirement and epigenetics reprogramming of Nrf2 in suppression of tumor promoter TPA-induced mouse skin cell transformation by sulforaphane
    Zheng Yuan Su
    Center for Cancer Prevention Research, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, New Jersey 08854
    Cancer Prev Res (Phila) 7:319-29. 2014
  4. pmc Total and individual antioxidant intake and risk of epithelial ovarian cancer
    Dina Gifkins
    The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    BMC Cancer 12:211. 2012
  5. ncbi Pharmacogenetics, pharmacogenomics and epigenetics of Nrf2-regulated xenobiotic-metabolizing enzymes and transporters by dietary phytochemical and cancer chemoprevention
    Tien Yuan Wu
    Center for Cancer Prevention Research and Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Curr Drug Metab 14:688-94. 2013
  6. pmc Targeting epigenetics for cancer prevention by dietary cancer preventive compounds--the case of miRNA
    Ah Ng Tony Kong
    Center for Cancer Prevention Research, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, Piscataway, NJ 08854, USA
    Cancer Prev Res (Phila) 6:622-4. 2013
  7. pmc Anti-oxidative stress regulator NF-E2-related factor 2 mediates the adaptive induction of antioxidant and detoxifying enzymes by lipid peroxidation metabolite 4-hydroxynonenal
    Ying Huang
    Department of Pharmaceutics, Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ, 08854, USA
    Cell Biosci 2:40. 2012
  8. ncbi Identification of Nrf2-regulated genes induced by chemopreventive isothiocyanate PEITC by oligonucleotide microarray
    Rong Hu
    Graduate Program in Pharmaceutical Science, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Life Sci 79:1944-55. 2006
  9. ncbi Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells
    Woo Sik Jeong
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    J Biochem Mol Biol 38:167-76. 2005
  10. ncbi Modulation of activator protein-1 (AP-1) and MAPK pathway by flavonoids in human prostate cancer PC3 cells
    Avanthika Gopalakrishnan
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway NJ 08854, USA
    Arch Pharm Res 29:633-44. 2006

Collaborators

Detail Information

Publications87

  1. pmc Natural compound-derived epigenetic regulators targeting epigenetic readers, writers and erasers
    Anne Yuqing Yang
    Rutgers, The State University of New Jersey, Ernest Mario School of Pharmacy, Room 228, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Curr Top Med Chem 16:697-713. 2016
    ..These advances provide insights into epigenetic alterations in cancers and the potential utility of these alterations as therapeutic targets for the future development of chemopreventive and chemotherapeutic drugs. ..
  2. pmc The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains
    J H Kim
    Graduate Program in Pharmaceutical Science, Rutgers, The State University of New Jersey, Piscataway, NJ, USA
    Oncogene 32:514-27. 2013
    ..These data suggest that Nrf2 activation is modulated and directly controlled through interactions with the RAC3 protein in HeLa cells...
  3. doi Requirement and epigenetics reprogramming of Nrf2 in suppression of tumor promoter TPA-induced mouse skin cell transformation by sulforaphane
    Zheng Yuan Su
    Center for Cancer Prevention Research, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, New Jersey 08854
    Cancer Prev Res (Phila) 7:319-29. 2014
    ....
  4. pmc Total and individual antioxidant intake and risk of epithelial ovarian cancer
    Dina Gifkins
    The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    BMC Cancer 12:211. 2012
    ..Our study aimed to evaluate the association between total antioxidant capacity (TAC) and individual antioxidant intakes (vitamin C, vitamin E, beta-carotene, selenium, lutein, and lycopene) and ovarian cancer risk...
  5. ncbi Pharmacogenetics, pharmacogenomics and epigenetics of Nrf2-regulated xenobiotic-metabolizing enzymes and transporters by dietary phytochemical and cancer chemoprevention
    Tien Yuan Wu
    Center for Cancer Prevention Research and Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Curr Drug Metab 14:688-94. 2013
    ..The pharmacogenomic expression of XMEs and transporters, with an emphasis on both genomics and epigenetics, will also be discussed. ..
  6. pmc Targeting epigenetics for cancer prevention by dietary cancer preventive compounds--the case of miRNA
    Ah Ng Tony Kong
    Center for Cancer Prevention Research, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, Piscataway, NJ 08854, USA
    Cancer Prev Res (Phila) 6:622-4. 2013
    ..This report, along with increasing evidence showing the impact of dietary phytochemicals on epigenetic activities, offers new perspectives on miRNA and epigenetic regulation in cancer prevention...
  7. pmc Anti-oxidative stress regulator NF-E2-related factor 2 mediates the adaptive induction of antioxidant and detoxifying enzymes by lipid peroxidation metabolite 4-hydroxynonenal
    Ying Huang
    Department of Pharmaceutics, Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ, 08854, USA
    Cell Biosci 2:40. 2012
    ..In this study, we examined the role of NRF2 in regulating the 4-HNE induced gene expression of antioxidant and detoxifying enzymes...
  8. ncbi Identification of Nrf2-regulated genes induced by chemopreventive isothiocyanate PEITC by oligonucleotide microarray
    Rong Hu
    Graduate Program in Pharmaceutical Science, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Life Sci 79:1944-55. 2006
    ....
  9. ncbi Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells
    Woo Sik Jeong
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    J Biochem Mol Biol 38:167-76. 2005
    ....
  10. ncbi Modulation of activator protein-1 (AP-1) and MAPK pathway by flavonoids in human prostate cancer PC3 cells
    Avanthika Gopalakrishnan
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway NJ 08854, USA
    Arch Pharm Res 29:633-44. 2006
    ..These results suggest the possible involvement of JNK pathway in genistein induced AP-1 activity while the ERK pathway seems to play an important role in kaempferol induced AP-1 activity...
  11. ncbi Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2
    Changjiang Xu
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, 08854, USA
    Mol Cancer Ther 5:1918-26. 2006
    ..Nuclear Nrf2 activates ARE elements and induces expression of stress-responsive genes, including HO-1...
  12. ncbi Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice
    Tin Oo Khor
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Biopharm Drug Dispos 27:407-20. 2006
    ....
  13. ncbi Pharmacogenomics of phenolic antioxidant butylated hydroxyanisole (BHA) in the small intestine and liver of Nrf2 knockout and C57BL/6J mice
    Sujit Nair
    Graduate Program in Pharmaceutical Sciences, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Pharm Res 23:2621-37. 2006
    ....
  14. ncbi Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin
    Guoxiang Shen
    Graduate Program in Pharmaceutical Science, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, 08854, USA
    Mol Cancer Ther 5:39-51. 2006
    ....
  15. ncbi Butylated hydroxyanisole regulates ARE-mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells
    Xiaoling Yuan
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Mol Carcinog 45:841-50. 2006
    ....
  16. ncbi ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells
    Changjiang Xu
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Carcinogenesis 27:437-45. 2006
    ..Taken together, our results indicate that the activation of the ERK and JNK signaling pathways is important for transcriptional activity of AP-1 and is involved in the regulation of cell death elicited by ITCs in PC-3 cells...
  17. ncbi Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with beta-phenylethyl isothiocyanate and curcumin
    Jung Hwan Kim
    Center for Cancer Prevention Research, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Carcinogenesis 27:475-82. 2006
    ....
  18. ncbi Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice
    Tin Oo Khor
    Center for Cancer Prevention Research, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers The State University of New Jersey, 160 Freilinghuysen Road, Piscataway, NJ 08854, USA
    Cancer Res 66:613-21. 2006
    ..Furthermore, we found that combination of PEITC and curcumin could be effective in the cancer-therapeutic treatment of prostate cancers...
  19. doi Epigenetic reactivation of Nrf2 in murine prostate cancer TRAMP C1 cells by natural phytochemicals Z-ligustilide and Radix angelica sinensis via promoter CpG demethylation
    Zheng Yuan Su
    Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, United States
    Chem Res Toxicol 26:477-85. 2013
    ..Epigenetic modifications of genes, including Nrf2, may therefore contribute to the overall health benefits of RAS, including the anticancer effect of RAS and its bioactive component, Lig...
  20. ncbi In vivo pharmacokinetics, activation of MAPK signaling and induction of phase II/III drug metabolizing enzymes/transporters by cancer chemopreventive compound BHA in the mice
    Rong Hu
    Graduate Program in Pharmaceutical Science, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Arch Pharm Res 29:911-20. 2006
    ..This is the first study to demonstrate the in vivo pharmacokinetics of BHA, the in vivo activation of MAPK signaling proteins, as well as the in vivo induction of Phase II/III drug metabolizing enzymes/transporters in the mouse livers...
  21. ncbi Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice
    Rong Hu
    Graduate Program in Pharmaceutical Science, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen, Piscataway, NJ 08854, USA
    Cancer Lett 243:170-92. 2006
    ....
  22. pmc The Ras GTPase-activating-like protein IQGAP1 mediates Nrf2 protein activation via the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)-ERK pathway
    Ka Lung Cheung
    Graduate Program in Pharmaceutical Science, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    J Biol Chem 288:22378-86. 2013
    ..In the aggregate, these results suggest that IQGAP1 may play an important role in the MEK-ERK-Nrf2 signaling pathway. ..
  23. ncbi Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2
    Changjiang Xu
    Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Cancer Res 66:8293-6. 2006
    ..Taken together, our results show for the first time that Nrf2(-/-) mice are more susceptible to skin tumorigenesis and that the chemopreventive effects of sulforaphane are mediated, at least in part, through Nrf2...
  24. pmc Epigenetic modifications of Nrf2 by 3,3'-diindolylmethane in vitro in TRAMP C1 cell line and in vivo TRAMP prostate tumors
    Tien Yuan Wu
    Center for Cancer Prevention Research, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Room 228, 160 Frelinghuysen Road, Piscataway, New Jersey, 08854, USA
    AAPS J 15:864-74. 2013
    ....
  25. pmc The complexity of the Nrf2 pathway: beyond the antioxidant response
    Ying Huang
    Department of Pharmaceutics, Earnest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Nutr Biochem 26:1401-13. 2015
    ....
  26. doi Nrf2 knockout enhances intestinal tumorigenesis in Apc(min/+) mice due to attenuation of anti-oxidative stress pathway while potentiates inflammation
    Ka Lung Cheung
    Graduate Program in Pharmaceutical Science, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey Center for Cancer Prevention Research, Rutgers, The State University of New Jersey, Piscataway, New Jersey
    Mol Carcinog 53:77-84. 2014
    ....
  27. pmc Plants vs. cancer: a review on natural phytochemicals in preventing and treating cancers and their druggability
    Hu Wang
    Graduate Program in Pharmaceutical Sciences, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Anticancer Agents Med Chem 12:1281-305. 2012
    ..The authors wish to expand this research area not only for their scientific soundness, but also for their potential druggability...
  28. pmc Pharmacokinetics and pharmacodynamics of phase II drug metabolizing/antioxidant enzymes gene response by anticancer agent sulforaphane in rat lymphocytes
    Hu Wang
    Graduate Program in Pharmaceutical Sciences, Department of Pharmaceutics, Ernest Mario School of Pharmacy, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Mol Pharm 9:2819-27. 2012
    ..This study may provide a conceptual framework for future clinical PK-PD studies of dietary cancer chemopreventive agents in human...
  29. pmc A γ-tocopherol-rich mixture of tocopherols maintains Nrf2 expression in prostate tumors of TRAMP mice via epigenetic inhibition of CpG methylation
    Ying Huang
    Department of Pharmaceutics, Center for Cancer Prevention Research, Earnest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA
    J Nutr 142:818-23. 2012
    ....
  30. pmc Epigenetic CpG demethylation of the promoter and reactivation of the expression of Neurog1 by curcumin in prostate LNCaP cells
    Limin Shu
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, 08854, USA
    AAPS J 13:606-14. 2011
    ....
  31. pmc Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression
    Jong Hun Lee
    Center for Cancer Prevention Research, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Pharmacol Ther 137:153-71. 2013
    ....
  32. pmc Nrf2 null enhances UVB-induced skin inflammation and extracellular matrix damages
    Constance Lay Lay Saw
    Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Cell Biosci 4:39. 2014
    ..Collectively, our results show that Nrf2 plays a key role in protecting against UVB irradiation and that the photo-protective effect of Nrf2 is closely related to the inhibition of ECM degradation and inflammation...
  33. pmc Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates
    Constance Lay Lay Saw
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Biopharm Drug Dispos 32:289-300. 2011
    ..In summary, the indole I3C or DIM alone could induce or syngergistically induce in combination with the ITCs SFN or PEITC, Nrf2-ARE-mediated gene expression, which could potentially enhance cancer chemopreventive activity...
  34. doi Effects of natural phytochemicals in Angelica sinensis (Danggui) on Nrf2-mediated gene expression of phase II drug metabolizing enzymes and anti-inflammation
    Constance Lay Lay Saw
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Biopharm Drug Dispos 34:303-11. 2013
    ..In summary, this study demonstrates that AS has anti-inflammatory effects and activates the Nrf2 pathway, which protects against oxidative stress...
  35. pmc Dietary tocopherols inhibit cell proliferation, regulate expression of ERα, PPARγ, and Nrf2, and decrease serum inflammatory markers during the development of mammary hyperplasia
    Amanda K Smolarek
    Department of Pharmacology and Toxicology, Rutgers, The State University of New Jersey, Piscataway, New Jersey
    Mol Carcinog 52:514-25. 2013
    ....
  36. pmc Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation
    Chengyue Zhang
    Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, USA
    Biochem Pharmacol 85:1398-404. 2013
    ....
  37. ncbi Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse
    Guoxiang Shen
    Center for Cancer Prevention Research, Department of Pharmaceutics, and Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Cancer Res 67:9937-44. 2007
    ..In conclusion, our results showed that both SFN and DBM alone as well as their combination are potent natural dietary compounds for chemoprevention of gastrointestinal cancers...
  38. doi Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation
    Tin Oo Khor
    Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, USA
    Biochem Pharmacol 82:1073-8. 2011
    ....
  39. pmc Pharmacodynamics of ginsenosides: antioxidant activities, activation of Nrf2, and potential synergistic effects of combinations
    Constance Lay Lay Saw
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Chem Res Toxicol 25:1574-80. 2012
    ..The Nrf2-ARE-mediated antioxidant pathway could play a role for the overall antioxidative stress activities, which could be important for ginseng's health beneficial effects such as cancer chemopreventive activities...
  40. ncbi Dietary cancer-chemopreventive compounds: from signaling and gene expression to pharmacological effects
    Chi Chen
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Trends Pharmacol Sci 26:318-26. 2005
    ....
  41. ncbi Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells
    Changjiang Xu
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Oncogene 24:4486-95. 2005
    ....
  42. pmc Anti-inflammatory/Anti-oxidative stress activities and differential regulation of Nrf2-mediated genes by non-polar fractions of tea Chrysanthemum zawadskii and licorice Glycyrrhiza uralensis
    Tien Yuan Wu
    Graduate Program in Pharmaceutical Science, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA
    AAPS J 13:1-13. 2011
    ....
  43. ncbi Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable
    Rong Hu
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Carcinogenesis 27:2038-46. 2006
    ....
  44. pmc Identification and functional studies of a new Nrf2 partner IQGAP1: a critical role in the stability and transactivation of Nrf2
    Jung Hwan Kim
    Graduate Program in Pharmaceutical Science, Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Antioxid Redox Signal 19:89-101. 2013
    ....
  45. doi Genome-wide analysis of DNA methylation in UVB- and DMBA/TPA-induced mouse skin cancer models
    Anne Yuqing Yang
    Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Piscataway, NJ 08854, USA Department of Pharmaceutics, Ernest Mario School of Pharmacy, Piscataway, NJ 08854, USA Graduate Program in Pharmaceutical Sciences, Ernest Mario School of Pharmacy, Piscataway, NJ 08854, USA
    Life Sci 113:45-54. 2014
    ..We aimed to study the genome-wide DNA methylation profiles of skin cancers induced by ultraviolet B (UVB) irradiation and 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-1,3-acetate (TPA)...
  46. doi Astaxanthin and omega-3 fatty acids individually and in combination protect against oxidative stress via the Nrf2-ARE pathway
    Constance Lay Lay Saw
    Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Food Chem Toxicol 62:869-75. 2013
    ..In summary, our study shows synergistic antioxidant effects of AST and PUFAs at low concentrations. The Nrf2/ARE pathway plays an important role in the antioxidative effects induced by AST, DHA, and EPA. ..
  47. ncbi Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway
    Woo Sik Jeong
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Pharm Res 21:661-70. 2004
    ..To study and compare effects of selected natural chemopreventive agents on the transcription activation of nuclear factor-kappa B (NF-kappaB) in human HT-29 colon cancer cells...
  48. pmc Toxicogenomics of endoplasmic reticulum stress inducer tunicamycin in the small intestine and liver of Nrf2 knockout and C57BL/6J mice
    Sujit Nair
    Graduate Program in Pharmaceutical Science, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Toxicol Lett 168:21-39. 2007
    ....
  49. doi Phenethyl isothiocyanate (PEITC) suppresses prostate cancer cell invasion epigenetically through regulating microRNA-194
    Chengyue Zhang
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, USA
    Mol Nutr Food Res 60:1427-36. 2016
    ..Here, we assessed the effects of PEITC on miRNA expression which is related to PCa cell invasiveness...
  50. pmc Epigenetic DNA methylation of antioxidative stress regulator NRF2 in human prostate cancer
    Tin Oo Khor
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey
    Cancer Prev Res (Phila) 7:1186-97. 2014
    ..Taken together, these findings suggest that epigenetic modification may contribute to the regulation of transcription activity of NRF2, which could be used as prevention and treatment target of human prostate cancer...
  51. pmc Modulation of keratinocyte expression of antioxidants by 4-hydroxynonenal, a lipid peroxidation end product
    Ruijin Zheng
    Pharmacology and Toxicology and Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USA
    Toxicol Appl Pharmacol 275:113-21. 2014
    ..Changes in expression of keratinocyte antioxidants may be important in protecting the skin from oxidative stress...
  52. ncbi Regulation of Nrf2 transactivation domain activity by p160 RAC3/SRC3 and other nuclear co-regulators
    Wen Lin
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, 08854, USA
    J Biochem Mol Biol 39:304-10. 2006
    ....
  53. pmc Nrf2 knockout attenuates the anti-inflammatory effects of phenethyl isothiocyanate and curcumin
    Sarandeep S S Boyanapalli
    Center for Cancer Prevention Research, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, New Jersey 08854, United States
    Chem Res Toxicol 27:2036-43. 2014
    ....
  54. doi The berry constituents quercetin, kaempferol, and pterostilbene synergistically attenuate reactive oxygen species: involvement of the Nrf2-ARE signaling pathway
    Constance Lay Lay Saw
    Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Food Chem Toxicol 72:303-11. 2014
    ..Collectively, our study demonstrated that the berry constituents quercetin, kaempferol, and pterostilbene activated the Nrf2-ARE signaling pathway and exhibited synergistic anti-oxidative stress activity at appropriate concentrations. ..
  55. pmc A perspective on dietary phytochemicals and cancer chemoprevention: oxidative stress, nrf2, and epigenomics
    Zheng Yuan Su
    Department of Pharmaceutics, Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, NJ 08854, USA
    Top Curr Chem 329:133-62. 2013
    ....
  56. ncbi Modulation of AP-1 by natural chemopreventive compounds in human colon HT-29 cancer cell line
    Woo Sik Jeong
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Pharm Res 21:649-60. 2004
    ..In this work, we studied several natural chemopreventive compounds for their potential chemopreventive properties in the modulation of AP-1 signaling pathway in HT-29 colon cancer cells...
  57. ncbi Regulation of Nrf2, NF-kappaB, and AP-1 signaling pathways by chemopreventive agents
    Guoxiang Shen
    Department of Pharmaceutics and Graduate Program in Pharmaceutical Science, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Antioxid Redox Signal 7:1648-63. 2005
    ....
  58. ncbi 3-Morpholinopropyl isothiocyanate is a novel synthetic isothiocyanate that strongly induces the antioxidant response element-dependent Nrf2-mediated detoxifying/antioxidant enzymes in vitro and in vivo
    Young Sam Keum
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Carcinogenesis 29:594-9. 2008
    ....
  59. doi Epigenetic reactivation of RASSF1A by phenethyl isothiocyanate (PEITC) and promotion of apoptosis in LNCaP cells
    Sarandeep S S Boyanapalli
    Center for Cancer Prevention Research, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road Piscataway, NJ, 08854, United States
    Pharmacol Res 114:175-184. 2016
    ..Collectively, the results of our study suggest that PEITC induces apoptosis in LNCaP cells potentially by reactivating RASSF1A via epigenetic mechanisms...
  60. doi Induction of NRF2-mediated gene expression by dietary phytochemical flavones apigenin and luteolin
    Ximena Paredes-Gonzalez
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA
    Biopharm Drug Dispos 36:440-51. 2015
    ..The results indicate that API and LUT significantly activate the PI3K/Nrf2/ARE system, and this activation may be responsible for their antiinflammatory effects, as demonstrated by the suppression of LPS-induced NO, iNOS and cPLA2...
  61. pmc Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction
    Longqin Hu
    Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Bioorg Med Chem Lett 23:3039-43. 2013
    ..The stereospecific nature of binding between (SRS)-5 and Keap1 as well as the preliminary but tractable structure-activity relationships support its use as a lead for our ongoing optimization...
  62. ncbi Antioxidants and oxidants regulated signal transduction pathways
    Edward D Owuor
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, and the Environmental and Occupational Health Sciences Institute EOHSI, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Biochem Pharmacol 64:765-70. 2002
    ..The studies of these signaling pathways may yield important insights into the pharmacodynamic and toxicodynamic effects of drugs and xenobiotics during pharmaceutical drug discovery and development...
  63. ncbi Chemopreventive functions of isothiocyanates
    Young Sam Keum
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA
    Drug News Perspect 18:445-51. 2005
    ....
  64. ncbi Activation of MAP kinases, apoptosis and nutrigenomics of gene expression elicited by dietary cancer-prevention compounds
    Rong Hu
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Nutrition 20:83-8. 2004
  65. ncbi Chemoprevention of familial adenomatous polyposis in Apc(Min/+) mice by phenethyl isothiocyanate (PEITC)
    Tin Oo Khor
    Center for Cancer Prevention Research, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Mol Carcinog 47:321-5. 2008
    ..In conclusion, our results demonstrate that PEITC is a potent natural dietary compound for chemoprevention of gastrointestinal cancers. Its mechanism of actions may include induction of apoptosis and cell cycle arrest...
  66. ncbi Dietary Phytochemicals and Cancer Chemoprevention: A Perspective on Oxidative Stress, Inflammation, and Epigenetics
    Wenji Li
    Center for Cancer Prevention Research, Department of Pharmaceutics, Graduate Program in Pharmaceutical Sciences, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United States
    Chem Res Toxicol 29:2071-2095. 2016
    ..Thus, the beneficial effects of dietary phytochemicals on cancer development warrant further investigation to provide additional impetus for clinical translational studies...
  67. doi tBHQ-induced HO-1 expression is mediated by calcium through regulation of Nrf2 binding to enhancer and polymerase II to promoter region of HO-1
    Ka Lung Cheung
    Graduate Program in Pharmaceutical Science, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United States
    Chem Res Toxicol 24:670-6. 2011
    ..Taken together, our results indicated that in addition to tBHQ-induced oxidative stress-mediated Nrf2 translocation, HO-1 induction by tBHQ also appears to be dependent on a series of Ca(2+)-regulated mechanisms...
  68. pmc Nuclear factor-erythroid 2-related factor 2 as a chemopreventive target in colorectal cancer
    Constance Lay Lay Saw
    Rutgers, The State University of New Jersey, Ernest Mario School of Pharmacy, Department of Pharmaceutics, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Expert Opin Ther Targets 15:281-95. 2011
    ..Recently, Nrf2 has emerged as a novel target for the prevention of CRC...
  69. ncbi Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells
    Young Sam Keum
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Cancer Res 66:8804-13. 2006
    ..In addition, our study shows that p38 MAPK can phosphorylate Nrf2 and promotes the association between Nrf2 and Keap1 proteins, thereby potentially inhibiting nuclear translocation of Nrf2...
  70. pmc Curcumin inhibits anchorage-independent growth of HT29 human colon cancer cells by targeting epigenetic restoration of the tumor suppressor gene DLEC1
    Yue Guo
    Graduate Program in Pharmaceutical Sciences, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Room 228, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Biochem Pharmacol 94:69-78. 2015
    ..Taken together, our results suggest that the inhibitory effect of CUR on anchorage-independent growth of HT29 cells could, at least in part, involve the epigenetic demethylation and up-regulation of DLEC1. ..
  71. doi In vitro and in vivo anti-inflammatory effects of a novel 4,6-bis ((E)-4-hydroxy-3-methoxystyryl)-1-phenethylpyrimidine-2(1H)-thione
    Jong Hun Lee
    Center for Cancer Prevention Research, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, New Jersey 08854, United States
    Chem Res Toxicol 27:34-41. 2014
    ..Thus, HPT demonstrated anti-inflammatory activity both in LPS-induced RAW 264.7 cells and TPA-stimulated mouse skin and may therefore serve as a potential anti-inflammatory agent. ..
  72. pmc Does vitamin E prevent or promote cancer?
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, 08854, USA
    Cancer Prev Res (Phila) 5:701-5. 2012
    ....
  73. ncbi Pharmacodynamics of fish oil: protective effects against prostate cancer in TRAMP mice fed with a high fat western diet
    Constance Lay Lay Saw
    Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, USA
    Asian Pac J Cancer Prev 12:3331-4. 2011
    ..Numerous epidemiological studies suggest that frequent consumption of fish would decrease certain major inflammatory-related chronic diseases including cancer...
  74. doi Role of Nrf2 in suppressing LPS-induced inflammation in mouse peritoneal macrophages by polyunsaturated fatty acids docosahexaenoic acid and eicosapentaenoic acid
    Hu Wang
    Graduate Program in Pharmaceutical Sciences, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Mol Pharm 7:2185-93. 2010
    ....
  75. pmc Epigenetic regulation of Keap1-Nrf2 signaling
    Yue Guo
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Free Radic Biol Med 88:337-49. 2015
    ..Studies of the epigenetic modification of Nrf2 and Keap1 have not only enhanced our understanding of this complex cellular defense system but have also provided potential new therapeutic targets for the prevention of certain diseases. ..
  76. pmc Design and synthesis of novel iminothiazinylbutadienols and divinylpyrimidinethiones as ARE inducers
    Lin Chen
    Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Bioorg Med Chem Lett 24:940-3. 2014
    ..In an ARE-luciferase reporter assay, some of these new curcumin analogues are more effective ARE activators than curcumin and isothiocyanates. ..
  77. pmc Apigenin reactivates Nrf2 anti-oxidative stress signaling in mouse skin epidermal JB6 P + cells through epigenetics modifications
    Ximena Paredes-Gonzalez
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, New Jersey, 08854, USA
    AAPS J 16:727-35. 2014
    ..These results may provide new therapeutic insights into the prevention of skin cancer by dietary phytochemicals...
  78. ncbi Induction of phase I, II and III drug metabolism/transport by xenobiotics
    Changjiang Xu
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Arch Pharm Res 28:249-68. 2005
    ..Consequently, this homeostatic response of the body plays a central role in the protection of the body against "environmental" insults such as those elicited by exposure to xenobiotics...
  79. ncbi Development and validation of an HPLC method for the determination of dibenzoylmethane in rat plasma and its application to the pharmacokinetic study
    Guoxiang Shen
    Graduate Program in Pharmaceutical Sciences, Ernest Mario School of Pharmacy, Rutgers The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 852:56-61. 2007
    ..The utility of the assay was confirmed by the successful analysis of plasma samples from DBM pharmacokinetics studies in the rats after oral and intravenous administrations...
  80. pmc Murine prostate cancer inhibition by dietary phytochemicals--curcumin and phenyethylisothiocyanate
    Avantika Barve
    Graduate Program in Pharmaceutical Sciences, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Pharm Res 25:2181-9. 2008
    ..Hence, this study was undertaken to examine the potential chemopreventive properties of the two agents against transgenic adenocarcinoma of the mouse prostate...
  81. pmc A semi-mechanistic integrated toxicokinetic-toxicodynamic (TK/TD) model for arsenic(III) in hepatocytes
    Spyros K Stamatelos
    Environmental and Occupational Health Sciences Institute EOHSI a Joint Institute of UMDNJ Robert Wood Johnson Medical School and Rutgers University, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA
    J Theor Biol 317:244-56. 2013
    ....
  82. pmc Optimization of fluorescently labeled Nrf2 peptide probes and the development of a fluorescence polarization assay for the discovery of inhibitors of Keap1-Nrf2 interaction
    Daigo Inoyama
    Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA
    J Biomol Screen 17:435-47. 2012
    ....
  83. pmc Dietary administration of δ- and γ-tocopherol inhibits tumorigenesis in the animal model of estrogen receptor-positive, but not HER-2 breast cancer
    Amanda K Smolarek
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Cancer Prev Res (Phila) 5:1310-20. 2012
    ..Both δ- and γ-tocopherols, but not α-tocopherol, seem to be promising agents for the prevention of hormone-dependent breast cancer...
  84. pmc PEITC induces G1 cell cycle arrest on HT-29 cells through the activation of p38 MAPK signaling pathway
    Ka Lung Cheung
    Graduate Program in Pharmaceutical Science, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA
    AAPS J 10:277-81. 2008
    ..In conclusion, this study shows for the first time that PEITC can arrest HT-29 cells in G1 phase by down-regulation of cyclins through the activation of p38 MAPK signaling pathway...
  85. pmc Kinetic analyses of keap1-nrf2 interaction and determination of the minimal nrf2 Peptide sequence required for keap1 binding using surface plasmon resonance
    Yu Chen
    Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA The Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA Department of Biochemistry, University of Missouri Columbia, Columbia, MO 65211, USA
    Chem Biol Drug Des 78:1014-21. 2011
    ..These results suggest that the minimal Nrf2 peptide sequence required for Keap1 binding is the 9mer sequence of LDEETGEFL...
  86. pmc Anti-cancer and potential chemopreventive actions of ginseng by activating Nrf2 (NFE2L2) anti-oxidative stress/anti-inflammatory pathways
    Constance Lay Lay Saw
    Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, USA
    Chin Med 5:37. 2010
    ....