Kenneth Irvine

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. ncbi request reprint Identification of a Drosophila gene encoding xylosylprotein beta4-galactosyltransferase that is essential for the synthesis of glycosaminoglycans and for morphogenesis
    Yoko Nakamura
    Department of Biochemistry II, Nagoya University School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    J Biol Chem 277:46280-8. 2002
  2. doi request reprint A notch sweeter
    Kenneth D Irvine
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway NJ 08854, USA
    Cell 132:177-9. 2008
  3. pmc Zyxin links fat signaling to the hippo pathway
    Cordelia Rauskolb
    Howard Hughes Medical Institute, Waksman Institute, and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey, United States of America
    PLoS Biol 9:e1000624. 2011
  4. pmc The Raine syndrome protein FAM20C is a Golgi kinase that phosphorylates bio-mineralization proteins
    Hiroyuki O Ishikawa
    Graduate School of Science, Chiba University, Chiba shi, Chiba, Japan
    PLoS ONE 7:e42988. 2012
  5. pmc Signal transduction by the Fat cytoplasmic domain
    Guohui Pan
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 140:831-42. 2013
  6. pmc Integration of intercellular signaling through the Hippo pathway
    Kenneth D Irvine
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Semin Cell Dev Biol 23:812-7. 2012
  7. ncbi request reprint Fringe, Notch, and making developmental boundaries
    K D Irvine
    Waksman Institute, Department of Molecular Biology and Biochemistry, 190 Frelinghuysen Rd, Rutgers University, Piscataway, New Jersey 08854, USA
    Curr Opin Genet Dev 9:434-41. 1999
  8. ncbi request reprint Boundaries in development: formation and function
    K D Irvine
    Howard Hughes Medical Institute, Waksman Institute, and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Annu Rev Cell Dev Biol 17:189-214. 2001
  9. ncbi request reprint Notch-mediated segmentation and growth control of the Drosophila leg
    C Rauskolb
    Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University, Piscataway, New Jersey, 08854, USA
    Dev Biol 210:339-50. 1999
  10. ncbi request reprint Fringe-dependent separation of dorsal and ventral cells in the Drosophila wing
    C Rauskolb
    Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University, Piscataway, New Jersey 08854, USA
    Nature 401:476-80. 1999

Research Grants

  1. Analysis of fringe-dependent cell-signaling
    Kenneth Irvine; Fiscal Year: 2004

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Identification of a Drosophila gene encoding xylosylprotein beta4-galactosyltransferase that is essential for the synthesis of glycosaminoglycans and for morphogenesis
    Yoko Nakamura
    Department of Biochemistry II, Nagoya University School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    J Biol Chem 277:46280-8. 2002
    ..Our results demonstrate that Drosophila beta4GalT7 has the in vitro and in vivo properties predicted for an ortholog of human beta4GalT7 and is essential for normal animal development through its role in proteoglycan biosynthesis...
  2. doi request reprint A notch sweeter
    Kenneth D Irvine
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway NJ 08854, USA
    Cell 132:177-9. 2008
    ..This gene encodes an O-glucosyltransferase that attaches glucose sugars to serine residues in the multiple EGF domains of the extracellular region of Notch. This modification by Rumi likely influences Notch folding and trafficking...
  3. pmc Zyxin links fat signaling to the hippo pathway
    Cordelia Rauskolb
    Howard Hughes Medical Institute, Waksman Institute, and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey, United States of America
    PLoS Biol 9:e1000624. 2011
    ..Our identification of Zyx as a regulator of Hippo signaling thus also raises the possibility that mechanical strain could be linked to the regulation of gene expression and growth through Hippo signaling...
  4. pmc The Raine syndrome protein FAM20C is a Golgi kinase that phosphorylates bio-mineralization proteins
    Hiroyuki O Ishikawa
    Graduate School of Science, Chiba University, Chiba shi, Chiba, Japan
    PLoS ONE 7:e42988. 2012
    ..Our results identify FAM20C as a kinase for secreted phosphoproteins and establish a biochemical basis for Raine syndrome...
  5. pmc Signal transduction by the Fat cytoplasmic domain
    Guohui Pan
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 140:831-42. 2013
    ....
  6. pmc Integration of intercellular signaling through the Hippo pathway
    Kenneth D Irvine
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Semin Cell Dev Biol 23:812-7. 2012
    ....
  7. ncbi request reprint Fringe, Notch, and making developmental boundaries
    K D Irvine
    Waksman Institute, Department of Molecular Biology and Biochemistry, 190 Frelinghuysen Rd, Rutgers University, Piscataway, New Jersey 08854, USA
    Curr Opin Genet Dev 9:434-41. 1999
    ..Lunatic Fringe has been shown to be required for vertebrate somitogenesis, where it appears to act as a crucial link between a molecular clock and the regulation of Notch signaling...
  8. ncbi request reprint Boundaries in development: formation and function
    K D Irvine
    Howard Hughes Medical Institute, Waksman Institute, and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Annu Rev Cell Dev Biol 17:189-214. 2001
    ..Much has been learned about the signaling pathways that establish boundaries, but a key challenge for the future remains to elucidate the cellular and molecular mechanisms that actually keep cell populations separated...
  9. ncbi request reprint Notch-mediated segmentation and growth control of the Drosophila leg
    C Rauskolb
    Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University, Piscataway, New Jersey, 08854, USA
    Dev Biol 210:339-50. 1999
    ..The Notch pathway is also deployed for segmentation during vertebrate somitogenesis, which raises the possibility of a common origin for the segmentation of these distinct tissues...
  10. ncbi request reprint Fringe-dependent separation of dorsal and ventral cells in the Drosophila wing
    C Rauskolb
    Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University, Piscataway, New Jersey 08854, USA
    Nature 401:476-80. 1999
    ..Our results indicate that the primary mechanism by which fng establishes a compartment border is by positioning a stripe of Notch activation, but also that fng may exert additional influences on compartmentalization...
  11. ncbi request reprint Dorsal-ventral signaling in the Drosophila eye
    V Papayannopoulos
    Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University, Piscataway, NJ 08854, USA
    Science 281:2031-4. 1998
    ..These observations imply that the developmental homology between Drosophila wings and vertebrate limbs extends to Drosophila eyes...
  12. ncbi request reprint Fringe modulates Notch-ligand interactions
    V M Panin
    Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University, Piscataway, New Jersey 08855, USA
    Nature 387:908-12. 1997
    ..This is achieved by fng through a cell-autonomous mechanism that inhibits a cell's ability to respond to Serrate protein and potentiates its ability to respond to Delta protein...
  13. ncbi request reprint Roles for scalloped and vestigial in regulating cell affinity and interactions between the wing blade and the wing hinge
    X Liu
    Howard Hughes Medical Institute, Rutgers The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Dev Biol 228:287-303. 2000
    ....
  14. ncbi request reprint Cell recognition, signal induction, and symmetrical gene activation at the dorsal-ventral boundary of the developing Drosophila wing
    J Kim
    Howard Hughes Medical Institute, University of Wisconsin, Madison 53706, USA
    Cell 82:795-802. 1995
    ..Ser in turn triggers the expression of genes involved in wing growth and patterning on both sides of the DV boundary...
  15. ncbi request reprint fringe and Notch specify polar cell fate during Drosophila oogenesis
    M Grammont
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 128:2243-53. 2001
    ..Our results indicate that fringe plays a key role in positioning Notch activation during early oogenesis, and establish a function for the polar cells in separating germline cysts into individual follicles...
  16. ncbi request reprint Dorsal-ventral signaling in limb development
    K D Irvine
    Waksman Institute, Rutgers, State University of New Jersey, Piscataway 08854 8020, USA
    Curr Opin Cell Biol 9:867-76. 1997
    ....
  17. pmc In vivo analysis of Yorkie phosphorylation sites
    H Oh
    Department of Molecular Biology and Biochemistry, Waksman Institute, Howard Hughes Medical Institute, Rutgers The State University of New Jersey, Piscataway, NJ 8854, USA
    Oncogene 28:1916-27. 2009
    ..We also identify two potential sites of phosphorylation by an unknown kinase, which could influence phosphorylation of Ser168 by Wts, suggesting that there are additional mechanisms for regulating Yki/YAP activity...
  18. ncbi request reprint Delineation of a Fat tumor suppressor pathway
    Eunjoo Cho
    Howard Hughes Medical Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Nat Genet 38:1142-50. 2006
    ..melanogaster tumor suppressors, establish a basic framework for Fat signaling from receptor to transcription factor and implicate Warts as an integrator of multiple growth control signals...
  19. ncbi request reprint Regulation of cell proliferation by a morphogen gradient
    Dragana Rogulja
    Howard Hughes Medical Institute, USA
    Cell 123:449-61. 2005
    ..Conversely, uniform activation of the DPP pathway inhibits cell proliferation in medial wing cells. Our observations provide a direct demonstration that the slope of a morphogen gradient regulates growth during development...
  20. ncbi request reprint Localization and requirement for Myosin II at the dorsal-ventral compartment boundary of the Drosophila wing
    Robert J Major
    Howard Hughes Medical Institute, Waksman Institute, and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, New Jersey, USA
    Dev Dyn 235:3051-8. 2006
    ....
  21. ncbi request reprint In vitro reconstitution of the modulation of Drosophila Notch-ligand binding by Fringe
    Aiguo Xu
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA
    J Biol Chem 282:35153-62. 2007
    ....
  22. pmc Fat and expanded act in parallel to regulate growth through warts
    Yongqiang Feng
    Howard Hughes Medical Institute, Waksman Institute, and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 104:20362-7. 2007
    ....
  23. pmc In vivo regulation of Yorkie phosphorylation and localization
    Hyangyee Oh
    Howard Hughes Medical Institute, Waksman Institute, Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 135:1081-8. 2008
    ..These results identify modulation of subcellular localization as a mechanism of Yki regulation, and establish that this regulation occurs in vivo through multiple sites of Warts-dependent phosphorylation on Yki...
  24. pmc Four-jointed is a Golgi kinase that phosphorylates a subset of cadherin domains
    Hiroyuki O Ishikawa
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Science 321:401-4. 2008
    ..Our results indicate that Four-jointed regulates Fat signaling by phosphorylating cadherin domains of Fat and Dachsous as they transit through the Golgi...
  25. ncbi request reprint Influence of Notch on dorsoventral compartmentalization and actin organization in the Drosophila wing
    Robert J Major
    Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 132:3823-33. 2005
    ....
  26. ncbi request reprint Regions of Drosophila Notch that contribute to ligand binding and the modulatory influence of Fringe
    Aiguo Xu
    Howard Hughes Medical Institute, Rutgers, The State University of New Jersey, Piscataway 08854, USA
    J Biol Chem 280:30158-65. 2005
    ....
  27. ncbi request reprint Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe
    Vladislav M Panin
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University, Piscataway, New Jersey 08854, USA
    J Biol Chem 277:29945-52. 2002
    ..A revised, broad consensus site, C(2)X(3-5)S/TC(3) (where X(3-5) are any 3-5 amino acid residues), is proposed...
  28. ncbi request reprint Organizer activity of the polar cells during Drosophila oogenesis
    Muriel Grammont
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway NJ 08854, USA
    Development 129:5131-40. 2002
    ..The origin of asymmetry during Drosophila development can thus be traced back to the specification of the polar cells during early oogenesis...
  29. ncbi request reprint Regulation of notch signaling by o-linked fucose
    Tetsuya Okajima
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Cell 111:893-904. 2002
    ....
  30. pmc Molecular genetic analysis of the glycosyltransferase Fringe in Drosophila
    Trudy Correia
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 100:6404-9. 2003
    ..Other missense mutations map to amino acids that are conserved among Fringe proteins, but not among other glycosyltransferases, and thus may identify structural motifs that are required for unique aspects of Fringe activity...
  31. ncbi request reprint Notch activity in neural cells triggered by a mutant allele with altered glycosylation
    Yanxia Li
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Development 130:2829-40. 2003
    ..These results suggest that the pattern of neurogenesis is determined by blocking Notch signaling, as well as by activating Notch signaling...
  32. ncbi request reprint Modulation of notch-ligand binding by protein O-fucosyltransferase 1 and fringe
    Tetsuya Okajima
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Biol Chem 278:42340-5. 2003
    ..Thus, Notch-ligand interactions are dependent upon both the presence and the type of O-fucose glycans...
  33. ncbi request reprint Glycosylation regulates Notch signalling
    Nicola Haines
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Nat Rev Mol Cell Biol 4:786-97. 2003
    ....
  34. ncbi request reprint Functional characterization of Drosophila sialyltransferase
    Kate Koles
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843, USA
    J Biol Chem 279:4346-57. 2004
    ....
  35. ncbi request reprint Chaperone activity of protein O-fucosyltransferase 1 promotes notch receptor folding
    Tetsuya Okajima
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Science 307:1599-603. 2005
    ..This ability of OFUT1 to facilitate folding of Notch did not require its fucosyltransferase activity. Thus, a glycosyltransferase can bind its substrate in the endoplasmic reticulum to facilitate normal folding...
  36. ncbi request reprint Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila
    Yaopan Mao
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 133:2539-51. 2006
    ..Our results implicate Dachs as a crucial downstream component of a Fat signaling pathway that influences growth, affinity and gene expression during development...
  37. ncbi request reprint Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling
    Eunjoo Cho
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 131:4489-500. 2004
    ....
  38. ncbi request reprint An O-fucose site in the ligand binding domain inhibits Notch activation
    Liang Lei
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 130:6411-21. 2003
    ..Thus, inhibition of Notch-Serrate binding by O-fucosylation of EGF12 might be needed in certain contexts to allow efficient Notch signaling...
  39. pmc Morphogen control of wing growth through the Fat signaling pathway
    Dragana Rogulja
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Dev Cell 15:309-21. 2008
    ..These observations identify Fat as a signaling pathway that links the morphogen-mediated establishment of gradients of positional values across developing organs to the regulation of organ growth...
  40. doi request reprint The Fat and Warts signaling pathways: new insights into their regulation, mechanism and conservation
    B V V G Reddy
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 135:2827-38. 2008
    ....
  41. ncbi request reprint Functional analysis of Drosophila beta1,4-N-acetlygalactosaminyltransferases
    Nicola Haines
    Howard Hughes Medical Institute, Waksman Institute, and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway NJ 08854, USA
    Glycobiology 15:335-46. 2005
    ..Thus Drosophila homologs of the mammalian beta4GalT family are essential for neuromuscular physiology or development but are not otherwise required for viability, fertility, or external morphology...
  42. pmc Contributions of chaperone and glycosyltransferase activities of O-fucosyltransferase 1 to Notch signaling
    Tetsuya Okajima
    Nagoya University Graduate School of Bioagricultural Sciences, Department of Applied Molecular Biosciences, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    BMC Biol 6:1. 2008
    ..OFUT1 also possesses a chaperone activity that promotes the folding and secretion of Notch. Here, we investigate the respective contributions of these activities to Notch signaling in Drosophila...

Research Grants1

  1. Analysis of fringe-dependent cell-signaling
    Kenneth Irvine; Fiscal Year: 2004
    ....