Xin Li

Summary

Affiliation: Rush University Medical Center
Country: USA

Publications

  1. ncbi request reprint HIPK2 associates with RanBPM
    Ying Wang
    Universitäts Kinderklinik Ulm, Forschungslabore, Prittwitzstr 43, D 89075 Ulm, Germany
    Biochem Biophys Res Commun 297:148-53. 2002
  2. pmc Regulation of plant innate immunity by three proteins in a complex conserved across the plant and animal kingdoms
    Kristoffer Palma
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
    Genes Dev 21:1484-93. 2007
  3. pmc Action of fibroblast growth factor-2 on the intervertebral disc
    Xin Li
    Department of Biochemistry, Rush University Medical Center, Cohn Research BD 516, 1735 W, Harrison, Chicago, IL 60612, USA
    Arthritis Res Ther 10:R48. 2008
  4. pmc Lactoferricin mediates anti-inflammatory and anti-catabolic effects via inhibition of IL-1 and LPS activity in the intervertebral disc
    Jae Sung Kim
    Section of Rheumatology, Department of Biochemistry, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Cell Physiol 228:1884-96. 2013
  5. pmc Lactoferricin enhances BMP7-stimulated anabolic pathways in intervertebral disc cells
    Michael B Ellman
    Department of Biochemistry, Section of Rheumatology, Rush University Medical Center, Chicago, IL 60612, USA
    Gene 524:282-91. 2013
  6. pmc Altered spinal microRNA-146a and the microRNA-183 cluster contribute to osteoarthritic pain in knee joints
    Xin Li
    Department of Biochemistry, Rush University Medical Center, Chicago, IL, USA
    J Bone Miner Res 28:2512-22. 2013
  7. pmc Toll-like receptor adaptor signaling molecule MyD88 on intervertebral disk homeostasis: in vitro, ex vivo studies
    Michael B Ellman
    Department of Biochemistry, Rush University Medical Center, Chicago, IL 606124, USA
    Gene 505:283-90. 2012
  8. pmc Prostaglandin E2 and its cognate EP receptors control human adult articular cartilage homeostasis and are linked to the pathophysiology of osteoarthritis
    Xin Li
    Rush University Medical Center, Chicago, Illinois
    Arthritis Rheum 60:513-23. 2009
  9. pmc Biological effects of the plant-derived polyphenol resveratrol in human articular cartilage and chondrosarcoma cells
    Hee Jeong Im
    Department of Biochemistry, Rush University Medical Center, Chicago, IL, USA
    J Cell Physiol 227:3488-97. 2012
  10. pmc The pathophysiologic role of the protein kinase Cδ pathway in the intervertebral discs of rabbits and mice: in vitro, ex vivo, and in vivo studies
    Michael B Ellman
    Rush University Medical Center, Chicago, IL, USA
    Arthritis Rheum 64:1950-9. 2012

Collaborators

Detail Information

Publications83

  1. ncbi request reprint HIPK2 associates with RanBPM
    Ying Wang
    Universitäts Kinderklinik Ulm, Forschungslabore, Prittwitzstr 43, D 89075 Ulm, Germany
    Biochem Biophys Res Commun 297:148-53. 2002
    ..Overexpressed wildtype RanBPM and a kinase defective mutant of HIPK2 co-localise with HIPK2 in defined nuclear structures. A carboxy- and an amino-terminal deletion of HIPK2 do not seem to be able to bind to RanBPM...
  2. pmc Regulation of plant innate immunity by three proteins in a complex conserved across the plant and animal kingdoms
    Kristoffer Palma
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
    Genes Dev 21:1484-93. 2007
    ..Since the complex components along with their interactions are highly conserved from fission yeast to Arabidopsis and human, they may also have a yet-to-be-identified function in mammalian innate immunity...
  3. pmc Action of fibroblast growth factor-2 on the intervertebral disc
    Xin Li
    Department of Biochemistry, Rush University Medical Center, Cohn Research BD 516, 1735 W, Harrison, Chicago, IL 60612, USA
    Arthritis Res Ther 10:R48. 2008
    ....
  4. pmc Lactoferricin mediates anti-inflammatory and anti-catabolic effects via inhibition of IL-1 and LPS activity in the intervertebral disc
    Jae Sung Kim
    Section of Rheumatology, Department of Biochemistry, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Cell Physiol 228:1884-96. 2013
    ....
  5. pmc Lactoferricin enhances BMP7-stimulated anabolic pathways in intervertebral disc cells
    Michael B Ellman
    Department of Biochemistry, Section of Rheumatology, Rush University Medical Center, Chicago, IL 60612, USA
    Gene 524:282-91. 2013
    ..We propose that combination growth factor therapy using BMP7 and LfcinB may be beneficial for treatment of disc degeneration...
  6. pmc Altered spinal microRNA-146a and the microRNA-183 cluster contribute to osteoarthritic pain in knee joints
    Xin Li
    Department of Biochemistry, Rush University Medical Center, Chicago, IL, USA
    J Bone Miner Res 28:2512-22. 2013
    ..MicroRNA therapy using miR-146a and the miR-183 cluster could be powerful therapeutic intervention for OA in alleviating joint pain and concomitantly regenerating peripheral knee joint cartilage...
  7. pmc Toll-like receptor adaptor signaling molecule MyD88 on intervertebral disk homeostasis: in vitro, ex vivo studies
    Michael B Ellman
    Department of Biochemistry, Rush University Medical Center, Chicago, IL 606124, USA
    Gene 505:283-90. 2012
    ....
  8. pmc Prostaglandin E2 and its cognate EP receptors control human adult articular cartilage homeostasis and are linked to the pathophysiology of osteoarthritis
    Xin Li
    Rush University Medical Center, Chicago, Illinois
    Arthritis Rheum 60:513-23. 2009
    ..To elucidate the pathophysiologic links between prostaglandin E(2) (PGE(2)) and osteoarthritis (OA) by characterizing the catabolic effects of PGE(2) and its unique receptors in human adult articular chondrocytes...
  9. pmc Biological effects of the plant-derived polyphenol resveratrol in human articular cartilage and chondrosarcoma cells
    Hee Jeong Im
    Department of Biochemistry, Rush University Medical Center, Chicago, IL, USA
    J Cell Physiol 227:3488-97. 2012
    ..Our findings suggest that RSV has potential as a unique biologic treatment for both prevention and treatment of cartilage degenerative diseases...
  10. pmc The pathophysiologic role of the protein kinase Cδ pathway in the intervertebral discs of rabbits and mice: in vitro, ex vivo, and in vivo studies
    Michael B Ellman
    Rush University Medical Center, Chicago, IL, USA
    Arthritis Rheum 64:1950-9. 2012
    ..The aim of this study was to assess the role of the PKC pathways, specifically PKCδ, in intervertebral disc tissue homeostasis...
  11. pmc The action of resveratrol, a phytoestrogen found in grapes, on the intervertebral disc
    Xin Li
    Department of Biochemistry, Section of Rheumatology, Rush University Medical Center, Chicago, IL 60612, USA
    Spine (Phila Pa 1976) 33:2586-95. 2008
    ..Basic science, biologic study...
  12. pmc Intraarticular slow-release triamcinolone acetate reduces allodynia in an experimental mouse knee osteoarthritis model
    Jeffrey S Kroin
    Department of Anesthesiology, Rush University Medical Center, Chicago, IL, United States Electronic address
    Gene 591:1-5. 2016
    ..Intraarticular TCA in a sustained release formulation of viscous 5% hyaluronic acid will produce a long-term attenuation of mechanical allodynia in the OA knees of mice. ..
  13. pmc The rat intervertebral disk degeneration pain model: relationships between biological and structural alterations and pain
    Jae Sung Kim
    Department of Biochemistry, Rush University Medical Center, Cohn Research BD 516, 1735 West Harrison Street, Chicago, IL 60612, USA
    Arthritis Res Ther 13:R165. 2011
    ..Degeneration of the interverterbral disk is as a cause of low-back pain is increasing. To gain insight into relationships between biological processes, structural alterations and behavioral pain, we created an animal model in rats...
  14. pmc Osteoarthritis-like pathologic changes in the knee joint induced by environmental disruption of circadian rhythms is potentiated by a high-fat diet
    Ranjan Kc
    Departments of Biochemistry, Rush University Medical Center, Chicago, IL, 60612
    Sci Rep 5:16896. 2015
    ..Thus, our findings may open new perspectives on the interactions of chronic circadian rhythms disruption with diet in the development of OA and may have potential clinical implications. ..
  15. pmc Species-specific biological effects of FGF-2 in articular cartilage: implication for distinct roles within the FGF receptor family
    Xin Li
    Department of Biochemistry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Cell Biochem 113:2532-42. 2012
    ..The complex interplay of FGFRs and the downstream signaling cascades induced by FGF-2 in human cartilage should add caution to the use of this particular growth factor for biological therapy in the future...
  16. pmc PKCδ null mutations in a mouse model of osteoarthritis alter osteoarthritic pain independently of joint pathology by augmenting NGF/TrkA-induced axonal outgrowth
    Ranjan Kc
    Department of Biochemistry, Rush University Medical Center, Chicago, Illinois, USA
    Ann Rheum Dis 75:2133-2141. 2016
    ..Here, we determined whether protein kinase Cδ (PKCδ), a key mediator of cartilage degeneration, is critical to the mechanism by which OA develops from an asymptomatic joint-degenerative condition to a painful disease...
  17. doi request reprint Osteoarthritic tissues modulate functional properties of sensory neurons associated with symptomatic OA pain
    Xin Li
    Department of Biochemistry, Rush University Medical Center, Chicago, IL 60612, USA
    Mol Biol Rep 38:5335-9. 2011
    ..These findings are consistent with a model in which cytokines and pain molecules produced by knee synovium sensitize nociceptive neurons in tissues peripheral to joint cartilage...
  18. pmc MicroRNA-146a reduces IL-1 dependent inflammatory responses in the intervertebral disc
    Su Xi Gu
    Department of Biochemistry, Rush University Medical Center, Chicago, IL 60612, USA Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA Department of Orthopedic Surgery, PLA309 Hospital, Beijing 100091, China
    Gene 555:80-7. 2015
    ....
  19. pmc Basic fibroblast growth factor accelerates matrix degradation via a neuro-endocrine pathway in human adult articular chondrocytes
    Hee Jeong Im
    Department of Biochemistry, Rush University Medical Center, Cohn Research BD, Chicago, Illinois 60612, USA
    J Cell Physiol 215:452-63. 2008
    ..We report that bFGF-mediated stimulation of substance P and its receptor NK(1)-R is, in part, through an IL-1beta-dependent pathway...
  20. pmc MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis
    Xin Li
    Department of Biochemistry, Rush University Medical Center, 1735 W Harrison, Chicago, IL 60612, USA
    Gene 480:34-41. 2011
    ..Hence, miR-146a may be useful for the treatment of both cartilage regeneration and pain symptoms caused by OA...
  21. pmc Alteration of sensory neurons and spinal response to an experimental osteoarthritis pain model
    Hee Jeong Im
    Rush University Medical Center and University of Illinois at Chicago, IL, USA
    Arthritis Rheum 62:2995-3005. 2010
    ....
  22. pmc Environmental disruption of circadian rhythm predisposes mice to osteoarthritis-like changes in knee joint
    Ranjan Kc
    Department of Biochemistry, Rush University Medical Center, Chicago, Illinois
    J Cell Physiol 230:2174-83. 2015
    ..Our results, for the first time, provide compelling in vivo evidence that environmental disruption of circadian rhythms is a risk factor for the development of OA-like pathological changes in the mouse knee joint...
  23. pmc Characterization of a new animal model for evaluation and treatment of back pain due to lumbar facet joint osteoarthritis
    Jae Sung Kim
    Rush University Medical Center, Chicago, Illinois 60612, USA
    Arthritis Rheum 63:2966-73. 2011
    ..This study was undertaken to investigate the biologic links between cellular and structural alterations within facet joint components and the development of symptomatic chronic back pain...
  24. pmc Targeting Runx2 expression in hypertrophic chondrocytes impairs endochondral ossification during early skeletal development
    Ming Ding
    Department of Anatomy and Cell Biology, Rush University Medical Center, Chicago, IL, USA
    J Cell Physiol 227:3446-56. 2012
    ..This will change the local matrix environment, delay chondrocyte maturation, reduce apoptosis and matrix mineralization, and eventually, lead to impaired endochondral ossification...
  25. pmc Lithocholic acid decreases expression of UGT2B7 in Caco-2 cells: a potential role for a negative farnesoid X receptor response element
    Yuan Lu
    Department of Biochemistry, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Drug Metab Dispos 33:937-46. 2005
    ..Therefore, it is postulated that lithocholic acid toxicity may be due to down-regulation of genes involved in its detoxification, including UGT2B7, leading to limited excretion of lithocholic acid from the body...
  26. pmc Effects of different animal waste treatment technologies on detection and viability of porcine enteric viruses
    Verónica P Costantini
    Food Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691 4096, USA
    Appl Environ Microbiol 73:5284-91. 2007
    ..These results indicate that only RV-A/C RNA, but no viral infectivity, was detected after treatment. Our findings address a public health concern regarding environmental quality surrounding swine production units...
  27. ncbi request reprint Up-regulated endogenous erythropoietin/erythropoietin receptor system and exogenous erythropoietin rescue retinal ganglion cells after chronic ocular hypertension
    Qing Ling Fu
    Department of Anatomy, The University of Hong Kong Li Ka Shing Faculty of Medicine, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China
    Cell Mol Neurobiol 28:317-29. 2008
    ..In this study, we investigate the role of the EPO/EPO receptor (EPOR) system in the rat retina after ocular hypertension injury that mimics glaucoma...
  28. pmc Human UGT1A8 and UGT1A10 mRNA are expressed in primary human hepatocytes
    Xin Li
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Drug Metab Pharmacokinet 22:152-61. 2007
    ..The discovery of these isoforms in hepatocytes is a novel discovery and will stimulate studies on the potential role for these isoforms in hepatic detoxification...
  29. ncbi request reprint Identification and characterization of scirr1, a novel gene up-regulated after spinal cord injury
    Tao Liu
    Department of Neurobiology, Institute of Basic Medical Sciences, 27 Taiping Road, Beijing 100850, P R China
    Exp Mol Med 39:255-66. 2007
    ..All these make scirr1 a new interesting start to study the spinal cord injury and regeneration mechanism...
  30. ncbi request reprint Determination of dual effects of parathyroid hormone on skeletal gene expression in vivo by microarray and network analysis
    Xin Li
    Department of Physiology and Biophysics, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    J Biol Chem 282:33086-97. 2007
    ..A novel signaling network was established that is differentially regulated in the two PTH treatment regimes. Key regulators are suggested to be AREG, CCL2, WNT4, and cAMP-responsive element modulator...
  31. ncbi request reprint Establishment and gene analysis of an oxaliplatin-resistant colon cancer cell line THC8307/L-OHP
    Hua Tang
    Tianjin Life Science Research Center, Tianjin Medical University, Tianjin, PRC
    Anticancer Drugs 18:633-9. 2007
    ..These results provide clues for understanding the oxaliplatin-resistant mechanisms and imply markers to predict drug sensitivities for 'personalized chemotherapy'...
  32. ncbi request reprint Changes in mRNA for CAPON and Dexras1 in adult rat following sciatic nerve transection
    Aiguo Shen
    The Jiangsu Province Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001, People s Republic of China
    J Chem Neuroanat 35:85-93. 2008
    ....
  33. ncbi request reprint Altered gene expression of NIDD in dorsal root ganglia and spinal cord of rats with neuropathic or inflammatory pain
    Meng ling Chen
    The Jiangsu Province Key Laboratory of Neuroregeneration, Nantong University, Nantong, 226001, P R China
    J Mol Histol 39:125-33. 2008
    ..Meanwhile, remarkable changes of nNOS were detected under such pain conditions. Our data suggest a potential role for NIDD in the maintenance of thermal pain hypersensitivity possibly via regulating the nNOS activity...
  34. pmc Structure of the Nitrosomonas europaea Rh protein
    Xin Li
    Biophysics Program and Departments of Biochemistry and Chemistry, Ohio State University, 484 West Twelfth Avenue, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 104:19279-84. 2007
    ..The implications of these findings on the functional role of the human Rh antigens are discussed...
  35. doi request reprint A differential role for BB0365 in the persistence of Borrelia burgdorferi in mice and ticks
    Utpal Pal
    Department of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    J Infect Dis 197:148-55. 2008
    ..burgdorferi life cycle...
  36. pmc Repetitive element-mediated recombination as a mechanism for new gene origination in Drosophila
    Shuang Yang
    Chinese Academy of Sciences Max Planck Junior Research Group, Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China
    PLoS Genet 4:e3. 2008
    ..Our dataset strongly suggests an important role for REs in the generation of chimeric genes within these species...
  37. ncbi request reprint [Immortalization of rat epiphysis cartilage cells induced by simian virus 40 large T antigen gene transfection]
    Xin Li
    Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Zhongguo Dang Dai Er Ke Za Zhi 10:51-4. 2008
    ..To establish immortalized epiphysis cartilage cell strains in order to provide a stable cell resource for cell substitution and gene therapies of growth retardation...
  38. doi request reprint Altered beta-1,4-galactosyltransferase I expression during early inflammation after spinal cord contusion injury
    Shuqiong Niu
    The Jiangsu Province Key Laboratory of Neuroregeneration, Nantong University, Nantong, People s Republic of China
    J Chem Neuroanat 35:245-56. 2008
    ..Thus, the transient expression of high levels of beta-1,4-GalT-I may provide new insight into the early inflammation after SCI...
  39. doi request reprint Bletilla striata polysaccharide stimulates inducible nitric oxide synthase and proinflammatory cytokine expression in macrophages
    Huajia Diao
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, People s Republic of China
    J Biosci Bioeng 105:85-9. 2008
    ..In this study, we partially elucidate the wound healing mechanism of BSP...
  40. pmc Role of decorin in the antimyeloma effects of osteoblasts
    Xin Li
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Blood 112:159-68. 2008
    ....
  41. ncbi request reprint Polarization-sensitive reflectance imaging in skeletal muscle
    Xin Li
    Department of Biological Engineering, University of Missouri Columbia, Columbia, MO 65211, USA
    Opt Express 16:9927-35. 2008
    ..Our analysis indicates that the unique muscle sarcomere structure plays an important role in modulating the propagation of polarized light in whole muscle...
  42. ncbi request reprint S100P contributes to chemosensitivity of human ovarian cancer cell line OVCAR3
    Zhijuan He
    Department of Obstetrics and Gynecology, The First Affiliated Hospital of Harbin Medical University, Harbin, HLJ 150010, People s Republic of China
    Oncol Rep 20:325-32. 2008
    ..Using S100P as a molecular biomarker may increase our ability to predict tumor drug response in ovarian cancer...
  43. ncbi request reprint [The genes associated with geldanamycin inhibiting replication of herpes simplex virus type 1]
    Yi Xuan Li
    Tianjin Life Science Research Center and Basic Medical School, Tianjin Medical University, Tianjin 300070, China
    Bing Du Xue Bao 24:208-12. 2008
    ..It is the first report of gene expression profile in cells infected by virus with GA treatment. The general impact of GA on cellular transcription may help to gain an insight into mechanism of its antiviral effect...
  44. pmc Tumor expressed PTHrP facilitates prostate cancer-induced osteoblastic lesions
    Jinhui Liao
    Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA
    Int J Cancer 123:2267-78. 2008
    ..Prostate cancer-derived PTHrP is actively involved in osteoblastic skeletal progression...
  45. ncbi request reprint Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways
    Yanqing Ding
    Department of Pathology, Nan Fang Hospital, First Military Medical University, Guangzhou, China
    J Pathol 203:622-30. 2004
    ..This data will be useful for designing new strategies for prevention and treatment of SARS...
  46. ncbi request reprint p16INK4A hypermethylation is associated with hepatitis virus infection, age, and gender in hepatocellular carcinoma
    Xin Li
    Hepato Biliary Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Clin Cancer Res 10:7484-9. 2004
    ..The possible clinical impact of p16INK4A methylation and the potential risk factors for this epigenetic alteration have not been thoroughly investigated...
  47. ncbi request reprint Carboxyl nonsteroidal anti-inflammatory drugs are efficiently glucuronidated by microsomes of the human gastrointestinal tract
    Nicole Sabolovic
    UMR 7561 CNRS Université Henri Poincaré, Nancy I, Faculte de Medecine, BP 184, F 54505 Vandoeuvre les Nancy cedex, France
    Biochim Biophys Acta 1675:120-9. 2004
    ..Despite interindividual variations in both the levels of mRNA and the distribution of activity through the intestine, UGTs in the GI tract may contribute significantly to the first pass metabolism of orally administered NSAIDs...
  48. ncbi request reprint Parathyroid hormone uses multiple mechanisms to arrest the cell cycle progression of osteoblastic cells from G1 to S phase
    Ling Qin
    Department of Physiology and Biophysics, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Biol Chem 280:3104-11. 2005
    ..In summary, our data suggest that one mechanism for PTH to exert its anabolic effect is to arrest the cell cycle progression of the osteoblast and hence increase its differentiation...
  49. ncbi request reprint Amphiregulin is a novel growth factor involved in normal bone development and in the cellular response to parathyroid hormone stimulation
    Ling Qin
    Physiology and Biophysics and Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Biol Chem 280:3974-81. 2005
    ..Moreover, AR null mice displayed significantly less tibial trabecular bone than wild-type mice. Taken together, we have identified a novel growth factor that is PTH-regulated and appears to have an important role in bone metabolism...
  50. ncbi request reprint Estrogen abrogates transcervical tight junctional resistance by acceleration of occludin modulation
    Robin Zeng
    Department of Reproductive Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Clin Endocrinol Metab 89:5145-55. 2004
    ..Collectively, the present data suggest that the occludin 50-kDa form is an estrogen-specific-induced occludin isoform and that the mechanism of estrogen-abrogation of transcervical R(TJ) involves occludin modulation...
  51. ncbi request reprint [mRNA expression of activin a and follistatin in rabbit mandibular distraction osteogenesis]
    Xin Li
    Department of Plastic Surgery, Baogang Hospital, Shanghai Second Medical University, Shanghai
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 18:376-9. 2004
    ..To examine the mRNA expression of activin A(ACT A) and follistatin(FS) during mandibular lengthening and to elucidate the regulating pattern of during mandibular distraction osteogenesis...
  52. ncbi request reprint cDNA cloning and mRNA expression of a FTZ-F1 homologue from the pituitary of the orange-spotted grouper, epinephelus coioides
    Weimin Zhang
    Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, College of Life Sciences, Zhongshan Sun Yat Sen University, Guangzhou 510275, P R China
    J Exp Zool A Comp Exp Biol 301:691-9. 2004
    ....
  53. ncbi request reprint P2X7 receptor-mediated apoptosis of human cervical epithelial cells
    Qifang Wang
    Department of Reproductive Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Am J Physiol Cell Physiol 287:C1349-58. 2004
    ..On the basis of these findings we propose a novel autocrine-paracrine mechanism of cervical cell apoptosis that operates by P2X7 receptor control of cytosolic calcium and utilizes the mitochondrial apoptotic pathway...
  54. ncbi request reprint Combinatorial selection and edited combinatorial selection of phosphorothioate aptamers targeting human nuclear factor-kappaB RelA/p50 and RelA/RelA
    Suzanne E Bassett
    Department of Human Biological Chemistry and Sealy Center for Structural Biology, Genetics, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Biochemistry 43:9105-15. 2004
    ....
  55. ncbi request reprint Cloning and expression of human UDP-glucuronosyltransferase 1A4 in Bac-to-Bac system
    Mingrong Qian
    Department of Pharmaceutical Analysis and Drug Metabolism, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310031, People s Republic of China
    Biochem Biophys Res Commun 319:386-92. 2004
    ..It paved the way for the further studies for drug glucuronidation by UGT1A4. The purification of the UGT1A4 can be done by Ni-resin. This is helpful to do research on the structure of the UFT1A4...
  56. pmc Heterologous expression of active human uridine diphosphate glucuronosyltransferase 1A3 in Chinese hamster lung cells
    Ya Kun Chen
    College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, Zhejiang Province, China
    World J Gastroenterol 11:118-21. 2005
    ..To obtain the active human recombinant uridine diphosphate glucuronosyltransferase 1A3 (UGT1A3) enzyme from Chinese hamster lung (CHL) cells...
  57. ncbi request reprint cDNA sequence and spatio-temporal expression of prolactin in the orange-spotted grouper, Epinephelus coioides
    Weimin Zhang
    Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, College of Life Sciences, Zhongshan Sun Yat Sen University, Guangzhou 510275, PR China
    Gen Comp Endocrinol 136:134-42. 2004
    ..Results from the current study suggest that PRL may have important paracrine or autocrine roles in diverse tissue types, including the brain and the gonads, and during embryonic development of the orange-spotted grouper...
  58. pmc Influence of transarterial chemoembolization on angiogenesis and expression of vascular endothelial growth factor and basic fibroblast growth factor in rat with Walker-256 transplanted hepatoma: an experimental study
    Xin Li
    Department of Interventional Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
    World J Gastroenterol 9:2445-9. 2003
    ..In this study, we examined the effect of TACE on angiogenesis and expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (b-FGF) and to assess their relevance to Walker-256 transplanted hepatoma...
  59. ncbi request reprint DNA binding to fluorescent ruthenium species released from calcium phosphate/nanoporous silicon structures
    Xin Li
    Department of Chemistry, Texas Christian University, Ft Worth, Texas, USA
    J Nanosci Nanotechnol 2:391-6. 2002
    ....
  60. ncbi request reprint [Mechanism of inhibition of tumor angiogenesis by Bletilla colloid: an experimental study]
    Gan sheng Feng
    Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Zhonghua Yi Xue Za Zhi 83:412-6. 2003
    ..To study the mechanism of inhibition of tumor angiogenesis by Bletilla colloid...
  61. pmc Immunofluorescence assay and flow-cytometry selection of bead-bound aptamers
    Xianbin Yang
    Sealy Center for Structural Biology and Department of Human Biological Chemistry and Genetics, The University of Texas Medical Branch, Galveston, TX 77555 1157, USA
    Nucleic Acids Res 31:e54. 2003
    ....
  62. ncbi request reprint Gene expression profiles and transcription factors involved in parathyroid hormone signaling in osteoblasts revealed by microarray and bioinformatics
    Ling Qin
    Department of Physiology and Biophysics, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway 08854, USA
    J Biol Chem 278:19723-31. 2003
    ..Our results suggest that a reliable bioinformatics approach can be easily applied for other systems...
  63. ncbi request reprint Three-dimensional analysis of post-Golgi carrier exocytosis in epithelial cells
    Geri Kreitzer
    Margaret M Dyson Vision Research Institute, Weill Medical College of Cornell University, New York, NY 10021, USA
    Nat Cell Biol 5:126-36. 2003
    ....
  64. pmc Overexpression of ETS2 in human esophageal squamous cell carcinoma
    Xin Li
    National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    World J Gastroenterol 9:205-8. 2003
    ..To study the expression pattern of ETS2 (erythroblastosis virus oncogene homolog 2) in human esophageal squamous cell carcinoma (ESCC)...
  65. ncbi request reprint Effects of sodium arsenite on catalase activity, gene and protein expression in HaCaT cells
    Xiance Sun
    Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning, PR China
    Toxicol In Vitro 20:1139-44. 2006
    ..CAT activity, mRNA expression and protein levels were decreased by 5-20 micromol/l of sodium arsenite. It is highly suggestive that CAT gene expression and protein levels are affected by arsenic...
  66. ncbi request reprint [Transforming growth factor-beta superfamily in the regulation of new bone formation]
    Xin Li
    Department of Plastic Surgery, Ninth People s Hospital of Shanghai, Second Medical University, Shanghai, P R China 200011
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 16:126-9. 2002
    ..To review the recent advances in transforming growth factor-beta(TGF-beta) superfamily study and its role in new bone formation...
  67. pmc Decreased expression of P2X7 in endometrial epithelial pre-cancerous and cancer cells
    Xin Li
    Department of Reproductive Biology, CASE Case Western Reserve University, Cleveland, OH 44106, USA
    Gynecol Oncol 106:233-43. 2007
    ..To understand the potential role of P2X(7) as biomarker of endometrial cancer, and the molecular mechanisms by which cancerous epithelial cells maintain low expression of P2X(7)...
  68. ncbi request reprint Significance of TWIST expression and its association with E-cadherin in bladder cancer
    Zheng Zhang
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong
    Hum Pathol 38:598-606. 2007
    ..Our results demonstrate TWIST as a novel positive factor in the development and progression of bladder cancer and suggest a marker for advanced bladder cancer...
  69. ncbi request reprint The ubiquitin pathway is required for innate immunity in Arabidopsis
    Sandra Goritschnig
    Michael Smith Laboratories, Room 301, 2185 East Mall, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
    Plant J 49:540-51. 2007
    ..Our data reveal the definite requirement for the ubiquitination pathway in the activation and downstream signalling of several R-proteins...
  70. ncbi request reprint [Effects of sodium arsenite on catalase in human keratinocytes]
    Xian Ce Sun
    Hygiene Department, Colleges of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning 116027, China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 24:605-7. 2006
    ..To evaluate the effects of sodium arsenite on the activity, the mRNA and the protein expression of CAT in human keratinocyte cell line (HaCaT)...
  71. ncbi request reprint The mRNA expression of P450 aromatase, gonadotropin beta-subunits and FTZ-F1 in the orange-spotted grouper (Epinephelus Coioides) during 17alpha-methyltestosterone-induced precocious sex change
    Weimin Zhang
    Institute of Aquatic Economic Animals, School of Life Sciences, Zhongshan Sun Yat Sen University, Guangzhou, P R China
    Mol Reprod Dev 74:665-73. 2007
    ....
  72. pmc The P2X7 receptor: a novel biomarker of uterine epithelial cancers
    Xin Li
    Department of Reproductive Biology, Case Western Reserve University, Cleveland, Ohio, USA
    Cancer Epidemiol Biomarkers Prev 15:1906-13. 2006
    ..The rationale was that the receptor P2X(7) regulates constitutive apoptosis in uterine epithelial cells, and previous studies showed diminished P2X(7)-mediated apoptosis in cancer uterine cells compared with normal cells...
  73. ncbi request reprint Intra- and inter-ethnic differences in the allele frequencies of cytochrome P450 2B6 gene in Chinese
    Su Guan
    Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat Sen University, 74 Zhongshan Road, Section 2, Guangzhou 510080, People s Republic of China
    Pharm Res 23:1983-90. 2006
    ..05). These results indicate that there were marked ethnic differences in the mutant frequencies of CYP2B6 between Chinese and other ethnic groups. Further studies are warranted to explore the clinical impact of such ethnic differences...
  74. pmc Estrogen regulates epithelial cell deformability by modulation of cortical actomyosin through phosphorylation of nonmuscle myosin heavy-chain II-B filaments
    Xin Li
    Department of Reproductive Biology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Endocrinology 147:5236-48. 2006
    ..This mechanism can explain estrogen regulation of paracellular permeability in cervical-vaginal epithelia in vivo...
  75. ncbi request reprint Significance of Id-1 up-regulation and its association with EGFR in bladder cancer cell invasion
    Yi Ding
    Cancer Biology Group, Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong, PR China
    Int J Oncol 28:847-54. 2006
    ..Inactivation of Id-1 may be a potential therapeutic target to inhibit the invasion by bladder cancer cells...
  76. pmc When patients have to pay a share of drug costs: effects on frequency of physician visits, hospital admissions and filling of prescriptions
    Aslam H Anis
    Department of Health Care and Epidemiology, University of British Columbia, Vancouver, BC
    CMAJ 173:1335-40. 2005
    ..We investigated the effect of prescription drug cost-sharing on overall health care utilization among elderly patients with rheumatoid arthritis...
  77. ncbi request reprint Insulin enhances growth hormone induction of the MEK/ERK signaling pathway
    Jie Xu
    Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, 35294, USA
    J Biol Chem 281:982-92. 2006
    ..These findings suggest that insulin may be necessary for sensitization of cells to GH-induced ERK1/2 activation and provides a potential cellular mechanism by which insulin promotes growth...
  78. ncbi request reprint Expression pattern and subcellular localization of five splice isoforms of human PXK
    Xianqiong Zou
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, PR China
    Int J Mol Med 16:701-7. 2005
    ..Mutation analysis of EGFP-PXK_v1 showed that PXK_v1-Tyr56 and Arg92 are essential for subcellular localization of the protein in the cytoplasm...
  79. ncbi request reprint [Kinetic patterns of cytokine expressions in H-2 haploidentical nonmyeloablative bone marrow transplantation in mice]
    Xin Li
    Department of Hematology, The Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100039, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 13:687-91. 2005
    ..CsA and MMF can reduce the incidence and severity of aGVHD by down-regulating the expression levels of IL-2 and INF-gamma...
  80. ncbi request reprint Molecular cloning and characterization of AAAS-V2, a novel splice variant of human AAAS
    Xin Li
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, People s Republic of China
    Mol Biol Rep 32:127-31. 2005
    ..3). RT-PCR analysis in our work revealed that AAAS-v2 and AAAS-v1 were ubiquitously detected in human multiple tissue cDNA (MTC) panels (CLONTECH)...
  81. ncbi request reprint Screening and analysis of bioactive compounds with biofingerprinting chromatogram analysis of traditional Chinese medicines targeting DNA by microdialysis/HPLC
    Xingye Su
    National Chromatographic R and A Centre, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
    J Chromatogr A 1076:118-26. 2005
    ..Three of them were identified as berberine, palmatine and jatrorrhizine and their association constants (K) to ct-DNA were determined by microdialysis/HPLC. Competitive binding behaviors of them to ct-DNA were also investigated...
  82. ncbi request reprint Molecular cloning and characterization of a novel human C4orf13 gene, tentatively a member of the sodium bile acid cotransporter family
    Xianqiong Zou
    School of Resource Processing and Bio engineering, Central South University, Changsha 410083, PR China
    Biochem Genet 43:165-73. 2005
    ....
  83. pmc ATP stimulates GRK-3 phosphorylation and beta-arrestin-2-dependent internalization of P2X7 receptor
    Ying Hong Feng
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Am J Physiol Cell Physiol 288:C1342-56. 2005
    ....