Laila Abdullah

Summary

Affiliation: Roskamp Institute
Country: USA

Publications

  1. doi request reprint Long title: Translational potential of long-term decreases in mitochondrial lipids in a mouse model of Gulf War Illness
    Laila Abdullah
    Roskamp Institute, Sarasota, FL, USA James A Haley VA Hospital, Tampa, FL, USA Open University, Milton Keynes, UK Electronic address
    Toxicology . 2016
  2. doi request reprint Translational potential of long-term decreases in mitochondrial lipids in a mouse model of Gulf War Illness
    Laila Abdullah
    Roskamp Institute, Sarasota, FL, USA James A Haley VA Hospital, Tampa, FL, USA Open University, Milton Keynes, UK Electronic address
    Toxicology 372:22-33. 2016
  3. doi request reprint Lipidomic analyses identify injury-specific phospholipid changes 3 mo after traumatic brain injury
    Laila Abdullah
    Roskamp Institute, Sarasota, Florida, USA and James A Haley Veterans Affairs Hospital, Tampa, Florida, USA
    FASEB J 28:5311-21. 2014
  4. doi request reprint Chronic elevation of phosphocholine containing lipids in mice exposed to Gulf War agents pyridostigmine bromide and permethrin
    Laila Abdullah
    Roskamp Institute, 2040 Whitfield Ave, Sarasota, FL 34243, United States Electronic address
    Neurotoxicol Teratol 40:74-84. 2013
  5. doi request reprint Lipidomic profiling of phosphocholine-containing brain lipids in mice with sensorimotor deficits and anxiety-like features after exposure to Gulf War agents
    Laila Abdullah
    Roskamp Institute, Sarasota, FL 34243, USA
    Neuromolecular Med 14:349-61. 2012
  6. doi request reprint Proteomic CNS profile of delayed cognitive impairment in mice exposed to Gulf War agents
    Laila Abdullah
    Roskamp Institute, 2040 Whitfield Ave, Sarasota, FL, 34243, USA
    Neuromolecular Med 13:275-88. 2011
  7. pmc Serum Abeta levels as predictors of conversion to mild cognitive impairment/Alzheimer disease in an ADAPT subcohort
    Laila Abdullah
    Roskamp Institute, Sarasota, Florida 34243, USA
    Mol Med 15:432-7. 2009
  8. pmc High serum Abeta and vascular risk factors in first-degree relatives of Alzheimer's disease patients
    Laila Abdullah
    Roskamp Institute, Sarasota, Florida 34243, USA
    Mol Med 15:95-100. 2009
  9. ncbi request reprint The influence of diagnosis, intra- and inter-person variability on serum and plasma Abeta levels
    Laila Abdullah
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, United States
    Neurosci Lett 428:53-8. 2007
  10. ncbi request reprint The cyclooxygenase 2 -765 C promoter allele is a protective factor for Alzheimer's disease
    Laila Abdullah
    Roskamp Institute, 2040 Whitfield Ave Sarasota, FL, USA
    Neurosci Lett 395:240-3. 2006

Collaborators

Detail Information

Publications25

  1. doi request reprint Long title: Translational potential of long-term decreases in mitochondrial lipids in a mouse model of Gulf War Illness
    Laila Abdullah
    Roskamp Institute, Sarasota, FL, USA James A Haley VA Hospital, Tampa, FL, USA Open University, Milton Keynes, UK Electronic address
    Toxicology . 2016
    ..Targeting mitochondrial function may provide effective therapies for GWI, and that lipid abnormalities could serve as biomarkers of GWI...
  2. doi request reprint Translational potential of long-term decreases in mitochondrial lipids in a mouse model of Gulf War Illness
    Laila Abdullah
    Roskamp Institute, Sarasota, FL, USA James A Haley VA Hospital, Tampa, FL, USA Open University, Milton Keynes, UK Electronic address
    Toxicology 372:22-33. 2016
    ..Targeting mitochondrial function may provide effective therapies for GWI, and that lipid abnormalities could serve as biomarkers of GWI...
  3. doi request reprint Lipidomic analyses identify injury-specific phospholipid changes 3 mo after traumatic brain injury
    Laila Abdullah
    Roskamp Institute, Sarasota, Florida, USA and James A Haley Veterans Affairs Hospital, Tampa, Florida, USA
    FASEB J 28:5311-21. 2014
    ..Given the importance of DHA in maintaining neuronal function and resolving inflammation and of peroxisomes in synthesis of ether PLs, normalizing these PLs may be a useful strategy for treating the chronic pathology of TBI...
  4. doi request reprint Chronic elevation of phosphocholine containing lipids in mice exposed to Gulf War agents pyridostigmine bromide and permethrin
    Laila Abdullah
    Roskamp Institute, 2040 Whitfield Ave, Sarasota, FL 34243, United States Electronic address
    Neurotoxicol Teratol 40:74-84. 2013
    ..Our studies provide a new direction for GWI research, which will be useful for developing suitable therapies for treating GWI. ..
  5. doi request reprint Lipidomic profiling of phosphocholine-containing brain lipids in mice with sensorimotor deficits and anxiety-like features after exposure to Gulf War agents
    Laila Abdullah
    Roskamp Institute, Sarasota, FL 34243, USA
    Neuromolecular Med 14:349-61. 2012
    ....
  6. doi request reprint Proteomic CNS profile of delayed cognitive impairment in mice exposed to Gulf War agents
    Laila Abdullah
    Roskamp Institute, 2040 Whitfield Ave, Sarasota, FL, 34243, USA
    Neuromolecular Med 13:275-88. 2011
    ..Evaluation of the potential role of these biological functions in GWI will be useful in identifying molecular pathways that can be targeted for the development of novel therapeutics against GWI...
  7. pmc Serum Abeta levels as predictors of conversion to mild cognitive impairment/Alzheimer disease in an ADAPT subcohort
    Laila Abdullah
    Roskamp Institute, Sarasota, Florida 34243, USA
    Mol Med 15:432-7. 2009
    ..In this subcohort of individuals at risk for AD, the association of Abeta with vascular risk factors and medications to treat these conditions did not interfere with Abeta's predictive value for MCI/AD...
  8. pmc High serum Abeta and vascular risk factors in first-degree relatives of Alzheimer's disease patients
    Laila Abdullah
    Roskamp Institute, Sarasota, Florida 34243, USA
    Mol Med 15:95-100. 2009
    ..Longitudinal evaluation of blood Abeta in this cohort will provide a better understanding of the significance of this association in AD etiology...
  9. ncbi request reprint The influence of diagnosis, intra- and inter-person variability on serum and plasma Abeta levels
    Laila Abdullah
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, United States
    Neurosci Lett 428:53-8. 2007
    ....
  10. ncbi request reprint The cyclooxygenase 2 -765 C promoter allele is a protective factor for Alzheimer's disease
    Laila Abdullah
    Roskamp Institute, 2040 Whitfield Ave Sarasota, FL, USA
    Neurosci Lett 395:240-3. 2006
    ..464, CI = [.351-.885], p = .013). In this sample, the C allele of COX-2 -765 promoter polymorphism is associated with decreased risk of Alzheimer's disease, a finding which further supports the involvement of COX-2 in AD etiology...
  11. doi request reprint Serum beta-amyloid correlates with neuropsychological impairment
    Cheryl A Luis
    Roskamp Institute, Sarasota, FL, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 16:203-18. 2009
    ....
  12. doi request reprint Diagnostic utility of APOE, soluble CD40, CD40L, and Abeta1-40 levels in plasma in Alzheimer's disease
    Ghania Ait-Ghezala
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Cytokine 44:283-7. 2008
    ..Thus, we present preliminary evidence for potential usefulness for combination of plasma sCD40, sCD40L along with Abeta(1-40) and APOE epsilon4 in improving the clinical diagnosis of AD...
  13. doi request reprint Plasma Lipidomic Profiling in a Military Population of Mild Traumatic Brain Injury and Post-Traumatic Stress Disorder with Apolipoprotein E ɛ4-Dependent Effect
    Tanja Emmerich
    1 The Roskamp Institute, Sarasota, Florida
    J Neurotrauma 33:1331-48. 2016
    ..In conclusion, PL profiling may facilitate clinical diagnosis of mTBI and PTSD currently hindered by comorbid pathology and overlapping symptomology of these two conditions. ..
  14. pmc Gulf War agent exposure causes impairment of long-term memory formation and neuropathological changes in a mouse model of Gulf War Illness
    Zuchra Zakirova
    The Roskamp Institute, Sarasota, Florida, United States of America The Open University, Walton Hall, Milton Keynes, Buckinghamshire, United Kingdom James A Haley Veteran s Hospital, Tampa, Florida, United States of America
    PLoS ONE 10:e0119579. 2015
    ..In summary, our findings in this mouse model of GW agent exposure are consistent with some GWI symptom manifestations, including delayed onset of symptoms and CNS disturbances observed in GWI veterans. ..
  15. pmc Chronic Repetitive Mild Traumatic Brain Injury Results in Reduced Cerebral Blood Flow, Axonal Injury, Gliosis, and Increased T-Tau and Tau Oligomers
    Joseph O Ojo
    From the Roskamp Institute, Sarasota, Florida JOO, BM, MA, PL, CL, LA, JE, MM, CB, FC James A Haley Veterans Hospital, Tampa, Florida BM, LA, CB, FC Open University, Milton Keynes, UK BM, MA, CL, CB, FC Bay Pines VA Healthcare System, Bay Pines, Florida CB Queen Elizabeth University Hospital, Glasgow, UK WS University of Glasgow, Glasgow, UK WS and University of Pennsylvania, Philadelphia, Pennsylvania WS
    J Neuropathol Exp Neurol 75:636-55. 2016
    ..These data support the relevance of this new mTBI injury model for studying the consequences of chronic repetitive mTBI in humans, and the role of tau in TBI. ..
  16. ncbi request reprint Mild TBI Results in a Long-Term Decrease in Circulating Phospholipids in a Mouse Model of Injury
    Tanja Emmerich
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL, 34243, USA
    Neuromolecular Med . 2016
    ..Our study provides information on biochemical abnormalities that persist long after the initial injury; these abnormalities may provide useful insight into the continuing pathogenesis and serve as diagnostic biomarkers...
  17. doi request reprint Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation
    Daniel Paris
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, Florida 34243, USA
    Eur J Pharmacol 698:145-53. 2013
    ..Overall our data show that the anti-inflammatory activity of anatabine in vitro and in vivo is mediated in part via an inhibition of STAT3 phosphorylation...
  18. pmc Feasibility of Predicting MCI/AD Using Neuropsychological Tests and Serum β-Amyloid
    Cheryl A Luis
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Int J Alzheimers Dis 2011:786264. 2011
    ....
  19. doi request reprint Acute or Delayed Treatment with Anatabine Improves Spatial Memory and Reduces Pathological Sequelae at Late Time-Points after Repetitive Mild Traumatic Brain Injury
    Scott Ferguson
    1 Roskamp Institute, Sarasota, Florida
    J Neurotrauma . 2017
    ..Future studies will characterize the treatment window, the time course of treatment needed, and the dose needed to achieve therapeutic levels of anatabine in humans after injury...
  20. ncbi request reprint Beneficial effect of cholinesterase inhibitor medications on recognition memory performance in mild to moderate Alzheimer's disease: preliminary findings
    Timothy A Crowell
    Roskamp Institute Memory Clinic, Tampa, Florida 33617, USA
    J Geriatr Psychiatry Neurol 19:13-5. 2006
    ..The implications of this on clinical care and functional abilities as well as future directions are discussed...
  21. ncbi request reprint CD45 isoform alteration in CD4+ T cells as a potential diagnostic marker of Alzheimer's disease
    Jun Tan
    Department of Psychiatry, Roskamp Institute, University of South Florida, 3515 E Fletcher Ave, Tampa, FL 33613, USA
    J Neuroimmunol 132:164-72. 2002
    ....
  22. doi request reprint Exposure to an organophosphate pesticide, individually or in combination with other Gulf War agents, impairs synaptic integrity and neuronal differentiation, and is accompanied by subtle microvascular injury in a mouse model of Gulf War agent exposure
    Joseph O Ojo
    Roskamp Institute, Sarasota, Florida, USA
    Neuropathology 34:109-27. 2014
    ..These data support early (subtle) neurotoxic effects on the brain following exposure to GW agents. ..
  23. ncbi request reprint Inhibition of angiogenesis by Abeta peptides
    Daniel Paris
    The Roskamp Institute, Sarasota, Florida 34243, USA
    Angiogenesis 7:75-85. 2004
    ..Similarly to the intra-tumoral injection regimen, Abeta delivered intraperitoneally also suppressed the growth of human lung adenocarcinoma tumor xenografts. Altogether our data show that Abeta is an angiogenesis inhibitor...
  24. ncbi request reprint Cocaine-induced oxidative stress precedes cell death in human neuronal progenitor cells
    H Fai Poon
    Roskamp Institute, 2040 Whitfield Ave, Sarasota, FL 34243, United States
    Neurochem Int 50:69-73. 2007
    ..This may have implications for the consequences of cocaine abuse in situations where antioxidant capacity is compromised, as in the aging brain...
  25. pmc Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib
    Barbara K Martin
    Arch Neurol 65:896-905. 2008
    ..Observational studies have shown reduced risk of Alzheimer dementia in users of nonsteroidal anti-inflammatory drugs...