Min Lu

Summary

Affiliation: Rosalind Franklin University of Medicine and Science
Country: USA

Publications

  1. pmc Structures of a Na+-coupled, substrate-bound MATE multidrug transporter
    Min Lu
    Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA
    Proc Natl Acad Sci U S A 110:2099-104. 2013
  2. pmc Structural insights into H+-coupled multidrug extrusion by a MATE transporter
    Min Lu
    Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA
    Nat Struct Mol Biol 20:1310-7. 2013
  3. pmc Structural basis for the blockade of MATE multidrug efflux pumps
    Martha Radchenko
    Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, Illinois 60064, USA
    Nat Commun 6:7995. 2015
  4. pmc Crystallographic study of a MATE transporter presents a difficult case in structure determination with low-resolution, anisotropic data and crystal twinning
    Jindrich Symersky
    Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA
    Acta Crystallogr D Biol Crystallogr 71:2287-96. 2015

Collaborators

Detail Information

Publications4

  1. pmc Structures of a Na+-coupled, substrate-bound MATE multidrug transporter
    Min Lu
    Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA
    Proc Natl Acad Sci U S A 110:2099-104. 2013
    ..Collectively, our findings provide an important step toward a detailed and mechanistic understanding of multidrug transport...
  2. pmc Structural insights into H+-coupled multidrug extrusion by a MATE transporter
    Min Lu
    Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA
    Nat Struct Mol Biol 20:1310-7. 2013
    ..Collectively, our results demonstrated heretofore-unrecognized mechanistic diversity among MATE transporters. ..
  3. pmc Structural basis for the blockade of MATE multidrug efflux pumps
    Martha Radchenko
    Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, Illinois 60064, USA
    Nat Commun 6:7995. 2015
    ..Our findings offer insights into how MATE transporters extrude chemically and structurally dissimilar drugs and could inform the design of new strategies for tackling multidrug resistance. ..
  4. pmc Crystallographic study of a MATE transporter presents a difficult case in structure determination with low-resolution, anisotropic data and crystal twinning
    Jindrich Symersky
    Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA
    Acta Crystallogr D Biol Crystallogr 71:2287-96. 2015
    ..The approaches taken to determine the NorM-NG structure and the lessons learned from this study are discussed, which may be useful for analyzing X-ray diffraction data with similar shortcomings...