G A Babbitt
Affiliation: Rochester Institute of Technology
- Can all heritable biology really be reduced to a single dimension?Gregory A Babbitt
Thomas H Gosnell School of Life Sciences, Rochester Institute of Technology, Rochester 14623, NY, USA Electronic address
Gene 578:162-8. 2016..However, we also note that these hybrid methods still ignore the most important element of gene function when attempting to improve outcomes; the fourth dimension of molecular dynamics over time. ..
- Synonymous codon bias and functional constraint on GC3-related DNA backbone dynamics in the prokaryotic nucleoidGregory A Babbitt
Thomas H Gosnell School of Life Sciences, Rochester Institute of Technology, Rochester NY, USA 14623
Nucleic Acids Res 42:10915-26. 2014..We propose that synonymous sites may have evolved as an 'accessory' during an early expansion of a primordial genetic code, allowing for multiplexed protein coding and structural dynamic information within the same molecular context. ..
- Functional conservation of nucleosome formation selectively biases presumably neutral molecular variation in yeast genomesGregory A Babbitt
School of Biological and Medical Sciences, Rochester Institute of Technology
Genome Biol Evol 3:15-22. 2011....
- Codons support the maintenance of intrinsic DNA polymer flexibility over evolutionary timescalesG A Babbitt
TH Gosnell School of Life Sciences, Rochester Institute of Technology, Rochester, NY, USA
Genome Biol Evol 4:954-65. 2012....
- The molecular evolution of nucleosome positioning through sequence-dependent deformation of the DNA polymerG A Babbitt
School of Biological and Medical Sciences, Rochester Institute of Technology, Rochester, NY, USA
J Biomol Struct Dyn 27:765-80. 2010....
- Relaxed selection against accidental binding of transcription factors with conserved chromatin contextsG A Babbitt
School of Biological and Medical Sciences, Rochester Institute of Technology, USA
Gene 466:43-8. 2010..These results indicate a role of chromatin context dependency in relaxing selection against spurious binding in nearly half of all TF binding motifs throughout the yeast genome...