A C Steere
Affiliation: Rhode Island Hospital
- Autoimmune mechanisms in antibiotic treatment-resistant lyme arthritisA C Steere
Division of Rheumatology Immunology Medicine and the Department of Pathology, Tufts University School of Medicine, New England Medical Center, Boston, MA, USA
J Autoimmun 16:263-8. 2001..Molecular mimicry between a dominant T cell epitope of OspA and hLFA-1 may be an important factor in the persistence of joint inflammation in genetically susceptible patients with treatment-resistant Lyme arthritis...
- Molecular mimicry in Lyme arthritis demonstrated at the single cell level: LFA-1 alpha L is a partial agonist for outer surface protein A-reactive T cellsC Trollmo
Laboratory of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 166:5286-91. 2001..Our analysis at the clonal level demonstrates that human LFA-1alpha(L326-345) behaves as a partial agonist, perhaps playing a role in perpetuating symptoms of arthritis...
- Persistence of immunoglobulin M or immunoglobulin G antibody responses to Borrelia burgdorferi 10-20 years after active Lyme diseaseR A Kalish
Division of Rheumatology Immunology, Tufts University School of Medicine, New England Medical Center, Boston, MA 02111, USA
Clin Infect Dis 33:780-5. 2001..IgM or IgG antibody responses to B. burgdorferi may persist for 10-20 years, but these responses are not indicative of active infection...
- Differences in synovial fluid levels of matrix metalloproteinases suggest separate mechanisms of pathogenesis in Lyme arthritis before and after antibiotic treatmentB Lin
New England Medical Center, Tufts University School of Medicine, Tupper Research Institute, Department of Medicine, Boston, Massachusetts 02111, USA
J Infect Dis 184:174-80. 2001..burgdorferi may be through CD14 and toll-like receptor-2, which were up-regulated in the presence of B. burgdorferi. These findings suggest different stimuli for MMP induction in untreated and antibiotic-resistant Lyme arthritis...
- Recognition of multiple antibody epitopes throughout Borrelia burgdorferi p66, a candidate adhesin, in patients with early or late manifestations of Lyme diseaseH Ntchobo
Division of Rheumatology and Immunology, Tufts-New England Medical Center, Boston, Massachusetts 02111, USA
Infect Immun 69:1953-6. 2001..Among patients with later manifestations of the illness, antibody responses to the C-terminal portion of the protein were more prominent. These results demonstrate that Lyme disease patient sera recognize epitopes throughout p66...
- Cellular and humoral immune responses to Borrelia burgdorferi antigens in patients with culture-positive early Lyme diseaseA Vaz
Division of Rheumatology/Immunology, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Infect Immun 69:7437-44. 2001..We conclude that cellular and humoral responses to B. burgdorferi antigens are often found among patients with early Lyme disease. In contrast with the other antigens tested, cellular but not humoral reactivity was often found with OspA...
- Expression of adhesion molecules in synovia of patients with treatment-resistant lyme arthritisE Akin
Division of Rheumatology Immunology, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts 02111, USA
Infect Immun 69:1774-80. 2001..Upregulation of LFA-1 on lymphocytes in this lesion may be critical in the pathogenesis of treatment-resistant Lyme arthritis...
- Host metalloproteinases in Lyme arthritisL T Hu
New England Medical Center, Boston, Massachusetts, USA
Arthritis Rheum 44:1401-10. 2001..burgdorferi. Inhibition of MMP activity prevents B. burgdorferi-induced cartilage degradation in vitro...
- Cross-reactivity of Borrelia burgdorferi and myelin basic protein-specific T cells is not observed in borrelial encephalomyelitisA Pohl-Koppe
Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, Massachusetts, 02115, USA
Cell Immunol 194:118-23. 1999..burgdorferi and MBP, T-cell clones from these lines responded only to the antigen of the original stimulation. Thus, our data do not provide evidence for cross-reactivity between MBP and B. burgdorferi...
- Evaluation of study patients with Lyme disease, 10-20-year follow-upR A Kalish
Division of Rheumatology Immunology, Tufts University School of Medicine, New England Medical Center, Tupper Research Institute, Boston, Massachusetts, USA
J Infect Dis 183:453-60. 2001..Thus, the overall current health status of each patient group was good, but sequelae were apparent primarily among patients with facial palsy who did not receive antibiotics for acute neuroborreliosis...
- Differential expression of cytokine mRNA in skin specimens from patients with erythema migrans or acrodermatitis chronica atrophicansR R Mullegger
Division of Rheumatology Immunology, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts, USA
J Invest Dermatol 115:1115-23. 2000..J Invest Dermatol 115:1115-1123 2000..
- Matrix metalloproteinases in the cerebrospinal fluid of patients with Lyme neuroborreliosisG Perides
Tupper Research Institute, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts 02111, USA
J Infect Dis 177:401-8. 1998..001). This pattern of CSF gelatinase activity may be a useful marker for neuroborreliosis...
- Optic neuropathy in children with Lyme diseaseH Rothermel
Division of Rheumatology/Immunology, Tufts University School of Medicine, New England Medical Center, Boston, MA 02111, USA
Pediatrics 108:477-81. 2001..If increased intracranial pressure persists despite antibiotic therapy, measures must be taken quickly to reduce the pressure...