Genomes and Genes
S C Bodine
Affiliation: Regeneron Pharmaceuticals
- Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivoS C Bodine
Regeneron Pharmaceuticals, Inc 777 Old Saw Mill River Road, Tarrytown, New York 10591 6707, USA
Nat Cell Biol 3:1014-9. 2001....
- Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathwaysC Rommel
Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591-6707, USA
Nat Cell Biol 3:1009-13. 2001..In contrast, in addition to demonstrating that calcineurin does not mediate IGF-1-induced hypertrophy, we show that IGF-1 unexpectedly acts via Akt to antagonize calcineurin signalling during myotube hypertrophy...
- Identification of ubiquitin ligases required for skeletal muscle atrophyS C Bodine
Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591 6707, USA
Science 294:1704-8. 2001..Overexpression of MAFbx in myotubes produced atrophy, whereas mice deficient in either MAFbx or MuRF1 were found to be resistant to atrophy. These proteins are potential drug targets for the treatment of muscle atrophy...
- Reduced Ia-afferent-mediated Hoffman reflex in streptozotocin-induced diabetic ratsJ R Tonra
Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA
Exp Neurol 172:220-7. 2001..The recovery of the H wave in STZ-treated rats distinguishes this deficit mechanistically from other STZ-induced electrophysiological changes and may model a similar recovery of the H wave reported in diabetic patients...