John S Bradley

Summary

Affiliation: Rady Children's Hospital
Country: USA

Publications

  1. ncbi request reprint Comparative study of levofloxacin in the treatment of children with community-acquired pneumonia
    John S Bradley
    Children s Hospital and Health Center, San Diego, CA, USA
    Pediatr Infect Dis J 26:868-78. 2007
  2. pmc Phase I Study Assessing the Pharmacokinetic Profile, Safety, and Tolerability of a Single Dose of Ceftazidime-Avibactam in Hospitalized Pediatric Patients
    John S Bradley
    University of California, San Diego, California, USA
    Antimicrob Agents Chemother 60:6252-9. 2016
  3. doi request reprint Assessment of musculoskeletal toxicity 5 years after therapy with levofloxacin
    John S Bradley
    University of California, San Diego School of Medicine and Rady Children s Hospital San Diego, San Diego, California
    Pediatrics 134:e146-53. 2014
  4. doi request reprint Which antibiotic for resistant Gram-positives, and why?
    John S Bradley
    University of California, San Diego, School of Medicine, Rady Children s Hospital, San Diego, USA Electronic address
    J Infect 68:S63-75. 2014
  5. pmc Genetic structure of community acquired methicillin-resistant Staphylococcus aureus USA300
    Ryan Tewhey
    Scripps Genomic Medicine, Scripps Translational Science Institute, La Jolla, CA, USA
    BMC Genomics 13:508. 2012
  6. pmc Executive summary: the management of community-acquired pneumonia in infants and children older than 3 months of age: clinical practice guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America
    John S Bradley
    Department of Pediatrics, University of California San Diego School of Medicine and Rady Children s Hospital of San Diego, San Diego, California, USA
    Clin Infect Dis 53:617-30. 2011
  7. doi request reprint Unique considerations in the evaluation of antibacterials in clinical trials for pediatric community-acquired pneumonia
    John S Bradley
    Division of Pediatric Infectious Diseases, Rady Children s Hospital San Diego, San Diego, California 92123, USA
    Clin Infect Dis 47:S241-8. 2008
  8. doi request reprint Intravenous ceftriaxone and calcium in the neonate: assessing the risk for cardiopulmonary adverse events
    John S Bradley
    Rady Children s Hospital San Diego, San Diego, California 92123, USA
    Pediatrics 123:e609-13. 2009
  9. doi request reprint Considerations unique to pediatrics for clinical trial design in hospital-acquired pneumonia and ventilator-associated pneumonia
    John S Bradley
    Rady Children s Hospital San Diego, University of California, San Diego, USA
    Clin Infect Dis 51:S136-43. 2010
  10. doi request reprint Prevalence of hepatitis C virus antibody in newborn infants in southern California in 2003
    John S Bradley
    Division of Infectious Diseases, Rady Children s Hospital San Diego, University of California at San Diego, San Diego, CA 92123, USA
    Pediatr Infect Dis J 30:618-20. 2011

Detail Information

Publications44

  1. ncbi request reprint Comparative study of levofloxacin in the treatment of children with community-acquired pneumonia
    John S Bradley
    Children s Hospital and Health Center, San Diego, CA, USA
    Pediatr Infect Dis J 26:868-78. 2007
    ..Levofloxacin has established efficacy and safety in the treatment of community-acquired pneumonia (CAP) in adults, and its use as an alternative therapy for children with CAP has been proposed...
  2. pmc Phase I Study Assessing the Pharmacokinetic Profile, Safety, and Tolerability of a Single Dose of Ceftazidime-Avibactam in Hospitalized Pediatric Patients
    John S Bradley
    University of California, San Diego, California, USA
    Antimicrob Agents Chemother 60:6252-9. 2016
    ..No new safety concerns were identified. (This study has been registered at ClinicalTrials.gov under registration no. NCT01893346.). ..
  3. doi request reprint Assessment of musculoskeletal toxicity 5 years after therapy with levofloxacin
    John S Bradley
    University of California, San Diego School of Medicine and Rady Children s Hospital San Diego, San Diego, California
    Pediatrics 134:e146-53. 2014
    ....
  4. doi request reprint Which antibiotic for resistant Gram-positives, and why?
    John S Bradley
    University of California, San Diego, School of Medicine, Rady Children s Hospital, San Diego, USA Electronic address
    J Infect 68:S63-75. 2014
    ....
  5. pmc Genetic structure of community acquired methicillin-resistant Staphylococcus aureus USA300
    Ryan Tewhey
    Scripps Genomic Medicine, Scripps Translational Science Institute, La Jolla, CA, USA
    BMC Genomics 13:508. 2012
    ..The broad range of disease severity may be influenced by bacterial genetic variation...
  6. pmc Executive summary: the management of community-acquired pneumonia in infants and children older than 3 months of age: clinical practice guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America
    John S Bradley
    Department of Pediatrics, University of California San Diego School of Medicine and Rady Children s Hospital of San Diego, San Diego, California, USA
    Clin Infect Dis 53:617-30. 2011
    ..Site-of-care management, diagnosis, antimicrobial and adjunctive surgical therapy, and prevention are discussed. Areas that warrant future investigations are also highlighted...
  7. doi request reprint Unique considerations in the evaluation of antibacterials in clinical trials for pediatric community-acquired pneumonia
    John S Bradley
    Division of Pediatric Infectious Diseases, Rady Children s Hospital San Diego, San Diego, California 92123, USA
    Clin Infect Dis 47:S241-8. 2008
    ..Clinical trials that require invasive techniques for diagnosis and placebo-controlled randomized trials are not acceptable for children, who are considered to be a vulnerable population...
  8. doi request reprint Intravenous ceftriaxone and calcium in the neonate: assessing the risk for cardiopulmonary adverse events
    John S Bradley
    Rady Children s Hospital San Diego, San Diego, California 92123, USA
    Pediatrics 123:e609-13. 2009
    ..This report describes and summarizes the reported cases that led to safety concerns regarding the concurrent administration of intravenous ceftriaxone and calcium in this age group...
  9. doi request reprint Considerations unique to pediatrics for clinical trial design in hospital-acquired pneumonia and ventilator-associated pneumonia
    John S Bradley
    Rady Children s Hospital San Diego, University of California, San Diego, USA
    Clin Infect Dis 51:S136-43. 2010
    ....
  10. doi request reprint Prevalence of hepatitis C virus antibody in newborn infants in southern California in 2003
    John S Bradley
    Division of Infectious Diseases, Rady Children s Hospital San Diego, University of California at San Diego, San Diego, CA 92123, USA
    Pediatr Infect Dis J 30:618-20. 2011
    ..With advances in HCV antiviral therapy providing decreasing morbidity from chronic HCV infection, prenatal HCV screening to identify both mothers and at-risk infants should be reconsidered...
  11. doi request reprint The management of community-acquired pneumonia in infants and children older than 3 months of age: clinical practice guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America
    John S Bradley
    Department of Pediatrics, University of California San Diego School of Medicine and Rady Children s Hospital of San Diego, San Diego, California, USA
    Clin Infect Dis 53:e25-76. 2011
    ..Site-of-care management, diagnosis, antimicrobial and adjunctive surgical therapy, and prevention are discussed. Areas that warrant future investigations are also highlighted...
  12. ncbi request reprint Pneumococcal endocarditis in children
    Laurence B Givner
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Clin Infect Dis 38:1273-8. 2004
    ..Pneumococcal endocarditis in children is unusual but often has serious complications...
  13. ncbi request reprint Streptococcus pneumoniae infections in the neonate
    Jill A Hoffman
    Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Pediatrics 112:1095-102. 2003
    ..The aim of this study was to review the current epidemiology and clinical course of SPIN...
  14. ncbi request reprint Antibiotic stewardship in pediatrics: a necessity
    John S Bradley
    Children s Hospital San Diego, University of California, San Diego, USA
    Pediatr Infect Dis J 26:538-9. 2007
  15. pmc Population Pharmacokinetic Assessment and Pharmacodynamic Implications of Pediatric Cefepime Dosing for Susceptible-Dose-Dependent Organisms
    Kensuke Shoji
    Center for Research in Pediatric and Developmental Pharmacology, University of California, San Diego, La Jolla, and Rady Children s Hospital, San Diego, California, USA National Center for Child Health and Development, Tokyo, Japan
    Antimicrob Agents Chemother 60:2150-6. 2016
    ..Prolonged i.v. infusions may be useful for this population. ..
  16. doi request reprint Invasive pneumococcal infections in children following transplantation in the pneumococcal conjugate vaccine era
    Liset Olarte
    Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    Transpl Infect Dis . 2016
    ..Data on IPI in this population are scarce. To our knowledge, this is the first study describing the epidemiology of IPI among pediatric transplant recipients in the pneumococcal conjugate vaccine (PCV) era...
  17. pmc In vitro activities of cethromycin (ABT-773), a new ketolide, against Streptococcus pneumoniae strains that are not susceptible to penicillin or macrolides
    Edward O Mason
    Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Antimicrob Agents Chemother 47:166-9. 2003
    ..The ketolides appear to be active antimicrobials against penicillin- and macrolide-resistant pneumococci...
  18. doi request reprint Meropenem pharmacokinetics, pharmacodynamics, and Monte Carlo simulation in the neonate
    John S Bradley
    Division of Infectious Diseases, Children s Hospital and Health Center, San Diego, CA 92123, USA
    Pediatr Infect Dis J 27:794-9. 2008
    ..Hospitalized neonates are exposed to antibiotic-resistant bacterial pathogens and develop nosocomial infections. Limited data are available regarding the neonatal pharmacokinetics of meropenem, a broad spectrum carbapenem antibiotic...
  19. pmc Oral acyclovir suppression and neurodevelopment after neonatal herpes
    David W Kimberlin
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    N Engl J Med 365:1284-92. 2011
    ..Poor neurodevelopmental outcomes and recurrences of cutaneous lesions remain unacceptably frequent among survivors of neonatal herpes simplex virus (HSV) disease...
  20. ncbi request reprint Pharmacodynamics and the prediction of efficacy in short-course antibiotic therapy: pediatric studies to validate the model
    John S Bradley
    Division of Infectious Diseases, Children s Hospital San Diego, San Diego, California 92123, USA
    Pharmacotherapy 25:159S-164S. 2005
    ..By using a mathematic model that integrates all important variables, one may be able to predict the probability of a cure with short-course therapy for each pathogen, antibiotic, site of infection, and host interaction...
  21. pmc Bayesian Estimation of Vancomycin Pharmacokinetics in Obese Children: Matched Case-Control Study
    Jennifer Le
    University of California, San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences and School of Medicine, La Jolla, California Miller Children s Hospital of Long Beach, Long Beach, California Electronic address
    Clin Ther 37:1340-51. 2015
    ..The study objective was to compare different body size descriptors that best estimate vancomycin Vd and clearance (CL)...
  22. ncbi request reprint Multicentre surveillance of the prevalence and molecular epidemiology of macrolide resistance among pharyngeal isolates of group A streptococci in the USA
    Michael D Green
    Department of Pediatrics, Division of Infectious Diseases, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine Pittsburgh, PA, USA
    J Antimicrob Chemother 57:1240-3. 2006
    ..In an effort to define the current prevalence of macrolide-resistant GAS in the US, a multicentre surveillance project was initiated...
  23. pmc Improved vancomycin dosing in children using area under the curve exposure
    Jennifer Le
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093 0714, USA
    Pediatr Infect Dis J 32:e155-63. 2013
    ....
  24. doi request reprint Pharmacokinetics and safety of extemporaneously compounded valacyclovir oral suspension in pediatric patients from 1 month through 11 years of age
    David W Kimberlin
    Department of Pediatrics, University of Alabama, Birmingham, AL 35233, USA
    Clin Infect Dis 50:221-8. 2010
    ..Valacyclovir provides enhanced acyclovir bioavailability in adults, but limited data are available in children...
  25. ncbi request reprint Guidelines for the selection of antibacterial therapy in children
    Alice L Pong
    Children s Hospital and Health Center, 3020 Children s Way, MC 5041, San Diego, CA 92123, USA
    Pediatr Clin North Am 52:869-94, viii. 2005
    ..This article reviews factors important in the selection of antimicrobial agents in infants and children. Recommendations for antibiotic therapy for a wide range of infections occurring in children are provided...
  26. ncbi request reprint Clinical challenges of nosocomial infections caused by antibiotic-resistant pathogens in pediatrics
    Alice Pong
    Division of Infectious Diseases, Children s Hospital and Health Center, San Diego, CA 92123, USA
    Semin Pediatr Infect Dis 15:21-9. 2004
    ..Nosocomial outbreaks caused by resistant organisms are described, and an approach to empiric therapy based on presumed pathogens, site of infection, and local resistance patterns is discussed...
  27. doi request reprint A Randomized, Prospective Study of Pediatric Patients With Community-acquired Pneumonia Treated With Ceftaroline Versus Ceftriaxone
    Christopher R Cannavino
    From the Division of Infectious Diseases, Department of Pediatrics, University of California at San Diego and Rady Children s Hospital, San Diego, California Faculty of Medicine, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary Medical College, University of Rzeszow, Rzeszow, Poland Department of Clinical Development, Cerexa, Inc, Oakland, California and Section of Pediatric Infectious Diseases, Department of Pediatrics, Baylor College of Medicine and Texas Children s Hospital, Feigin Center, Houston, Texas
    Pediatr Infect Dis J 35:752-9. 2016
    ....
  28. pmc Oseltamivir pharmacokinetics, dosing, and resistance among children aged <2 years with influenza
    David W Kimberlin
    Department of Pediatrics, University of Alabama at Birmingham, AL 35233, USA
    J Infect Dis 207:709-20. 2013
    ..Children <2 years of age are at high risk of influenza-related mortality and morbidity. However, the appropriate dose of oseltamivir for children <2 years of age is unknown...
  29. doi request reprint Transmission of meropenem in breast milk
    Jason B Sauberan
    Department of Pharmacy, University of California, San Diego Medical Center and UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, CA, USA
    Pediatr Infect Dis J 31:832-4. 2012
    ..18%. There were no dermatologic or gastrointestinal side effects noted in the breastfed infant. Meropenem appears to be acceptable to use during breast-feeding...
  30. ncbi request reprint Old and new antibiotics for pediatric pneumonia
    John S Bradley
    University of California San Diego, School of Medicine, San Diego, CA, USA
    Semin Respir Infect 17:57-64. 2002
    ....
  31. ncbi request reprint Newer antistaphylococcal agents
    John S Bradley
    Division of Infectious Diseases, Children s Hospital San Diego, San Diego, California 92123, USA
    Curr Opin Pediatr 17:71-7. 2005
    ....
  32. ncbi request reprint Management of community-acquired pediatric pneumonia in an era of increasing antibiotic resistance and conjugate vaccines
    John S Bradley
    Division of Infectious Diseases, Children s Hospital, San Diego, CA, USA
    Pediatr Infect Dis J 21:592-8; discussion 613-4. 2002
    ..pneumoniae. In contrast antibiotic regimens for life-threatening pulmonary infections in which Staphylococcus aureus is a suspected pathogen should include vancomycin...
  33. doi request reprint Evolution of Ceftaroline-Resistant Mrsa in a Child with Cystic Fibrosis Following Repeated Antibiotic Exposure
    Christopher R Cannavino
    From the Division of Infectious Diseases, Department of Pediatrics, University of California at San Diego and Rady Children s Hospital San Diego, San Diego, California JMI Laboratories, North Liberty, Iowa Cerexa, Inc, Oakland, California and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, California
    Pediatr Infect Dis J 35:813-5. 2016
    ..Noncompartmental ceftaroline pharmacokinetic evaluation in our patient documented increased clearance and volume of distribution compared with adults. ..
  34. doi request reprint Dalbavancin Pharmacokinetics and Safety in Children 3 Months to 11 Years of Age
    Daniel Gonzalez
    1Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 2University of California San Diego School of Medicine and Rady Children s Hospital, San Diego, CA 3University of Toledo Medical Center, Toledo, OH 4Ann and Robert H Lurie Children s Hospital of Chicago, Feinberg School of Medicine, Northwestern University, Chicago, IL 5Department of Pediatrics, Duke University Medical Center, Durham, NC 6Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 7Arkansas Children s Hospital Research Institute and University of Arkansas for Medical Sciences, Little Rock, AR 8Infectious Diseases Section, Baylor College of Medicine, Houston, TX 9College of Pharmacy and Department of Pediatrics, University of Michigan, Ann Arbor, MI 10Kosair Charities Pediatric Clinical Research Unit, Department of Pediatrics, University of Louisville, and Kosair Children s Hospital, Louisville, KY 11Institute for Clinical Pharmacodynamics, Latham, NY 12Durata Therapeutics, a subsidiary of Actavis plc, Branford, Connecticut
    Pediatr Infect Dis J . 2017
    ..Dalbavancin is a novel lipoglycopeptide antibiotic that has potent in vitro activity against Gram-positive microorganisms...
  35. pmc Safety of oseltamivir compared with the adamantanes in children less than 12 months of age
    David W Kimberlin
    Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Alabama, Birmingham, Birmingham, AL 35233, USA
    Pediatr Infect Dis J 29:195-8. 2010
    ..To assess potential neurologic adverse effects of oseltamivir use in infants, a retrospective chart review was performed in infants less than 12 months of age who received oseltamivir, amantadine, or rimantadine...
  36. doi request reprint A comparison of early versus late conversion from intravenous to oral therapy in the treatment of septic arthritis
    ROBERT TRACY BALLOCK
    Rady Children s Hospital, San Diego, California, USA
    J Pediatr Orthop 29:636-42. 2009
    ....
  37. doi request reprint A Multicenter, Randomized, Observer-blinded, Active-controlled Study Evaluating the Safety and Effectiveness of Ceftaroline Compared With Ceftriaxone Plus Vancomycin in Pediatric Patients With Complicated Community-acquired Bacterial Pneumonia
    Jeffrey L Blumer
    From the Toledo Children s Hospital, Toledo, Ohio Children s New Clinic, Tbilisi, Georgia University of California at San Diego and Rady Children s Hospital, San Diego, California and Cerexa, Inc, Oakland, California
    Pediatr Infect Dis J 35:760-6. 2016
    ..The broad-spectrum cephalosporin ceftaroline, a metabolite of the prodrug ceftaroline fosamil, has shown in vitro activity against clinical isolates from pediatric patients...
  38. pmc Vancomycin monitoring in children using bayesian estimation
    Jennifer Le
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla Miller Children s Hospital, Long Beach and Rady Children s Hospital, San Diego, CA
    Ther Drug Monit 36:510-8. 2014
    ....
  39. ncbi request reprint Prediction of neurologic sequelae in childhood tuberculous meningitis: a review of 20 cases and proposal of a novel scoring system
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, CA, USA
    Pediatr Infect Dis J 24:207-12. 2005
    ..In the current era of critical care medicine and corticosteroid therapy, a new scoring system is needed to predict NS more accurately in children with TBM...
  40. ncbi request reprint Acute disseminated encephalomyelitis in childhood: epidemiologic, clinical and laboratory features
    John A D Leake
    Divisions of Infectious Diseases, Children s Hospital and Health Center, San Diego, CA 92123, USA
    Pediatr Infect Dis J 23:756-64. 2004
    ..The epidemiology, infectious antecedents and pathogenesis of ADEM are poorly characterized, and some ADEM patients are subsequently diagnosed with multiple sclerosis (MS)...
  41. pmc Antimicrobial agents for complicated skin and skin-structure infections: justification of noninferiority margins in the absence of placebo-controlled trials
    Brad Spellberg
    Division of Infectious Diseases, Harbor University of California at Los Angeles Medical Center, Torrance, California 90502, USA
    Clin Infect Dis 49:383-91. 2009
    ..In the absence of placebo-controlled trials, we sought to define the magnitude of efficacy of antimicrobial agents and resulting noninferiority margins for studies of complicated skin and skin-structure infection (SSSI)...
  42. ncbi request reprint New antibiotics for Gram-positive infections
    John S Bradley
    Division of Infectious Diseases, Children s Hospital, San Diego, CA 92123, USA
    Adv Exp Med Biol 582:151-65. 2006
  43. pmc Pharmacokinetics of gatifloxacin in infants and children
    Edmund V Capparelli
    Pediatric Pharmacology Research Unit, University of California, San Diego, California, USA
    Antimicrob Agents Chemother 49:1106-12. 2005
    ..h/ml (estimated free AUC/MIC ratio of > or =34 for MIC of < or =0.5 microg/ml). These data suggest that gatifloxacin at a dose of 10 mg/kg every 24 h will achieve therapeutic concentrations in plasma in infants and children...
  44. ncbi request reprint Invasive pneumococcal infections in children with asplenia
    Gordon E Schutze
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, USA
    Pediatr Infect Dis J 21:278-82. 2002
    ..Asplenia is associated with an increased risk of infections caused by Streptococcus pneumoniae. Overwhelming infection can be fulminate and lead to a fatal outcome...