Dexiang Chen

Summary

Affiliation: Program for Appropriate Technology in Health
Country: USA

Publications

  1. doi request reprint Thermostable formulations of a hepatitis B vaccine and a meningitis A polysaccharide conjugate vaccine produced by a spray drying method
    D Chen
    PATH, Seattle, WA 98121, USA
    Vaccine 28:5093-9. 2010
  2. doi request reprint Desirable attributes of vaccines for deployment in low-resource settings
    Dexiang Chen
    PATH, Seattle, Washington 98121, USA
    J Pharm Sci 102:29-33. 2013
  3. doi request reprint Opportunities and challenges of developing thermostable vaccines
    Dexiang Chen
    PATH, Seattle, WA 98107, USA
    Expert Rev Vaccines 8:547-57. 2009
  4. doi request reprint Spray drying and vaccine stabilization
    David McAdams
    PATH, 2201 Westlake Avenue, Suite 200, Seattle, WA 98121, USA
    Expert Rev Vaccines 11:1211-9. 2012
  5. doi request reprint Vaccine stabilization: research, commercialization, and potential impact
    Debra Kristensen
    PATH, Seattle, WA, United States
    Vaccine 29:7122-4. 2011
  6. ncbi request reprint Characterization of the freeze sensitivity of a hepatitis B vaccine
    Dexiang Chen
    PATH, Seattle, Washington, USA
    Hum Vaccin 5:26-32. 2009
  7. doi request reprint Stability of live attenuated rotavirus vaccine with selected preservatives and primary containers
    Manjari Lal
    PATH, Seattle, WA, USA Electronic address
    Vaccine 34:2483-9. 2016
  8. doi request reprint Strategies to advance vaccine technologies for resource-poor settings
    Debra Kristensen
    PATH, Seattle, WA 98121, USA
    Vaccine 31:B157-62. 2013
  9. doi request reprint Development of a fast-dissolving tablet formulation of a live attenuated enterotoxigenic E. coli vaccine candidate
    Manjari Lal
    PATH, PO Box 900922, Seattle, WA 98121, USA Electronic address
    Vaccine 31:4759-64. 2013
  10. pmc Development of a stable liquid formulation of live attenuated influenza vaccine
    Jessica A White
    PATH, Seattle, Washington, United States Electronic address
    Vaccine 34:3676-83. 2016

Collaborators

  • Debra Kristensen
  • Darin Zehrung
  • Vidadi Yusibov
  • Manjari Lal
  • Changcheng Zhu
  • David McAdams
  • Alexander Flood
  • Marcus Estrada
  • Jessica A White
  • Melissa S Burger
  • E Alexander Flood
  • David M Koelle
  • Eugene Saxon
  • Nancy A Hosken
  • Courtney Jarrahian
  • Kutub Mahmood
  • Chris L McClurkan
  • Rajeev Dhere
  • Andrew Roehrig
  • Yuhua Ji
  • Jessica A Chichester
  • Jeff Breit
  • SCOTT MCCRAY
  • Caitlin E Hartman
  • Yoko Shoji
  • Michael Burke
  • James Desai
  • Scott Priddy
  • Walt Pebley
  • Richard Walker
  • James Brown
  • Michael J Darsley
  • Lou Bourgeois
  • Qili Chu
  • Xiaoyan Gao
  • Cindy L Zuleger
  • Lendon G Payne

Detail Information

Publications13

  1. doi request reprint Thermostable formulations of a hepatitis B vaccine and a meningitis A polysaccharide conjugate vaccine produced by a spray drying method
    D Chen
    PATH, Seattle, WA 98121, USA
    Vaccine 28:5093-9. 2010
    ..This study demonstrates the feasibility of producing thermostable vaccines with advanced processing and formulation technologies...
  2. doi request reprint Desirable attributes of vaccines for deployment in low-resource settings
    Dexiang Chen
    PATH, Seattle, Washington 98121, USA
    J Pharm Sci 102:29-33. 2013
    ....
  3. doi request reprint Opportunities and challenges of developing thermostable vaccines
    Dexiang Chen
    PATH, Seattle, WA 98107, USA
    Expert Rev Vaccines 8:547-57. 2009
    ..The challenges associated with the implementation of these novel formulations are discussed, as well as the potential benefits and opportunities of taking vaccines out of the cold chain...
  4. doi request reprint Spray drying and vaccine stabilization
    David McAdams
    PATH, 2201 Westlake Avenue, Suite 200, Seattle, WA 98121, USA
    Expert Rev Vaccines 11:1211-9. 2012
    ..This article reviews the status of spray-drying technology and discusses barriers and opportunities for its future application to vaccines...
  5. doi request reprint Vaccine stabilization: research, commercialization, and potential impact
    Debra Kristensen
    PATH, Seattle, WA, United States
    Vaccine 29:7122-4. 2011
    ..Public sector agencies can incentivize vaccine developers to prioritize stabilization efforts through advocacy and by implementing policies that increase demand for thermostable vaccines...
  6. ncbi request reprint Characterization of the freeze sensitivity of a hepatitis B vaccine
    Dexiang Chen
    PATH, Seattle, Washington, USA
    Hum Vaccin 5:26-32. 2009
    ....
  7. doi request reprint Stability of live attenuated rotavirus vaccine with selected preservatives and primary containers
    Manjari Lal
    PATH, Seattle, WA, USA Electronic address
    Vaccine 34:2483-9. 2016
    ..Selection of an optimal primary container should take into consideration additional factors, including stability as well as cold chain volume, usability, cost, and manufacturing feasibility. ..
  8. doi request reprint Strategies to advance vaccine technologies for resource-poor settings
    Debra Kristensen
    PATH, Seattle, WA 98121, USA
    Vaccine 31:B157-62. 2013
    ....
  9. doi request reprint Development of a fast-dissolving tablet formulation of a live attenuated enterotoxigenic E. coli vaccine candidate
    Manjari Lal
    PATH, PO Box 900922, Seattle, WA 98121, USA Electronic address
    Vaccine 31:4759-64. 2013
    ....
  10. pmc Development of a stable liquid formulation of live attenuated influenza vaccine
    Jessica A White
    PATH, Seattle, Washington, United States Electronic address
    Vaccine 34:3676-83. 2016
    ..5% recombinant human serum albumin that provided storage stability of one year at 2-8°C for the influenza A and B strains tested. ..
  11. pmc Development of a Freeze-Dried, Heat-Stable Influenza Subunit Vaccine Formulation
    Alexander Flood
    Devices and Tools Program, PATH, Seattle, Washington, United States of America
    PLoS ONE 11:e0164692. 2016
    ..These freeze-dried thermostable influenza subunit vaccines could also reduce the frequency of vaccine stockpile turnover, offering a cost-effective option for pandemic preparedness...
  12. doi request reprint Stabilization of HAC1 influenza vaccine by spray drying: formulation development and process scale-up
    Changcheng Zhu
    PATH, PO Box 900922, Seattle, Washington, 98109, USA
    Pharm Res 31:3006-18. 2014
    ..Our aim was to develop a stable formulation of a recombinant H1N1 influenza hemagglutinin vaccine candidate and take it to pilot-scale spray-drying production...
  13. ncbi request reprint An antigen-independent but not antigen-specific T(H)1 response provides protection in the murine airway inflammation model
    Melissa S Burger
    PowderJect Vaccines, Inc, Seattle, WA, USA
    J Allergy Clin Immunol 114:1301-8. 2004
    ..Synthetic oligodeoxynucleotides containing unmethylated CG dinucleotides (CpG) are strong T(H)1 adjuvants and are being investigated for allergy immunotherapy...