Genomes and Genes
Alistair P McGregor
Affiliation: Princeton University
- Morphological evolution through multiple cis-regulatory mutations at a single geneAlistair P McGregor
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA
Nature 448:587-90. 2007..These data support the view that alleles of large effect that distinguish species may sometimes reflect the accumulation of multiple mutations of small effect at select genes...
- Cupiennius salei and Achaearanea tepidariorum: Spider models for investigating evolution and developmentAlistair P McGregor
Institute for Genetics, Evolutionary Genetics, University of Cologne, Koln, Germany
Bioessays 30:487-98. 2008..We suggest that further comparisons between these two spiders and other chelicerates will prove useful for understanding the evolution of development in metazoans...
- How to get ahead: the origin, evolution and function of bicoidAlistair P McGregor
Department of Ecology and Evolutionary Biology, Princeton University, New Jersey 08540, USA
Bioessays 27:904-13. 2005..I suggest further comparative studies may allow us to identify the intermediate steps in bcd evolution. This will make bcd a paradigm for the origin and evolution of genes and regulatory networks...
- Wasps, beetles and the beginning of the endsAlistair P McGregor
Department of Ecology and Evolutionary Biology, Guyot Hall, Princeton University, Princeton, New Jersey 08540, USA
Bioessays 28:683-6. 2006....
- Shape and function of the Bicoid morphogen gradient in dipteran species with different sized embryosThomas Gregor
Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA
Dev Biol 316:350-8. 2008..However, a shallow gradient was observed using eGFP-NLS, suggesting nuclear localization may be necessary but not sufficient for gradient formation...
- Morphological evolution caused by many subtle-effect substitutions in regulatory DNANicolas Frankel
Howard Hughes Medical Institute and Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA
Nature 474:598-603. 2011..These data provide unprecedented resolution of the phenotypic effects of substitutions and show how individual nucleotide changes in a transcriptional enhancer have caused morphological evolution...
- Stability and nuclear dynamics of the bicoid morphogen gradientThomas Gregor
Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
Cell 130:141-52. 2007..A new model is presented emphasizing the possible role of nuclear dynamics in shaping and scaling the gradient...
- Evolutionary and functional analysis of the tailless enhancer in Musca domestica and Drosophila melanogasterNaomi S Wratten
Department of Genetics, University of Leicester, Leicester LE1 7RH, UK
Evol Dev 8:6-15. 2006..Therefore, during the rapid evolution of enhancer sequences individual binding sites are continually lost and gained, but the transcriptional output is maintained by compensatory mutations in cis and in trans...