Chuenlei Parng

Summary

Affiliation: Phylonix Pharmaceuticals
Country: USA

Publications

  1. ncbi Zebrafish apoptosis assays for drug discovery
    Chuenlei Parng
    Phylonix Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    Methods Cell Biol 76:75-85. 2004
  2. ncbi Zebrafish: a preclinical model for drug screening
    Chuenlei Parng
    Phylonix, Cambridge, MA 02139, USA
    Assay Drug Dev Technol 1:41-8. 2002
  3. ncbi In vivo zebrafish assays for toxicity testing
    Chuenlei Parng
    Phylonix Pharmaceuticals Inc, Cambridge, MA 02139, USA
    Curr Opin Drug Discov Devel 8:100-6. 2005
  4. ncbi Neurotoxicity assessment using zebrafish
    Chuenlei Parng
    Phylonix Pharmaceuticals, Inc, 100 Inman St, Cambridge, MA 02139, USA
    J Pharmacol Toxicol Methods 55:103-12. 2007
  5. ncbi A zebrafish assay for identifying neuroprotectants in vivo
    Chuenlei Parng
    Phylonix Pharmaceuticals, Inc, 100 Inman Street, Cambridge, MA 02139, USA
    Neurotoxicol Teratol 28:509-16. 2006
  6. ncbi The use of zebrafish for assessing ototoxic and otoprotective agents
    Christopher Ton
    Phylonix Pharmaceuticals, Inc, 100 Inman St, Cambridge, MA 02139, USA
    Hear Res 208:79-88. 2005

Research Grants

  1. NOVEL USE OF ZEBRAFISH FOR APOPTOSIS ASSAY
    Chuenlei Parng; Fiscal Year: 2004
  2. ASSAY FOR DETERMINING DRUG TOXICITY
    Chuenlei Parng; Fiscal Year: 2004
  3. Cardiotoxicity Drug Screening Using Zebrafish
    Chuenlei Parng; Fiscal Year: 2004
  4. Zebrafish Screen for Neuroprotective Anti-oxidants
    Chuenlei Parng; Fiscal Year: 2005

Collaborators

  • Christopher Ton

Detail Information

Publications6

  1. ncbi Zebrafish apoptosis assays for drug discovery
    Chuenlei Parng
    Phylonix Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    Methods Cell Biol 76:75-85. 2004
  2. ncbi Zebrafish: a preclinical model for drug screening
    Chuenlei Parng
    Phylonix, Cambridge, MA 02139, USA
    Assay Drug Dev Technol 1:41-8. 2002
    ..After in vivo staining, acridine orange can be extracted and quantitated using a fluorescence microplate reader, providing a screening system for agents that modulate apoptosis...
  3. ncbi In vivo zebrafish assays for toxicity testing
    Chuenlei Parng
    Phylonix Pharmaceuticals Inc, Cambridge, MA 02139, USA
    Curr Opin Drug Discov Devel 8:100-6. 2005
    ..Straightforward in vivo zebrafish assays can serve as an intermediate step between cell-based and mammalian testing, thus streamlining the drug development time-line...
  4. ncbi Neurotoxicity assessment using zebrafish
    Chuenlei Parng
    Phylonix Pharmaceuticals, Inc, 100 Inman St, Cambridge, MA 02139, USA
    J Pharmacol Toxicol Methods 55:103-12. 2007
    ..Transparency is a unique attribute of zebrafish that permits direct assessment of drug effects on the nervous system using whole mount antibody immunostaining and histochemistry...
  5. ncbi A zebrafish assay for identifying neuroprotectants in vivo
    Chuenlei Parng
    Phylonix Pharmaceuticals, Inc, 100 Inman Street, Cambridge, MA 02139, USA
    Neurotoxicol Teratol 28:509-16. 2006
    ..Our results in zebrafish were similar to results reported in mammals supporting the utility of this in vivo method for identifying potential neuroprotective anti-oxidants...
  6. ncbi The use of zebrafish for assessing ototoxic and otoprotective agents
    Christopher Ton
    Phylonix Pharmaceuticals, Inc, 100 Inman St, Cambridge, MA 02139, USA
    Hear Res 208:79-88. 2005
    ..Our data indicate that results of ototoxicity and otoprotection in zebrafish correlated with results in humans, supporting use of zebrafish for preliminary drug screening...

Research Grants4

  1. NOVEL USE OF ZEBRAFISH FOR APOPTOSIS ASSAY
    Chuenlei Parng; Fiscal Year: 2004
    ..Complementary visual and flow cytometry based assays will also be developed to provide comprehensive analysis of apoptosis in zebrafish. ..
  2. ASSAY FOR DETERMINING DRUG TOXICITY
    Chuenlei Parng; Fiscal Year: 2004
    ..abstract_text> ..
  3. Cardiotoxicity Drug Screening Using Zebrafish
    Chuenlei Parng; Fiscal Year: 2004
    ..Zebrafish drug screens can serve as an intermediate step between cell-based and mammalian testing, streamlining the drug development timeline. ..
  4. Zebrafish Screen for Neuroprotective Anti-oxidants
    Chuenlei Parng; Fiscal Year: 2005
    ..Assessment of drug effects in a convenient vertebrate model, prior to evaluation in a complex system, such as mouse, can potentially streamline the drug development process and dramatically reduce costs. ..