P David Adelson

Summary

Affiliation: Phoenix Children's Hospital
Country: USA

Publications

  1. doi request reprint Comparison of hypothermia and normothermia after severe traumatic brain injury in children (Cool Kids): a phase 3, randomised controlled trial
    P David Adelson
    Barrow Neurological Institute at Phoenix Children s Hospital, Phoenix, AZ 85016, USA
    Lancet Neurol 12:546-53. 2013
  2. doi request reprint Morris water maze function and histologic characterization of two age-at-injury experimental models of controlled cortical impact in the immature rat
    P David Adelson
    Barrow Neurological Institute at Phoenix Children s Hospital, 1919 East Thomas Road, Building B, 4th Floor, Phoenix, AZ 85016, USA
    Childs Nerv Syst 29:43-53. 2013
  3. pmc Hypothermia following pediatric traumatic brain injury
    P David Adelson
    Children s Neuroscience Institute, Phoenix Children s Hospital, Phoenix, Arizona 85016, USA
    J Neurotrauma 26:429-36. 2009
  4. doi request reprint Cerebrovascular response in children following severe traumatic brain injury
    P David Adelson
    Phoenix Children s Neuroscience Institute and Pediatric Neurosurgery, AZ 85016, USA
    Childs Nerv Syst 27:1465-76. 2011
  5. pmc Diffuse traumatic brain injury affects chronic corticosterone function in the rat
    Rachel K Rowe
    Phoenix Veterans Affairs Health Care SystemPhoenix, Arizona, USA BARROW Neurological Institute at Phoenix Children s HospitalPhoenix, Arizona, USA Department of Child HealthUniversity of Arizona College of Medicine Phoenix, Phoenix, Arizona, USA
    Endocr Connect 5:152-66. 2016
  6. ncbi request reprint Aging with Traumatic Brain Injury: Effects of Age at Injury on Behavioral Outcome following Diffuse Brain Injury in Rats
    Rachel K Rowe
    Barrow Neurological Institute at Phoenix Children s Hospital, Phoenix, Ariz, USA
    Dev Neurosci 38:195-205. 2016
  7. pmc Resolvins AT-D1 and E1 differentially impact functional outcome, post-traumatic sleep, and microglial activation following diffuse brain injury in the mouse
    Jordan L Harrison
    Barrow Neurological Institute at Phoenix Children s Hospital, Phoenix, AZ, USA Department of Child Health, University of Arizona College of Medicine Phoenix, Phoenix, AZ, USA Interdisciplinary Graduate Program in Neuroscience, Arizona State University, Tempe, AZ, USA
    Brain Behav Immun 47:131-40. 2015
  8. pmc Clinical relevance of midline fluid percussion brain injury: Acute deficits, chronic morbidities and the utility of biomarkers
    Jonathan Lifshitz
    a Translational Neurotrauma Research Program, Barrow Neurological Institute at Phoenix Children s Hospital, Phoenix, AZ, USA
    Brain Inj . 2016
  9. doi request reprint Aging with a traumatic brain injury: Could behavioral morbidities and endocrine symptoms be influenced by microglial priming?
    Jenna M Ziebell
    Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, Tasmania, Australia Barrow Neurological Institute at Phoenix Children s Hospital, Phoenix, AZ, USA Department of Child Health, University of Arizona College of Medicine Phoenix, Phoenix, AZ, USA Electronic address
    Brain Behav Immun 59:1-7. 2017
  10. doi request reprint Acute over-the-counter pharmacological intervention does not adversely affect behavioral outcome following diffuse traumatic brain injury in the mouse
    Jordan L Harrison
    Barrow Neurological Institute at Phoenix Children s Hospital, Phoenix, AZ, 85016, USA
    Exp Brain Res 232:2709-19. 2014

Research Grants

  1. Efficacy of Hypothermia in Pediatric TBI
    P David Adelson; Fiscal Year: 2004

Collaborators

  • Jonathan Lifshitz
  • S Mitchell Harman
  • J Patrick Card
  • Stephen R Wisniewski
  • C Edward Dixon
  • Sue R Beers
  • John Beca
  • Rachel K Rowe
  • Jordan L Harrison
  • Jenna M Ziebell
  • Jorge I Arango
  • Theresa Currier Thomas
  • Benjamin M Rumney
  • Hazel G May
  • Theresa C Thomas
  • Bruce F O'Hara
  • Eric M Casella
  • Philip E Empey
  • Jonathan P Godbout
  • Megan M Muccigrosso
  • Jack T Reddaway
  • Paska Permana
  • Sarah B Ogle
  • L Matthew Law
  • Nicole S Yee
  • Timothy W Ellis
  • Remy Wahnoun
  • Wendy Fellows-Mayle
  • Parita Soni
  • Dana L Vanino
  • Cristina Carballo
  • Kimberlee Allred
  • Ryan Stradleigh
  • Michael J Bell
  • Patrick M Kochanek
  • James R Pauly
  • Samuel M Poloyac
  • Nieves Velez de Mendizabal
  • Kacey B Anderson
  • Robert R Bies
  • Christopher P Deibert
  • Igor Dvorchik
  • Michael Bell
  • Danielle Brown

Detail Information

Publications17

  1. doi request reprint Comparison of hypothermia and normothermia after severe traumatic brain injury in children (Cool Kids): a phase 3, randomised controlled trial
    P David Adelson
    Barrow Neurological Institute at Phoenix Children s Hospital, Phoenix, AZ 85016, USA
    Lancet Neurol 12:546-53. 2013
    ..On the basis of mixed results from previous trials, we assessed whether therapeutic hypothermia for 48-72 h with slow rewarming improved mortality in children after brain injury...
  2. doi request reprint Morris water maze function and histologic characterization of two age-at-injury experimental models of controlled cortical impact in the immature rat
    P David Adelson
    Barrow Neurological Institute at Phoenix Children s Hospital, 1919 East Thomas Road, Building B, 4th Floor, Phoenix, AZ 85016, USA
    Childs Nerv Syst 29:43-53. 2013
    ..Controlled cortical impact (CCI) is commonly used in adult animals to study focal traumatic brain injury (TBI). Our study aims to further study injury mechanisms in children and variable models of pathology in the developing brain...
  3. pmc Hypothermia following pediatric traumatic brain injury
    P David Adelson
    Children s Neuroscience Institute, Phoenix Children s Hospital, Phoenix, Arizona 85016, USA
    J Neurotrauma 26:429-36. 2009
    ..It is expected that hypothermia initiated early after severe TBI will have a protective effect on the pediatric brain and can be done safely, but this still remains to be definitively tested...
  4. doi request reprint Cerebrovascular response in children following severe traumatic brain injury
    P David Adelson
    Phoenix Children s Neuroscience Institute and Pediatric Neurosurgery, AZ 85016, USA
    Childs Nerv Syst 27:1465-76. 2011
    ..To describe the pathophysiologic response in cerebral blood flow (CBF) and autoregulation after severe traumatic brain injury (TBI), Glasgow Coma Score (GCS) ≤8 on admission, in children, defining a baseline for future studies...
  5. pmc Diffuse traumatic brain injury affects chronic corticosterone function in the rat
    Rachel K Rowe
    Phoenix Veterans Affairs Health Care SystemPhoenix, Arizona, USA BARROW Neurological Institute at Phoenix Children s HospitalPhoenix, Arizona, USA Department of Child HealthUniversity of Arizona College of Medicine Phoenix, Phoenix, Arizona, USA
    Endocr Connect 5:152-66. 2016
    ..Future experiments aim to evaluate additional HP-related hormones and endocrine circuit pathology following diffuse TBI. ..
  6. ncbi request reprint Aging with Traumatic Brain Injury: Effects of Age at Injury on Behavioral Outcome following Diffuse Brain Injury in Rats
    Rachel K Rowe
    Barrow Neurological Institute at Phoenix Children s Hospital, Phoenix, Ariz, USA
    Dev Neurosci 38:195-205. 2016
    ..More complete understanding of these factors can direct rehabilitative efforts and personalized medicine for TBI survivors...
  7. pmc Resolvins AT-D1 and E1 differentially impact functional outcome, post-traumatic sleep, and microglial activation following diffuse brain injury in the mouse
    Jordan L Harrison
    Barrow Neurological Institute at Phoenix Children s Hospital, Phoenix, AZ, USA Department of Child Health, University of Arizona College of Medicine Phoenix, Phoenix, AZ, USA Interdisciplinary Graduate Program in Neuroscience, Arizona State University, Tempe, AZ, USA
    Brain Behav Immun 47:131-40. 2015
    ..This suggests AT-RvD1 may impart functional benefit through mechanisms other than resolution of inflammation alone. ..
  8. pmc Clinical relevance of midline fluid percussion brain injury: Acute deficits, chronic morbidities and the utility of biomarkers
    Jonathan Lifshitz
    a Translational Neurotrauma Research Program, Barrow Neurological Institute at Phoenix Children s Hospital, Phoenix, AZ, USA
    Brain Inj . 2016
    ..Among FPI models, midline FPI may best represent clinical diffuse TBI, because of the acute behavioural deficits, the transition to late-onset behavioural morbidities and the absence of gross histopathology...
  9. doi request reprint Aging with a traumatic brain injury: Could behavioral morbidities and endocrine symptoms be influenced by microglial priming?
    Jenna M Ziebell
    Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, Tasmania, Australia Barrow Neurological Institute at Phoenix Children s Hospital, Phoenix, AZ, USA Department of Child Health, University of Arizona College of Medicine Phoenix, Phoenix, AZ, USA Electronic address
    Brain Behav Immun 59:1-7. 2017
    ..Overall, brain injury may influence the aging process and expedite glial and neuronal alterations that impact mental health...
  10. doi request reprint Acute over-the-counter pharmacological intervention does not adversely affect behavioral outcome following diffuse traumatic brain injury in the mouse
    Jordan L Harrison
    Barrow Neurological Institute at Phoenix Children s Hospital, Phoenix, AZ, 85016, USA
    Exp Brain Res 232:2709-19. 2014
    ..These data indicate that acute administration of OTC analgesics did not exacerbate or attenuate brain-injury deficits which may inform clinical recommendations for the at-home treated mildly concussed patient...
  11. doi request reprint Does time heal all wounds? Experimental diffuse traumatic brain injury results in persisting histopathology in the thalamus
    Theresa Currier Thomas
    Barrow Neurological Institute at Phoenix Children s Hospital, Phoenix, AZ, USA Department of Child Health, University of Arizona College of Medicine Phoenix, Phoenix, AZ, USA Phoenix VA Health Care System, Phoenix, AZ, USA Electronic address
    Behav Brain Res . 2016
    ....
  12. doi request reprint Traumatic brain injury alters long-term hippocampal neuron morphology in juvenile, but not immature, rats
    Eric M Casella
    Barrow Neurological Institute, Phoenix Children s Hospital, Ambulatory Building B, 4th Floor, 1919 East Thomas Road, Phoenix, AZ, 85016, USA
    Childs Nerv Syst 30:1333-42. 2014
    ..We hypothesize that experimental brain injury in juvenile rats, with behavioral deficits that resolve, will lead to quantifiable structural changes in hippocampal neurons at chronic time points post-injury...
  13. pmc Therapeutic hypothermia decreases phenytoin elimination in children with traumatic brain injury
    Philip E Empey
    1Department of Pharmacy and Therapeutics, Center for Clinical Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 2Division of Clinical Pharmacology, School of Medicine and Indiana Clinical and Translational Sciences Institute, Indiana University, Indianapolis, IN 3Department of Critical Care Medicine, School of Medicine, and The Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 4Department of Neurological Surgery, School of Medicine, and The Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 5Department of Pharmaceutical Sciences, Center for Clinical Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 6Division of Neurosurgery Children s Neuroscience, Department of Child Health, Barrow Neurological Institute, Phoenix Children s Hospital, Phoenix, AZ
    Crit Care Med 41:2379-87. 2013
    ..The objective of this study was to evaluate the impact of therapeutic hypothermia on phenytoin levels and pharmacokinetics in children with severe traumatic brain injury...
  14. doi request reprint Hypothermia in hypoxic ischemic encephalopathy: a 5-year experience at Phoenix Children's Hospital Neuro NICU
    Jorge I Arango
    Barrow Neurological Institute at Phoenix Children s Hospital, 1919 East Thomas Road, Phoenix, AZ 85016, USA
    Adv Pediatr 61:215-23. 2014
    ..Our study, however, had the limitation of including only retrospective data from patients in whom TH was provided. This makes it difficult to identify the specific sources for the improved outcomes and/or the presence of complications...
  15. pmc Microglia: dismantling and rebuilding circuits after acute neurological injury
    Jenna M Ziebell
    Department of Child Health, University of Arizona College of Medicine, Phoenix, AZ, USA
    Metab Brain Dis 30:393-400. 2015
    ..Increased understanding of microglia roles could identify therapeutic targets to mitigate the consequences of neurological disease. ..
  16. pmc Using anesthetics and analgesics in experimental traumatic brain injury
    Rachel K Rowe
    Barrow Neurological Institute at Phoenix Children s Hospital, Phoenix, AZ, USA
    Lab Anim (NY) 42:286-91. 2013
    ..They suggest that drugs should be selected for or excluded from experimental TBI protocols on the basis of IACUC-approved experimental objectives in order to protect animal welfare and preserve the validity of TBI models. ..
  17. doi request reprint Posttraumatic seizures in children with severe traumatic brain injury
    Jorge I Arango
    Department of Neurosurgery and Neuroscience Research, Barrow Neurological Institute at Phoenix Children s Hospital, Ambulatory Building B, 1919 East Thomas Road, Phoenix, AZ 85016, USA
    Childs Nerv Syst 28:1925-9. 2012
    ..The proper management of children sustaining severe TBI is still controversial. Our study aims to share our experience contributing to build evidence for better care...

Research Grants2

  1. Efficacy of Hypothermia in Pediatric TBI
    P David Adelson; Fiscal Year: 2004
    ..Parallel clinical specific aims will define the effect of neurotransmitter release in response to treatment with HYPO and the age-related impact of HYPO on early and delayed cell death in children. ..