C M Trepod
Affiliation: Pharmacia and Upjohn
- Modification of the carboxy-terminal amino acid sequence alters the Escherichia coli expression of a gene encoding multiple repeats of a bovine growth hormone releasing factor analogC M Trepod
Biology I, 7263 209 713, Pharmacia, Kalamazoo, MI 49007, USA
J Biotechnol 84:273-84. 2000..Negative extensions exert their influence through a more complex mechanism, appearing to interfere with the ability of ribosomes to be efficiently released from their cognate mRNA...
- A spontaneous runaway vector for production-scale expression of bovine somatotropin from Escherichia coiC M Trepod
Pharmacia, Infectious Diseases Biology, Kalamazoo, MI 49007, USA
Appl Microbiol Biotechnol 58:84-8. 2002..Copy number analysis also confirmed the stability of pURA-4 spontaneous runaway from the shake-flask scale through the production scale...
- Structural characterizations of nonpeptidic thiadiazole inhibitors of matrix metalloproteinases reveal the basis for stromelysin selectivityB C Finzel
Structural, Analytical and Medicinal Chemistry, Pharmacia and Upjohn, Kalamazoo, Michigan 49007, USA
Protein Sci 7:2118-26. 1998..A conformational rearrangement of the catalytic domain occurs that reveals an inherent flexibility of the substrate binding region leading to speculation about a possible mechanism for modulation of stromelysin activity and selectivity...