Amy E Rudolph

Summary

Affiliation: Pharmacia Corporation
Country: USA

Publications

  1. ncbi request reprint The role of the factor X activation peptide: a deletion mutagenesis approach
    Amy E Rudolph
    Department of Pathology, Division of Laboratory Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Thromb Haemost 88:756-62. 2002
  2. ncbi request reprint Structural, functional, and molecular characterization of the SHHF model of heart failure
    Jonathan R R Heyen
    Pharmacia Corporation, 800 N Lindbergh Boulevard, St Louis, MO 63167, USA
    Am J Physiol Heart Circ Physiol 283:H1775-84. 2002
  3. ncbi request reprint Transgenic model of aldosterone-driven cardiac hypertrophy and heart failure
    Wenning Qin
    Department of Genomics Sciences, Pfizer, Inc, St Louis, MO 63167, USA
    Circ Res 93:69-76. 2003
  4. ncbi request reprint Aldosterone target organ protection by eplerenone
    Amy E Rudolph
    Pharmacia Corporation, Cardiovascular and Metabolic Diseases, 800 N Lindbergh Blvd, T1G T108W, St Louis, MO 63167, USA
    Mol Cell Endocrinol 217:229-38. 2004
  5. ncbi request reprint Molecular mechanisms of mineralocorticoid receptor antagonism by eplerenone
    Xiao Hu
    Department of Genomics and Biotechnology, Pfizer Inc, St Louis, MO 63017, USA
    Mini Rev Med Chem 5:709-18. 2005
  6. ncbi request reprint Effects of long-term monotherapy with eplerenone, a novel aldosterone blocker, on progression of left ventricular dysfunction and remodeling in dogs with heart failure
    George Suzuki
    Department of Medicine, Division of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute, Detroit, Mich, USA
    Circulation 106:2967-72. 2002
  7. ncbi request reprint Role of a selective aldosterone blocker in mice with chronic heart failure
    Dahai Wang
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202 2689, USA
    J Card Fail 10:67-73. 2004
  8. ncbi request reprint Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats
    Eileen R Blasi
    Pharmacia Corporation, Cardiovascular and Metabolic Diseases, Global Medical Affairs, and Global Toxicology, St Louis, Missouri 63167, USA
    Kidney Int 63:1791-800. 2003
  9. ncbi request reprint Aldosterone induces a vascular inflammatory phenotype in the rat heart
    Ricardo Rocha
    Division of Cardiovascular and Metabolic Diseases, Pharmacia Corporation, Skokie, IL 60077, USA
    Am J Physiol Heart Circ Physiol 283:H1802-10. 2002
  10. ncbi request reprint Eplerenone, a selective aldosterone blocker, improves diastolic function in aged rats with small-to-moderate myocardial infarction
    Serge Masson
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Card Fail 10:433-41. 2004

Collaborators

Detail Information

Publications11

  1. ncbi request reprint The role of the factor X activation peptide: a deletion mutagenesis approach
    Amy E Rudolph
    Department of Pathology, Division of Laboratory Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Thromb Haemost 88:756-62. 2002
    ..We propose that the fX AP and Asn191 carbohydrate serve primarily as negative autoregulation mechanisms to prevent spurious activation of fX and secondarily in cofactor dependence and activator specificity...
  2. ncbi request reprint Structural, functional, and molecular characterization of the SHHF model of heart failure
    Jonathan R R Heyen
    Pharmacia Corporation, 800 N Lindbergh Boulevard, St Louis, MO 63167, USA
    Am J Physiol Heart Circ Physiol 283:H1775-84. 2002
    ..In summary, the SHHF rat shares many hallmark features of the human disease state and represents a key experimental model for the dissection of complex human heart failure pathophysiology...
  3. ncbi request reprint Transgenic model of aldosterone-driven cardiac hypertrophy and heart failure
    Wenning Qin
    Department of Genomics Sciences, Pfizer, Inc, St Louis, MO 63167, USA
    Circ Res 93:69-76. 2003
    ..In addition, these data support the hypothesis that aldosterone blockade may provide additional therapeutic benefit in the treatment of heart failure...
  4. ncbi request reprint Aldosterone target organ protection by eplerenone
    Amy E Rudolph
    Pharmacia Corporation, Cardiovascular and Metabolic Diseases, 800 N Lindbergh Blvd, T1G T108W, St Louis, MO 63167, USA
    Mol Cell Endocrinol 217:229-38. 2004
    ....
  5. ncbi request reprint Molecular mechanisms of mineralocorticoid receptor antagonism by eplerenone
    Xiao Hu
    Department of Genomics and Biotechnology, Pfizer Inc, St Louis, MO 63017, USA
    Mini Rev Med Chem 5:709-18. 2005
    ....
  6. ncbi request reprint Effects of long-term monotherapy with eplerenone, a novel aldosterone blocker, on progression of left ventricular dysfunction and remodeling in dogs with heart failure
    George Suzuki
    Department of Medicine, Division of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute, Detroit, Mich, USA
    Circulation 106:2967-72. 2002
    ..Eplerenone is a novel selective aldosterone blocker. The present study examined the effects of long-term monotherapy with eplerenone on the progression of LV dysfunction and remodeling in dogs with chronic HF...
  7. ncbi request reprint Role of a selective aldosterone blocker in mice with chronic heart failure
    Dahai Wang
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202 2689, USA
    J Card Fail 10:67-73. 2004
    ....
  8. ncbi request reprint Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats
    Eileen R Blasi
    Pharmacia Corporation, Cardiovascular and Metabolic Diseases, Global Medical Affairs, and Global Toxicology, St Louis, Missouri 63167, USA
    Kidney Int 63:1791-800. 2003
    ..We evaluated the role of aldosterone as a mediator of renal inflammation and fibrosis in a rat model of aldosterone/salt hypertension using the selective aldosterone blocker, eplerenone...
  9. ncbi request reprint Aldosterone induces a vascular inflammatory phenotype in the rat heart
    Ricardo Rocha
    Division of Cardiovascular and Metabolic Diseases, Pharmacia Corporation, Skokie, IL 60077, USA
    Am J Physiol Heart Circ Physiol 283:H1802-10. 2002
    ....
  10. ncbi request reprint Eplerenone, a selective aldosterone blocker, improves diastolic function in aged rats with small-to-moderate myocardial infarction
    Serge Masson
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Card Fail 10:433-41. 2004
    ..05). Eplerenone normalized echocardiographic and hemodynamic evidences of diastolic dysfunction, as well as myocardial interstitial collagen and aortic fibrosis (all parameters statistically different from untreated MI)...
  11. ncbi request reprint Inhibition of p38 mitogen-activated protein kinase protects the heart against cardiac remodeling in mice with heart failure resulting from myocardial infarction
    Yun He Liu
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI 48202 2689, USA
    J Card Fail 11:74-81. 2005
    ....