Affiliation: Pharmacia and Upjohn
- Synthesis and anticonvulsant activity of a new class of 2-[(arylalky)amino]alkanamide derivativesP Pevarello
Department of Chemistry, CNS Preclinical Research, Nerviano, MI, Italy
J Med Chem 41:579-90. 1998....
- Synthesis and preliminary biological evaluation of new alpha-amino amide anticonvulsants incorporating a dextromethorphan moietyP Pevarello
Pharmacia and Upjohn, Chem Dept, Nerviano, Milan, Italy
Bioorg Med Chem Lett 9:1783-8. 1999..Here we describe the enantioselective and enantiospecific syntheses and the initial in vitro and in vivo biological evaluation of new hybrid structures between 1 and a previously disclosed alpha-amino amide anticonvulsant (3)...
- Sodium channel activity and sigma binding of 2-aminopropanamide anticonvulsantsP Pevarello
Pharmacia and Upjohn, Chem Dept, Milan, Italy
Bioorg Med Chem Lett 9:2521-4. 1999..No correlation could be drawn with sigma1 binding. Both anticonvulsant and Na+ channel blocking activities were independent of stereochemistry, while sigma1 binding seems to be favoured by an S-configuration on the aminoamide moiety...
- PNU-151774E protects against kainate-induced status epilepticus and hippocampal lesions in the ratR Maj
CNS Preclinical Research, Pharmacia and Upjohn SpA, Nerviano, MI, Italy
Eur J Pharmacol 359:27-32. 1998..Glutamate release inhibition may play a major role in neuroprotection, but an additional mechanism(s) of action might be relevant for the anticonvulsant activity of PNU-151774E in this model...